Download or read book Gene Therapy and Tissue Engineering in Orthopaedic and Sports Medicine written by Johnny Huard and published by Springer Science & Business Media. This book was released on 2013-03-11 with total page 294 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book has been written in response to the many physicians and scien tists working on the development of biological approaches to providing therapies for many orthopaedic disorders as well as to improving the healing of many tissues of the musculoskeletal system. The first goal of this book is to make the language compatible between the bench scientist and the clinician working in orthopaedic and sports medicine in order to cover specific areas of the orthopaedic discipline where the treatment can be improved and/or changed by the advancements in molecular medicine. Advancements in molecular biology, which encompass the study of the genetic basis of disease, have produced new diagnostic methods and drug therapies for genetic diseases and acquired disorders. The growth in the understanding of human genetics has also led to the initiation of many human gene therapy experiments. Although many approved therapeutic clinical trials using this new technology have been performed in the last ten years, the first clinical trial using this technology in the area of orthopaedics was performed at the University of Pittsburgh.
Download or read book Orthobiologics written by Giuseppe Filardo and published by Springer Nature. This book was released on 2021-12-02 with total page 394 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents the evidence related to the use of injectable biologics to provide faster and better healing for musculoskeletal lesions and conditions. The authors discuss approaches, such as blood derivatives and cell concentrates, applied to lesions of muscles, ligaments, tendons, bones, meniscus and cartilage, as well as osteoarthritis. Chapters are written by some of the most influential opinion leaders in the field, with up-to-date review of the current literature, where the authors explore both the potential and the limitations of these minimally invasive and promising treatments. The first section is devoted to the formulations and rationale for the use of injectable orthobiologics, while the second section reviews current treatment methods applied to specific joints and pathologies – ranging from tendinopathies through non-unions to articular degenerative processes – as well as the results of these treatment approaches. The third section explores future perspectives, such as pluripotent stem cells, gene therapy, and the stimulation of intrinsic stromal cell niches. Appealing to a broad readership, this book will be of interest to both laboratory research scientists and clinicians, including orthopedists, sports physicians, physiatrists, and regenerative medicine experts.
Download or read book Genetics of Bone Biology and Skeletal Disease written by Rajesh V. Thakker and published by Academic Press. This book was released on 2017-10-31 with total page 880 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genetics of Bone Biology and Skeletal Disease, Second Edition, is aimed at students of bone biology and genetics and includes general introductory chapters on bone biology and genetics. More specific disease orientated chapters comprehensively summarize the clinical, genetic, molecular, animal model, molecular pathology, diagnostic, counseling, and treatment aspects of each disorder. The book is organized into five sections that each emphasize a particular theme, general background to bone biology, general background to genetics and epigenetics, disorders of bone and joint, parathyroid and related disorders, and vitamin D and renal disorders. The first section is specifically devoted to providing an overview of bone biology and structure, joint and cartilage biology, principles of endocrine regulation of bone, and the role of neuronal regulation and energy homeostasis. The second section reviews the principles and progress of medical genetics and epigenetics related to bone disease, including genome-wide association studies (GWAS), genomic profiling, copy number variation, prospects of gene therapy, pharmacogenomics, genetic testing and counseling, as well as the generation and utilizing of mouse models. The third section details advances in the genetics and molecular biology of bone and joint diseases, both monogenic and polygenic, as well as skeletal dysplasias, and rarer bone disorders. The fourth section highlights the central role of the parathyroids in calcium and skeletal homeostasis by reviewing the molecular genetics of: hyperparathyroidism, hypoparathyrodism, endocrine neoplasias, and disorders of the PTH and calcium-sensing receptors. The fifth section details molecular and cellular advances across associated renal disorders such as vitamin D and rickets. - Identifies and analyzes the genetic basis of bone disorders in humans and demonstrates the utility of mouse models in furthering the knowledge of mechanisms and evaluation of treatments - Demonstrates how the interactions between bone and joint biology, physiology, and genetics have greatly enhanced the understanding of normal bone function as well as the molecular pathogenesis of metabolic bone disorders - Summarizes the clinical, genetic, molecular, animal model, molecular pathology, diagnostic, counseling, and treatment aspects of each disorder
Download or read book Gene Therapy and Tissue Engineering in Orthopaedic and Sports Medicine written by Johnny Huard and published by . This book was released on 2000 with total page 286 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book has been written in response to the many physicians and scien- tists working on the development of biological approaches to providing therapies for many orthopaedic disorders as well as to improving the healing of many tissues of the musculoskeletal system. The first goal of this book is to make the language compatible between the bench scientist and the clinician working in orthopaedic and sports medicine in order to cover specific areas of the orthopaedic discipline where the treatment can be improved and/or changed by the advancements in molecular medicine. Advancements in molecular biology, which encompass the study of the genetic basis of disease, have produced new diagnostic methods and drug therapies for genetic diseases and acquired disorders. The growth in the understanding of human genetics has also led to the initiation of many human gene therapy experiments. Although many approved therapeutic clinical trials using this new technology have been performed in the last ten years, the first clinical trial using this technology in the area of orthopaedics was performed at the University of Pittsburgh.
Download or read book Orthopaedic Surgery written by Mark Baratz and published by Thieme. This book was released on 1999 with total page 982 pages. Available in PDF, EPUB and Kindle. Book excerpt: Offering a complete, fully integrated approach to the entire field of orthopaedic surgery, this reference covers basic science, anatomy, surgical approaches, evaluation, treatment and anticipated outcome. Highlights include full discussions of: musculoskeletal soft tissues, joint pathology, imaging techniques, trauma, oncology, adult and pediatric orthopaedics, medical malpractice, and evolving telemedicine technology. The book's detailed yet easy-to-read format aids in implementing the practical tips and guidelines, highlighted throughout. With its complete approach, this book also provides the core curriculum for orthopaedic residents, including state-of-the-art sections on gene therapy, outpatient orthopaedics, new surgical procedures, and resource management.
Download or read book Orthobiologics written by Scott P Bruder and published by Lippincott Williams & Wilkins. This book was released on 2023-01-06 with total page 720 pages. Available in PDF, EPUB and Kindle. Book excerpt: Developed in partnership with the American Academy of Orthopaedic Surgeons (AAOS) and edited by internationally renowned experts Drs. Scott P. Bruder and Roy K. Aaron, Orthobiologics: Scientific and Clinical Solutions for Orthopaedic Surgeons provides authoritative, comprehensive coverage of this fast-growing field. This one-stop reference is an ideal resource, covering technology and basic science through specific clinical applications.
Download or read book Gene Therapy Applications written by Chunsheng Kang and published by BoD – Books on Demand. This book was released on 2011-08-23 with total page 506 pages. Available in PDF, EPUB and Kindle. Book excerpt: The aim of our book is to provide a detailed discussion of gene therapy application in human diseases. The book brings together major approaches: (1) Gene therapy in blood and vascular system, (2) Gene therapy in orthopedics, (3) Gene therapy in genitourinary system, (4) Gene therapy in other diseases. This source will make clinicians and researchers comfortable with the potential and problems of gene therapy application.
Download or read book Pediatric Orthopedic Deformities written by Frederic Shapiro and published by Elsevier. This book was released on 2002-01-16 with total page 975 pages. Available in PDF, EPUB and Kindle. Book excerpt: Specific operative and nonoperative techniques and their results are stressed. The book is extensively illustrated with drawings, most of which were made for this book, microscopy photos, and serial radiographs. The reader learns of pediatric orthopedic deformity in relation to normal and abnormal developmental biology, the worsening of untreated disease with growth, and the diagnostic and treatment interventions required based on the stage of progression.* Treatments are correlated with the pathologic state of the disorder* Discusses disorders from earliest onset to the final state showing how the altered biology leads to progressively greater clinical deformity* Initial chapter focuses on development bone biology stressing a broad based approach involving histologic, gene and molecular, and biomechanical features* Subsequent chapters discuss the pathogenesis of the various deformities, natural history, radiographic and imaging findings and orthopaedic and surgical management
Download or read book Translating Gene Therapy to the Clinic written by Jeffrey Laurence and published by Academic Press. This book was released on 2014-11-14 with total page 347 pages. Available in PDF, EPUB and Kindle. Book excerpt: Translating Gene Therapy to the Clinic, edited by Dr. Jeffrey Laurence and Michael Franklin, follows the recent, much-lauded special issue of Translational Research in emphasizing clinical milestones and critical barriers to further progress in the clinic. This comprehensive text provides a background for understanding the techniques involved in human gene therapy trials, and expands upon the disease-specific situations in which these new approaches currently have the greatest therapeutic application or potential, and those areas most in need of future research. It emphasizes methods, tools, and experimental approaches used by leaders in the field of translational gene therapy. The book promotes cross-disciplinary communication between the sub-specialties of medicine, and remains unified in theme. - Presents impactful and widely supported research across the spectrum of science, method, implementation and clinical application - Offers disease-based coverage from expert clinician-scientists, covering everything from arthritis to congestive heart failure, as it details specific progress and barriers for current translational use - Provides key background information from immune response through genome engineering and gene transfer, relevant information for practicing clinicians contemplating enrolling patients in gene therapy trials
Download or read book Repair and Regeneration of Ligaments Tendons and Joint Capsule written by William R. Walsh and published by Springer Science & Business Media. This book was released on 2007-10-28 with total page 332 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive and authoritative review of the most important scientific and clinically relevant topics today in ligaments, tendons, and capsular biology, including their biomechanics and surgical reconstruction. The authors review the basic science of tendons in the hand and shoulder ligaments, the current clinical status of the shoulder and cruciate ligaments, and the latest advances in research on the healing of ligament and tendon to bone, artificial ligaments, and gene therapy. They also cover the major type 1 collagen soft tissues that are of particular interest to upper extremity surgeons and sports medicine specialists.
Download or read book Regulatory Aspects of Gene Therapy and Cell Therapy Products written by Maria Cristina Galli and published by Springer. This book was released on 2015-09-15 with total page 235 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book discusses the different regulatory pathways for gene therapy (GT) and cell therapy (CT) medicinal products implemented by national and international bodies throughout the world (e.g. North and South America, Europe, and Asia). Each chapter, authored by experts from various regulatory bodies throughout the international community, walks the reader through the applications of nonclinical research to translational clinical research to licensure for these innovative products. More specifically, each chapter offers insights into fundamental considerations that are essential for developers of CT and GT products, in the areas of product manufacturing, pharmacology and toxicology, and clinical trial design, as well as pertinent "must-know" guidelines and regulations. Regulatory Aspects of Gene Therapy and Cell Therapy Products: A Global Perspective is part of the American Society of Gene and Cell Therapy sub-series of the highly successful Advances in Experimental Medicine and Biology series. It is essential reading for graduate students, clinicians, and researchers interested in gene and cell therapy and the regulation of pharmaceuticals.
Download or read book Tachdjian s Pediatric Orthopaedics E Book written by John A. Herring and published by Elsevier Health Sciences. This book was released on 2013-12-02 with total page 2662 pages. Available in PDF, EPUB and Kindle. Book excerpt: Continuing the tradition of excellence that began in 1972, this latest edition of Tachdjian s Pediatric Orthopaedics offers the detailed visual guidance; and unmatched expertise you need to effectively diagnose and treat pediatric musculoskeletal disorders. Extensive updates offer you the latest knowledge on etiology, imaging, differential diagnosis, and non-operative and surgical techniques for a wide range of pediatric orthopaedic conditions. "... delivers the most comprehensive text on this subject." Reviewed by Dr. Neel Kamal on behalf of BACCH Newsletter, March 2015 Access expert guidance on difficult diagnostic and clinical management issues for your most challenging cases. Perfect your technique with the visual guidance of nearly 2,500 full-color illustrations and 60 videos of pediatric surgical procedures, including a number that highlight clinical examination and unusual clinical findings. Produce the best possible outcomes using today's most effective approaches for management of severe spinal deformities, hip impingement, early-onset scoliosis, and other pediatric musculoskeletal conditions. See exactly how to proceed step-by-step with instructional videos demonstrating repair of bilateral dislocated hips, triple arthrodesis for planovalgus foot, patellofemoral ligament reconstruction, elbow arthroscopy, and more. Access the full contents online at Expert Consult.
Download or read book Rothman Simeone The Spine E Book written by Steven R. Garfin and published by Elsevier Health Sciences. This book was released on 2017-09-11 with total page 2127 pages. Available in PDF, EPUB and Kindle. Book excerpt: Get comprehensive, practical coverage of both surgical and non-surgical treatment approaches from the world's most trusted authorities in spine surgery and care. Rothman-Simeone and Herkowitz's The Spine, 7th Edition, edited by Drs. Steven R. Garfin, Frank J. Eismont, Gordon R. Bell, Jeffrey S. Fischgrund, and Christopher M. Bono, presents state-of-the-art techniques helping you apply today's newest developments in your practice. - Highlights critical information through the use of pearls, pitfalls, and key points throughout the text, as well as more than 2,300 full-color photographs and illustrations. - Offers a newly revised, streamlined format that makes it easier than ever to find the information you need. - Contains new chapters on the clinical relevance of finite element modeling and SI joint surgery. - Includes an expanded section on minimally invasive spine surgery, including recent developments and future directions. - Provides the latest evidence-based research from high-quality studies, including new randomized controlled trials for lumbar stenosis, surgery, fusion, and injections. - Presents the knowledge and expertise of new international contributors, as well as new editorial leadership from Dr. Steven Garfin. - Expert ConsultTM eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, and references from the book on a variety of devices.
Download or read book Turek s Orthopaedics written by Stuart L. Weinstein and published by Lippincott Williams & Wilkins. This book was released on 2005 with total page 830 pages. Available in PDF, EPUB and Kindle. Book excerpt: Now in its revised, updated Sixth Edition, this text provides residents and medical students with a broad overview of adult and pediatric orthopaedics. Major sections focus on general and regional disorders of the musculoskeletal system. This edition’s chapters on regional disorders have separate adult and pediatric sections and include sports medicine information and reviews of anatomy. Coverage of each disorder includes more details on treatment and prognosis. This edition also provides expanded coverage of molecular orthopaedics, biomaterials, orthotics and prosthetics, diagnosis by physical examination, commonly ordered laboratory tests, rehabilitation, biomechanics, principles of fractures, osteoporosis, overuse syndromes, and Achilles tendon rupture.
Download or read book Campbell s Operative Orthopaedics E Book written by Frederick M. Azar and published by Elsevier Health Sciences. This book was released on 2020-12-23 with total page 5530 pages. Available in PDF, EPUB and Kindle. Book excerpt: Still the most widely used comprehensive resource in orthopaedic surgery, Campbell's Operative Orthopaedics is an essential reference for trainees, a trusted clinical tool for practitioners, and the gold standard for worldwide orthopaedic practice. Unparalleled in scope and depth, this 14th Edition contains updated diagnostic images, practical guidance on when and how to perform every procedure, and rapid access to data in preparation for surgical cases or patient evaluation. Drs. Frederick M. Azar and James H. Beaty, along with other expert contributors from the world-renowned Campbell Clinic, have collaborated diligently to ensure that this 4-volume text remains a valuable resource in your practice, helping you achieve optimal outcomes with every patient. - Features evidence-based surgical coverage throughout to aid in making informed clinical choices for each patient. - Covers multiple procedures for all body regions to provide comprehensive coverage. - Keeps you up to date with even more high-quality procedural videos, a new chapter on biologics in orthopaedics, and expanded and updated content on hip arthroscopy, patellofemoral arthritis and more. - Follows a standard template for every chapter that features highlighted procedural steps, high-quality illustrations for clear visual guidance, and bulleted text. - Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices
Download or read book Cell Biology and Translational Medicine Volume 4 written by Kursad Turksen and published by Springer. This book was released on 2019-01-08 with total page 192 pages. Available in PDF, EPUB and Kindle. Book excerpt: Much research has focused on the basic cellular and molecular biological aspects of stem cells. Much of this research has been fueled by their potential for use in regenerative medicine applications, which has in turn spurred growing numbers of translational and clinical studies. However, more work is needed if the potential is to be realized for improvement of the lives and well-being of patients with numerous diseases and conditions. This book series 'Cell Biology and Translational Medicine (CBTMED)' as part of SpringerNature’s longstanding and very successful Advances in Experimental Medicine and Biology book series, has the goal to accelerate advances by timely information exchange. Emerging areas of regenerative medicine and translational aspects of stem cells are covered in each volume. Outstanding researchers are recruited to highlight developments and remaining challenges in both the basic research and clinical arenas. This current book is the fourth volume of a continuing series.
Download or read book Postgraduate Orthopaedics written by Paul A. Banaszkiewicz and published by Cambridge University Press. This book was released on 2012-08-16 with total page 301 pages. Available in PDF, EPUB and Kindle. Book excerpt: The must-have book for candidates preparing for the oral component of the FRCS (Tr and Orth).
