Download or read book Optimization of Flow through Radioactivity Detection in High performance Liquid Chromatography written by Antonie Cornelis Veltkamp and published by . This book was released on 1990 with total page 234 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Flow Through Radioactivity Detection in Hplc written by H. Parvez and published by VSP. This book was released on 1988-12 with total page 226 pages. Available in PDF, EPUB and Kindle. Book excerpt: First published in 1988. Routledge is an imprint of Taylor & Francis, an informa company.

Download or read book Analytical and Chromatographic Techniques in Radiopharmaceutical Chemistry written by Donald M. Wieland and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 305 pages. Available in PDF, EPUB and Kindle. Book excerpt: In 1906, Michael T. Sweet first developed the chromatographic method by using an adsorbant to separate pigments. Since that time, the technological advances in TLC and HPLC have brought about new definitions of purity in parallel with the advances. Radiopharmaceutical chemistry is especially dependent on the chromat ographic technique because of the relatively small amount of material in most radiopharmaceuticals-often so small that the usual physical methods of analytical chemistry cannot be used. As a result, this collection of papers represents the key to successful radiopharmaceutical development by setting the standard for the pres of radiochemical purity. ent-day definition William C. Eckelman, Ph.D. Diagnostics Associate Director The Squibb Institute for Medical Research New Brunswick, New Jersey Preface The chapters herein are updated and expanded versions of presentations that the authors made at a symposium held on June 4, 1984 in Los Angeles, California under the sponsorship of the Radiopharmaceutical Science Council of the Society of Nuclear Medicine. All manuscripts were refereed. The intent of the symposium organizers was to enlist participants who work on a day-to-day basis with the analytical and chromatographic techniques to be discussed at the symposium. We feel confident that this distillation of hands-on experience will be of value to graduate students as well as experienced researchers in radio pharmaceutical chemistry and related fields which use radiotracer methodology.

Download or read book Selective Sample Handling and Detection in High Performance Liquid Chromatography written by K. Zech and published by Elsevier. This book was released on 1989-10-30 with total page 407 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the second of a two-volume project which treats the handling, separation and detection of complex samples as an integrated, interconnected process. On the basis of this philosophy the editors have selected those contributions which demonstrate that optimal sample preparation leads to a simplification of detection or reduced demands on the separation process. Throughout the book emphasis is on chemical principles with minimum discussion of the equipment required - an approach which reflects the editors' view that the limiting factor in the analysis of complex samples is an incomplete knowledge of the underlying chemistry rather than the hardware available. This lack of knowledge becomes more evident as the demands for lower detection limits grow, as solving complex matrix problems requires a greater understanding of the chemical interaction between the substance to be analysed and the stationary phase. Thus, apart from one chapter dealing with chemically modified silicas, the main theme of the book is developed in three chapters on sample preparation and three on detection. The opening chapter outlines concentration and chromatography on chemically modified silicas with complexing properties, and gives examples of the use of these phases with organic and inorganic compounds. Chapter II, the first of the three contributions dealing with sample preparation, addresses such questions as whether the prepared sample is representative of the material to be analysed; how to avoid contamination; which separation procedure should be used to avoid tedious sample preparation. Chapter III describes the processing of whole blood for drug analysis. The determination of cyclosporine and its metabolites (an especially difficult case) demonstrates how comprehensive the optimisation of sample preparation must be to successfully perform the analysis. Several other examples are also given. Chapter IV deals with radio-column liquid chromatography and introduces the other theme of the book, i.e. selective detection methods. The widespread use of radioisotopes requires a high degree of purification during the manufacture of the compounds, as well as highly accurate detection methods in biological and biochemical studies. Chapter V continues the theme of selective detection with an overview of post-column reaction detection. The use of immobilised enzymes in post-column reactors or `pumpless' reactor systems for on-line reagent generation after the chromatographic separation step is discussed in detail. Various examples of the separation of biological compounds show how the production of electrochemical reagents and photochemical reaction detection have increased the selectivity of the detection, leading to more economical analytical systems. Selective detection employing luminescence detection techniques is outlined in Chapter VI. The use of immobilised fluorophores or the coupling to photochemical reactions leads to highly selective detection systems which can greatly simplify the sample handling. The final chapter reviews the use of continuous separation techniques in flow injection analysis thus revealing the need for a strong interdisciplinary dependence between sample handling and separation in this area. Written by experienced practitioners, this book will be extremely useful to investigators in many areas of application. Each chapter includes sufficient references to the literature to serve as a valuable starting point for more detailed investigation. The strong emphasis on sample handling makes the book unique in many ways and it will be welcomed by environmental scientists as well as those active in the clinical, pharmaceutical and bioanalytical fields.

Download or read book Methods for Improved Detection and Separation in High Performance Liquid Chromatography written by Siriwan Ratanathanawongs and published by . This book was released on 1986 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Optimization in HPLC written by Rudolf E. Kaiser and published by . This book was released on 1981 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Optimization of the Mobile Phase in High Performance Liquid Chromatography written by Bharati S. Patankar and published by . This book was released on 1985 with total page 168 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book High Performance Liquid Chromatography written by Phyllis R. Brown and published by Wiley-Interscience. This book was released on 1989-01-19 with total page 710 pages. Available in PDF, EPUB and Kindle. Book excerpt: Detectors for Liquid Chromatography Edited by Edward S. Yeung Written by an expert in the field, this comprehensive guide explains the basic principles behind detector response instrumentation and selected applications. Early chapters cover absorption detectors for high performance liquid chromatography, FTIR detection, indirect absorbance detectors, fluorometric detection, and polarimetric detectors. Coverage continues with detection based on electrical and electrochemical measurements, mass spectrometry as an online detector for HPLC, and miscellaneous methods. 1986 0 471-82169-1 366 pp. Small Bore High Performance Liquid Chromatography Edited by Raymond R. W. Scott A state-of-the-art guide that demonstrates how to design, construct, and pack optimized small bore columns, the center of any chromatography system. Case examples show the use of these columns for high resolution, very fast analysis, and special methods for molecular weight determinations. Applications from a wide range of industrial and forensic analyses aid in developing sophistication in a number of useful techniques. The book provides essential information on topics such as calculating the minimum column radius, detectors, and molecular diffusion. Includes 92 illustrations and 14 tables to enhance explanations of microbore HPLC methods. 1984 0 471-80052-X 271 pp. Reversed-Phase High Performance Liquid Chromatography: Theory, Practice, and Biomedical Applications Ante M. Krstulovic and Phyllis R. Brown Reversed-phase liquid chromatography has increased tremendously in popularity over the past ten years. Estimates show that more than 80% of all HPLC separations are performed using this technique. This book covers both theoretical aspects of RPLC and practical information needed in diverse areas of research; it also contains a review of the RPLC applications in the biomedical/biochemical field, with references and collateral readings. Material is presented in a practical, problem-solving manner and should be immensely useful in theoretical aspects of RPLC and all areas of scientific research, particularly the biomedical/biochemical field, where RPLC has made its largest impact. 1982 0 471-05369-4 296 pp.

Download or read book Applications of High Performance Liquid Chromatography written by Andrew Pryde and published by Chapman & Hall. This book was released on 1979 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Optimization of High Performance Liquid Chromatography by Computer Simulation written by Teresa J. Amiss and published by . This book was released on 1985 with total page 238 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Computer aided Optimisation in Liquid Chromatography written by A. G. Wright and published by . This book was released on 1988 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Studies Using Flow Injection Analysis and Post column Reaction Detection Analysis with High Performance Liquid Chromatography written by and published by . This book was released on 1985 with total page 175 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Radiotracers in Drug Development written by Graham Lappin and published by CRC Press. This book was released on 2006-04-03 with total page 321 pages. Available in PDF, EPUB and Kindle. Book excerpt: Although there are numerous books on drug metabolism, Radiotracers in Drug Development is unique in explaining how radiotracers are used to elucidate a drug's absorption, distribution, metabolism, and excretion (ADME). Covering traditional and recent technologies and applications, the book takes a strong industrial approach, discussing the b

Download or read book Radiochromatography written by and published by Elsevier. This book was released on 2011-08-26 with total page 185 pages. Available in PDF, EPUB and Kindle. Book excerpt: Radiochromatography

Download or read book Scientific and Technical Aerospace Reports written by and published by . This book was released on 1991 with total page 1460 pages. Available in PDF, EPUB and Kindle. Book excerpt: Lists citations with abstracts for aerospace related reports obtained from world wide sources and announces documents that have recently been entered into the NASA Scientific and Technical Information Database.

Download or read book Charged Aerosol Detection for Liquid Chromatography and Related Separation Techniques written by Paul H. Gamache and published by John Wiley & Sons. This book was released on 2017-05-30 with total page 548 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first book devoted exclusively to a highly popular, relatively new detection technique Charged Aerosol Detection for Liquid Chromatography and Related Separation Techniques presents a comprehensive review of CAD theory, describes its advantages and limitations, and offers extremely well-informed recommendations for its practical use. Using numerous real-world examples based on contributors’ professional experiences, it provides priceless insights into the actual and potential applications of CAD across a wide range of industries. Charged aerosol detection can be combined with a variety of separation techniques and in numerous configurations. While it has been widely adapted for an array of industrial and research applications with great success, it is still a relatively new technique, and its fundamental performance characteristics are not yet fully understood. This book is intended as a tool for scientists seeking to identify the most effective and efficient uses of charged aerosol detection for a given application. Moving naturally from basic to advanced topics, the author relates fundamental principles, practical uses, and applications across a range of industrial settings, including pharmaceuticals, petrochemicals, biotech, and more. Offers timely, authoritative coverage of the theory, experimental techniques, and end-user applications of charged aerosol detection Includes contributions from experts from various fields of applications who explore CAD’s advantages over traditional HPLC techniques, as well its limitations Provides a current theoretical and practical understanding of CAD, derived from authorities on aerosol technology and separation sciences Features numerous real-world examples that help relate fundamental properties and general operational variables of CAD to its performance in a variety of conditions Charged Aerosol Detection for Liquid Chromatography and Related Separation Techniques is a valuable resource for scientists who use chromatographic techniques in academic research and across an array of industrial settings, including the biopharmaceutical, biotechnology, biofuel, chemical, environmental, and food and beverage industries, among others.

Download or read book Handbook of Radioactivity Analysis written by Michael F. L'Annunziata and published by Academic Press. This book was released on 2020-03-07 with total page 1076 pages. Available in PDF, EPUB and Kindle. Book excerpt: Handbook of Radioactivity Analysis: Radiation Physics and Detectors, Volume One, and Radioanalytical Applications, Volume Two, Fourth Edition, constitute an authoritative reference on the principles, practical techniques and procedures for the accurate measurement of radioactivity - everything from the very low levels encountered in the environment, to higher levels measured in radioisotope research, clinical laboratories, biological sciences, radionuclide standardization, nuclear medicine, nuclear power, and fuel cycle facilities, and in the implementation of nuclear forensic analysis and nuclear safeguards. It includes sample preparation techniques for all types of matrices found in the environment, including soil, water, air, plant matter and animal tissue, and surface swipes.Users will find the latest advances in the applications of radioactivity analysis across various fields, including environmental monitoring, radiochemical standardization, high-resolution beta imaging, automated radiochemical separation, nuclear forensics, and more. Spans two volumes, Radiation Physics and Detectors and Radioanalytical Applications Includes a new chapter on the analysis of environmental radionuclides Provides the latest advances in the applications of liquid and solid scintillation analysis, alpha- and gamma spectrometry, mass spectrometric analysis, Cherenkov counting, flow-cell radionuclide analysis, radionuclide standardization, aerosol analysis, high-resolution beta imaging techniques, analytical techniques in nuclear forensics, and nuclear safeguards Describes the timesaving techniques of computer-controlled automatic separation and activity analysis of radionuclides Provides an extensive table of the radiation characteristics of most radionuclides of interest for the radioanalytical chemist