Download or read book Optimization of Chromatographic Selectivity written by P.J. Schoenmakers and published by Elsevier. This book was released on 1986-08-01 with total page 344 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the first detailed description of method development in chromatography - the overall process of which may be summarized as: method selection, phase selection, selectivity optimization, and system optimization. All four aspects receive attention in this book. Chapter 1 gives a short introduction, describes chromatographic theory and nomenclature, and outlines the method development process. Chapter 2 describes guidelines for method selection, and quantitative concepts for characterizing and classifying chromatographic phases. Selective separation methods, from both gas and liquid chromatography are given in Chapter 3; the main parameters of each method are identified and simple, quantitative relations are sought to describe their effects. Criteria by which to judge the quality of separation are discussed in Chapter 4 with clear recommendations for different situations. The specific problems involved in the optimization of chromatographic selectivity are explained in Chapter 5. Optimization procedures, illustrated by examples, are extensively described and compared on the basis of a number of criteria. Suggestions are made both for the application of different procedures and for further research. The optimization of programmed analysis receives special attention in Chapter 6, and the last chapter summarizes the optimization of the chromatographic system, including the optimization of the efficiency, sensitivity and instrumentation. Those involved in developing chromatographic methods or wishing to improve existing methods will value the detailed, structured way in which the subject is presented. Because optimization procedures and criteria are described as elements of a complete optimization package, the book will help the reader to understand, evaluate and select current and future commercial systems.
Download or read book Optimization of Chromatographic Selectivity written by Peter J. Schoenmakers and published by . This book was released on 1986 with total page 345 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Selectivity and Detectability Optimizations in HPLC written by Satinder Ahuja and published by John Wiley & Sons. This book was released on 1989-06-06 with total page 642 pages. Available in PDF, EPUB and Kindle. Book excerpt: High Performance Liquid Chromatography Edited by Phyllis Brown and Richard Hartwick This contributed volume is designed to consolidate the basic theories of chromatography along with the more exciting developments in the field. This monograph addresses some questions that concern researchers in separation science, including: what is the current state of the art in liquid chromatography; has the development of liquid chromatography plateaued; if so, what new methods will take its place or complement it; and if not, where will the new frontiers be and what direction will liquid chromatography take? 1989 (0 471-84506-X) 688 pp. Quantitative Structure-Chromatographic Retention Relationships R. Kaliszan Written by a pioneer in the field, this book extends and updates research on quantitative structure retention relationships by consolidating and critically reviewing the extensive literature on the subject, while also providing the basic theoretical and practical information required in all investigations involving chromatography, analytical chemistry, biochemistry, and pharmaceutical research. Among the topics covered are the nature of chromatographic interactions, molecular interpretation of distribution processes in chromatography, topological indices as retention descriptors, and multiparameter structure-chromatographic retention relationships. 1987 (0 471-85983-4) 303 pp. Detectors for Liquid Chromatography Edited by Edward S. Yeung With its singular coverage of this fast-growing field, Detectors for Liquid Chromatography presents the state of the art in this subject area. It offers a comprehensive examination of the basic principles behind the detector response, instrumentation, and selected applications for comparison and evaluation of potential. Specifically, topics given in-depth coverage include polarimetric, indirect absorbance, refractive index detectors, absorption detectors for HPLC, FTIR and fluorometric detection, detection based on electrical and electromechanical measurements, and mass spectroscopy as an on-line detector for HPLC. 1986 (0 471-82169-1) 366 pp.
Download or read book HPLC Made to Measure written by Stavros Kromidas and published by John Wiley & Sons. This book was released on 2008-06-05 with total page 786 pages. Available in PDF, EPUB and Kindle. Book excerpt: The only topical HPLC book to focus on optimization, this volume addresses the needs of HPLC users who wish to constantly improve their methods, in particular in terms of throughput, accuracy and cost-effectiveness. This handbook features contributions from such bestselling authors as John W. Dolan, Michael McBrien, Veronika R. Meyer, Uwe D. Neue, Lloyd R. Snyder, and Klaus K. Unger, as well as from scientists working for major companies, including Agilent, AstraZeneca, Merck, Schering, Tosoh Biosep, VWR, and Waters. It covers essential aspects of optimization in general, optimization in different LC-modi, hyphenated techniques and computer-aided optimization. The whole is rounded off with a section of user reports.
Download or read book Selectivity and Optimization in Capillary Electrophoresis written by Ziad El Rassi and published by Elsevier Science & Technology. This book was released on 1998 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: As in all chemical separation methods, selectivity is an important parameter for achieving separation. Also important is the optimization of the separation conditions to achieve high plate counts, speed and resolution. Obviously, in any given separation process, no separation can take place in the absence of selectivity even if millions of theoretical plates are easily attained.This thematic issue of Journal of Chromatography A recognizes the importance of selectivity and optimization in maximizing separation in capillary electrophoresis by providing the reader with several review and research articles from experts in the field. The thematic issue is organized into six major parts, and in each part pertinent review articles are collected first followed by a number of original contributions.This special volume has treated many of the selectivity and optimization issues that address the needs of those who use capillary electrophoresis. This will facilitate the widespread use of capillary electrophoresis as an important analytical separation tool for solving separation problems of practical importance in the life and other sciences.
Download or read book Retention and Selectivity in Liquid Chromatography written by R.M. Smith and published by Elsevier. This book was released on 1995-01-13 with total page 456 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book brings together a number of studies which examine the ways in which the retention and selectivity of separations in high-performance liquid chromatography are dependent on the chemical structure of the analytes and the properties of the stationary and mobile phases. Although previous authors have described the optimisation of separations by alteration of the mobile phase, little emphasis has previously been reported of the influence of the structure and properties of the analyte. The initial chapters describe methods based on retention index group increments and log P increments for the prediction of the retention of analytes and the ways in which these factors are influenced by mobile phases and intramolecular interactions. The values of a wide range of group increments in different eluents are tabulated. Different scales of retention indices in liquid chromatography are described for the comparison of separations, the identification of analytes and the comparison of stationary phases. Applications of these methods in the pharmaceutical, toxicology, forensic, metabolism, environmental, food and other fields are reviewed. The effects of different mobile phases on the selectivity of the retention indices are reported. A compilation of sources of reported retention index values are given. Methods for the comparison of stationary phases based on the interactions of different analytes are covered, including lipophilic and polar indices, shape selectivity comparisons, their application to novel stationary phases, and chemometric methods for column comparisons.
Download or read book Chromatography Today written by C.F. Poole and published by Elsevier. This book was released on 2012-12-02 with total page 1037 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chromatography Today provides a comprehensive coverage of various separation methods: gas, liquid, thin-layer, and supercritical fluid-chromatography, and capillary electrophoresis. Particular attention is paid to the optimization of these techniques in terms of kinetic parameters and retention mechanisms. When these facts are understood, method selection and optimization becomes a more logical process. Sample preparation methods are treated fully as they frequently represent an integral part of the total analytical method. Also described are preparative-scale separations used for isolating significant amounts of product which are generally achieved under conditions that are not identical to those used for analytical separations. The most common hyphenated methods used for sample identification are discussed from the perspective of the information they yield and the requirements of common interfaces. The scope and level of discussion are designed to be appropriate for various user groups. This book should be suitable for use as a graduate-level student textbook in separation science, a text for professional institutes offering short courses in chromatography, and as a self-study guide for chromatographers to refresh their knowledge of the latest developments in the field. The book is extensively illustrated with over 200 figures, 110 tables and 3,300 references, largely to the contemporary literature.
Download or read book Modern Practice of Gas Chromatography written by Robert L. Grob, PhD and published by John Wiley & Sons. This book was released on 2004-08-04 with total page 1059 pages. Available in PDF, EPUB and Kindle. Book excerpt: The bible of gas chromatography-offering everything the professional and the novice need to know about running, maintaining, and interpreting the results from GC Analytical chemists, technicians, and scientists in allied disciplines have come to regard Modern Practice of Gas Chomatography as the standard reference in gas chromatography. In addition to serving as an invaluable reference for the experienced practitioner, this bestselling work provides the beginner with a solid understanding of gas chromatographic theory and basic techniques. This new Fourth Edition incorporates the most recent developments in the field, including entirely new chapters on gas chromatography/mass spectrometry (GC/MS); optimization of separations and computer assistance; high speed or fast gas chromatography; mobile phase requirements: gas system requirements and sample preparation techniques; qualitative and quantitative analysis by GC; updated information on detectors; validation and QA/QC of chromatographic methods; and useful hints for good gas chromatography. As in previous editions, contributing authors have been chosen for their expertise and active participation in their respective areas. Modern Practice of Gas Chromatography, Fourth Edition presents a well-rounded and comprehensive overview of the current state of this important technology, providing a practical reference that will greatly appeal to both experienced chomatographers and novices.
Download or read book Handbook of HPLC written by Danilo Corradini and published by CRC Press. This book was released on 2011-01-03 with total page 1018 pages. Available in PDF, EPUB and Kindle. Book excerpt: Delineating its usage in separation, purification and detection processes across a variety of disciplines, from industry to applied research, this work discusses the principles, techniques and instrumentation involving HPLC within a detailed framework. Over 100 tables present previously scattered experimental data.
Download or read book High Performance Liquid Chromatography written by Mary T. Gilbert and published by Elsevier. This book was released on 2013-10-22 with total page 397 pages. Available in PDF, EPUB and Kindle. Book excerpt: High Performance Liquid Chromatography focuses on the developments, operating techniques, practices, equipment, and packing materials involved in High Performance Liquid Chromatography (HPLC). The book first offers information on basic chromatographic theory, equipment, and the column. Topics include resolution, efficiency, pumps and gradient systems, connectors, detectors, injectors, column packing and testing, packing materials, and coupling of columns. The text also ponders on sample treatment and separation methods, as well as trace analysis, reversed phase chromatography, and selection/optimization conditions. The publication examines adjustment of selectivity by the use of eluent additives and preparative liquid chromatography. Discussions focus on chromatography on dynamically modified oxide gels, metal complexation, crown ethers, ion pair chromatography, materials for preparative chromatography, and separation strategy. The text also reviews the trends in the practice of HPLC and chiral chromatography. The book is a dependable reference for readers interested in High Performance Liquid Chromatography.
Download or read book Optimization in HPLC written by Stavros Kromidas and published by John Wiley & Sons. This book was released on 2021-11-08 with total page 418 pages. Available in PDF, EPUB and Kindle. Book excerpt: Learn to maximize the performance of your HPLC or UHPLC system with this resource from leading experts in the field Optimization in HPLC: Concepts and Strategies delivers tried-and-tested strategies for optimizing the performance of HPLC and UHPLC systems for a wide variety of analytical tasks. The book explains how to optimize the different HPLC operation modes for a range of analyses, including small molecules, chiral substances, and biomolecules. It also shows readers when and how computational tools may be used to optimize performance. The practice-oriented text describes common challenges faced by users and developers of HPLC and UHPLC systems, as well as how those challenges can be overcome. Written for first-time and experienced users of HPLC technology and keeping pace with recent developments in HPLC instrumentation and operation modes, this comprehensive guide leaves few questions unanswered. Readers will also benefit from the inclusion of: A thorough introduction to optimization strategies for different modes and uses of HPLC, including working under regulatory constraints An exploration of computer aided HPLC optimization, including ChromSwordAuto and Fusion QbD A treatment of current challenges for HPLC users in industry as well as large and small analytical service providers Discussions of current challenges for HPLC equipment suppliers Tailor-made for analytical chemists, chromatographers, pharmacologists, toxicologists, and lab technicians, Optimization in HPLC: Concepts and Strategies will also earn a place on the shelves of analytical laboratories in academia and industry who seek a one-stop reference for optimizing the performance of HPLC systems.
Download or read book Practical High Performance Liquid Chromatography written by Veronika R. Meyer and published by John Wiley & Sons. This book was released on 2004-10 with total page 378 pages. Available in PDF, EPUB and Kindle. Book excerpt: Publisher Description
Download or read book Chemometrics in Chromatography written by Łukasz Komsta and published by CRC Press. This book was released on 2018-02-02 with total page 678 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chemometrics uses advanced mathematical and statistical algorithms to provide maximum chemical information by analyzing chemical data, and obtain knowledge of chemical systems. Chemometrics significantly extends the possibilities of chromatography and with the technological advances of the personal computer and continuous development of open-source software, many laboratories are interested in incorporating chemometrics into their chromatographic methods. This book is an up-to-date reference that presents the most important information about each area of chemometrics used in chromatography, demonstrating its effective use when applied to a chromatographic separation.
Download or read book Liquid Chromatography written by G. Ramis-Ramos and published by Elsevier Inc. Chapters. This book was released on 2013-01-08 with total page 520 pages. Available in PDF, EPUB and Kindle. Book excerpt: Many solvents can be used to prepare mobile phases in liquid chromatography. Also, mixtures of solvents at different ratios are used to modify the mobile phase properties. This can make solvent selection for method development a hard task, unless suitable guidelines are followed. This chapter summarizes the most common strategies used by skilled chromatographists in reversed-phase, normal-phase, and hydrophilic interaction liquid chromatography. These are based on considerations about the global polarity of solutes, stationary phase and mobile phase, which determine the elution strength, and on the particular profile of the contributions of intermolecular interactions to the global polarity, which determines the selectivity. The optimization of selectivity using isoeluotropic mixtures on the rational basis provided by solvent selectivity triangles and systematic trial-and-error procedures in the isocratic and gradient elution modes is described. Additional considerations for mobile-phase selection, including computer-assisted interpretive optimization, sustainability criteria, and the use of high temperatures, are also commented.
Download or read book Encyclopedia of Chromatography written by Jack Cazes and published by CRC Press. This book was released on 2005 with total page 996 pages. Available in PDF, EPUB and Kindle. Book excerpt: A convenient source of information for workers in analytical chemistry, experimental biology, physics, and engineering, this Second Edition stands as a quick reference source and clear guide to specific chromatographic techniques and principles-providing a basic introduction to the science and technology of the method, as well as additional references on the theory and methodology for analysis of specific chemicals and applications in a range of industries.
Download or read book Chromatography A Century of Discovery 1900 2000 The Bridge to The Sciences Technology written by and published by Elsevier. This book was released on 2001-12-18 with total page 740 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chromatography - A Century of Discovery 1900-2000 represents the combined thinking and contributions of many chromatographers. It includes several in-depth feature chapters covering the Beginnings of Chromatography, which highlights M.S. Tswett, the inventor of chromatography, and several other early pioneers. Included are the contributions of several Nobel Laureates,and 125 Chromatography Award Winners and contributors, an extensive bibliography of publications on the History of the Evolution of Chromatography; a presentation of Major International Symposia supporting chromatography and as a bridge to selected sciences. Special chapters are written by well-known Chromatographers on Support and Stationary Phases, and Separations followed by a chapter on Milestones and Paradigm Shifts in Science. New discoveries in the life sciences and medicine, agriculture, the environment and separations technology in the 21st century will rely immeasurably on the 20th century research tools in chromatography and those yet to be developed.
Download or read book High Performance Liquid Chromatography in Pesticide Residue Analysis written by Tomasz Tuzimski and published by CRC Press. This book was released on 2015-12-01 with total page 582 pages. Available in PDF, EPUB and Kindle. Book excerpt: HPLC is the principal separation technique for identification of the pesticides in environmental samples and for quantitative analysis of analytes. At each stage of the HPLC procedure, the chromatographer should possess both the practical and theoretical skills required to perform HPLC experiments correctly and to obtain reliable, repeatable, and reproducible results. Developed to serve as a detailed practical guide, High Performance Liquid Chromatography in Pesticide Residue Analysis is a comprehensive source of information and training on state-of-the-art pesticide residue methods performed with the aid of HPLC. The book presents the pros and cons of HPLC as a flexible and versatile separation and analysis tool with multiple purposes and advantages in investigations of pesticides for food and plant drugs standardization, promotion of health, protection of new herbal medicines, and more.
