Download or read book Optimization of Aerosol Drug Delivery written by Leon Gradon and published by Springer Science & Business Media. This book was released on 2003-11-30 with total page 330 pages. Available in PDF, EPUB and Kindle. Book excerpt: Aerosol therapy has significantly improved the treatment of a variety of respiratory diseases. Besides the treatment of respiratory diseases there is currently also a great interest to use the lungs as a portal to introduce drugs for systemic therapy. The success of therapy with the application of aerosolized medicaments depends on the possibility to deliver the proper amount of drug to the appropriate sites in the respiratory system, thus limiting the side effects to a minimum. Aerosolized delivery of drugs to the lung is optimized if, for a given chemical composition of a medicine, the target of deposition and the required mass of drug to be deposited are precisely defined. The next step is the specification of the number of respirable particles or droplets, to be generated by appropriate devices. Another very important factor for successful aerosol therapy is the condition of the patient coupled with his or her inhalation technique.
Download or read book Quality by Design Optimization of Intraperitoneal Drug Delivery with Pressurized Aerosols written by Iaroslav Sautkin and published by . This book was released on 2024 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Controlled Pulmonary Drug Delivery written by Hugh D.C. Smyth and published by Springer Science & Business Media. This book was released on 2011-06-24 with total page 560 pages. Available in PDF, EPUB and Kindle. Book excerpt: The pace of new research and level of innovation repeatedly introduced into the field of drug delivery to the lung is surprising given its state of maturity since the introduction of the pressurized metered dose inhaler over a half a century ago. It is clear that our understanding of pulmonary drug delivery has now evolved to the point that inhalation aerosols can be controlled both spatially and temporally to optimize their biological effects. These abilities include controlling lung deposition, by adopting formulation strategies or device technologies, and controlling drug uptake and release through sophisticated particle technologies. The large number of contributions to the scientific literature and variety of excellent texts published in recent years is evidence for the continued interest in pulmonary drug delivery research. This reference text endeavors to bring together the fundamental theory and practice of controlled drug delivery to the airways that is unavailable elsewhere. Collating and synthesizing the material in this rapidly evolving field presented a challenge and ultimately a sense of achievement that is hopefully reflected in the content of the volume.
Download or read book Treatise on Controlled Drug Delivery written by Agis F. Kydonieus and published by CRC Press. This book was released on 2017-10-02 with total page 568 pages. Available in PDF, EPUB and Kindle. Book excerpt: An introductory but detailed treatise which includes some 1,000 references and solved examples and end-of-chapter problems, making it useful to both students and practitioners. The pharmokinetics, pharmacodynamics, and biological and biopharmaceutical parameters pertinent to each route of administra
Download or read book Respiratory Drug Delivery IV written by and published by . This book was released on 1994 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Aerosolized Surfactants written by Susan Boc and published by . This book was released on 2018 with total page 283 pages. Available in PDF, EPUB and Kindle. Book excerpt: The overall aim of this research project was to develop surfactant dry powder formulations and devices for efficient delivery of aerosol formulations to infants using the excipient enhanced growth (EEG) approach. Use of novel formulations and inline delivery devices would allow for more efficient treatment of infants suffering from neonatal respiratory distress syndrome and bronchiolitis. A dry powder aerosol formulation has been developed using the commercial product, Survanta ® (beractant) and EEG technology to produce micrometer-sized hygroscopic particles. Spray drying and formulation parameters were initially determined with dipalmitoylphosphatidylcholine (DPPC, the dominant phospholipid in pulmonary surfactant), which produced primary particles 1 mm in size with a mass median aerodynamic diameter of 1-2 mm. Investigation of dry powder dispersion enhancers and alcohol concentration on the effect of powder aerosol characteristics were performed with the Survanta-EEG formulation. The optimal formulation consisted of Survanta®, mannitol and sodium chloride as hygroscopic excipients, and leucine as the dry powder dispersion enhancer, prepared in 20% v/v ethanol/water. The powders produced primary particles of 1 mm with>50% of the particles less than 1 mm. The presence of surfactant proteins and surface activity were demonstrated with the Survanta-EEG formulation following processing. A novel containment unit dry powder inhaler (DPI) was designed for delivery of the surfactant-EEG formulation using a low volume of dispersion air. Studies explored optimization of air entrainment pathway, inlet hole pattern, delivery tube internal diameter and length. With 3-10 mg fill masses of spray dried surfactant powder, the DPI enabled delivery of>2 mg using one 3-mL actuation of dispersion air. Overall, it was possible to deliver>85% of the loaded fill mass using three actuations. Nebulized aerosol formulations are characterized with low delivered doses. Using a novel mixer-heater delivery system, the highest estimated percent lung dose achieved during realistic in vitro testing of a Survanta-EEG formulation aerosolized with a commercial mesh nebulizer was when nebulization was synchronized with inhalation of the breathing profile. Design changes to the mixer-heater system eliminated the need for synchronization, achieving an estimated percent lung dose of 31% of the nominal, an improvement compared with existing systems that achieve approximately
Download or read book Pharmaceutical Drug Product Development and Process Optimization written by Sarwar Beg and published by CRC Press. This book was released on 2020-05-01 with total page 382 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pharmaceutical manufacturers are constantly facing quality crises of drug products, leading to an escalating number of product recalls and rejects. Due to the involvement of multiple factors, the goal of achieving consistent product quality is always a great challenge for pharmaceutical scientists. This volume addresses this challenge by using the Quality by Design (QbD) concept, which was instituted to focus on the systematic development of drug products with predefined objectives to provide enhanced product and process understanding. This volume presents and discusses the vital precepts underlying the efficient, effective, and cost effective development of pharmaceutical drug products. It focuses on the adoption of systematic quality principles of pharmaceutical development, which is imperative in achieving continuous improvement in end-product quality and also leads to reducing cost, time, and effort, while meeting regulatory requirements. The volume covers the important new advances in the development of solid oral dosage forms, modified release oral dosage forms, parenteral dosage forms, semisolid dosage forms, transdermal drug, delivery systems, inhalational dosage forms, ocular drug delivery systems, nanopharmaceutical products, and nanoparticles for oral delivery.
Download or read book RDD 2010 Florida written by and published by . This book was released on 2010 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Advances in Pulmonary Drug Delivery written by Philip Chi Lip Kwok and published by CRC Press. This book was released on 2016-12-19 with total page 201 pages. Available in PDF, EPUB and Kindle. Book excerpt: The respiratory tract has been used to deliver biologically active chemicals into the human body for centuries. However, the lungs are complex in their anatomy and physiology, which poses challenges to drug delivery. Inhaled formulations are generally more sophisticated than those for oral and parenteral administration. Pulmonary drug development is therefore a highly specialized area because of its many unique issues and challenges. Rapid progress is being made and offers novel solutions to existing treatment problems. Advances in Pulmonary Drug Delivery highlights the latest developments in this field.
Download or read book RDD 2012 Arizona Conference papers written by Richard N. Dalby and published by . This book was released on 2012 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Respiratory Drug Delivery X 2006 Scientific poster abstracts written by Richard N. Dalby and published by . This book was released on 2006 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Optimization of topical drug delivery by the application of physiochemical principles to in vitro and in vivo diffusion of drugs from liquid formulations written by Janet Carol Walkow and published by . This book was released on 1982 with total page 340 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Controversies in COPD written by Antonio Anzueto and published by European Respiratory Society. This book was released on 2015-09-01 with total page 341 pages. Available in PDF, EPUB and Kindle. Book excerpt: COPD is one of the most common diseases worldwide and is projected to be the third leading cause of death by 2020. But that does not mean it is easy to understand or manage. In everyday practice, pulmonologists face areas of controversy in COPD, for which evidence-based medicine is often unavailable. This ERS Monograph considers where the current controversies in COPD lie, discussing areas such as screening, premature birth, asthma–COPD overlap syndrome, treatment, rehabilitation and palliative care. This book will be of great interest to both clinicians and scientists, and aims to stimulate further discussion about this diverse and fascinating disease. "...contains a vast amount of information on the disease, its prevalence, signs and symptoms, diagnositc tests and treatment options. The book's format makes it quick and simple to find out what you need to know, and its size would make it easy to take to work for use in practice [...] invaluable for anyone working with patients with the disease." Emma Vincent, Nursing Standard
Download or read book Strategies and Devices for Improving Respiratory Drug Delivery to Infants and Children with Cystic Fibrosis written by Karl Bass and published by . This book was released on 2020 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Cystic Fibrosis (CF) is a degenerative disease, which causes thickening of the airway surface liquid and reduced mucociliary clearance, which provides an ideal habitat for bacterial infections. Early treatment of CF in children can prevent chronic infection, improve quality of life, and increase life expectancy. The most predominant bacteria found in CF-diseased lungs is Pseudomonas aeruginosa (Pa), which can be treated with inhaled tobramycin. Excipient enhanced growth (EEG) powder formulations are well suited for administering tobramycin to children, as the EEG approach provides minimal upper airway loss and targeted drug delivery. This method uses an initially small aerosol for high extrathroacic transmission, and includes hygroscopic excipients within the formulation that absorb moisture from the humid airways and increase lung retention of the aerosol. The overarching goal of this work was to develop delivery systems and strategies for improving respiratory drug delivery to children with CF, which was based on insights from computational fluid dynamics (CFD) simulations and in vitro models. The studies presented in this dissertation have three distinct and sequential phases: (i) CFD methods development; (ii) respiratory device design and optimization; and (iii) complete-airway modeling for aerosol delivery strategy development. The methods development phase produced meshing and solution guidelines that were computationally-efficient, accurate, and validated based on in vitro data. Results showed that the two-equation k-Ï9 model, with near-wall corrections, was capable of matching experimental data across a range of Reynolds numbers and particle sizes that are specific to respiratory drug delivery. The guidelines also provided comparable accuracy to the more complex Large Eddy Simulation (LES) model, while providing multiple order-of-magnitude savings in computational time. The device optimization phase developed a highly efficient delivery system for tobramycin administration to pediatric CF patients. Correlations were developed, based on flow field quantities, that were predictive of aerosolization performance and depositional loss. Successful a priori validation with experimental testing highlighted the predictive capabilities of the correlations and CFD model accuracy. The best-case delivery system demonstrated an aerosol size of approximately 1.5 ℗æm and expected lung dose of greater than 75% of loaded dose, which is a marked improvement compared to commercial devices. The delivery strategy development phase identified optimal EEG aerosol properties that better unify drug surface concentration. These studies present numerical models of a tobramycin EEG powder formulation for the first time, and provide the first instance of a complete-airway CFD model evaluating pediatric CF lungs. Results show that EEG aerosols are capable of delivering the drug above the minimum inhibitory concentration in all airway regions, reducing regional dose variability, and targeting the lower airways where infection is more predominant. In conclusion, results from this dissertation demonstrate: (i) accurate and efficient CFD models of respiratory drug delivery; (ii) optimized designs for respiratory delivery systems; and (iii) optimal delivery strategies for inhaled tobramycin to pediatric patients with CF.
Download or read book Aerosol Drug Delivery Device Design Verification Requirements and Test Methods written by British Standards Institute Staff and published by . This book was released on 1913-02-28 with total page 54 pages. Available in PDF, EPUB and Kindle. Book excerpt: Medical equipment, Aerosols, Drug administration, Nebulizers, Respiratory system, Inhalers, Drugs, Sprays, Drug containers, Design, Verification, Marking, Instructions for use, Testing
Download or read book Respiratory Drug Delivery 8 written by Virginia Commonwealth University. School of Pharmacy and published by . This book was released on 2002 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Respiratory Drug Delivery 8 written by Virginia Commonwealth University. School of Pharmacy and published by . This book was released on 2002 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
