Download or read book Optimization and Characterization of Self assembled Monolayer Multilayer Surface enhanced Raman Scattering Substrate for Immuno nanosensors written by Charles Kofi Klutse and published by . This book was released on 2012 with total page 404 pages. Available in PDF, EPUB and Kindle. Book excerpt: Surface-enhanced Raman scattering (SERS) is a powerful analytical tool and the recent expansion of substrates for SERS measurement broadens its field of applications, including SERS-based immuno-nanosensing. This dissertation describes the optimization and characterization of self-assembled monolayer (SAM) multilayer SERS substrates for improving performance of different types of substrates. SERS substrates derived from metal film on nanostructures were modified with multiple metal films interspaced with SAM dielectric spacers to achieve multilayered SERS substrates. The fundamental concept of this substrate geometry exploited the cumulative effect of the multiple electromagnetic fields and various properties of SAMs to optimize SERS enhancement of multilayer SERS substrates to about 20-fold compared to conventional substrates.
Download or read book Biomedical Photonics Handbook written by Tuan Vo-Dinh and published by CRC Press. This book was released on 2014-07-29 with total page 767 pages. Available in PDF, EPUB and Kindle. Book excerpt: Shaped by Quantum Theory, Technology, and the Genomics RevolutionThe integration of photonics, electronics, biomaterials, and nanotechnology holds great promise for the future of medicine. This topic has recently experienced an explosive growth due to the noninvasive or minimally invasive nature and the cost-effectiveness of photonic modalities in
Download or read book Biomedical Photonics Handbook 3 Volume Set written by Tuan Vo-Dinh and published by CRC Press. This book was released on 2014-07-29 with total page 2465 pages. Available in PDF, EPUB and Kindle. Book excerpt: This handbook presents the most recent technological advances and applications in the areas of biomedical photonics. This second edition contains introductory material and covers the state-of-the-art methods and instrumentation for biomedical photonic technologies. It integrates interdisciplinary research and development critically needed for scientists, engineers, manufacturers, teachers, students, and clinical providers to learn about the most recent advances and predicted trends in instrumentation and methods as well as clinical applications in important areas of biomedical photonics. Extensive references are provided to enhance further study.
Download or read book Biomedical Photonics Handbook Second Edition written by Tuan Vo-Dinh and published by CRC Press. This book was released on 2014-07-29 with total page 772 pages. Available in PDF, EPUB and Kindle. Book excerpt: Shaped by Quantum Theory, Technology, and the Genomics Revolution The integration of photonics, electronics, biomaterials, and nanotechnology holds great promise for the future of medicine. This topic has recently experienced an explosive growth due to the noninvasive or minimally invasive nature and the cost-effectiveness of photonic modalities in medical diagnostics and therapy. The second edition of the Biomedical Photonics Handbook presents recent fundamental developments as well as important applications of biomedical photonics of interest to scientists, engineers, manufacturers, teachers, students, and clinical providers. The third volume, Therapeutics and Advanced Biophotonics, focuses on therapeutic modalities, advanced biophotonic technologies, and future trends. Represents the Collective Work of over 150 Scientists, Engineers, and Clinicians Designed to display the most recent advances in instrumentation and methods, as well as clinical applications in important areas of biomedical photonics to a broad audience, this three-volume handbook provides an inclusive forum that serves as an authoritative reference source for a broad audience involved in the research, teaching, learning, and practice of medical technologies. What’s New in This Edition: A wide variety of photonic biochemical sensing technologies has already been developed for clinical monitoring of early disease states and physiological parameters, such as blood pressure, blood chemistry, pH, temperature, and the presence of pathological organisms or biochemical species of clinical importance. Advanced photonic detection technologies integrating the latest knowledge of genomics, proteomics, and metabolomics allow sensing of early disease states, thus revolutionizing the medicine of the future. Nanobiotechnology has opened new possibilities for detection of biomarkers of disease, imaging single molecules and in situ diagnostics at the single-cell level. In addition to these state-of-the-art advancements, the second edition contains new topics and chapters including: • Fiber Optic Probe Design • Laser and Optical Radiation Safety • Photothermal Detection • Multidimensional Fluorescence Imaging • Surface Plasmon Resonance Imaging • Molecular Contrast Optical Coherence Tomography • Multiscale Photoacoustics • Polarized Light for Medical Diagnostics • Quantitative Diffuse Reflectance Imaging • Interferometric Light Scattering • Nonlinear Interferometric Vibrational Imaging • Nanoscintillator-Based Therapy • SERS Molecular Sentinel Nanoprobes • Plasmonic Coupling Interference Nanoprobes Comprised of three books: Volume I: Fundamentals, Devices, and Techniques; Volume II: Biomedical Diagnostics; and Volume III: Therapeutics and Advanced Biophotonics, this second edition contains eight sections, and provides introductory material in each chapter. It also includes an overview of the topic, an extensive collection of spectroscopic data, and a list of references for further reading.
Download or read book Surface Enhanced Raman Spectroscopy for Biophysical Applications written by Claudia Fasolato and published by Springer. This book was released on 2018-12-05 with total page 167 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book explores the phenomenon of surface-enhanced Raman scattering (SERS), the huge amplification of Raman signal from molecules in the proximity of a metallic nanostructured surface, allowing readers to gain an in-depth understanding of the mechanisms affecting the spectroscopic response of SERS-active systems for effective applications. SERS spectroscopy is an ultrasensitive analytical technique with great potential for applications in the field of biophysics and nanomedicine. As examples, the author presents the design of nanocolloid-based SERS-active substrates for molecular sensing and of a folate-based SERS-active nanosensor capable of selectively interacting with cancer cells, enabling cancer diagnostics and therapy at the single-cell level. The author also suggests novel paths for the systematization of the SERS nanosystem design and experimental protocols to maximize sensitivity and reproducibility, which is essential when real-world biomedical applications are the goal of the study. With a combined approach, both fundamental and applied, and a detailed analysis of the state of the art, this book provides a valuable overview both for students new to SERS spectroscopy and for experts in the field.
Download or read book Surface Enhanced Raman Spectroscopy of Functionalized Self assembled Monolayers written by Qi Ye and published by . This book was released on 1997 with total page 616 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Characterization of Substrates for Surface enhanced Raman Scattering written by B. M. Atkinson and published by . This book was released on 1992 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Characterization and Optimization of Novel Nanostructured Metallic Substrates for Surface Enhanced Raman Spectroscopy written by and published by . This book was released on 2001 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Surface enhanced Raman spectroscopy (SERS) is a highly sensitive technique for quantifying trace amounts of analyte adsorbed at a roughened metal surface. We have shown that novel gold nanostructured films, simply fabricated using gold nanoparticles and latex microspheres, can be used as highly sensitive SERS substrates. The films are templated by layers of colloidal crystals and display long ranged ordered regions, and porosity on two length scales that results in high surface area. By integrating these substrates into a flow chamber we have obtained consistent reproducible data and demonstrated the quantitative detection of sodium cyanide in the concentration range from 5 to 500 ppb, with detection significantly enhanced by lowering the pH after cyanide adsorption. We have found that the optimum size of the latex microspheres is approximately equal to the wavelength of the laser. Finally, the SERS activity of the gold substrates coated with silver nanoparticles was investigated using methyl phosphonic acid (MPA). Detection of MPA was dependent on the time between substrate coating and the SERS measurement. These studies show that novel materials formed by simple wet chemistry techniques can be used efficiently in practical devices for the detection of chemical agents.
Download or read book Surface Enhanced Raman Scattering New Theoretical Approaches Materials and Strategies written by Ivano Alessandri and published by Frontiers Media SA. This book was released on 2020-03-25 with total page 175 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Raman Spectroscopy for Nanomaterials Characterization written by Challa S.S.R. Kumar and published by Springer Science & Business Media. This book was released on 2012-03-30 with total page 659 pages. Available in PDF, EPUB and Kindle. Book excerpt: First volume of a 40-volume series on nanoscience and nanotechnology, edited by the renowned scientist Challa S.S.R. Kumar. This handbook gives a comprehensive overview about Raman spectroscopy for the characterization of nanomaterials. Modern applications and state-of-the-art techniques are covered and make this volume essential reading for research scientists in academia and industry.
Download or read book Substrates for Surface enhanced Raman Spectroscopy written by Muḥammad Ajmal K̲h̲ān and published by . This book was released on 2008 with total page 730 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Frontiers of Surface Enhanced Raman Scattering written by Yukihiro Ozaki and published by John Wiley & Sons. This book was released on 2014-02-19 with total page 466 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive presentation of Surface-Enhanced Raman Scattering (SERS) theory, substrate fabrication, applications of SERS to biosystems, chemical analysis, sensing and fundamental innovation through experimentation. Written by internationally recognized editors and contributors. Relevant to all those within the scientific community dealing with Raman Spectroscopy, i.e. physicists, chemists, biologists, material scientists, physicians and biomedical scientists. SERS applications are widely expanding and the technology is now used in the field of nanotechnologies, applications to biosystems, nonosensors, nanoimaging and nanoscience.
Download or read book Construction and Characterization of Monolayer and Multilayer Self assembled Systems in Ionically Bound Redox Centers written by Daniel Andrei Lowy and published by . This book was released on 1996 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Characterization of Self assembled Monolayers by Sum Frequency Generation Spectroscopy and Imaging Microscopy written by Jack Deodato C. Jacob and published by . This book was released on 2013 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This dissertation reports the characterization of self-assembled monolayers utilizing sum frequency generation (SFG) vibrational spectroscopy and imaging microscopy. Several variables were studied for their effect on the conformational order of the formed monolayers. In the analysis of octadecanoxy-phenylethanethiolate monolayers on gold, it was determined that the presence of an aromatic ring near the gold substrate caused no significant loss of the conformational order of the monolayer. Gauche and kink defects were observed by SFG spectroscopy, caused by the cross-sectional difference of the alkoxy chains and the aromatic ring, forcing the chains to tilt and kink until the methylene groups further above the chains can align to form the all-trans conformation. Additional octadecyl chains attached to the aromatic ring led to an increase in gauche defects, implying the decrease of conformational order is also due to steric effects. SFG imaging microscopy was used to determine the effect of the grain size of the gold substrate on the quality of monolayers produced. Analysis of the resulting images revealed that dodecanethiolate monolayers grown on surfaces with a large average grain size have fewer gauche defects within the alkyl chain assembly and thus are more conformationally ordered than those deposited on smaller-grained substrates. This variance between surfaces was not observed with octadecanethiolate monolayers, possibly due to the increased conformational ordering associated with their longer chain length enables the these thiolates to reduce any chain disordering induced by the grain size of the substrate. Finally, the in situ SFG spectroscopy was used to monitor self-assembled monolayers as they reductively desorb in alkaline solution.
Download or read book Development Characterization and Optimization of Novel Surface Enhanced Raman Scattering SERS Direct and Indirect Assays written by Virginia Lyn Schmit and published by . This book was released on 2011 with total page 106 pages. Available in PDF, EPUB and Kindle. Book excerpt: The objective of this study was to develop direct and indirect capture assays for use with Surface Enhanced Raman Scattering (SERS) spectroscopy. Spectroscopically bright gold nanoparticle reporters may be used as detectors for any number of SERS assays. Direct capture assays directly couple the compound of interest to gold coating a sample concentrator. For our proof of concept direct capture assay, we detected cyanide in an aqueous solution. Indirect capture assays couple a Raman reporter (gold nanoparticle tagged with a Raman active compound) to the sample concentrator via antibody antigen interactions. The Raman reporter presents a unique spectrum when excited by an 808 nm laser, and the complex is pulled out of solution using a three separate approaches, paramagnetic, buoyant and neutrally buoyant--the latter two are novel sample concentrating approaches and will be discussed in further detail within this report. The paramagnetic particles are strongly attracted to a magnet and thus the complex is pulled out of solution for interrogation with the laser. The buoyant design physically separates the positively coupled reaction from non-coupled nanoparticles. In the indirect coupled assays, the Raman reporter provides the unique spectrum for identification, and in future work, the assays can be multiplexed. Each compound of interest will be coupled to a unique Raman reporter that will allow multiplexing of this assay development. The method of detection will be SERS. SERS was chosen as the method of choice due to its high sensitivity and selectivity. The ultimate application of this technology will be for use in point of care diagnostics in the emergency department at hospitals, in ambulances, or in developing countries for diagnostic assessment of pathogenic human diseases in small, clinical settings. In this manner, the complex SERS spectra from a multiplexed assay will be reduced to an 'answer box' indicating presence or absence of a marker of interest.
Download or read book Synthesis Characterization and Self assembly of Gold Nanorods an Surface enhanced Raman Studies written by Babak Nikoobakht and published by . This book was released on 2002 with total page 542 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Optochemical Nanosensors written by Andrea Cusano and published by CRC Press. This book was released on 2012-11-20 with total page 625 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nanosized sensors enable the study of chemical and biochemical processes at a level and in dimensions that may not have been envisioned some 20 years ago. Fueled by their inherent small size and the unusual optical, magnetic, catalytic, and mechanical properties of nanoparticles, remarkable progress has been made in recent years in the development and utilization of nanosensors and optical nanotechnology will further widen the field. However, the design of new sensors requires new materials, new methods for their characterization, new optical sensing schemes, new approaches for creating nanosized structures, and new techniques for their interrogation in complex environments such as small living cells for studying biological signals or big public spaces for environmental monitoring . Optochemical Nanosensors covers the rapidly growing field of optical chemical nanosensing, a new and exciting area of research and development within the large field of optical chemical sensing and biosensing. Its many applications, including the detection of bioterrorist threats, food security, virology, explosive detection and more, are covered in these self-contained yet interrelated chapters. The book reviews optochemical sensors, starting from the basics in optoelectronicsand concluding with the presentation of diverse nanosensors. The authors offer insight into future trends in this growing field and present applications in the fields of medicine, security, and bioterrorism.
