Download or read book Mechanistic modelling a BOLD response to the fMRI information loss problem written by Karin Lundengård and published by Linköping University Electronic Press. This book was released on 2017-11-08 with total page 80 pages. Available in PDF, EPUB and Kindle. Book excerpt: Functional Magnetic Resonance Imaging (fMRI) is a common technique for imaging brain activity in humans. However, the fMRI signal stems from local changes in oxygen level rather than from neuronal excitation. The change in oxygen level is referred to as the Blood Oxygen Level Dependent (BOLD) response, and is connected to neuronal excitation and the BOLD response are connected by the neurovascular coupling. The neurons affect the oxygen metabolism, blood volume and blood flow, and this in turn controls the shape of the BOLD response. This interplay is complex, and therefore fMRI analysis often relies on models. However, none of the previously existing models are based on the intracellular mechanisms of the neurovascular coupling. Systems biology is a relatively new field where mechanistic models are used to integrate data from many different parts of a system in order to holistically analyze and predict system properties. This thesis presents a new framework for analysis of fMRI data, based on mechanistic modelling of the neurovascular coupling, using systems biology methods. Paper I presents the development of the first intracellular signaling model of the neurovascular coupling. Using models, a feed-forward and a feedback hypothesis are tested against each other. The resulting model can mechanistically explain both the initial dip, the main response and the post-peak undershoot of the BOLD response. It is also fitted to estimation data from the visual cortex and validated against variations in frequency and intensity of the stimulus. In Paper II, I present a framework for separating activity from noise by investigating the influence of the astrocytes on the blood vessels via release of vasoactive sub- stances, using observability analysis. This new method can recognize activity in both measured and simulated data, and separate differences in stimulus strength in simulated data. Paper III investigates the effects of the positive allosteric GABA modulator diazepam on working memory in healthy adults. Both positive and negative BOLD was measured during a working memory task, and activation in the cingulate cortex was negatively correlated to the plasma concentration of diazepam. In this area, the BOLD response had decreased below baseline in test subjects with >0.01 mg/L diazepam in the blood. Paper IV expands the model presented in Paper I with a GABA mechanism so that it can describe neuronal inhibition and the negative BOLD response. Sensitization of the GABA receptors by diazepam was added, which enabled the model to explain how changes to the BOLD response described in Paper III could occur without a change in the balance between the GABA and glutamate concentrations. The framework presented herein may serve as the basis for a new method for identification of both brain activity and useful potential biomarkers for brain diseases and disorders, which will bring us a deeper understanding of the functioning of the human brain.

Download or read book Machine learning in neuroscience written by Hamid R. Rabiee and published by Frontiers Media SA. This book was released on 2023-01-27 with total page 361 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Origins of the Resting State fMRI Signal written by Jean Chen and published by Frontiers Media SA. This book was released on 2020-12-28 with total page 188 pages. Available in PDF, EPUB and Kindle. Book excerpt: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.

Download or read book Handbook of Functional MRI Data Analysis written by Russell A. Poldrack and published by Cambridge University Press. This book was released on 2011-08-22 with total page 239 pages. Available in PDF, EPUB and Kindle. Book excerpt: Functional magnetic resonance imaging (fMRI) has become the most popular method for imaging brain function. Handbook of Functional MRI Data Analysis provides a comprehensive and practical introduction to the methods used for fMRI data analysis. Using minimal jargon, this book explains the concepts behind processing fMRI data, focusing on the techniques that are most commonly used in the field. This book provides background about the methods employed by common data analysis packages including FSL, SPM and AFNI. Some of the newest cutting-edge techniques, including pattern classification analysis, connectivity modeling and resting state network analysis, are also discussed. Readers of this book, whether newcomers to the field or experienced researchers, will obtain a deep and effective knowledge of how to employ fMRI analysis to ask scientific questions and become more sophisticated users of fMRI analysis software.

Download or read book The Oxford Handbook of Social Neuroscience written by Jean Decety and published by Oxford University Press. This book was released on 2015-04-15 with total page 1124 pages. Available in PDF, EPUB and Kindle. Book excerpt: The complexities of the brain and nervous system make neuroscience an inherently interdisciplinary pursuit, one that comprises disparate basic, clinical, and applied disciplines. Behavioral neuroscientists approach the brain and nervous system as instruments of sensation and response; cognitive neuroscientists view the same systems as a solitary computer with a focus on representations and processes. The Oxford Handbook of Social Neuroscience marks the emergence of a third broad perspective in this field. Social neuroscience emphasizes the functions that emerge through the coaction and interaction of conspecifics, the neural mechanisms that underlie these functions, and the commonality and differences across social species and superorganismal structures. With an emphasis on the neural, hormonal, cellular, and genetic mechanisms underlying social behavior, social neuroscience places emphasis on the associations and influences between social and biological levels of organization. This complex interdisciplinary perspective demands theoretical, methodological, statistical, and inferential rigor to effectively integrate basic, clinical, and applied perspectives on the nervous system and brain. Reflecting the diverse perspectives that make up this field, The Oxford Handbook of Social Neuroscience brings together perspectives from across the sciences in one authoritative volume.

Download or read book Handbook of Neuroscience for the Behavioral Sciences Volume 1 written by Gary G. Berntson and published by John Wiley & Sons. This book was released on 2009-10-12 with total page 722 pages. Available in PDF, EPUB and Kindle. Book excerpt: As technology has made imaging of the brain noninvasive and inexpensive, nearly every psychologist in every subfield is using pictures of the brain to show biological connections to feelings and behavior. Handbook of Neuroscience for the Behavioral Sciences, Volume I provides psychologists and other behavioral scientists with a solid foundation in the increasingly critical field of neuroscience. Current and accessible, this volume provides the information they need to understand the new biological bases, research tools, and implications of brain and gene research as it relates to psychology.

Download or read book Handbook of Neuroimaging Data Analysis written by Hernando Ombao and published by CRC Press. This book was released on 2016-11-18 with total page 702 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book explores various state-of-the-art aspects behind the statistical analysis of neuroimaging data. It examines the development of novel statistical approaches to model brain data. Designed for researchers in statistics, biostatistics, computer science, cognitive science, computer engineering, biomedical engineering, applied mathematics, physics, and radiology, the book can also be used as a textbook for graduate-level courses in statistics and biostatistics or as a self-study reference for Ph.D. students in statistics, biostatistics, psychology, neuroscience, and computer science.

Download or read book Introduction to Neuroimaging Analysis written by Mark Jenkinson and published by Oxford University Press. This book was released on 2018 with total page 277 pages. Available in PDF, EPUB and Kindle. Book excerpt: This accessible primer gives an introduction to the wide array of MRI-based neuroimaging methods that are used in research. It provides an overview of the fundamentals of what different MRI modalities measure, what artifacts commonly occur, the essentials of the analysis, and common 'pipelines'.

Download or read book Evaluating and Optimizing FMRI Processing Pipelines with the NPAIRS Approach for Decision Support in FMRI Applications written by Jing Zhang (Ph.D.) and published by . This book was released on 2005 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Introduction to Functional Magnetic Resonance Imaging written by Richard B. Buxton and published by Cambridge University Press. This book was released on 2009-08-27 with total page 479 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the second edition of a useful introductory book on a technique that has revolutionized neuroscience, specifically cognitive neuroscience. Functional magnetic resonance imaging (fMRI) has now become the standard tool for studying the brain systems involved in cognitive and emotional processing. It has also been a major factor in the consilience of the fields of neurobiology, cognitive psychology, social psychology, radiology, physics, mathematics, engineering, and even philosophy. Written and edited by a clinician-scientist in the field, this book remains an excellent user's guide to t

Download or read book Clinical Functional MRI written by Christoph Stippich and published by Springer Nature. This book was released on 2021-12-03 with total page 444 pages. Available in PDF, EPUB and Kindle. Book excerpt: The third, revised edition of this successful book describes up-to-date preoperative fMRI and complementary advanced imaging methods (DTI, MEG, PET, etc.) to diagnose and treat patients with brain tumors and epilepsy. It presents the state of the art fMRI and complementary imaging procedures and discusses practical aspects, imaging and data processing steps, normal and pathological findings, and diagnostic possibilities and limitations. Experts in the field explain relevant information on brain physiology, functional neuroanatomy, and imaging techniques. All chapters of the second edition have been fully updated to reflect the latest developments. Multimodality functional neuroimaging was rewritten by new authors. Further chapters address brain plasticity, and pitfalls, tips, and tricks.

Download or read book Temporal Features in Resting State fMRI Data written by Xiaoping Philip Hu and published by Frontiers Media SA. This book was released on 2021-01-20 with total page 136 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Human Brain Function written by Karl J. Friston and published by Elsevier. This book was released on 2004-01-26 with total page 1161 pages. Available in PDF, EPUB and Kindle. Book excerpt: This updated second edition provides the state of the art perspective of the theory, practice and application of modern non-invasive imaging methods employed in exploring the structural and functional architecture of the normal and diseased human brain. Like the successful first edition, it is written by members of the Functional Imaging Laboratory - the Wellcome Trust funded London lab that has contributed much to the development of brain imaging methods and their application in the last decade. This book should excite and intrigue anyone interested in the new facts about the brain gained from neuroimaging and also those who wish to participate in this area of brain science.* Represents an almost entirely new book from 1st edition, covering the rapid advances in methods and in understanding of how human brains are organized* Reviews major advances in cognition, perception, emotion and action* Introduces novel experimental designs and analytical techniques made possible with fMRI, including event-related designs and non-linear analysis

Download or read book Fetal Development written by Nadja Reissland and published by Springer. This book was released on 2016-03-15 with total page 497 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides an overview of fetal psychobiological research, focusing on brain and behavior, genetic and epigenetic factors affecting both short and long-term development, and technological breakthroughs in the field. These focal points intersect throughout the chapters, as in the challenges of evaluating the fetal central nervous system, the myriad impacts of maternal stressors and resiliencies, and the salience of animal studies. It also discusses specific monitoring and assessment methods, including cardiotocography, biomagnetometry, 4D ultrasound, in utero MRI, and the KANET test. Spanning assessment, identification, and pre- and postnatal intervention, the book weighs the merits of standardized evaluations and argues for more integrative research in the future. Included in the coverage: Effects on the fetus of maternal anxiety, depression, and stress during pregnancy. Clinical and experimental research in human fetuses and animal models. Observational research including the use of behaviors in developing tests to assess fetal health. Fetal auditory processing and implications for language development. Fetal effects of prenatal exposure to selective SRI antidepressant exposure. Structural and functional imaging of the prenatal brain. The effects of alcohol exposure on fetal development. Fetal Development: Research on Brain and Behavior, Environmental Influences, and Emerging Technologies is an essential resource for researchers, clinicians and related professionals, as well as students in a wide range of fields such as developmental psychology, pediatric and obstetrical medicine, neuroscience, nursing, social work, and early childhood education.

Download or read book Brain Mapping written by and published by Academic Press. This book was released on 2015-02-14 with total page 2668 pages. Available in PDF, EPUB and Kindle. Book excerpt: Brain Mapping: A Comprehensive Reference, Three Volume Set offers foundational information for students and researchers across neuroscience. With over 300 articles and a media rich environment, this resource provides exhaustive coverage of the methods and systems involved in brain mapping, fully links the data to disease (presenting side by side maps of healthy and diseased brains for direct comparisons), and offers data sets and fully annotated color images. Each entry is built on a layered approach of the content – basic information for those new to the area and more detailed material for experienced readers. Edited and authored by the leading experts in the field, this work offers the most reputable, easily searchable content with cross referencing across articles, a one-stop reference for students, researchers and teaching faculty. Broad overview of neuroimaging concepts with applications across the neurosciences and biomedical research Fully annotated color images and videos for best comprehension of concepts Layered content for readers of different levels of expertise Easily searchable entries for quick access of reputable information Live reference links to ScienceDirect, Scopus and PubMed

Download or read book fMRI Neurofeedback written by Michelle Hampson and published by Academic Press. This book was released on 2021-10-09 with total page 366 pages. Available in PDF, EPUB and Kindle. Book excerpt: fMRI Neurofeedback provides a perspective on how the field of functional magnetic resonance imaging (fMRI) neurofeedback has evolved, an introduction to state-of-the-art methods used for fMRI neurofeedback, a review of published neuroscientific and clinical applications, and a discussion of relevant ethical considerations. It gives a view of the ongoing research challenges throughout and provides guidance for researchers new to the field on the practical implementation and design of fMRI neurofeedback protocols. This book is designed to be accessible to all scientists and clinicians interested in conducting fMRI neurofeedback research, addressing the variety of different knowledge gaps that readers may have given their varied backgrounds and avoiding field-specific jargon. The book, therefore, will be suitable for engineers, computer scientists, neuroscientists, psychologists, and physicians working in fMRI neurofeedback. - Provides a reference on fMRI neurofeedback covering history, methods, mechanisms, clinical applications, and basic research, as well as ethical considerations - Offers contributions from international experts—leading research groups are represented, including from Europe, Japan, Israel, and the United States - Includes coverage of data analytic methods, study design, neuroscience mechanisms, and clinical considerations - Presents a perspective on future translational development

Download or read book Between Theory and Clinic The Contribution of Neuroimaging in the Field of Consciousness Disorders written by Olivia Gosseries and published by Frontiers Media SA. This book was released on 2019-05-16 with total page 194 pages. Available in PDF, EPUB and Kindle. Book excerpt: The amount of patients surviving severe brain injury has gradually increased over these last decades thanks to the development of intensive care. These patients either recover quickly from coma or go through prolonged disorders of consciousness such as vegetative state/unresponsive wakefulness syndrome (VS/UWS) or minimally conscious state (MCS). While patients in a minimally conscious state are to some extent aware of themselves and the environment, and show fluctuating but reproducible signs of consciousness, patients in a vegetative state/unresponsive wakefulness syndrome are awake but only show reflexive behaviors. These patients are unable to communicate and present vigilance fluctuation, sensory deficits as well as severe motor and language impairments. Even though behavioral assessment currently remains the gold standard for diagnosis, a number of studies highlights the difficulty in making the distinction between conscious and unconscious patients based on clinical examinations and show a misdiagnosis rate as high as 40%. Misdiagnosis can nevertheless have serious consequences on patient’s management, medically but also ethically (i.e., regarding end-of-life decision). The emergence of functional neuroimaging techniques (such as positron emission tomography – PET and functional magnetic resonance imaging – fMRI) opened new opportunities to study brain activity in patients with disorders of consciousness (DOC). Recent neuroimaging tools have brought new understandings on how the brain functions after coma, and how these tools can complement bedside assessment by improving diagnosis and prognosis of DOC patients. Indeed, we know now that most patients in VS/UWS present partial activation of sensory networks and impaired functional connectivity contrary to patients in MCS. The reemergence of thalamo-cortical connections has also been associated with recovery of consciousness; whereas, thalamic atrophy has been associated to chronic DOC. Recent findings have also stressed the interest of neuroimaging in the management and the treatment of these patients. fMRI has been used as brain computer interfaces to detect consciousness in unresponsive patients and to allow basic communication in minimally conscious patients. Neuroimaging techniques are also currently being used to examine the effects of potential therapy such as pharmacological medications (e.g., Amantadine or Zolpidem) and brain stimulations (e.g., transcranial direct current stimulation or repetitive transcranial magnetic stimulation).