Download or read book Optimal Control in Bioprocesses written by Jérôme Harmand and published by John Wiley & Sons. This book was released on 2019-05-21 with total page 276 pages. Available in PDF, EPUB and Kindle. Book excerpt: Optimal control is a branch of applied mathematics that engineers need in order to optimize the operation of systems and production processes. Its application to concrete examples is often considered to be difficult because it requires a large investment to master its subtleties. The purpose of Optimal Control in Bioprocesses is to provide a pedagogical perspective on the foundations of the theory and to support the reader in its application, first by using academic examples and then by using concrete examples in biotechnology. The book is thus divided into two parts, the first of which outlines the essential definitions and concepts necessary for the understanding of Pontryagin’s maximum principle – or PMP – while the second exposes applications specific to the world of bioprocesses. This book is unique in that it focuses on the arguments and geometric interpretations of the trajectories provided by the application of PMP.

Download or read book Optimal Control in Bioprocesses written by Jérôme Harmand and published by John Wiley & Sons. This book was released on 2019-03-01 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt: Optimal control is a branch of applied mathematics that engineers need in order to optimize the operation of systems and production processes. Its application to concrete examples is often considered to be difficult because it requires a large investment to master its subtleties. The purpose of Optimal Control in Bioprocesses is to provide a pedagogical perspective on the foundations of the theory and to support the reader in its application, first by using academic examples and then by using concrete examples in biotechnology. The book is thus divided into two parts, the first of which outlines the essential definitions and concepts necessary for the understanding of Pontryagin’s maximum principle – or PMP – while the second exposes applications specific to the world of bioprocesses. This book is unique in that it focuses on the arguments and geometric interpretations of the trajectories provided by the application of PMP.

Download or read book Optimal Control written by Terence Bayen and published by Academic Press. This book was released on 2020-11-01 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt: Optimal Control: New Trends in Applications to Bioprocesses aims to bridge the gap between mathematical optimization methods to solve problems in dynamical systems and bioprocess modeling which involves various techniques to build mathematical models for applications in the bio-production of chemical and pharmaceutical products, covering different length and time scales, from single cells, to cell population, to bioreactors. The two fields are natural partners, however there is a disconnect and literature gap between the mathematical theory of optimal control and the optimization of systems arising in the field of bioprocesses engineering. Provides optimal control techniques applicable to bioprocessing and biotechnology Includes application to waste water treatment, bio-gas optimization and bioremediation problems Presents case studies from real-world examples

Download or read book Optimal Control written by Terence Bayen and published by Academic Press. This book was released on 2020-01-15 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt: Optimal Control: New Trends in Applications to Bioprocesses aims to bridge the gap between mathematical optimization methods to solve problems in dynamical systems and bioprocess modeling which involves various techniques to build mathematical models for applications in the bio-production of chemical and pharmaceutical products, covering different length and time scales, from single cells, to cell population, to bioreactors. The two fields are natural partners, however there is a disconnect and literature gap between the mathematical theory of optimal control and the optimization of systems arising in the field of bioprocesses engineering. Provides optimal control techniques applicable to bioprocessing and biotechnology Includes application to waste water treatment, bio-gas optimization and bioremediation problems Presents case studies from real-world examples

Download or read book Control in Bioprocessing written by Pablo A. López Pérez and published by John Wiley & Sons. This book was released on 2020-06-08 with total page 293 pages. Available in PDF, EPUB and Kindle. Book excerpt: Closes the gap between bioscience and mathematics-based process engineering This book presents the most commonly employed approaches in the control of bioprocesses. It discusses the role that control theory plays in understanding the mechanisms of cellular and metabolic processes, and presents key results in various fields such as dynamic modeling, dynamic properties of bioprocess models, software sensors designed for the online estimation of parameters and state variables, and control and supervision of bioprocesses Control in Bioengineering and Bioprocessing: Modeling, Estimation and the Use of Sensors is divided into three sections. Part I, Mathematical preliminaries and overview of the control and monitoring of bioprocess, provides a general overview of the control and monitoring of bioprocesses, and introduces the mathematical framework necessary for the analysis and characterization of bioprocess dynamics. Part II, Observability and control concepts, presents the observability concepts which form the basis of design online estimation algorithms (software sensor) for bioprocesses, and reviews controllability of these concepts, including automatic feedback control systems. Part III, Software sensors and observer-based control schemes for bioprocesses, features six application cases including dynamic behavior of 3-dimensional continuous bioreactors; observability analysis applied to 2D and 3D bioreactors with inhibitory and non-inhibitory models; and regulation of a continuously stirred bioreactor via modeling error compensation. Applicable across all areas of bioprocess engineering, including food and beverages, biofuels and renewable energy, pharmaceuticals and nutraceuticals, fermentation systems, product separation technologies, wastewater and solid-waste treatment technology, and bioremediation Provides a clear explanation of the mass-balance–based mathematical modelling of bioprocesses and the main tools for its dynamic analysis Offers industry-based applications on: myco-diesel for implementing "quality" of observability; developing a virtual sensor based on the Just-In-Time Model to monitor biological control systems; and virtual sensor design for state estimation in a photocatalytic bioreactor for hydrogen production Control in Bioengineering and Bioprocessing is intended as a foundational text for graduate level students in bioengineering, as well as a reference text for researchers, engineers, and other practitioners interested in the field of estimation and control of bioprocesses.

Download or read book Bioreactors written by Goutam Saha and published by CRC Press. This book was released on 2017-12-01 with total page 136 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bioreactors: Animal Cell Culture Control for Bioprocess Engineering presents the design, fabrication, and control of a new type of bioreactor meant especially for animal cell line culture. The new bioreactor, called the "see-saw bioreactor," is ideal for the growth of cells with a sensitive membrane. The see-saw bioreactor derives its name from its principle of operation in which liquid columns in either limb of the reactor alternately go up and down. The working volume of the reactor is small, to within 15 L. However, it can easily be scaled up for large production in volume of cell mass in the drug and pharmaceutical industries. The authors describe the principle of operation of the see-saw bioreactor and how to automatically control the bioprocess. They discuss different control strategies as well as the thorough experimental research they conducted on this prototype bioreactor in which they applied a time delay control for yield maximization. To give you a complete understanding of the design and development of the see-saw bioreactor, the authors cover the mathematical model they use to describe the kinetics of fermentation, the genetic algorithms used for deriving the optimal time trajectories of the bioprocess variables, and the corresponding control inputs for maximizing the product yield. One chapter is devoted to the application of time delay control. Following a description of the bioreactor’s working setup in the laboratory, the authors sum up their investigation and define the future scope of work in terms of design, control, and software sensors.

Download or read book Automatic Control of Bioprocesses written by Denis Dochain and published by John Wiley & Sons. This book was released on 2013-03-01 with total page 183 pages. Available in PDF, EPUB and Kindle. Book excerpt: Giving an overview of the challenges in the control of bioprocesses, this comprehensive book presents key results in various fields, including: dynamic modeling; dynamic properties of bioprocess models; software sensors designed for the on-line estimation of parameters and state variables; control and supervision of bioprocesses.

Download or read book Advances in Applied Nonlinear Optimal Control written by Gerasimos Rigatos and published by Cambridge Scholars Publishing. This book was released on 2020-11-19 with total page 741 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume discusses advances in applied nonlinear optimal control, comprising both theoretical analysis of the developed control methods and case studies about their use in robotics, mechatronics, electric power generation, power electronics, micro-electronics, biological systems, biomedical systems, financial systems and industrial production processes. The advantages of the nonlinear optimal control approaches which are developed here are that, by applying approximate linearization of the controlled systems’ state-space description, one can avoid the elaborated state variables transformations (diffeomorphisms) which are required by global linearization-based control methods. The book also applies the control input directly to the power unit of the controlled systems and not on an equivalent linearized description, thus avoiding the inverse transformations met in global linearization-based control methods and the potential appearance of singularity problems. The method adopted here also retains the known advantages of optimal control, that is, the best trade-off between accurate tracking of reference setpoints and moderate variations of the control inputs. The book’s findings on nonlinear optimal control are a substantial contribution to the areas of nonlinear control and complex dynamical systems, and will find use in several research and engineering disciplines and in practical applications.

Download or read book Control in Bioprocessing written by Pablo A. López Pérez and published by John Wiley & Sons. This book was released on 2020-03-10 with total page 325 pages. Available in PDF, EPUB and Kindle. Book excerpt: Closes the gap between bioscience and mathematics-based process engineering This book presents the most commonly employed approaches in the control of bioprocesses. It discusses the role that control theory plays in understanding the mechanisms of cellular and metabolic processes, and presents key results in various fields such as dynamic modeling, dynamic properties of bioprocess models, software sensors designed for the online estimation of parameters and state variables, and control and supervision of bioprocesses Control in Bioengineering and Bioprocessing: Modeling, Estimation and the Use of Sensors is divided into three sections. Part I, Mathematical preliminaries and overview of the control and monitoring of bioprocess, provides a general overview of the control and monitoring of bioprocesses, and introduces the mathematical framework necessary for the analysis and characterization of bioprocess dynamics. Part II, Observability and control concepts, presents the observability concepts which form the basis of design online estimation algorithms (software sensor) for bioprocesses, and reviews controllability of these concepts, including automatic feedback control systems. Part III, Software sensors and observer-based control schemes for bioprocesses, features six application cases including dynamic behavior of 3-dimensional continuous bioreactors; observability analysis applied to 2D and 3D bioreactors with inhibitory and non-inhibitory models; and regulation of a continuously stirred bioreactor via modeling error compensation. Applicable across all areas of bioprocess engineering, including food and beverages, biofuels and renewable energy, pharmaceuticals and nutraceuticals, fermentation systems, product separation technologies, wastewater and solid-waste treatment technology, and bioremediation Provides a clear explanation of the mass-balance–based mathematical modelling of bioprocesses and the main tools for its dynamic analysis Offers industry-based applications on: myco-diesel for implementing "quality" of observability; developing a virtual sensor based on the Just-In-Time Model to monitor biological control systems; and virtual sensor design for state estimation in a photocatalytic bioreactor for hydrogen production Control in Bioengineering and Bioprocessing is intended as a foundational text for graduate level students in bioengineering, as well as a reference text for researchers, engineers, and other practitioners interested in the field of estimation and control of bioprocesses.

Download or read book Current Developments in Biotechnology and Bioengineering written by Christian Larroche and published by Elsevier. This book was released on 2016-09-17 with total page 852 pages. Available in PDF, EPUB and Kindle. Book excerpt: Current Developments in Biotechnology and Bioengineering: Bioprocesses, Bioreactors and Controls provides extensive coverage of new developments, state-of-the-art technologies, and potential future trends, reviewing industrial biotechnology and bioengineering practices that facilitate and enhance the transition of processes from lab to plant scale, which is becoming increasingly important as such transitions continue to grow in frequency. Focusing on industrial bioprocesses, bioreactors for bioprocesses, and controls for bioprocesses, this title reviews industrial practice to identify bottlenecks and propose solutions, highlighting that the optimal control of a bioprocess involves not only maximization of product yield, but also taking into account parameters such as quality assurance and environmental aspects. Describes industrial bioprocesses based on the reaction media Lists the type of bioreactors used for a specific bioprocess/application Outlines the principles of control systems in various bioprocesses

Download or read book Optimal Control Theory written by Suresh P. Sethi and published by Taylor & Francis US. This book was released on 2006 with total page 536 pages. Available in PDF, EPUB and Kindle. Book excerpt: Optimal control methods are used to determine optimal ways to control a dynamic system. The theoretical work in this field serves as a foundation for the book, which the authors have applied to business management problems developed from their research and classroom instruction. Sethi and Thompson have provided management science and economics communities with a thoroughly revised edition of their classic text on Optimal Control Theory. The new edition has been completely refined with careful attention to the text and graphic material presentation. Chapters cover a range of topics including finance, production and inventory problems, marketing problems, machine maintenance and replacement, problems of optimal consumption of natural resources, and applications of control theory to economics. The book contains new results that were not available when the first edition was published, as well as an expansion of the material on stochastic optimal control theory.

Download or read book New Directions in Bioprocess Modeling and Control written by Michael A. Boudreau and published by ISA. This book was released on 2007 with total page 356 pages. Available in PDF, EPUB and Kindle. Book excerpt: Models offer benefits even before they are put on line. Based on years of experience, the authors reveal in New Directions in Bioprocess Modeling and Control that significant improvements can result from the process knowledge and insight that are gained when building experimental and first-principle models for process monitoring and control. Doing modeling in the process development and early commercialization phases is advantageous because it increases process efficiency and provides ongoing opportunities for improving process control. This technology is important for maximizing benefits from analyzers and control tool investments. If you are a process design, quality control, information systems, or automation engineer in the biopharmaceutical, brewing, or bio-fuel industry, this handy resource will help you define, develop, and apply a virtual plant, model predictive control, first-principle models, neural networks, and multivariate statistical process control. The synergistic knowledge discovery on bench top or pilot plant scale can be ported to industrial scale processes. This learning process is consistent with the intent in the Process Analyzer and Process Control Tools sections of the FDA_s Guidance for Industry PAT _ A Framework for Innovative Pharmaceutical Development, Manufacturing and Quality Assurance. It states in the Process Analyzer section of the FDA_s guidance: _For certain applications, sensor-based measurements can provide a useful process signature that may be related to the underlying process steps or transformations. Based on the level of process understanding these signatures may also be useful for the process monitoring, control, and end point determination when these patterns or signatures relate to product and process quality._

Download or read book Sensors in Bioprocess Control written by John Twork and published by CRC Press. This book was released on 2020-07-24 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume presents the reader with an overview of current chemical sensor technology and outlines a framework relating industrial bioprocess monitoring to modern process control technology. It deals with conventional multivariable control technology, focusing on bioprocess applications.

Download or read book Computational Intelligence Techniques for Bioprocess Modelling Supervision and Control written by Maria Carmo Nicoletti and published by Springer Science & Business Media. This book was released on 2009-06-29 with total page 349 pages. Available in PDF, EPUB and Kindle. Book excerpt: Computational Intelligence (CI) and Bioprocess are well-established research areas which have much to offer each other. Under the perspective of the CI area, Biop- cess can be considered a vast application area with a growing number of complex and challenging tasks to be dealt with, whose solutions can contribute to boosting the development of new intelligent techniques as well as to help the refinement and s- cialization of many of the already existing techniques. Under the perspective of the Bioprocess area, CI can be considered a useful repertoire of theories, methods and techniques that can contribute and offer interesting alternative approaches for solving many of its problems, particularly those hard to solve using conventional techniques. Although throughout the past years CI and Bioprocess areas have accumulated substantial specific knowledge and progress has been quick and with a high degree of success, we believe there is still a long way to go in order to use the potentialities of the available CI techniques and knowledge at their full extent, as tools for supporting problem solving in bioprocesses. One of the reasons is the fact that both areas have progressed steadily and have been continuously accumulating and refining specific knowledge; another reason is the high level of technical expertise demanded by each of them. The acquisition of technical skills, experience and good insights in either of the two areas is very demanding and a hard task to be accomplished by any professional.

Download or read book Computer Applications in Biotechnology 2004 written by Marie-Noelle Pons and published by Elsevier. This book was released on 2005-08-02 with total page 610 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Neural Networks in Bioprocessing and Chemical Engineering written by D. R. Baughman and published by Academic Press. This book was released on 2014-06-28 with total page 509 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neural networks have received a great deal of attention among scientists and engineers. In chemical engineering, neural computing has moved from pioneering projects toward mainstream industrial applications. This book introduces the fundamental principles of neural computing, and is the first to focus on its practical applications in bioprocessing and chemical engineering. Examples, problems, and 10 detailed case studies demonstrate how to develop, train, and apply neural networks. A disk containing input data files for all illustrative examples, case studies, and practice problems provides the opportunity for hands-on experience. An important goal of the book is to help the student or practitioner learn and implement neural networks quickly and inexpensively using commercially available, PC-based software tools. Detailed network specifications and training procedures are included for all neural network examples discussed in the book. Each chapter contains an introduction, chapter summary, references to further reading, practice problems, and a section on nomenclature Includes a PC-compatible disk containing input data files for examples, case studies, and practice problems Presents 10 detailed case studies Contains an extensive glossary, explaining terminology used in neural network applications in science and engineering Provides examples, problems, and ten detailed case studies of neural computing applications, including: Process fault-diagnosis of a chemical reactor Leonard Kramer fault-classification problem Process fault-diagnosis for an unsteady-state continuous stirred-tank reactor system Classification of protein secondary-structure categories Quantitative prediction and regression analysis of complex chemical kinetics Software-based sensors for quantitative predictions of product compositions from flourescent spectra in bioprocessing Quality control and optimization of an autoclave curing process for manufacturing composite materials Predictive modeling of an experimental batch fermentation process Supervisory control of the Tennessee Eastman plantwide control problem Predictive modeling and optimal design of extractive bioseparation in aqueous two-phase systems

Download or read book Comprehensive Biotechnology written by and published by Newnes. This book was released on 2011-08-26 with total page 5304 pages. Available in PDF, EPUB and Kindle. Book excerpt: The second edition of Comprehensive Biotechnology, Six Volume Set continues the tradition of the first inclusive work on this dynamic field with up-to-date and essential entries on the principles and practice of biotechnology. The integration of the latest relevant science and industry practice with fundamental biotechnology concepts is presented with entries from internationally recognized world leaders in their given fields. With two volumes covering basic fundamentals, and four volumes of applications, from environmental biotechnology and safety to medical biotechnology and healthcare, this work serves the needs of newcomers as well as established experts combining the latest relevant science and industry practice in a manageable format. It is a multi-authored work, written by experts and vetted by a prestigious advisory board and group of volume editors who are biotechnology innovators and educators with international influence. All six volumes are published at the same time, not as a series; this is not a conventional encyclopedia but a symbiotic integration of brief articles on established topics and longer chapters on new emerging areas. Hyperlinks provide sources of extensive additional related information; material authored and edited by world-renown experts in all aspects of the broad multidisciplinary field of biotechnology Scope and nature of the work are vetted by a prestigious International Advisory Board including three Nobel laureates Each article carries a glossary and a professional summary of the authors indicating their appropriate credentials An extensive index for the entire publication gives a complete list of the many topics treated in the increasingly expanding field