Download or read book Optical Imaging of Brain Function and Metabolism 2 written by Arno Villringer and published by Springer Science & Business Media. This book was released on 2013-11-21 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume covers the latest developments in optical imaging of the brain which is becoming an increasingly important functional neuroimaging method. Optical intrinsic signals offer unrivaled temporal and spatial resolution of functional measurements of the exposed brain cortex in animals and humans. Near-infrared spectroscopy and imaging ap proaches permit the noninvasive functional assessment of the human brain at bedside. Main advantages of these optical techniques are the biochemical specificity of the meas urements and the potential of measuring correlates of intracellular and intravascular oxy genation simultaneously. Recent data indicate that one may also measure a more direct correlate of neuronal activity associated with changes in light scattering. In this volume, recent technical progress of the optical method is covered as well as the physiological basis of the measurements. In simultaneous studies, near-infrared spec troscopy measurements are directly compared to other functional methods, especially PET and fMRI and examples are given for new applications of the NIRS-method. Based on re sults obtained with optical methods and other functional techniques the latest in our under standing of the coupling of neuronal activity and cerebral blood flow response is reviewed. This is an important basis for a better understanding of all functional neuroi maging methods which rely on neurovascular coupling such as PET, SPET and fMRI. Fi nally the optical method is put into the perspective of presently available functional neuroimaging methods including fMRI, PET, MEG and EEG.

Download or read book Optical Imaging of Brain Function and Metabolism 2 written by Arno Villringer and published by . This book was released on 2014-09-01 with total page 264 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Optical Imaging of Brain Function and Metabolism written by Ulrich Dirnagl and published by Springer Science & Business Media. This book was released on 2013-11-21 with total page 290 pages. Available in PDF, EPUB and Kindle. Book excerpt: • . . . . At last the doctor will be freed from the tedious interpretation of screens and photographs. Instead, he will examine and scan through his patient directly. Wearing optical-shutter spectacles and aiming a pulsed laser torch, he will be able to peer at the beating heart, study the movement of a joint or the flexing of a muscle, press on suspect areas to see how the organs beneath respond, check that pills have been correctly swallowed or that an implant is savely in place, and so on. A patient wearing white cotton or nylon clothes that scatter but hardly absorb light, may not even have to undress . . . . •. David Jones, Nature (1990) 348:290 Optical imaging of the brain is a rapidly growing field of heterogenous techniques that has attracted considerable interest recently due to a number of theoretical advantages in comparison with other brain imaging modalities: it uses non ionizing radiation, offers high spatial and temporal resolution, and supplies new types of metabolic and functional information. From a practical standpoint it is important that bedside examinations seem feasible and that the implementations will be considerably less expensive compared with competing techniques. In October 1991, a symposium was held at the Eibsee near Garmisch, Germany to bring together the leading scientists in this new field.

Download or read book Optical Imaging of Brain Function and Metabolism written by and published by . This book was released on 19?? with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book In Vivo Optical Imaging of Brain Function written by Ron D. Frostig and published by CRC Press. This book was released on 2009-05-06 with total page 494 pages. Available in PDF, EPUB and Kindle. Book excerpt: These are exciting times for the field of optical imaging of brain function. Rapid developments in theory and technology continue to considerably advance understanding of brain function. Reflecting changes in the field during the past five years, the second edition of In Vivo Optical Imaging of Brain Function describes state-of-the-art techniques a

Download or read book Imaging the Brain with Optical Methods written by Anna W. Roe and published by Springer Science & Business Media. This book was released on 2009-11-11 with total page 271 pages. Available in PDF, EPUB and Kindle. Book excerpt: Monitoring brain function with light in vivo has become a reality. The technology 33 of detecting and interpreting patterns of reflected light has reached a degree of 34 maturity that now permits high spatial and temporal resolution visualization at both 35 the systems and cellular levels. There now exist several optical imaging methodolo- 36 gies, based on either hemodynamic changes in nervous tissue or neurally induced 37 light scattering changes, that can be used to measure ongoing activity in the brain. 38 These include the techniques of intrinsic signal optical imaging, near-infrared optical 39 imaging, fast optical imaging based on scattered light, optical imaging with voltage 40 sensitive dyes, and two-photon imaging of hemodynamic signals. The purpose of 41 this volume is to capture some of the latest applications of these methodologies to 42 the study of cerebral cortical function. 43 This volume begins with an overview and history of optical imaging and its use 44 in the study of brain function. Several chapters are devoted to the method of intrin- 45 sic signal optical imaging, a method used to record the minute changes in optical 46 absorption due to hemodynamic changes that accompanies cortical activity. Since the 47 detected hemodynamic changes are highly localized, this method has excellent 48 spatial resolution (50–100 μm ), a resolution sufficient for visualization of fundamen- 49 tal modules of cerebral cortical function.

Download or read book Dynamic Brain Imaging written by Hyder Fahmeed and published by Humana Press. This book was released on 2014-11-03 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: If a picture is worth a thousand words, then dynamic images of brain activity certainly warrant many, many more. This book will help users learn to decipher the dynamic imaging data that will be critical to our future understanding of complex brain functions. In recent years, there have been unprecedented methodological advancements in the imaging of brain activity. These techniques allow the measurement of everything from neural activity (e.g., membrane potential, ion ?ux, neurotransmitter ?ux) to energy metabolism (e.g., glucose consumption, oxygen consumption, creatine kinase ?ux) and functional hyperemia (e.g., blood ?ow, volume, oxygenation). This book deals with a variety of magnetic resonance, electrophysiology, and optical methods that are often used to measure some of these dynamic processes. All chapters were written by leading experts, spanning three continents, specializing in state-of-the-art methods. Brie?y, the book has ?ve sections. In the introductory section, there are two chapters; the ?rst one contains a brief pre- ble to dynamic brain imaging and the other presents a novel, analytical approach to processing of dynamically acquired data. The second section has four chapters and delves into a wide range of optical imaging methods. I am privileged to include a chapter from Lawrence B. Cohen, considered by many to be the authority on optical imaging and spectroscopy, both in vitro and in vivo [Cohen LB (1973) Physiol Rev.

Download or read book Optical Imaging of Neocortical Dynamics written by Bruno Weber and published by Humana Press. This book was released on 2014-01-24 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt: The application of optical methods for investigating neocortical circuit dynamics has greatly expanded in recent years, providing novel insights into the fascinating world of brain function. Optical Imaging of Neocortical Dynamics presents a guide to these indispensible tools, which cover a broad range of spatiotemporal scales and a large variety of signaling aspects, ranging from voltage changes to metabolic states. This detailed volume specifically explores methods that are applied in experiments on living brains (in vivo) and that relate to functional properties on the spatial scale of cortical circuits. Beginning with an introductory section that focuses on physical fundamentals of optical imaging as well as molecular tools used for in vivo optical imaging and optogenetic control, the book continues with the most relevant methods and their applications to investigate changes in neuronal and glial activity states as well as optical imaging methods probing metabolic states. Written for the Neuromethods series, this volume contains the kind of detail and key implementation advice that ensures successful results in the lab. Practical and easy to use, Optical Imaging of Neocortical Dynamics serves as an ideal guide for researchers who aim to apply these highly valuable tools to their own neuroscientific studies.

Download or read book Atlas of Epilepsies written by S.R. Benbadis and published by Springer Science & Business Media. This book was released on 2010-09-20 with total page 1966 pages. Available in PDF, EPUB and Kindle. Book excerpt: Atlas of Epilepsies is a landmark, all-encompassing, illustrated reference work and hands-on guide to the diagnosis, management and treatment of epilepsy in all its forms and across all age groups. The premier text in the field with over one thousand images, the Atlas’s highly illustrative approach tackles the difficult subject of epileptic seizures and epileptic syndromes, accompanied by sequential photographs of each management step. Intraoperative photographs are accompanied by detailed figure legends describing nuances, subtleties, and the thought processes involved in each step, providing a fuller understanding of each procedure. The Atlas draws on the expertise of over 300 internationally-renowned experts, and is liberally interspersed with clinical insights and personal vignettes that offer helpful tips, technical advice and critical knowledge to the clinician and scholar. The thorough and complete table of contents includes dedicated sections or chapters on important topics such as neonatal and pediatric seizures; imitators of epilepsy; EEG and neuroimaging; psychiatric and quality of life aspects of epilepsy; and a complete guide to treatment options including current and up-to-date chapters on pharmaceuticals, surgical procedures, and additional and alternative treatments. No other publication addresses epilepsies as thoroughly and completely as the Atlas of Epilepsies. Exhaustive and illustrative, convenient and current, this reference is sure to be the premier text on epilepsy for many years to come.

Download or read book Neurophotonics and Brain Mapping written by Yu Chen and published by CRC Press. This book was released on 2017-06-14 with total page 669 pages. Available in PDF, EPUB and Kindle. Book excerpt: Understanding how the brain works and developing effective therapeutics are important in advancing neuroscience and improving clinical patient care. Neurophotonics and Brain Mapping covers state-of-the-art research and development in optical technologies and applications for brain mapping and therapeutics. It provides a comprehensive overview of various methods developed using light, both microscopic and macroscopic techniques. Recent developments in minimally-invasive endoscopic imaging of deep brain structure and function, as well as light-based therapy are also reviewed.

Download or read book Neurovascular Imaging written by Anna Devor and published by Frontiers E-books. This book was released on 2012-02-01 with total page 218 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent technological advances are significantly enhancing ones ability to image the interplay of neuronal activity, metabolism, and the associated vascular response with high spatial and temporal resolution. This Research Topic will cover these recent technological advances as well as the impact they have had on understanding the coupling of neuronal, metabolic, and vascular responses. We invite contributions to highlight new original research and to provide a forum for discussion of hot neurovascular topics. Potential contributions include, but are not limited by the following examples: - Development and application of novel optical technologies for imaging of neuronal, metabolic and vascular activity. Examples include 2-Photon Microscopy, Optical Coherence Tomography, and Second Harmonic Microscopy. - Intravital imaging of metabolites such as NADH and flavoproteins - Application of optical methods for manipulation of neuroglial circuits and vascular architectonics - Development of novel Magnetic Resonance contrasts for noninvasive imaging of blood flow, volume, and oxygen consumption. - Application of imaging tools for studying of neurovascular dysfunctions such as stroke, vascular dementia and Alzheimer’s Disease - Hypotheses, Perspectives, Commentaries and Opinions with regards to the body of recent publications that utilize imaging tools for investigation of neurogliovascular communication and the regulation of cerebral blood flow

Download or read book Optical Methods and Instrumentation in Brain Imaging and Therapy written by Steen J. Madsen and published by Springer Science & Business Media. This book was released on 2012-11-13 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive up-to-date review of optical approaches used in brain imaging and therapy. It covers a variety of imaging approaches including diffuse optical imaging, laser speckle imaging, photoacoustic imaging and optical coherence tomography. A number of laser-based therapeutic techniques are reviewed, including photodynamic therapy, fluorescence guided resection and photothermal therapy. Fundamental principles and instrumentation are discussed for each imaging and therapeutic approach.

Download or read book Handbook of Neurophotonics written by Francesco S. Pavone and published by CRC Press. This book was released on 2020-05-10 with total page 439 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Handbook of Neurophotonics provides a dedicated overview of neurophotonics, covering the use of advanced optical technologies to record, stimulate, and control the activity of the brain, yielding new insight and advantages over conventional tools due to the adaptability and non-invasive nature of light. Including 32 colour figures, this book addresses functional studies of neurovascular signaling, metabolism, electrical excitation, and hemodynamics, as well as clinical applications for imaging and manipulating brain structure and function. The unifying theme throughout is not only to highlight the technology, but to show how these novel methods are becoming critical to breakthroughs that will lead to advances in our ability to manage and treat human diseases of the brain. Key Features: Provides the first dedicated book on state-of-the-art optical techniques for sensing and imaging across at the cellular, molecular, network, and whole brain levels. Highlights how the methods are used for measurement, control, and tracking of molecular events in live neuronal cells, both in basic research and clinical practice. Covers the entire spectrum of approaches, from optogenetics to functional methods, photostimulation, optical dissection, multiscale imaging, microscopy, and structural imaging. Includes chapters that show use of voltage-sensitive dye imaging, hemodynamic imaging, multiphoton imaging, temporal multiplexing, multiplane microscopy, optoacoustic imaging, near-infrared spectroscopy, and miniature neuroimaging devices to track cortical brain activity.

Download or read book Handbook of Neurophotonics written by Francesco S. Pavone and published by CRC Press. This book was released on 2020-05-10 with total page 579 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Handbook of Neurophotonics provides a dedicated overview of neurophotonics, covering the use of advanced optical technologies to record, stimulate, and control the activity of the brain, yielding new insight and advantages over conventional tools due to the adaptability and non-invasive nature of light. Including 32 colour figures, this book addresses functional studies of neurovascular signaling, metabolism, electrical excitation, and hemodynamics, as well as clinical applications for imaging and manipulating brain structure and function. The unifying theme throughout is not only to highlight the technology, but to show how these novel methods are becoming critical to breakthroughs that will lead to advances in our ability to manage and treat human diseases of the brain. Key Features: Provides the first dedicated book on state-of-the-art optical techniques for sensing and imaging across at the cellular, molecular, network, and whole brain levels. Highlights how the methods are used for measurement, control, and tracking of molecular events in live neuronal cells, both in basic research and clinical practice. Covers the entire spectrum of approaches, from optogenetics to functional methods, photostimulation, optical dissection, multiscale imaging, microscopy, and structural imaging. Includes chapters that show use of voltage-sensitive dye imaging, hemodynamic imaging, multiphoton imaging, temporal multiplexing, multiplane microscopy, optoacoustic imaging, near-infrared spectroscopy, and miniature neuroimaging devices to track cortical brain activity.

Download or read book Advances in Metabolic Mapping Techniques for Brain Imaging of Behavioral and Learning Functions written by Francisco Gonzalez-Lima and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 539 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years, revolutionary technical advances have permitted neuroscientists to map the functioning of the brain in exquisite detail. Of interest are the new techniques that visually display cell energy metabolism which is coupled to functional brain activity in behaving animals. This is the first book dealing with the application of 2-deoxyglucose and related metabolic mapping techniques for brain imaging of behavioral and learning functions. Quantitative autoradiographic techniques based on the use of exogenous markers include radiolabeled glucose and its analogs, especially 2-deoxyglucose and fluorodeoxyglucose. Other mapping techniques are based on the histochemical staining of endogenous metabolic markers such as cytochrome oxidase, as well as immunohistochemistry for expression of c-fos genes. In spite of the great potential capabilities of the new imaging techniques, relatively few neuroscientists are using this approach to study brain functions related to behavior. There is a need to review state-of-the-art applications of these methods in behavioral neuroscience, and to formulate recommendations for future research in this area. This book is intended to fulfill these needs by bringing together leading neuroscientists using metabolic mapping approaches to elucidate brain mechanisms of behavior. Discussions are not limited to one animal species, but they cover a broad range of vertebrates with unique behavioral capabilities.

Download or read book Neural Metabolism In Vivo written by In-Young Choi and published by Springer Science & Business Media. This book was released on 2012-03-14 with total page 1168 pages. Available in PDF, EPUB and Kindle. Book excerpt: From the preface: “Neural Metabolism In Vivo aims to provide a comprehensive overview of neurobiology by presenting the basic principles of up-to-date and cutting-edge technology, as well as their application in assessing the functional, morphological and metabolic aspects of the brain. Investigation of neural activity of the living brain via neurovascular coupling using multimodal imaging techniques extended our understanding of fundamental neurophysiological mechanisms, regulation of cerebral blood flow in connection to neural activity and the interplay between neurons, astrocytes and blood vessels. Constant delivery of glucose and oxygen for energy metabolism is vital for brain function, and the physiological basis of neural activity can be assessed through measurements of cerebral blood flow and consumption of glucose and oxygen.... This book presents the complex physiological and neurochemical processes of neural metabolism and function in response to various physiological conditions and pharmacological stimulations. Neurochemical detection technologies and quantitative aspects of monitoring cerebral energy substrates and other metabolites in the living brain are described under the “Cerebral metabolism of antioxidants, osmolytes and others in vivo” section. Altogether, the advent of new in vivo tools has transformed neuroscience and neurobiology research, and demands interdisciplinary approaches as each technology could only approximate a very small fraction of the true complexity of the underlying biological processes. However, translational values of the emerging in vivo methods to the application of preclinical to clinical studies cannot be emphasized enough. Thus, it is our hope that advances in our understanding of biochemical, molecular, functional and physiological processes of the brain could eventually help people with neurological problems, which are still dominated by the unknowns.” -- In-Young Choi and Rolf Gruetter

Download or read book Imaging and Metabolism written by Jason S. Lewis and published by Springer. This book was released on 2017-09-25 with total page 331 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents advanced molecular imaging techniques used to assess metabolic function. Covering state-of-the art modalities, it discusses the evaluation of a wide range of diseases that have a metabolic component, including cancer, inflammatory conditions, diabetes, neurodegeneration, and cardiovascular disorders. Imaging provides a quantitative perspective to the assessment of metabolic function and complements genetic analysis of disorders related to disrupted metabolism. Organized into four parts, the book highlights basic principles in molecular imaging techniques; metabolic imaging approaches, including magnetic resonance imaging (MRI), single-photon emission computed tomography (SPECT), positron emission tomography (PET), and hybrid modalities; metabolic diseases; and future perspectives. Featuring contributions from leading authorities in radiology, oncology, cardiology, and neurology, Imaging and Metabolism is a pioneering exploration of the role of imaging modalities in assessing the physiological status of abnormal cells and diagnosing disease.