Download or read book OCT and Imaging in Central Nervous System Diseases written by Andrzej Grzybowski and published by Springer Nature. This book was released on 2020-01-01 with total page 560 pages. Available in PDF, EPUB and Kindle. Book excerpt: The second edition of OCT and Imaging in Central Nervous System Diseases offers updated state-of-the-art advances using optical coherence tomography (OCT) regrading neuronal loss within the retina. Detailed information on the OCT imaging and interpretation is provided for the evaluation of disease progression in numerous neurodegenerative disorders and as a biological marker of neuroaxonal injury. Covering disorders like multiple sclerosis, Parkinson’s disease, Alzheimer’s disease, intracranial hypertension, Friedreich’s ataxia, schizophrenia, hereditary optic neuropathies, glaucoma, and amblyopia, readers will given insights into effects on the retina and the and optic nerve. Individual chapters are also devoted to OCT technique, new OCT technology in neuro-ophthalmology, OCT and pharmacological treatment, and the use of OCT in animal models. Similar to the first edition, this book is an excellent and richly illustrated reference for diagnosis of many retinal diseases and monitoring of surgical and medical treatment. OCT allows to study vision from of the retina to the optic tracts. Retinal axons in the retinal nerve fiber layer (RNFL) are non-myelinated until they penetrate the lamina cribrosa. Hence, the RNFL is an ideal structure for visualization of any process of neurodegeneration, neuroprotection, or regeneration. By documenting the ability of OCT to provide key information on CNS diseases, this book illustrates convincingly that the eye is indeed the “window to the brain”.

Download or read book OCT in Central Nervous System Diseases written by Andrzej Grzybowski and published by Springer. This book was released on 2016-03-30 with total page 343 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book reviews recent important advances in the use of optical coherence tomography (OCT) in order to analyze neurodegeneration within the retina through the quantification of axonal loss. Detailed information is provided on the role of OCT as a promising tool for the evaluation of disease progression in numerous neurodegenerative disorders and as a biological marker of neuroaxonal injury. The disorders considered include multiple sclerosis, Parkinson’s disease, Alzheimer’s disease, intracranial hypertension, Friedreich’s ataxia, schizophrenia, hereditary optic neuropathies, glaucoma, and amblyopia. Individual chapters are also devoted to OCT technique, new OCT technology in neuro-ophthalmology, OCT and pharmacological treatment, and the use of OCT in animal models. By documenting the ability of OCT to provide key information on CNS diseases, this book illustrates convincingly that the eye is indeed the “window to the brain”.

Download or read book Optical Coherence Tomography in Neurologic Diseases written by Peter A. Calabresi and published by Cambridge University Press. This book was released on 2015-05-14 with total page 235 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first comprehensive review of the use of optical coherence tomography in neurological diseases for neurologists, neuro-ophthalmologists, and neuroradiologists.

Download or read book Optical Coherence Tomography in Neurodegenerative Disorders written by Hannah Maree Kersten and published by . This book was released on 2016 with total page 562 pages. Available in PDF, EPUB and Kindle. Book excerpt: Purpose Ophthalmic findings, including abnormalities of the optic nerve and retina, are common features of a number of neurodegenerative disorders. These ophthalmic abnormalities have emerged as potential biomarkers of disease progression in several neurodegenerative conditions. In addition, anterior visual system changes have clinical relevance because they can be a significant cause of disability. Optical coherence tomography (OCT) allows for rapid, non-invasive imaging and quantitative analysis of the optic nerve and retina. Over the past 15 years, OCT has been widely used to investigate axonal and neuronal degeneration in the eye, and the relationship with disease severity in multiple sclerosis, neuromyelitis optica Alzheimer's disease and Parkinson's disease. OCT is now frequently utilised in observational studies, clinical practice and therapeutic trials of potential neuroprotective agents. The objectives of the studies outlined in this research thesis were twofold: Firstly, to investigate the morphology of the optic nerve head and retina, using OCT, in patients with neurodegenerative disorders, and to determine the relationship between OCT measurements and disease duration and severity. Methods Subjects with neurodegenerative disorders including muscular dystrophies, Huntington's disease, Parkinson's disease, motor neuron disease, ataxias and hereditary spastic paraplegia were recruited. All participants underwent a complete neuro-ophthalmic assessment including retinal photography and OCT examination of the peripapillary retinal nerve fibre layer (RNFL) and macula. Ophthalmic findings were compared with those from a healthy control group. Additionally, neurological assessment was undertaken in order to be able to assess the relationship between OCT findings and disease severity. Results OCT examination was performed in patients with a diverse range of neurodegenerative disorders. There was preferential thinning of the temporal RNFL in the Huntington's disease and cerebellar ataxia neuropathy vestibular areflexia syndrome (CANVAS) cohorts. Global RNFL thickness was reduced in the Friedreich's ataxia and hereditary spastic paraplegia (HSP) groups. In the myotonic dystrophy type 1 (DM1), Parkinson's disease, motor neuron disease and facioscapulohumeral muscular dystrophy (FSHD) groups, there was no significant difference in RNFL thickness between patients and controls. Macular thickness was greater in the myotonic dystrophy type 1 group compared with controls. This was due to a high prevalence of epiretinal membrane, detected with OCT examination. Macular volume was significantly reduced in the Freidreich's ataxia patient group. There was no significant difference in macular thickness or volume between patients and controls in the Parkinson's disease, motor neuron disease, Huntington's disease, CANVAS, FSHD or HSP groups. In the Huntington's disease group there was a significant correlation between disease duration and both temporal RNFL thickness and macular volume, and a significant relationship between motor assessment scores and macular volume. There was no significant relationship between symptom duration, measures of disability and/or cognitive function and OCT findings in the DM1, Parkinson's disease, motor neuron disease, CANVAS, HSP, Friedreich's ataxia or FSHD groups. Conclusions OCT measurements may be potential biomarkers of disease progression in Huntington's disease patients. The preferential thinning of the temporal RNFL in Huntington's disease may be due to mitochondrial dysfunction. In addition, OCT assessment has a role in the clinical assessment of patients with myotonic dystrophy, in the detection and monitoring of patients with epiretinal membranes. Larger, longitudinal studies are required in order to determine the relationship between ophthalmic and neurological findings in neurodegenerative disorders, and to further investigate the utility of OCT measurements as potential biomarkers of disease progression in these conditions.

Download or read book Optical Coherence Tomography in Neurologic Diseases written by Peter A. Calabresi and published by Cambridge University Press. This book was released on 2015-05-14 with total page 235 pages. Available in PDF, EPUB and Kindle. Book excerpt: Optical coherence tomography (OCT) provides tissue morphology imagery at much higher resolution than other imaging modalities such as MRI or ultrasound, and the machines are comparatively cheaper. It is an easy technique to perform; is non-ionizing, and therefore safe. These benefits are driving a rapid transformation of OCT, from its principal application as a research tool, into an extension of the 'neurological examination' in routine office practice. Originally used in assessing the severity of tissue damage and prognosis of multiple sclerosis and various neuro-ophthalmic conditions, OCT is increasingly used in other neurological disorders such as Parkinson's disease, ALS, and Alzheimer's disease. This book is the first comprehensive review of the use of OCT in neurological diseases. The coverage includes a description of the technique and its utilization in a variety of neurologic conditions. Essential reading for neurologists, neuro-ophthalmologists, and neuroradiologists wanting an introductory account of the clinical applications of OCT.

Download or read book OCT and Imaging in Central Nervous System Diseases written by and published by . This book was released on 2020 with total page 560 pages. Available in PDF, EPUB and Kindle. Book excerpt: The second edition of OCT and Imaging in Central Nervous System Diseases offers updated state-of-the-art advances using optical coherence tomography (OCT) regrading neuronal loss within the retina. Detailed information on the OCT imaging and interpretation is provided for the evaluation of disease progression in numerous neurodegenerative disorders and as a biological marker of neuroaxonal injury. Covering disorders like multiple sclerosis, Parkinson's disease, Alzheimer's disease, intracranial hypertension, Friedreich's ataxia, schizophrenia, hereditary optic neuropathies, glaucoma, and amblyopia, readers will given insights into effects on the retina and the and optic nerve. Individual chapters are also devoted to OCT technique, new OCT technology in neuro-ophthalmology, OCT and pharmacological treatment, and the use of OCT in animal models. Similar to the first edition, this book is an excellent and richly illustrated reference for diagnosis of many retinal diseases and monitoring of surgical and medical treatment. OCT allows to study vision from of the retina to the optic tracts. Retinal axons in the retinal nerve fiber layer (RNFL) are non-myelinated until they penetrate the lamina cribrosa. Hence, the RNFL is an ideal structure for visualization of any process of neurodegeneration, neuroprotection, or regeneration. By documenting the ability of OCT to provide key information on CNS diseases, this book illustrates convincingly that the eye is indeed the "window to the brain".

Download or read book Retinal Changes in Neurological Diseases written by Yuyi You and published by Frontiers Media SA. This book was released on 2022-02-23 with total page 126 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Scattering Angle Resolved Optical Coherence Tomography for Early Retinal Detection of Alzheimer s Disease in a Murine Model written by Michael Ryan Gardner and published by . This book was released on 2018 with total page 314 pages. Available in PDF, EPUB and Kindle. Book excerpt: Alzheimer’s disease (AD), a debilitating neurodegenerative disease, is becoming more prevalent with an aging population. Early detection of AD is critical to extending healthy lives, but current techniques for AD detection are invasive and cost-prohibitive. The retina is embryonically derived from the forebrain and, with recent mounting evidence that it may reveal markers of brain injury, is considered a “window to the brain.” Early neurodegenerative changes in the brain are likely to be observed in the retina—synaptic failure and shifts in mitochondrial dynamics. Optical imaging techniques could hold the key to non-invasive early detection of AD in the retina since these disruptions may be observed with light. In particular, optical coherence tomography (OCT) retinal imaging offers 3D images of retinal neurons, but the resolution of clinical OCT systems is not fine enough to observe disruptions in the sub-cellular space. Scattering angle resolved (SAR-) OCT, a new method introduced in this work, aims to access sub-resolution scattering properties which could expose fundamental changes in the neurons associated with AD. In this dissertation, a custom SAR-OCT system and new image processing protocols are designed and constructed for murine retinal imaging. Then, three in-vivo studies are conducted using the imaging system to demonstrate its potential use in disease detection. In the first study, which establishes fundamental measures provided by SAR OCT, the imaging system discerns native scattering differences between retinal layers and regions in healthy mice. In the second study, significant scattering angle shifts are observed in ischemic retinas. Finally, a cross-sectional study compares a transgenic murine model of AD (3xTg-AD) with age-matched wild type controls. By examining the distribution of scattering angles detected by the SAR-OCT system, significant differences are observed in the earliest ages of the diseased mice compared the control mice. In the final chapter, limitations of these studies as well as the imaging and image processing protocols are examined, and recommendations are made for future studies to leverage SAR-OCT for early detection of AD or other neurodegenerative diseases

Download or read book Optical Coherence Tomography in Neurological Diseases written by Peter A. Calabresi and published by . This book was released on 2015 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first comprehensive review of the use of optical coherence tomography in neurological diseases for neurologists, neuro-ophthalmologists, and neuroradiologists.

Download or read book Glaucoma A Neurodegenerative Disease of the Retina and Beyond Part B written by Giacinto Bagetta and published by Academic Press. This book was released on 2020-09-26 with total page 182 pages. Available in PDF, EPUB and Kindle. Book excerpt: Glaucoma: A Neurodegenerative Disease of the Retina and Beyond Part B, Volume 257, the latest release in the Progress in Brain Research series, highlights new advances in the field, with this new volume presenting interesting chapters written by an international board of authors. Topics covered in this new release include Glaucoma neurodegeneration and myopia, Links between obstructive sleep apnea and glaucoma neurodegeneration, Artificial intelligence and deep learning in glaucoma: Current state and future prospects, Brain networks reorganization and functional disability in glaucoma, Advanced vascular examinations of the retina and optic nerve head in glaucoma, and much more. Covers all key aspects of current research on glaucoma Provides extensively referenced chapters, giving readers a comprehensive list of resources on topics covered Includes comprehensive and in-depth background information written in a clear form that is accessible to both specialists and non-specialists

Download or read book Advances in Brain Imaging Techniques written by Nirmal Mazumder and published by Springer Nature. This book was released on 2022-05-19 with total page 265 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book reviews the recent developments in brain imaging and their technological advancements to understand molecular mechanisms associated with neurological disorders and basic behaviors in humans and rodents at the structural, molecular, and functional levels. It discusses the usefulness of advanced optical microscopy techniques, including optical coherence tomography (OCT), miniscope, multiphoton fluorescence (2PF & 3PF), adaptive optics, harmonic generation, and Raman microscopy for understanding pathomechanism of brain disorders and pathological and physiological changes associated with neurodegenerative diseases. Also, the book presents conventional imaging modalities, including Magnetic Resonance Imaging (MRI), for delineating underlying mechanisms and precise early diagnosis of neurological disorders. This book is a useful resource for neuroscientists and researchers working in biomedical engineering and optics.

Download or read book Optical Coherence Tomography in Multiple Sclerosis written by Axel Petzold and published by Springer. This book was released on 2015-08-28 with total page 203 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book gives a clinical context to optical coherence tomography (OCT) findings, while considering the differential diagnosis and providing patient management guidance. Relevant anatomical and technical aspects are discussed, followed by a pragmatic illustration of the use of OCT for the clinical spectrum of multiple sclerosis and optic neuritis, and finishing with information on monitoring ocular side effects of recently approved disease-modifying treatments in multiple sclerosis. Optical Coherence Tomography in Multiple Sclerosis: Clinical Applications is aimed at clinical neurologists working with patients suffering from MS and general neurologists who see patients with visual symptoms in their daily practice. Ophthalmologists sharing clinical responsibilities with neurologists for patients under disease-modifying treatments will also find the book of interest.

Download or read book Optical Coherence Tomography Angiography for Choroidal and Vitreoretinal Disorders Part 2 written by Miguel A. Quiroz-Reyes, Virgilio Lima-Gomez and published by Bentham Science Publishers. This book was released on 2023-12-28 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt: This handbook covers Optical Coherence Tomography Angiography (OCT-A) with a specific focus on choroidal and vitreoretinal disorders. It serves as an invaluable resource for teaching and aiding daily clinical decision-making in the field. Book chapters dissect the fundamentals of angiography through OCT, offering guidance on OCT-A and insights into macular perfusional findings across various vitreoretinal and choroidal pathologies. From diabetic retinopathy to autoimmune diseases and neovascularization, the book addresses prevalent vascular entities encountered in routine practice. Furthermore, it explores innovative approaches, including antivascular endothelial growth factor molecules and extended-release delivery devices, contributing significantly to the diagnostic and decision-making processes in clinical and surgical retina care. Each chapter is contributed by experts in the relevant subspecialty. Key Features: Practical, patient-centered guide emphasizing a clinical approach. Demonstrative clinical cases for enhanced understanding. Evaluation of perfusional indices using noninvasive and noncontact imaging techniques. High histopathological correlation of structural tissue characterization with microvascular evaluation. Exploration of new perfusion concepts and their role in disease pathogenesis. Part 2 covers advanced topics in OCT-A for choroidal and vitreoretinal disorders. Chapters explore macular perfusional repercussions in obstructive venous vascular phenomena, OCT-A findings in retinal infarction, and the role of macular perfusion in myopic macular traction maculopathy. Further discussions include postoperative perfusional findings in vitreoretinopathy, distinctions in choroidal vasculopathies, and the application of OCT-A in managing pathological choroidal neovascularization. The part concludes with a review of postoperative membrane formation, the usefulness of OCT-A in neurodegenerative diseases, and the evaluation of arterial occlusions and choroidal neovascularization management. Readership Ophthalmology students, residents and clinicians, who want to learn about on choroid and vitreoretinal diseases and complex cases.

Download or read book High Resolution Imaging in Microscopy and Ophthalmology written by Josef F. Bille and published by Springer. This book was released on 2019-08-13 with total page 407 pages. Available in PDF, EPUB and Kindle. Book excerpt: This open access book provides a comprehensive overview of the application of the newest laser and microscope/ophthalmoscope technology in the field of high resolution imaging in microscopy and ophthalmology. Starting by describing High-Resolution 3D Light Microscopy with STED and RESOLFT, the book goes on to cover retinal and anterior segment imaging and image-guided treatment and also discusses the development of adaptive optics in vision science and ophthalmology. Using an interdisciplinary approach, the reader will learn about the latest developments and most up to date technology in the field and how these translate to a medical setting. High Resolution Imaging in Microscopy and Ophthalmology – New Frontiers in Biomedical Optics has been written by leading experts in the field and offers insights on engineering, biology, and medicine, thus being a valuable addition for scientists, engineers, and clinicians with technical and medical interest who would like to understand the equipment, the applications and the medical/biological background. Lastly, this book is dedicated to the memory of Dr. Gerhard Zinser, co-founder of Heidelberg Engineering GmbH, a scientist, a husband, a brother, a colleague, and a friend.

Download or read book Glaucoma A Neurodegenerative Disease of the Retina and Beyond Part A written by and published by Elsevier. This book was released on 2020-09-22 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: Glaucoma: A Pancitopatia of the Retina and Beyond, Volume 257, the latest release in the Progress in Brain Research series, highlights new advances in the field, with this new volume presenting interesting chapters written by an international board of authors. Chapters in this volume include the Genetics of glaucoma, Artificial intelligence and deep learning in glaucoma detection and monitoring, The role of commensal microflora-induced T cells responses in glaucoma neurodegeneration, Retinal cell death in experimental glaucoma, Experimental and clinical evidence on the neuroprotective properties of Citicoline in glaucoma, Glaucoma neurodegeneration and myopia, Neuronal regeneration with pluripotent stem cells in glaucoma, and more. Covers all key aspects of current research on glaucoma Provides extensively referenced chapters, giving readers a comprehensive list of resources on topics covered Includes comprehensive and in-depth background information written in a clear form that is accessible to both specialists and non-specialists

Download or read book Alzheimer s Disease and the Eye written by Jeffrey N. Weiss and published by Springer Nature. This book was released on with total page 146 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Optical Coherence Tomography of Ocular Diseases written by Joel S. Schuman and published by CRC Press. This book was released on 2024-06-01 with total page 1093 pages. Available in PDF, EPUB and Kindle. Book excerpt: The most comprehensive text and definitive guide for nearly 30 years about optical coherence tomography (OCT) imaging in ophthalmology, Optical Coherence Tomography of Ocular Diseases, Fourth Edition covers a range of subjects, from principles and operation techniques to clinical interpretation and the latest innovations in OCT. Written by the pioneers of OCT technologies and the world-renowned OCT researchers Drs. Joel S. Schuman, James G. Fujimoto, Jay S. Duker, Hiroshi Ishikawa, and Gadi Wollstein, Optical Coherence Tomography of Ocular Diseases, Fourth Edition is an essential text for imaging technology. OCT now occupies a dominant role as a diagnostic tool for retinal conditions and glaucoma. At the same time, the technology continues to show potential for emerging clinical and research applications across all the ophthalmological subspecialties. To reflect these rapid advances, this new edition of Optical Coherence Tomography of Ocular Diseases features a complete and thorough revision of the existing text as well as the addition of cutting-edge content to bring this classic resource completely up to date. New content in the Fourth Edition includes: • OCT angiography • Swept-source OCT • OCT in multimodal imaging • Clinical utility of OCT in glaucoma prediction and progression detection • OCT for neuro-ophthalmology Optical Coherence Tomography of Ocular Diseases, Fourth Edition is the one and only book needed by practitioners who use OCT for clinical eye care.