Download or read book Opsin free Optogenetics written by Yubin Zhou and published by CRC Press. This book was released on 2022-12-14 with total page 221 pages. Available in PDF, EPUB and Kindle. Book excerpt: Optogenetics represents a breakthrough technology capable of dynamically modulating molecular and cellular activity in live cells with high precision. This transformative technology made it possible to reversibly interrogate protein actions, cellular events, and animal behaviors with a simple flash of light. Manipulating the temporal and spatial profile of light enabled precise control of membrane potentials. This feature has inspired non-opsin-based optogenetics, which not only inherits the precise spatiotemporal resolution but also expands the targets into a diverse pool of biomolecules such as membrane receptors, ion channels, kinases, GTPases, and transcription factors. This book is unique because it emphasizes the design and applications of opsin-free optogenetic tools. Key Features Describes new developments in non-opsin-based optogenetic tools Introduces cutting-edge methods for precise modulation of cell signaling Highlights applications of optogenetic regulation of cellular functions Covers contributions from an international team of leading experts Related Titles Lim, W. & B. Mayer – Cell Signaling (ISBN 9780815342441) Ayyanathan, K., ed. – Cancer Cell Signaling: Targeting Signaling Pathways Toward Therapeutic Approaches to Cancer (ISBN 9781774630839) Zhang , J. et al., eds. – Optical Probes in Biology (ISBN 9781138199934)

Download or read book Optogenetics written by Hiromu Yawo and published by Springer Nature. This book was released on 2021-01-05 with total page 648 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book, now in a thoroughly revised second edition, offers a comprehensive review of the rapidly growing field of optogenetics, in which light-sensing proteins are genetically engineered into cells in order to acquire information on cellular physiology in optical form or to enable control of specific network in the brain upon activation by light. Light-sensing proteins of various living organisms are now available to be exogenously expressed in neurons and other target cells both in vivo and in vitro. Cellular functions can thus be manipulated or probed by light. The new edition documents fully the extensive progress since publication of the first edition to provide an up-to-date overview of the physical, chemical, and biological properties of light-sensing proteins and their application in biological systems, particularly in neuroscience but also in medicine and the optical sciences. Underlying principles are explained and detailed information provided on a wide range of optogenetic tools for the observation and control of cellular signaling and physiology, gene targeting technologies, and optical methods for biological applications. In presenting the current status of optogenetics and emerging directions, this milestone publication will be a “must read” for all involved in research in any way related to optogenetics.

Download or read book Optogenetics written by and published by Elsevier. This book was released on 2012-12-06 with total page 289 pages. Available in PDF, EPUB and Kindle. Book excerpt: Optogenetics is a fast-growing field concerning the invention, and use, of molecules that are genetically expressed in cells, and then either report on cellular physiology in optical form, or enable control of specific pathways in cells when actuated by light. This book reviews the current state, as well as the underlying principles and future directions, of a diversity of optogenetic tools of importance for observing and controlling cellular signaling and physiology. These tools are already revolutionizing neuroscience, and are starting to have impact on fields ranging from metabolism to development to cardiology. The book contains a dozen chapters written by world experts on these topics, half focusing on the optogenetic molecular tools themselves, and half on the genetic and hardware approaches that make them powerfully useful in intact tissues and organisms. Leading authors review the state-of-the-art in their field of investigation and provide their views and perspectives for future research Chapters are extensively referenced to provide readers with a comprehensive list of resources on the topics covered All chapters include comprehensive background information and are written in a clear form that is also accessible to the non-specialist

Download or read book Recent Advances in Measuring and Controlling Synaptic Communication written by Jacopo Lamanna and published by Frontiers Media SA. This book was released on 2023-11-10 with total page 117 pages. Available in PDF, EPUB and Kindle. Book excerpt: Synapses represent a unique neuronal compartment specialized in communication. The morpho-functional investigation of the synapse has always been hindered by its tiny size and high density of molecular elements, but specific technological and methodological advances helped us to reduce these limitations. As the matter of fact, in recent years, we have witnessed the continuous development of new methods allowing measuring and controlling synaptic activation both in vitro and in vivo. These include new genetically encoded sensors of synaptic exo-endocytosis, but also engineered synaptic proteins able to inhibit the release of neurotransmitters. Furthermore, new promising tools allow changing the functional properties of synapses in a plasticity-like manner. All these methodological advances are likely to generate unprecedented knowledge about the dynamics of synaptic transmission and plasticity at several levels of the nervous system. Nevertheless, in most cases, the implementation of these new methods remains technically demanding, likely due to the high complexity of their operating principle. Hence, it would be worth refining and potentiating these tools in order to extend the range of experimental settings for their application.

Download or read book Cell based Biosensors written by Qingjun Liu and published by Artech House. This book was released on 2009-10 with total page 291 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by recognized experts the field, this leading-edge resource is the first book to systematically introduce the concept, technology, and development of cell-based biosensors. You find details on the latest cell-based biosensor models and novel micro-structure biosensor techniques. Taking an interdisciplinary approach, this unique volume presents the latest innovative applications of cell-based biosensors in a variety of biomedical fields. The book also explores future trends of cell-based biosensors, including integrated chips, nanotechnology and microfluidics. Over 140 illustrations help clarify key topics throughout the book.

Download or read book Basic Electrophysiological Methods written by Ellen Covey and published by Oxford University Press. This book was released on 2015-02-25 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt: Basic Electrophysiological Methods provides a concise and easy-to-read guide on a selection of the most important contemporary electrophysiological techniques, their implementation, applications, and ways in which they can be combined and integrated with neuroscientific techniques. Intended for students, postdocs, and faculty with a basic neuroscience background, this text will not obscure the relevant technical details with textbook neuroscience tutorials as many other books do. Instead, each chapter provides a conscientious overview of the underlying theory -- a comprehensive description of equipment, materials, methods, data management, and analysis -- a troubleshooting guide, and a list of frequently asked questions. No book or online resource can function as strictly a DIY set of instructions on how to implement a complex technique. However, this book provides a fundamental and accessible set of information intended to form a foundation prior to, during, and after hands-on experience and training, greatly facilitating the initial learning process and subsequent fine-tuning of technical details.

Download or read book Lung Biology and Pathophysiology written by Yutong Zhao and published by CRC Press. This book was released on 2024-02-20 with total page 436 pages. Available in PDF, EPUB and Kindle. Book excerpt: The lungs are the organ for gas exchange between the body and the external environment. Dysfunction of upper airway epithelium and smooth muscle cells leads to pathogenesis of asthma, chronic obstructive pulmonary disease (COPD), cystic fibrosis, and other conditions, resulting in airway inflammation and narrowing. Injury to alveolar epithelium and endothelium causes influx of neutrophil and protein-rich fluid from circulation, resulting in edema and disruption of gas exchange. In addition to lung structural cells, immune cells, including alveolar macrophages and lymphocytes play critical roles in the maintenance of lung function. This book contributes to the understanding homeostasis of lung cells in the physiological and pathological conditions critical to the development of novel therapeutics. Key Features Highlights the role the lungs play as an interface between the body and the environment Describes the underlying mechanism of lung diseases Emphasizes the ways nutrition contributes to lung health as well as the ways pollution adversely affect lung function Includes contributions from leading researchers Chapters 8 and 13 of this book are available for free in PDF format as Open Access from the individual product page at www.routledge.com. It has been made available under a Creative Commons Attribution-Non Commercial-No Derivatives 4.0 license.

Download or read book Neuromodulation written by Elliot Krames and published by Academic Press. This book was released on 2018-01-05 with total page 1828 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neuromodulation: Comprehensive Textbook of Principles, Technologies, and Therapies, Second Edition, serves as a comprehensive and in-depth reference textbook covering all aspects of the rapidly growing field of neuromodulation. Since the publication of the first edition seven years ago, there has been an explosion of knowledge in neuromodulation, optogenetics, bioelectronics medicine and brain computer interfacing. Users will find unique discussions of the fundamental principles of neuromodulation and therapies, and how they are applied to the brain, spinal cord, peripheral nerves, autonomic nerves and various organs. The book focuses on comprehensive coverage of spinal cord stimulation, non-interventional and interventional brain stimulation, peripheral nerve stimulation, and the emerging fields of neuromodulation, including optogenetics and bioelectronics medicine. Provides a comprehensive reference that covers all aspects of the growing field of neuromodulation Written by international, leading authorities in their respective fields of neuromodulation, pain management, functional neurosurgery and biomedical engineering Includes new chapters on optogenetics, bioelectronics medicine and brain computer interfacing

Download or read book SfN 2010 Daily Books written by Society for Neuroscience and published by Coe-Truman Technologies. This book was released on 2011-02-18 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Optogenetics A Roadmap written by Albrecht Stroh and published by . This book was released on 2018 with total page 302 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume focuses on the optogenetics workflow, and covers topics on viral vectors, targeting strategies, choice on opsins, animal models and readouts, and applications in systems neuroscience. This book shows readers how to identify the critical aspects of each methodological step, and how to determine the necessary level of complexity to address the particular research question. In Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory. Comprehensive and cutting-edge, Optogenetics: A Roadmap is a valuable guide for both the optogenetics novices and the experts.

Download or read book Optogenetics written by Krishnarao Appasani and published by Cambridge University Press. This book was released on 2017-04-27 with total page 537 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides applications for the revolutionary technique of optogenetics, which combines genetic and optical methods to observe the function of neurons.

Download or read book Biomedical Photonic Technologies written by Zhenxi Zhang and published by John Wiley & Sons. This book was released on 2023-02-06 with total page 309 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biomedical Photonic Technologies A state-of-the-art examination of biomedical photonic research, technologies, and applications In Biomedical Photonic Technologies, a team of distinguished researchers delivers a methodical inquiry and evaluation of the latest developments in the field of biomedical photonics, with a focus on novel technologies, including optical microscopy, optical coherence tomography, fluorescence imaging-guided surgery, photodynamic therapy dosimetry, and optical theranostic technologies. Each discussion of individual technologies includes examples of their contemporary application in areas like cancer therapy and drug delivery. Readers will discover the major research advancements in biomedical photonics from the last 20 years, ascertaining the basic principles of formation, development, and derivation of biomedical photonics phenomena at a variety of scales. Readers will also find: A thorough introduction to advanced wide-field fluorescent microscopy for biomedicine Comprehensive explorations of fluorescence resonance energy transfer and optical coherence tomography for structural and functional imaging Practical exploration of coherent Raman scattering microscopy and biomedical applications, as well as fluorescence image-guided surgery Complete analyses of enhanced photodynamic therapy, optogenetics, and optical theranostics employing gold nanoparticles Perfect for biophysicists and applied physicists, Biomedical Photonic Technologies will also benefit bioengineers and biotechnologists in academia and in industry.

Download or read book The Advances and Applications of Optogenetics written by Elena G. Govorunova and published by MDPI. This book was released on 2020-12-28 with total page 164 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides an update for the rapidly developing technology known as “optogenetics”, which is the use of genetically encoded light-sensitive molecular elements (usually derived from lower organisms) to control or report various physiological and biochemical processes within the cell. Two ongoing clinical trials use optogenetic tools for vision restoration, and optogenetic strategies have been suggested as novel therapies for several neurological, psychiatric and cardiac disorders. This Special Issue comprises two reviews and seven experimental papers on different types of light-sensitive modules widely used in optogenetic studies. These papers demonstrate the efficiency and versatility of optogenetics and are expected to be equally relevant for advanced users and beginners considering using optogenetic tools in their research.

Download or read book Optical Neural Interfaces written by Massimo De Vittorio and published by Frontiers Media SA. This book was released on 2019-11-01 with total page 88 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book From Photon to Neuron written by Philip Nelson and published by Princeton University Press. This book was released on 2017-05-09 with total page 512 pages. Available in PDF, EPUB and Kindle. Book excerpt: What is light? -- Photons and life -- Color vision -- How photons know where to go -- Optical phenomena and life -- Direct image formation -- Imaging as inference -- Imaging by X-ray diffraction -- Vision in dim light -- The mechanism of visual transduction -- The first synapse and beyond -- Electrons, photons, and the Feynman principle -- Field quantization, polarization, and the orientation of a single molecule -- Quantum-mechanical theory of FRET

Download or read book Micro Light Emitting Diode Fabrication and Devices written by Jong-Hyun Ahn and published by Springer Nature. This book was released on 2022-01-04 with total page 161 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on basic fundamental and applied aspects of micro-LED, ranging from chip fabrication to transfer technology, panel integration, and various applications in fields ranging from optics to electronics to and biomedicine. The focus includes the most recent developments, including the uses in large large-area display, VR/AR display, and biomedical applications. The book is intended as a reference for advanced students and researchers with backgrounds in optoelectronics and display technology. Micro-LEDs are thin, light-emitting diodes, which have attracted considerable research interest in the last few years. They exhibit a set of exceptional properties and unique optical, electrical, and mechanical behaviors of fundamental interest, with the capability to support a range of important exciting applications that cannot be easily addressed with other technologies. The content is divided into two parts to make the book approachable to readers of various backgrounds and interests. The first provides a detailed description with fundamental materials and production approaches and assembly/manufacturing strategies designed to target readers who seek an understanding ofof essential materials and production approaches and assembly/manufacturing strategies designed to target readers who want to understand the foundational aspects. The second provides detailed, comprehensive coverage of the wide range of device applications that have been achieved. This second part targets readers who seek a detailed account of the various applications that are enabled by micro-LEDs.

Download or read book Cardiac Bioelectric Therapy written by Igor R. Efimov and published by Springer Nature. This book was released on 2021-01-28 with total page 421 pages. Available in PDF, EPUB and Kindle. Book excerpt: The updated and expanded second edition of this book presents a contemporary review of the basic science, engineering technology, and clinical practice of cardiac bioelectric therapy. It covers the rapidly expanding technological development of pacemakers and defibrillators as well as ablative therapy, electrophysiological mapping, and other clinical diagnostic and therapeutic breakthroughs. The book highlights many different aspects of bioelectric therapy, including history, biophysical and computational concepts, basic electrophysiology studies, engineering technology advances, and clinical perspectives. In this revised edition, leading clinical and basic electrophysiologists share their perspectives on the science behind the mechanisms of cardiac arrhythmias; breakthrough technologies for scientific and clinical investigation of heart rhythm disorders; theoretical conceptualization of arrhythmias and treatment using state-of-the-art computational approaches; and novel approaches to treatment of cardiac arrhythmias using implantable devices, percutaneous ablation therapies, machine learning, and other approaches. The Second Edition of Cardiac Bioelectric Therapy is an essential resource for physicians, residents, fellows, and graduate students in clinical cardiac electrophysiology, cardiology, and cardiac surgery as well as researchers, professionals, and students in biomedical, mechanical, and electrical engineering.