Download or read book Oncogene Techniques written by Peter K. Vogt and published by Academic Press. This book was released on 1995-08-29 with total page 746 pages. Available in PDF, EPUB and Kindle. Book excerpt: General Description of the Volume: Oncogenes have become a central focus of cancer research. All involved in this discipline will find this volume an invaluable aid in developing protocols needed for their research. General Description of the Series: The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with more than 300 volumes (all of them still in print), the series contains much material still relevant today--truly an essential publication for researchers in all fields of life sciences. Cell culture Molecular cloning Gene function Protein-protein interactions Protein-DNA interactions
Download or read book Holland Frei Cancer Medicine written by Robert C. Bast, Jr. and published by John Wiley & Sons. This book was released on 2017-03-10 with total page 2004 pages. Available in PDF, EPUB and Kindle. Book excerpt: Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies Cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates
Download or read book Molecular Biology of The Cell written by Bruce Alberts and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Oncogene Directed Therapies written by Janusz W. Rak and published by Springer Science & Business Media. This book was released on 2002-12-03 with total page 487 pages. Available in PDF, EPUB and Kindle. Book excerpt: Prominent investigators and clinicians summarize in a balanced blend of fundamental science, basic research, experimental therapeutics, and early clinical experiences, what is known about oncogenes and oncogenesis, and describe how that knowledge can be used to treat the cancer. The contributors explain how, why, and under what conditions certain proteins acquire the ability to transform eukaryotic cells, and detail the crucial biological consequences of this oncogenic transformation, particularly for cellular mitogenesis, survival, differentiation, migration, proteolysis, or angiogenic competence. Their articles thoroughly explicate the premises, principles, techniques, and approaches to oncogene targeting in various types of human cancer by using signal transduction inhibitors, immunological targeting methods, and antisense gene therapy.
Download or read book Oncogene and Transgenics Correlates of Cancer Risk Assessments written by Constantine Zervos and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 351 pages. Available in PDF, EPUB and Kindle. Book excerpt: The data, the information, and even the overarching knowledge necessary for risk assessments of economically important environmental carcinogens come, for the most part, from the applied biological disciplines, e. g. , toxicology, epidemiology, biostatistics, etc. The more fundamental biological disciplines, e. g. , biochemistry, cell biology, molecular biology, molecular genetics of cancer, etc. , have enormous but unrealized potential to improve current cancer risk assessment methods. The objective of this advanced research workshop ARW was to advance the state of the art of cancer risk assessment methods by identifying potential short and long term contributions to such methods from the more fundamental disciplines. Attention was paid to short and long term contributions from research advances in the biochemistry and physiology of oncogenes (oncogenes research) and in the construction and utilization of transgenic animals (transgenics research). In the last 20 years, researchers in the fundamental biological disciplines, i. e. , biochemists, geneticists, molecular and cell biologists, etc. , have, inter alia, advanced spectacularly our understanding of the nature of neoplastic diseases. Their phenomenal progress is the combined result of both advances and refinements of the techniques available to them and of new fundamental discoveries. Among the latter the most significant are the discoveries of oncogenes and of the feasibility of creating transgenic animals, i. e. , of transferring well defined and expressible genes from the cells of one species of organisms to the embryonic cells of another.
Download or read book Oncogene Induced Senescence Methods and Protocols written by Mikhail A. Nikiforov and published by Methods in Molecular Biology. This book was released on 2018-11-17 with total page 234 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book offers in a single volume a unique collection of the state-of the-art experimental procedures utilized for the induction, detection, and modeling of this complex cellular program of oncogene-induced senescence. The book encompasses protocols for studying this multi-step program in human specimens and a variety of experimental models including cultured mammalian cells, laboratory mice, and Drosophila melanogaster, as well as offering a description of high throughput approaches. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Oncogene-Induced Senescence: Methods and Protocols represents a valuable asset for a wide audience of medical oncologists and researchers in the fields of oncology, molecular and cellular biology, biochemistry, and animal development.
Download or read book New Molecular Genetic Techniques in Cancer Patient Management written by Kate Ruddon and published by . This book was released on 1987 with total page 20 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Cancer and Zebrafish written by David M. Langenau and published by Springer. This book was released on 2016-05-23 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume focuses on defining the unique attributes of using the zebrafish cancer model for discovering important pathways and potential drug targets for the treatment of human cancers. Using the zebrafish model, the volume explores oncogene and tumor suppressor discovery, chemical genetic approaches, genomics, epigenetics, cancer imaging, and cell transplantation. Contributed chapters come from the most prominent laboratories working in this field, which provides a unique perspective on zebrafish models from a wide spectrum of the research community. In addition, the book offers a detailed analysis of the most current research in the area for specific zebrafish cancer models, including T cell leukemia, rhabdomyosarcoma, liver and pancreatic cancer, melanoma, neuroblastoma, germ cell tumors, and malignant peripheral sheath tumors. A chapter is also dedicated to the development and utilization of other piscine models of cancer. The compilation of chapters in the volume culminates into a comprehensive and definitive text on zebrafish and cancer, providing a much needed resource on the powerful attributes of the zebrafish model system.
Download or read book Oncogenes written by Kathy B. Burck and published by Springer. This book was released on 1988-05-17 with total page 326 pages. Available in PDF, EPUB and Kindle. Book excerpt: This topical, handy volume is the perfect guide for physicians or scientists not specializing in the field, but wishing to understand exciting recent developments in cellular and molecular biology relevant to oncogene research. The terminology used in discussing oncogenes and their products is straightforwardly defined, and the concepts crucial to an understanding of oncogene research are clearly presented. Key topics are explored, including assay techniques used in molecular biology; methods for assessing behavior of normal genes and oncogenes; DNA and RNA tumor viruses; viruses inducing immunodeficiency; cellular proto-oncogenes and their relation to retroviral oncogenes; and possible roles of gene amplification and mutation, chromosomal translocation, and cellular growth factors in human cancer. An up-to-date survey of research on the major oncogenes and a discussion of the possibilities for future diagnostic and therapeutic applications of oncogene research are provided. The presentation is enhanced through many original illustrations, an appendix on oncogenes and related genes, and an up-to-date bibliography.
Download or read book Oncogene Techniques written by and published by Academic Press. This book was released on 1995-09-12 with total page 703 pages. Available in PDF, EPUB and Kindle. Book excerpt: General Description of the Volume: Oncogenes have become a central focus of cancer research. All involved in this discipline will find this volume an invaluable aid in developing protocols needed for their research. General Description of the Series: The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with more than 300 volumes (all of them still in print), the series contains much material still relevant today--truly an essential publication for researchers in all fields of life sciences. Cell culture Molecular cloning Gene function Protein-protein interactions Protein-DNA interactions
Download or read book Cancer Cell Signaling written by David M. Terrian and published by Springer Science & Business Media. This book was released on 2008-02-05 with total page 330 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cells respond to environmental cues through a complex and dynamic network of signaling pathways that normally maintain a critical balance between cellular proliferation, differentiation, senescence, and death. One current research challenge is to identify those aberrations in signal transd- tion that directly contribute to a loss of this division-limited equilibrium and the progression to malignant transformation. The study of cell-signaling m- ecules in this context is a central component of cancer research. From the knowledge of such targets, investigators have been able to productively advance many insightful hypotheses about how a particular cancer cell may misinterpret, or respond inappropriately to, growth regulatory cues in their environment. Despite these key insights, the rapidly evolving nature of cell signaling research in cancer has necessitated a continuous revision of these theoretical constructs and the updating of methods used in their study. One contemporary example of the evolution of this field is provided by an analysis of the Human Genome Project data, which reveal a previously unsuspected diversity in the multigene families encoding for most signaling pathway int- mediates. In assessing the usefulness of a particular methodological approach, therefore, we will need to keep in mind that there is a premium on those p- tocols that can be easily adapted for the analysis of multiple members within a gene family. Cancer Cell Signaling: Methods and Protocols brings together several such methods in cell signaling research that are scientifically grounded within the cancer biology field.
Download or read book Oncogene and Cancer written by Yahwardiah Siregar and published by Inst za onkologiju i radiol. This book was released on 2013-01-24 with total page 497 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes a course of cancer growth starting from normal cells to cancerous form and the genomic instability, the cancer treatment as well as its prevention in form of the invention of a vaccine. Some diseases are also discussed in detail, such as breast cancer, leucaemia, cervical cancer, and glioma. Understanding cancer through its molecular mechanism is needed to reduce the cancer incidence. How to treat cancer more effectively and the problems like drug resistance and metastasis are very clearly illustrated in this publication as well as some research result that could be used to treat the cancer patients in the very near future. The book was divided into six main sections: 1. HER2 Carcinogenesis: Etiology, Treatment and Prevention; 2. DNA Repair Mechanism and Cancer; 3. New Approach to Cancer Mechanism; 4. New Role of Oncogenes and Tumor Suppressor Genes; 5. Non Coding RNA and Micro RNA in Tumorigenesis; 6. Oncogenes for Transcription Factors
Download or read book Mechanisms of Oncogenesis written by Domenico Coppola and published by Springer Science & Business Media. This book was released on 2010-03-17 with total page 317 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book offers a comprehensive update on mechanisms of tumorigenesis. The first portion discusses pediatric cancer, the influence of environmental factors and oncogene activity in tumorigenesis; the second portion is structured by organ site for easy access.
Download or read book Cancer Gene Therapy written by David T. Curiel and published by Springer Science & Business Media. This book was released on 2007-11-03 with total page 491 pages. Available in PDF, EPUB and Kindle. Book excerpt: A complete introduction and guide to the latest developments in cancer gene therapy-from bench to bedside. The authors comprehensively review the anticancer genes and gene delivery methods currently available for cancer gene therapy, including the transfer of genetic material into the cancer cells, stimulation of the immune system to recognize and eliminate cancer cells, and the targeting of the nonmalignant stromal cells that support their growth. They also thoroughly examine the advantages and limitations of the different therapies and detail strategies to overcome obstacles to their clinical implementation. Topics of special interest include vector-targeting techniques, the lessons learned to date from clinical trials of cancer gene therapy, and the regulatory guidelines for future trials. Noninvasive techniques to monitor the extent of gene transfer and disease regression during the course of treatment are also discussed.
Download or read book Oncogenes and Carcinogenesis written by Pinar Erkekoglu and published by BoD – Books on Demand. This book was released on 2019-03-06 with total page 108 pages. Available in PDF, EPUB and Kindle. Book excerpt: Oncogenes are mutated and/or overexpressed at high levels in tumor cells. Tumors of the lung, breast, pancreas, and colon may display specific oncogenetic features. These tumors have been largely associated with exposure to environmental carcinogens and a variety of biological agents, including viruses. These carcinogens can induce specific genetic and epigenetic alterations in these tissues, leading to aberrant functioning of oncogenes and tumor suppressor genes. On the microRNAs (miRNAs) there are significant modifiers of both transcription and translation of oncogenes in carcinogenesis. In the last 50 years, several oncogenes and microRNAs related to these oncogenes have been identified in different types of human cancers. It is now clear that high expression of oncogenes, DNA damage response, and regulation of the cell cycle are related to the circadian clock. This book will mainly focus on the expressions of different oncogenes in breast, colon, and lung cancers. Moreover, readers will gain qualified scientific knowledge of the alterations in miRNAs in different types of cancers and the effects of the circadian clock on the expression of oncogenes in carcinogenesis.
Download or read book Oncogenes as Transcriptional Regulators written by Moshe Yaniv and published by Birkhäuser. This book was released on 2013-12-01 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt: The intensive study of molecular events leading to cellular transformation in tissue culture or in intact organisms culminated in the identification of 100 or more genes that can be defined as oncogenes or tumor suppressor genes. Functionally, these genes can be divided into several classes, each involved in a different step in transmission of signals from the exterior of the cell to the nucleus. The first oncogenes to be biochemically character ized included membrane receptors for growth factors, growth factors themselves, protein kinases or small GTP binding proteins involved in signal transduction. Later, the development of techniques to study pro teins-DNA interaction in eucaryotes and the isolation and characterization of many promoter and enhancer sequences revealed that a number of the classical retroviral oncogenes were indeed transcription factors. In paral lel, the rapid progress in the identification and cloning of chromosomal translocations in human and animal malignancies and the increased reper toire of known transcription factors families revealed that many other transcription factors can playa critical role in cancer. A more recent devel opment concerns tumor suppressor genes. The realization that human tumors are frequently associated with a loss of function of one or several genes is also one of the landmarks of cancer research in the last 15 years. Again, as we will see below, some of these genes encode transcription factors. It is becoming increasingly difficult to cover in a single monograph all oncogenes and tumor suppressor genes.
Download or read book Gene Therapy of Cancer written by Wolfgang Walther and published by Springer Science & Business Media. This book was released on 2008-02-01 with total page 633 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the discovery of the molecular structure of genes and the unveiling of the molecular basis of numerous human diseases, scientists have been fas- nated with the possibility of treating certain diseases by transducing foreign DNA into the affected cells. Initially, it was proposed that the foreign DNA could either replace defective nonfunctional genes, or code for therapeutic proteins. This concept has evolved into the rapidly growing field of gene therapy. Even though surgery, radiotherapy, and chemotherapy are widely ava- able and routinely used for cancer treatment, these therapies fail to cure approximately 50 percent of cancer patients. Therefore, since it is a disease characterized by aberrant gene expression, cancer has been a target of gene therapy research since the inception of this treatment modality. Numerous cancer gene therapy strategies are currently being investigated, including gene replacement therapy, the regulation of gene expression to modulate immu- logical responses to tumors, the direct killing of tumor cells, and direct int- ference with tumor growth. In this context, gene transfer systems, tumor-specific expression vectors, and novel therapeutic genes have been extensively st- ied. All these strategies aim for the selective destruction of human malignant disease while circumventing the destruction of nonmalignant cells and tissues thereby minimizing toxicity to the patient.
