Download or read book On the Tissue Response to Titanium Nanotube Modified Implants written by Garrett Cale Smith and published by . This book was released on 2012 with total page 119 pages. Available in PDF, EPUB and Kindle. Book excerpt: A major emphasis in biomaterials research is the design of the implant surface because of its profound influence on the tissue response. Many clinically used implants attempt to improve the tissue response through surface treatments. These physical or chemical modifications are known to alter the biological events at the tissue-implant interface. Recent advances in nano-fabrication offer the ability to create novel 3D surface structures at the molecular scale. The nano-fabrication technique selected was electrochemical anodization. We anodized titanium (Ti) implants to form vertically aligned titanium dioxide (TiO2) nanotube arrays. The nanotubes had precisely controlled dimensions with diameters of either 30 nm or 100 nm with a 3:1 height to diameter aspect ratio. The controls used were micron-roughened titanium or chemically inert surfaces. This dissertation investigated the in vivo tissue response to these nano-modified implant surface modifications. First, the in vivo soft tissue response was measured by fibrotic capsule thickness and nitric oxide presence. These inflammatory parameters were significantly lower for TiO2 nanotubes surface compared with the titanium control. Second, the in vivo bone response was investigated histologically for bone-implant- contact area, and mechanically with a tensile pull-out test to quantify the interfacial adhesion force. TiO2 nanotubes exhibited close contact with bone, and increased the interfacial adhesion strength by approximately 9-fold compared with a Ti micron roughened control surface. Lastly, we modified the structure and chemistry of the nanotube surface to examine how these factors influence adhesion to bone. The TiO2 100 nm diameter nanotube increased bone adhesion by approximately 1-fold compared with the TiO2 30 nm diameter nanotube and by approximately 6-fold compared to the chemically inert 100 nm diameter nanotube surface. The increased bone adhesion observed on the TiO2 nanotube surfaces is thus dependent on both the nanotube structure and chemistry. These findings may be significant for the interaction between implants in soft tissue as well as bone tissue to improve future clinical implants.

Download or read book Bone Tissue and Cell Response to Nano Modified Surface Structures written by Gary William Johnston and published by . This book was released on 2015 with total page 182 pages. Available in PDF, EPUB and Kindle. Book excerpt: Extensive research for biomaterial development and implant technology has focused on the surface of the material used because of the influence the surface has on cellular and tissue response. The events at the tissue-implant interface are known to be altered by physical or chemical modifications to the surface of an implant. Due to advances in nanotechology, there is particular interest in materials and processing techniques that can be engineered to elicit specific biological responses. Electrochemical anodization is a nano-fabrication technique that enables precise nano-structures to be formed on the surface of titanium. The vertically aligned, laterally spaced titanium oxide (TiO2) nanotube arrays that are formed via the electrochemical anodization process allow for controlled nano-geometries to be studied. The advantages of the nanotube structure has be previously been demonstrated to significantly accelerate osteoblast cell growth [1], improve bone-forming functionality [2], and direct mesenchymal stem cell fate [3]. These findings raise questions such as : (i) the optimization of the outer limits of the nano-geometry, (ii) the application of a similar nano-architecture to different materials without such properties, and (iii) the effects of nano-structures in vivo. This work investigated the cell response of nanotube structures that were larger than previously researched, as well as the use of a nanotube structure thin film on the surface of polymer for additional orthopedic applications. In addition, this dissertation investigated in vivo bone tissue response to nano-modified implant surface modifications. In order to examine the bone response the structure and chemistry of the nanotube surface to were modified to distinguish adhesion to bone. It was found the increased bone adhesion observed on the TiO2 nanotube surfaces is dependent on both the nanotube structure and chemistry. These findings may be significant for understanding the interaction between bone tissue and implant surfaces. The understanding of tissue and cell response to surface geometry and chemistry is critical to advance the field of orthopedic surface technology, and to further the understanding of cellular interactions with complex nano-interfaces.

Download or read book Titanium Dioxide written by Dongfang Yang and published by BoD – Books on Demand. This book was released on 2018-06-27 with total page 520 pages. Available in PDF, EPUB and Kindle. Book excerpt: Titanium dioxide is currently being used in many industrial products. It provides unique photocatalytic properties for water splitting and purification, bacterial inactivation, and organics degradation. It has also been widely used as the photoanode for dye-sensitized solar cells and coatings for self-cleaning surfaces, biomedical implants, and nanomedicine. This book covers various aspects of titanium dioxide nanomaterials including their unique one-dimensional, two-dimensional, mesoporous, and hierarchical nanostructures and their synthetic methods such as sol-gel, hydrothermal, anodic oxidation, and electrophoretic deposition, as well as its key applications in environmental and energy sectors. Through these 24 chapters written by experts from the international scientific community, readers will have access to a comprehensive overview of the recent research and development findings on the titanium dioxide nanomaterials.

Download or read book Surface Modification of Titanium Dental Implants written by Karan Gulati and published by Springer Nature. This book was released on 2023-02-27 with total page 259 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive technical and scientific overview of the surface modification of titanium dental implants. Coverage ranges from basic concepts of surface modification to advanced micro- and nano-engineering strategies employed to achieve augmented bioactivity to meet the needs of compromised patient conditions. A special focus of the book is advanced state-of-the-art electrochemically anodized nanostructures fabricated on implants towards enhanced bioactivity and local therapy. Surface Modification of Titanium Dental Implants will keep you current in the domain of titanium dental implants and will provide an improved understanding of their performance and application. The book will benefit engineers, clinicians, and researchers in biomaterials, biomedical engineering, dental and bone implants, nano-engineering, and technology.

Download or read book Nitrogen Oxides Advances in Research and Application 2012 Edition written by and published by ScholarlyEditions. This book was released on 2012-12-26 with total page 413 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nitrogen Oxides—Advances in Research and Application: 2012 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Nitrogen Oxides. The editors have built Nitrogen Oxides—Advances in Research and Application: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Nitrogen Oxides in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Nitrogen Oxides—Advances in Research and Application: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Download or read book Growth and Thermal Degradation of Titanium Oxide Nanotubes on Titanium for Bone Implants written by Amit M. Sharma and published by . This book was released on 2009 with total page 39 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Titanium in Medical and Dental Applications written by Francis Froes and published by Woodhead Publishing. This book was released on 2018-05-09 with total page 656 pages. Available in PDF, EPUB and Kindle. Book excerpt: Titanium in Medical and Dental Applications is an essential reference book for those involved in biomedical materials and advanced metals. Written by well-known experts in the field, it covers a broad array of titanium uses, including implants, instruments, devices, the manufacturing processes used to create them, their properties, corrosion resistance and various fabrication approaches. Biomedical titanium materials are a critically important part of biomaterials, especially in cases where non-metallic biomedical materials are not suited to applications, such as the case of load-bearing implants. The book also covers the use of titanium for implants in the medical and dental fields and reviews the use of titanium for medical instruments and devices. - Provides an understanding of the essential and broad applications of Titanium in both the medical and dental industries - Discusses the pathways to manufacturing titanium into critical biomedical and dental devices - Includes insights into further applications within the industry

Download or read book Nano engineered Titanium Implants for Complex Bone Therapies written by Karan Gulati and published by . This book was released on 2015 with total page 664 pages. Available in PDF, EPUB and Kindle. Book excerpt: A number of bone pathologies, such as fracture, infection or cancer, require drug therapy. However, conventional systemic drug administration is inefficient, wasteful, may not reach the target bone tissue in effective concentrations, and may cause unwanted side effects in other tissues. Ideally, drug should be delivered locally at the specific site, and in an optimal therapeutic concentration. Surface modification of the titanium implants can meet these challenges effectively by enabling effective delivery of therapeutics directly at the bone site for an extended period. Among the various suggested implant modifications, titania (TiO2) nanotubes (TNTs), which can easily be fabricated on Ti surfaces via cost-effective electrochemical anodization, is emerging as a possible strategy for local drug delivery. This thesis describes advances in TNT/Ti implant technology towards achieving effective therapeutic and cellular modulating action from the surface of Ti wire implants, which have been nano-engineered to fabricate TNTs. The concept was to design and optimize novel therapeutic features of TNTs, using simple and scalable technologies that can ensure easy integration into implants currently on the market. Specifically, in order to address complex bone conditions such as infection, inflammation, and cancers of bone, TNTs were fabricated on Ti wires that could be inserted into bone for 3D in-bone therapeutic release. The main points of the thesis can be summarized as: 1. Structural engineering of TNTs: Periodic tailoring of the TNT structures using a modulated electrochemical anodization process in an attempt to enhance drug loading and releasing abilities of the TNTs. 2. Fabrication optimization of TNTs on curved surfaces: Optimization of anodization conditions was undertaken, with a special focus on defining the role of electrolyte ageing, in order to fabricate a mechanically robust anodic layer (TNTs) on complex curved surfaces such as Ti wires. The purpose of this was to enable easy integration of TNT technology into the current implant market, which includes widely varied geometries (pins, screws, plates, meshes, etc.). 3. Therapies for complex bone conditions: Demonstration of TNTs/Ti wire abilities to meet a range of therapeutic needs was modelled, by determining the effect of local release of osteoporotic drugs from TNTs, when inserted into collagen gels containing human osteoblasts. This was followed by analysis of the therapeutic effect on cells, and cell spread/migration morphology on the TNT surfaces. 4. Formation of chitosan-microtubes on TNTs in-situ: Investigation of the fate of chitosan-modified TNT/Ti implants in phosphate buffer (isotonic to human blood). Chitosan degradation into micro-tubes on the surface of TNTs was investigated to elucidate the mechanism underlying the in-situ formation of these novel structures. 5. Titanium (Ti) nanotubes vs titania (TiO2) nanotubes: Conventional titania (TiO2) nanotubes were chemically reduced into titanium while preserving the nano-topography. The converted conducting titanium nanotube implants were proposed for electrical stimulation therapy and local drug delivery. 6. TNTs on 3D printed Ti alloys: Fabrication optimization of TNTs on a unique micro-rough 3D printed Ti alloy, to enable varied surface features, including irregular micro-roughness combined with nano-topography of TNTs. Comparison was then made of cell adhesion, attachment and modulation of osteoblast function by TNTs/Ti 3D implants with conventional smooth, micro-rough and TNTs/Ti flat foil surfaces. The investigations presented in the thesis are expected to open doors towards the development of advanced in-bone therapeutic implants, in the form of easy-to-tailor nano-engineered Ti wires, with superior 3D drug releasing abilities and enhanced bone healing functionalities. The emphasis has been on designing the simplest and most cost-effective methodologies to permit easy integration into the current implant market. Applications for these implants could be in the treatment of fractures, bone infections/cancers and 'local' osteoporosis in bones.

Download or read book Electrochemically Engineered Nanoporous Materials written by Dusan Losic and published by Springer. This book was released on 2015-07-18 with total page 377 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides in-depth knowledge about the fabrications, structures, properties and applications of three outstanding electrochemically engineered nanoporous materials including porous silicon, nanoporous alumina and nanotubular titania. The book integrates three major themes describing these materials. The first theme is on porous silicon reviewing the methods for preparation by electrochemical etching, properties and methods for surface functionalization relevant for biosensing applications. Biomedical applications of porous silicon are major focus, described in several chapters reviewing recent developments on bioanalysis, emerging capture probes and drug delivery. The second theme on nanoporous alumina starts with describing the concept of self-organized electrochemical process used for synthesis nanopore and nanotube structures of valve metal oxides and reviewing recent development and progress on this field. The following chapters are focused mainly on optical properties and biosensing application of nanoporous alumina providing the reader with the depth of understanding of the structure controlled optical and photonic properties and design of optical biosensing devices using different detection principles such as photoluminescence, surface plasmon resonance, reflective spectrometry, wave guiding, Raman scattering etc. The third theme is focused on nanotubular titania reviewing three key applications including photocatalysis, solar cells and drug delivery. The book represents an important resource for academics, researchers, industry professionals, post-graduate and high-level undergraduate students providing them with both an overview of the current state-of-the-art on these materials and their future developments.

Download or read book Nanotechnology Applications for Improvements in Energy Efficiency and Environmental Management written by Shah, M. A. and published by IGI Global. This book was released on 2014-07-31 with total page 498 pages. Available in PDF, EPUB and Kindle. Book excerpt: As nanoscale research continues to advance, scientists and engineers are developing new applications for many different disciplines, including environmental remediation and energy optimization. Nanotechnology Applications for Improvements in Energy Efficiency and Environmental Management combines up-to-date research findings and relevant theoretical frameworks on the subject of micro-scale technologies being used to promote environmental sustainability. Highlighting the impacts this technology has on energy production and remediation, this book is an all-inclusive reference source for professionals and researchers interested in understanding the multi-disciplinary applications of nanotechnology and nanoscience.

Download or read book An Extensive Analysis of Modified Nanotube Surfaces for Next generation Orthopedic Implants written by Christine Jeanette Frandsen and published by . This book was released on 2012 with total page 196 pages. Available in PDF, EPUB and Kindle. Book excerpt: The biological response to implant materials has been a topic of extensive research and discussion throughout the years. More recently, the field has become particularly exciting due to advances in nanotechnology, and the indications and belief that living cells sense and respond to cues on the nanoscale. A nanostructured material of special interest for orthopedic implant applications is the vertically aligned, laterally spaced titanium oxide (TiO2) nanotube arrays formed via electrochemical anodization techniques. Foundational work in the Jin Lab has demonstrated the advantages of the TiO2 nanotube surface due to indications that the nanotube architecture significantly accelerates osteoblast cell growth, improves bone-forming functionality, and even directs mesenchymal stem cell fate. However, these findings raise questions such as whether the same nano-architecture can be equally effective when exhibiting different surface chemistries. In addition, the feasibility of fabricating the nanotube structure from a thin film of titanium on the surface of an orthopedic implant composed of another material as a bioactive coating has been uncertain. The work reviewed in this dissertation attempts to answer these questions by providing in-depth experimental analysis of (a) comparative osteogenic behavior on nanotube surfaces of varying surface chemistries including ZrO2, TiO2, Ta, and Ta2O5, and (b) optimized anodization parameters for thin film TiO2 nanotube layers applied to industry-supplied orthopedic implant materials (i.e. zirconia and CoCr alloy), and initial osteoblast cell response to such coatings. The research of this dissertation conveys substantial contributions towards the field of orthopedic surface technology, and for furthered understanding of cellular interactions with complex nano-interfaces.

Download or read book Nanomedicine written by and published by Elsevier. This book was released on 2012-10-19 with total page 705 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nanotechnology is at the forefront of advances in medicine. Nanomedicine: Technologies and applications provides an important review of this exciting technology and its growing range of applications. After an introduction to nanomedicine, part one discusses key materials and their properties, including nanocrystalline metals and alloys, nanoporous gold and hydroxyapatite coatings. Part two goes on to review nanomedicine for therapeutics and imaging, before nanomedicine for soft tissue engineering is discussed in part three, including organ regeneration, skin grafts, nanotubes and self-assembled nanomaterials. Finally, nanomedicine for bone and cartilage tissue engineering is the focus of part four, with electrically active biocomposites as smart scaffolds investigated, as is cartilage and bone tissue engineering, regeneration and replacement. With its distinguished editor and international team of expert contributors, Nanomedicine: Technologies and applications is an indispensable guide for all those involved in the research, development and application of this exciting technology, whilst providing a comprehensive introduction for students and academics interested in this field. Provides an important review of nanomedicine technology and its growing range of applications Discusses key nanomedicine materials and their properties, including nanocrystalline metals and alloys, nanoporous gold and hydroxyapatite coatings Reviews nanomedicine for therapeutics and imaging and nanomedicine for soft tissue engineering

Download or read book On the bone tissue response to titanium implants written by Lars Sennerby and published by . This book was released on 1991 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Extra t.p. with thesis statement inserted.

Download or read book Smart Nanoparticles for Biomedicine written by Gianni Ciofani and published by Elsevier. This book was released on 2018-05-12 with total page 270 pages. Available in PDF, EPUB and Kindle. Book excerpt: Smart Nanoparticles for Biomedicine explores smart nanoparticles that change their structural or functional properties in response to specific external stimuli (electric or magnetic fields, electromagnetic radiation, ultrasound, etc.). Particular attention is given to multifunctional nanostructured materials that are pharmacologically active and that can be actuated by virtue of their magnetic, dielectric, optically-active, redox-active, or piezoelectric properties. This important reference resource will be of great value to readers who want to learn more on how smart nanoparticles can be used to create more effective treatment solutions. Nanotechnology has enabled unprecedented control of the interactions between materials and biological entities, from the microscale, to the molecular level. Nanosurfaces and nanostructures have been used to mimic or interact with biological microenvironments, to support specific biological functions, such as cell adhesion, mobility and differentiation, and in tissue healing. Recently, a new paradigm has been proposed for nanomedicine to exploit the intrinsic properties of nanomaterials as active devices rather than as passive structural units or carriers for medications. - Discusses the synthesis, characterization and applications of a new generation of smart nanoparticles for nanomedicine applications - Explores the problems relating to the biocompatibility of a range of nanoparticles, outlining potential solutions - Describes techniques for manipulating specific classes of nanoparticles for a variety of treatment types

Download or read book TiO2 Nanotubes on Titanium for Early Stage Osseointegration written by Anish Shivaram and published by . This book was released on 2017 with total page 230 pages. Available in PDF, EPUB and Kindle. Book excerpt: The results show mechanically stable TiO2 nanotubes up to 1microm length used on titanium surface were successful in improving the early stage osseointegrative properties. The use of silver coatings can provide a solution for infection control in vivo. The use of dopants and surface charge further helped enhancing the surface properties of TiO 2 nanotubes which would further enhance the early stage osseointegrative properties.

Download or read book Emerging Nanotechnologies in Dentistry written by Karthikeyan Subramani and published by William Andrew. This book was released on 2011-11-22 with total page 435 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nanotechnology and the future of Dentistry -- Nanoparticles for Dental Materials: Synthesis, analysis and Applications -- Antimicrobial nanoparticles in Restorative Composites -- Nanotechnology in operative dentistry: a perspective approach of history, mechanical behavior and clinical application -- Nanotechnology and dental implants -- Titanium surface modification techniques for dental implants - From microscale to nanoscale -- Titanium nanotubes as carriers of osteogenic growth factors and antibacterial drugs for applications in dental implantology -- Cellular responses to nanoscale surface modifications of titanium implants for dentistry and bone tissue engineering applications -- Corrosion Resistance of Ti6Al4V with Nanostructured TiO2 Coatings -- Multiwalled Carbon Nanotubes/Hydroxyapatite Nanoparticles incorporated GTR membranes -- Fabrication of PEG hydrogel micropatterns by Soft-photolithography and PEG hydrogel as Guided Bone Regeneration membrane in dental implantology -- Na ...

Download or read book Bioscience and Bioengineering of Titanium Materials written by Yoshiki Oshida and published by Newnes. This book was released on 2012-12-31 with total page 517 pages. Available in PDF, EPUB and Kindle. Book excerpt: The second edition of Bioscience and Bioengineering of Titanium Materials is an essential resource for anyone researching titanium in its fundamental aspects and in medical/dental applications. The book organizes and processes the findings from over 2,000 published articles and studies into a coherent and easily accessible volume, deftly weaving together older and newer technologies to give a clear overview. Bridging the gap between medical/dental and engineering/technology areas, the book covers material classification, fabrication and modification, as well as applications and biological reactions to titanium implants. The author, with extensive work in academics and industry, helps medical practitioners and students answer many practical questions, including: What is titanium? What type of titanium materials should I use in this case? How can I fabricate my design using titanium? Are there any alternative materials or methods? In the second edition, macro-, micro-, and nano-texturing of titanium surfaces, tissue engineering-related materials including scaffolds, and functionally graded materials and structures are extensively included and analyzed. - Provides quick access to the primary literature in this field - Up-to-date information on nanoscience and nanotechnology developments - Helps answer questions about the most appropriate materials to use and when to use them