Download or read book On Possibly Bioactive CP Titanium Implant Surfaces written by Anna Göransson and published by . This book was released on 2006 with total page 101 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book New Bioactive Surfaces for Titanium Implants written by Laëtitia Salou and published by . This book was released on 2015 with total page 212 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biocompatible and corrosion resistant regarding biological fluids, titanium is still an inert material: it does not participate actively at the tissue-integration around the implant. Surface modification of titanium at nanoscale can promote cell adhesion and differentiation by modulate genes expression due to a phenomenon of mechano-transduction. In this thesis, we have focused on the development, the characterization and the direct application of our nanostructured surface of medical devices. First of all, our study focused on the preparation and physicochemical characterization. After obtaining reproducible surfaces on small samples, our research has focused on the biological characterization of the surface. In-vivo studies conducted in rabbits have allowed us to show similar biomechanical attachment and good osseointegration of the nanostructured surface compared to commonly used surfaces on the market. The application of this new surface on more complex titanium implant such as tracheal prosthesis, has allowed us to observe delamination phenomenon of the nanostructure layer. Therefore, our research was oriented towards the problem of mechanical strength of the surface with the realization of nano scratch test and tribology. A topic in the zeitgeist, as a new EU regulation for medical devices which incorporate nanomaterials will take effect in 2017. To conclude, this work enable to propose a nanosurface with promising results of tissues integration required for medical device.

Download or read book Implant Surfaces and their Biological and Clinical Impact written by Ann Wennerberg and published by Springer. This book was released on 2015-01-05 with total page 190 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides the reader with the knowledge required in order to understand the chemical, physical, mechanical, and topographical aspects of implant surfaces, as well as their impact on the biological response. Common ways to modify implant surfaces are described, and methods for the evaluation of surface properties are presented in an easy-to-read style. Experimental results that have contributed to surface modifications relevant for commercial available implants are presented, with emphasis on in vivo and clinical studies. While the focus is primarily on surface modifications at the micrometer and nanometer levels, alterations at the millimeter level are also covered, including thread designs and their possible influence on stress distribution. In addition, it is analyzed how surface alterations have changed the clinical long-term results for certain groups of patients.

Download or read book Modification of Titanium to Generate Biocompatible and Bioactive Implant Surfaces written by Nina Adden and published by . This book was released on 2006 with total page 130 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Bioscience and Bioengineering of Titanium Materials written by Yoshiki Oshida and published by Elsevier. This book was released on 2010-07-07 with total page 447 pages. Available in PDF, EPUB and Kindle. Book excerpt: This unique book about bioscience and the bioengineering of titanium materials is based on more than 1,000 published articles. It bridges the gap between the medical/dental fields and the engineering/technology areas, due to the author's unique experience in both during the last 30 years. The book covers Materials Classifications, Chemical and Electrochemical Reactions, Oxidation, Biological Reactions, Implant-related Biological Reactions, Applications, Fabri-cation Technologies, Surface Modifications, and Future Perspectives.* Provides quick access to the primary literature in this field* Reviews studies of titanium materials in medical and dental applications, as reported in nearly 1,500 articles published over last several years* Draws information from several types of studies and reports* Helps readers answer questions about the most appropriate materials and when to use them

Download or read book On Biomimetics written by Lilyana Pramatarova and published by BoD – Books on Demand. This book was released on 2011-08-29 with total page 658 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bio-mimicry is fundamental idea "How to mimic the Nature" by various methodologies as well as new ideas or suggestions on the creation of novel materials and functions. This book comprises seven sections on various perspectives of bio-mimicry in our life; Section 1 gives an overview of modeling of biomimetic materials; Section 2 presents a processing and design of biomaterials; Section 3 presents various aspects of design and application of biomimetic polymers and composites are discussed; Section 4 presents a general characterization of biomaterials; Section 5 proposes new examples for biomimetic systems; Section 6 summarizes chapters, concerning cells behavior through mimicry; Section 7 presents various applications of biomimetic materials are presented. Aimed at physicists, chemists and biologists interested in biomineralization, biochemistry, kinetics, solution chemistry. This book is also relevant to engineers and doctors interested in research and construction of biomimetic systems.

Download or read book Titanium in Medicine written by Donald Maxwell Brunette and published by Springer Science & Business Media. This book was released on 2001 with total page 1062 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive book provides state-of-the-art scientific and technical information in a clear format and consistent structure making it suitable for formal course work or self-instruction. The authors are drawn not only from academic institutions but also from industry, so that practical aspects of implant fabrication and material handling are covered that are often lacking in biomaterials texts. Besides readers with a general interest in biomaterials, the book will interest materials investigators, surgeons and dentists using titanium implants, medical scientists and engineers, as well as lecturers at universities or institutes who would benefit by having ready access to authoritative information on the use of titanium for implants, devices and instruments. More information: http://www.titaniuminmedicine.com.

Download or read book Advanced Techniques in Bone Regeneration written by Alessandro Rozim Zorzi and published by BoD – Books on Demand. This book was released on 2016-08-31 with total page 388 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advanced Techniques in Bone Regeneration is a book that brings together over 15 chapters, written by leading practitioners and researchers, of the latest advances in the area, including surgical techniques, new discoveries, and promising methods involving biomaterials and tissue engineering. This book is intended for all who work in the treatment of disorders involving problems with the regeneration of bone tissue, are doctors or dentists, as well as are researchers and teachers involved in this exciting field of scientific knowledge.

Download or read book Titanium in Medical and Dental Applications written by Francis Froes and published by Woodhead Publishing. This book was released on 2018-05-09 with total page 656 pages. Available in PDF, EPUB and Kindle. Book excerpt: Titanium in Medical and Dental Applications is an essential reference book for those involved in biomedical materials and advanced metals. Written by well-known experts in the field, it covers a broad array of titanium uses, including implants, instruments, devices, the manufacturing processes used to create them, their properties, corrosion resistance and various fabrication approaches. Biomedical titanium materials are a critically important part of biomaterials, especially in cases where non-metallic biomedical materials are not suited to applications, such as the case of load-bearing implants. The book also covers the use of titanium for implants in the medical and dental fields and reviews the use of titanium for medical instruments and devices. - Provides an understanding of the essential and broad applications of Titanium in both the medical and dental industries - Discusses the pathways to manufacturing titanium into critical biomedical and dental devices - Includes insights into further applications within the industry

Download or read book Biological Responses of Fibroblasts and Osteoblasts on Modified Bioactive Titanium Implant Surfaces written by Mariana Cruz and published by . This book was released on 2017 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Background: Calcium-phosphate bioactive coatings have been suggested to improve the biological response of titanium. We have developed a new manufacturing protocol that enables integration of these bioactive materials in a titanium scaffold, overcoming the mechanical limitations of coatings. However, the biological behavior of these new materials is not yet described. Objectives: The aim of this study was to evaluate the behavior of human fetal osteoblasts and human gingival fibroblasts in contact with Titanium (Ti), Ti with 5% hydroxyapatite (TiHA) or Ti with 5% beta tricalcium phosphate (Ti-bTCP). Materials and methods: Ti, TiHA and Ti-bTCP discs were produced with homogeneous surface roughness. Human fetal osteoblasts and human gingival fibroblasts were cultured on discs for 14 days using previously established methods. Morphology and cellular adhesion were analyzed using scanning electron microscopy (SEM) after 1 and 7 days. Cell viability and proliferation were evaluated at pre-defined time-points (1,3,7 and 14 days) using a commercial resazurin-based method. Alkaline phosphatase (ALP) activity was evaluated at 7 and 14 days for osteoblasts. All results were presented as mean fluorescence intensity (AU) u00b1 standard deviation (SD). Mineralization patterns were evaluated using hydroxyapatite fluorescence staining. Group comparisons were tested using Anova (Tukeyu2019s post-hoc) using appropriate statistical software and significance was set p

Download or read book Surface Modification of Titanium Dental Implants written by Karan Gulati and published by Springer Nature. This book was released on 2023-02-27 with total page 259 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive technical and scientific overview of the surface modification of titanium dental implants. Coverage ranges from basic concepts of surface modification to advanced micro- and nano-engineering strategies employed to achieve augmented bioactivity to meet the needs of compromised patient conditions. A special focus of the book is advanced state-of-the-art electrochemically anodized nanostructures fabricated on implants towards enhanced bioactivity and local therapy. Surface Modification of Titanium Dental Implants will keep you current in the domain of titanium dental implants and will provide an improved understanding of their performance and application. The book will benefit engineers, clinicians, and researchers in biomaterials, biomedical engineering, dental and bone implants, nano-engineering, and technology.

Download or read book Plasma Electrolytic Oxidation PEO Coatings written by Marta Mohedano and published by MDPI. This book was released on 2021-06-02 with total page 172 pages. Available in PDF, EPUB and Kindle. Book excerpt: Plasma electrolytic oxidation (PEO), also known as micro-arc oxidation (MAO), functionalizes surfaces, improving the mechanical, thermal, and corrosion performance of metallic substrates, along with other tailored properties (e.g., biocompatibility, catalysis, antibacterial response, self-lubrication, etc.). The extensive field of applications of this technique ranges from structural components, in particular, in the transport sector, to more advanced fields, such as bioengineering. The present Special Issue covers the latest advances in PEO‐coated light alloys for structural (Al, Mg) and biomedical applications (Ti, Mg), with 10 research papers and 1 review from leading research groups around the world.

Download or read book Bioceramics written by and published by . This book was released on 2003 with total page 1188 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Evaluation of Bioactivity of Titanium After Varied Surface Treatments written by Raj Gaurav Singh and published by LAP Lambert Academic Publishing. This book was released on 2013 with total page 84 pages. Available in PDF, EPUB and Kindle. Book excerpt: Replacing missing teeth with osseointegrated implants can be regarded as the most significant breakthrough in the dental profession. Titanium is the implant material of choice for use in dental and orthopaedic applications because of its osseointegration ability. The stable oxide that forms readily on titanium surfaces was reported to contributes to its excellent biocompatibility. The nature of the oxide (thickness, porosity and crystallinity) also affect in vivo performance. However, it was also found that bone response to implant surface was dependent on the chemical and physical properties of titanium surfaces thereby affecting implant success.Bone formation around an implant is a complex process, and it is not fully understood. Apart from patient metabolism, physicochemical and topographical surface characteristics are some of the most influential factors in the improvement of osseointegration. The mechanical interlocking of micro and nano-irregularities with the tissue plays an important role in bioactivity.

Download or read book Investigation on the Surface Modification of Titanium Based Alloys for Improved Bioactivity written by Mohammad Mohsin Hossain and published by . This book was released on 2012 with total page 538 pages. Available in PDF, EPUB and Kindle. Book excerpt: Titanium-based engineering materials are currently considered to be the best artificial implant materials because of their good mechanical strength, resistance to corrosion, and their nontoxic compatibility with the stable oxide, TiO2. Ti6Al4V alloy is biologically inert, showing limited interaction with human tissue to their native oxide surface, which generally results in mechanical fixation. If the material is able to interact directly with tissue through chemical bonding, thus leading to a bioactive fixation, this will make a better and stronger implant for the promotion of cell attachment and migration and bone growth. Surface modification can improve the properties of surface oxide, leading to the formation of a stable oxide layer on the alloy's surface, and thus resulting in greater bioactivity. Surface modification is performed through surface chemical treatments, coatings deposition and chemical and thermal oxidation at a variety of process temperatures. The acid-alkaline-treated surface shows rougher, higher wettability and the presence of oxide of TiO2, as per the averaged results. In a comparison of roughness, wettability, and surface chemistry, no differences are observed between the original and solvent-treated surfaces. The crystalline structure of the surface treated samples reveals alpha and beta phases of Ti6Al4V alloy. However, the alpha 110 peak has only appeared on acid-alkaline substrate. This appearance is probably caused by a change of orientation of the crystallographic plane. Bioactivity results show no differences in Ca-P deposition between the surfaces, leading to CaHPO4, Ca/P~1.0. Some clusters deposit only on the original and solvent-treated surfaces which contain higher Ca-P than the surfaces in the non-cluster region, as observed by SEMEDS. Chemical oxidation treatments are conducted on the original surfaces by the H2O2, 37°C and H2O2, 80°C. Crystalline phases are generally associated with titanium alpha-beta, and a few with anatase and rutile. All the oxidised surfaces are defected by the presence of pores. Ti peaks are seen on the surfaces oxidised by H2O2, 37°C but no longer seen on the surfaces oxidised by H2O2, 80°C, except on the oxidised original surface. TiO2 concentrations are found quantitatively in the Ti 2p and O 1s spectra. A hydroxyl-rich oxides concentration is found at similar levels on all the oxidised surfaces. The oxidised acid-alkaline surface appears to be rougher than the other oxidised surfaces but the effects on the surface hydrophilicity are similar. Bioactivity results show a higher concentration of Ca-P deposits, leading to hydroxyapatite, Ca/P~1.6±0.1. The Ca-P deposition in SBF is increased from 3 to 14 days, as observed by XPS. Thick cluster layers are observed on the oxidised surfaces of the samples incubated for 14 days; these are composed of O, Ca and P; Ca/P~1.5, as observed by SEMEDS. Coating depositions of Ti and TiO2 are performed on the solvent-treated surface. XPS results show no Ti peaks present on the TiO2-deposited surface. The TiO2-deposited surface appears to be rougher and less hydrophilic than other surfaces. No significantly different Ca-P depositions are found on the deposited surfaces as results of CaHPO4 and Ca/P~1.0, which do not exhibit a good bioactive response. The chemically oxidised surfaces show a similarly roughened effect on all the oxidised surfaces. The oxidised Ti- and TiO2-deposited surfaces appear to be more hydrophilic than the oxidised solvent-treated alloys. The chemically oxidised surfaces reveal that Ca-P depositions increase, leading to hydroxyapatite, Ca/P~1.6±0.1 and that there are no differences in the oxidised deposited surfaces of any of the samples incubated from between 3 to 14 days. The Ca-P depositions on the oxidised deposited surfaces are found to have almost half the value of those on the oxidised solventtreated surfaces. The effects of thermal and chemical oxidation on the Ti-deposited samples are investigated. The crystalline structure is transformed from anatase to rutile in an increasing thermal temperature treatment of up to 800°C. At higher magnification, a thin layer with a porous structure is observed on the chemically oxidised surfaces. Shiny oxide layers are seen on the thermally oxidised surfaces. The concentration of atomic oxygen increases as the thermal temperature is increased from 100°C to 800°C, as observed by EDS. The surface chemistry results show that the content of chemically and thermally oxidised surfaces comprises hydroxyl-rich oxides and hydroxyl-poor oxides, respectively. Bioactivity results show that the chemically oxidised surface is able to deposit more Ca-P, leading to the formation of hydroxyapatite, Ca/P~1.7±0.1. However, the thermally oxidised surfaces deposit Ca(H2PO4)2 and, CaCO3 and P2O5 at temperatures of 100°C, 400°C and 800°C, respectively, at Ca/P~0.5. It has been conclusively proved that Ca-P depositions are dependent on the presence of hydroxyl-rich oxides. Apatite nucleation can be formally initiated at the stage of the completion of Ca-P depositions and can actively promote bone-growth after the material has been implanted.

Download or read book Corrosion Behavior of Anodized Titanium Nanotube Used in Implant Mater written by Abdulkareem Mohammed and published by . This book was released on 2015-06-16 with total page 144 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Phytic Acid Calcium Hydroxide Composite Coating on Titanium Implants Promote Early Osseointegration written by Hao Zhang and published by . This book was released on 2017 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Abstract:Titanium surfaces have been constantly modified to improve bioactivity and osseointegration. In this study, we modified titanium surfaces through hydrothermal treatment with a mixed solution of phytic acid and calcium hydroxide, then evaluated their bioactive and osteogenic activities. In vitro tests, calcium-decorated titanium surface enhanced the cell adhesion, proliferation and osteogenic differentiation of human bone marrow mesenchymal stem cells (hBMSCs). In vivo tests, Micro- CT and histological evaluations indicated that the modified implants promoted new bone formation and osseointegration between the implants and the host bone. These findings provided evidence that this simple modification would be promising solution to improve bioactivity and osseointegration, which would be beneficial not only for titanium implants but also other implanted biomaterials.Background: Titanium (Ti) or titanium alloys coated with various bioactive calcium phosphates (CaPs), including hydroxyapatite (HA) and u03b2-tricalcium phosphate (u03b2-TCP), are considered as satisfactory implant materials. CaP coatings provide nanostructural or microstructuctural characteristics on titanium or titanium alloys, thereby increasing the adhesion of osteoblasts, which enhance the osseointegration and shorten the healing time.Aim: To prepare and evaluate the effect of calcium-containing chemical conversion coating on promoting new bone formation and early osseointegration in vivo.Material and methods: We designed and prepared a phytic acid/calcium hydroxide composite coating on the pure titanium implant (Ti-SLA-2/10) through hydrothermal treatment with a mixed solution of phytic acid (PA) and saturated calcium hydroxide solution [Ca (OH)2]. The pure titanium implant with a sandblasted/acid-etched (SLA) surface was used as the control group (Ti-SLA). The surface morphology, elemental composition, surface roughness, wettability, and calcium ion release were investigated separately. Twenty-four SLA and calcium-containing SLA implants were immediately inserted into the mandibles of twelve New Zealand white rabbits. The biological effects were evaluated by Micro-computed tomography (Micro-CT) analysis and histological evaluation after 1, 2, and 4 weeks of healing. Results: Phytic acid/calcium hydroxide composite coating with superior hydrophilicity were successfully prepared on titanium implants. The surface characteristics showed Ti-SLA-2/10 implants with multiple pits and craters can release calcium ions continuously. In vivo, the volume of new bone around the Ti-SLA-2/10 implants was significantly higher than that of the Ti-SLA implants, but more fibrous tissue was observed surround the Ti-SLA implants after 1 week of healing. The Ti-SLA-2/10 implants showed higher bone volume fraction (bone volume/total volume, BV/TV, %) than that of the Ti-SLA implants at each time points (p