Download or read book Of Urfs And Orfs written by Russell F. Doolittle and published by University Science Books. This book was released on 1986 with total page 118 pages. Available in PDF, EPUB and Kindle. Book excerpt: In these days of facile cloning and rapid DNA sequencing, it is not uncommon for investigators to find themselves with a DNA sequence that may or may not code for a known gene product. The sequence is 'open' when read in an appropriate frame, which is to say that there is a long run of amino acid codons before the appearance of a terminator codon. How can we find out if this 'unidentified reading frame' (URF) really codes for a genuine protein, and how can we identify it if it exists? There are two general strategies, both of which can also be applied to the characterization of any 'open reading frame' (ORF), whether or not it has been 'identified'. The first and simplest approach involves computer searching and analysis; the second employs antibodies raised against synthetic peptides patterned on the sequence of the expected gene product. Both methods have been used with great success by many investigators. Each has, nonetheless, its pitfalls and frustrations. This primer is meant to guide the researcher past those obstacles as much as possible. Graduate students and researchers interested in amino acid sequencing; molecular biologists, biochemists, chemists, and biotechnologists.
Download or read book Molecular Biology written by Abraham Marcus and published by Elsevier. This book was released on 1989-01-01 with total page 725 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Biochemistry of Plants, Volume 15: Molecular Biology presents information pertinent to gene expression, cytoskeletal proteins, and hydroxyproline-rich glycoprotein. This book discusses the specific gene systems and examines the regulatory regions within the genes. Organized into 17 chapters, this volume starts with an overview of the important mechanism for regulating gene expression, which is significant in the selective turnover of gene products. This book then proceeds with a discussion of the concept of protein degradation and the extracellular carriers of genetic information. Other chapters review the viral and plasmid systems, which are relevant to plants. This text discusses as well the phenotypic changes in plants, including plant genetic tumor and habituated plant tissues that exhibit hormone autotrophic growth. The final chapter examines the importance of genetic manipulation at the cellular level via protoplast fusion, cell selection, and transformation. Biologists, biochemists, enzymologists, biophysicists, and plant scientists will find this book extremely useful.
Download or read book The Practices of Human Genetics written by Michael Fortun and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt: That concern about human genetics is at the top of many lists of issues requiring intense discussion from scientific, political, social, and ethical points of view is today no surprise. It was in the spirit of attempting to establish the basis for intelligent discussion of the issues involved that a group of us gathered at a meeting of the International Society for the History, Philosophy, and Social Studies of Biology in the Summer of 1995 at Brandeis University and began an exploration of these questions in earlier versions of the papers presented here. Our aim was to cross disciplines and jump national boundaries, to be catholic in the methods and approaches taken, and to bring before readers interested in the emerging issues of human genetics well-reasoned, informative, and provocative papers. The initial conference and elements of the editorial work which have followed were generously supported by the Stifterverband fUr die Deutsche Wissenschaft. We thank Professor Peter Weingart of Bielefeld University for his assistance in gaining this support. As Editors, we thank the anonymous readers who commented upon and critiqued many of the papers and in tum made each paper a more valuable contribution. We also thank the authors for their understanding and patience. Michael Fortnn Everett Mendelsohn Cambridge, MA September 1998 vii INTRODUCTION In 1986, the annual symposium at the venerable Cold Spring Harbor laboratories was devoted to the "Molecular Biology of Homo sapiens.
Download or read book Bioinformatics Basics written by Hooman H. Rashidi and published by CRC Press. This book was released on 1999-12-15 with total page 210 pages. Available in PDF, EPUB and Kindle. Book excerpt: Scientists in the throes of research use an extensive data bank to access structural information on proteins and nucleic acids. Meanwhile, geneticists use a highly specialized form of software to analyze the hybridization pattern of DNA chips. The past decade has been tremendously successful for biotechnology and pharmaceutical industries. This success has been a result of astounding technical advancements in genome sequencing (genomics), protein identification (proteomics), and data analysis-collectively called bioinformatics. The exponential increase in computer processing and disk storage has served as a catalyst and been instrumental in the development of bioinformatics. Bioinformatics Basics: Applications in Biological Science and Medicine describes the origin of this field and the organization of public domain databases with an introductory tutorial for the services described. This book explains these services in a relatively simple fashion. Nevertheless, a biological background is necessary to understand and properly utilize the various software components and services described in this book. A basic biological background is also necessary for understanding the biological and medical significance of the collected data. Bioinformatics Basics is a fast growing field, and it will take some years for a stabilization to occur. Until then, hundreds of Internet sites allow us to search, compare, and manipulate this data in its relatively raw format. Bioinformatics Basics: Applications in Biological Science and Medicine concentrates on three major database clusters and relevant software tools that are maintained in the United States, Europe, and Japan, offering free access and analysis through the Internet.
Download or read book Advances in Computational Biology written by H.O. Villar and published by Elsevier. This book was released on 1996-05-31 with total page 267 pages. Available in PDF, EPUB and Kindle. Book excerpt: The second volume in a series which aims to focus on advances in computational biology. This volume discusses such topics as: statistical analysis of protein sequences; progress in large-scale sequence analysis; and the architecture of loops in proteins.
Download or read book Advances in Microbial Physiology written by and published by Academic Press. This book was released on 1998-10-06 with total page 473 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Microbial Physiology
Download or read book Route Maps in Gene Technology written by Mark Walker and published by John Wiley & Sons. This book was released on 2009-07-17 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt: Route Maps in Gene Technology is an exciting new introductory textbook for first-year undergraduates in molecular biology and molecular genetics. The subject is broken down into 140 to 150 key concepts or topics, each of which is dealt with in one doublepaged spread. These range from basic introductory principles to applied topics at the cutting edge of research. A control strip along the top of the page shows the student which pages need to have been read beforehand and which topics may be followed afterward. In addition, at the front of the book are a selection of 'routes,' which the student or teacher may choose in order to study a particular topic. Because courses have become more 'modular' and many students arrive at college with little or no biology background, this approach enables teachers and students to structure a course of study to best suit their disparate exposure to biology. An exciting new concept in textbook design, allowing unparalleled flexibility on the part of the student and the teacher Covers the full range of modern molecular biology, from basic principles to the latest applications Attractive, clear and simple presentation with copious two-colour illustrations
Download or read book Biochemistry written by Donald Voet and published by John Wiley & Sons. This book was released on 2010-11-16 with total page 1520 pages. Available in PDF, EPUB and Kindle. Book excerpt: The "Gold Standard" in Biochemistry text books, Biochemistry 4e, is a modern classic that has been thoroughly revised. Don and Judy Voet explain biochemical concepts while offering a unified presentation of life and its variation through evolution. Incorporates both classical and current research to illustrate the historical source of much of our biochemical knowledge.
Download or read book Science Librarianship at America s Liberal Arts Colleges written by Tony Stankus and published by Routledge. This book was released on 2019-12-06 with total page 175 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this book, first published in 1992, science librarians analyse the life and times of small liberal arts college science libraries and the workday life of librarians serving scientists from a main campus library. They describe their efforts to defend expensive science collections in the face of tight budgets, to singlehandedly monitor and select literature in all areas from astronomy through zoology, and to compete with the humanities and social studies for library shelf space.
Download or read book Modern Protein Chemistry written by Gary C. Howard and published by CRC Press. This book was released on 2001-09-12 with total page 272 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years, interest in proteins has surged. This resurgence has been driven by the expansion of the post-genomic era when structural genomics and proteomics require new techniques in protein chemistry and new applications of older techniques. Protein chemistry methods are used by nearly every discipline of biomedical research. Many techniques
Download or read book Introduction to Computational Genomics written by Nello Cristianini and published by Cambridge University Press. This book was released on 2006-12-14 with total page 7 pages. Available in PDF, EPUB and Kindle. Book excerpt: Where did SARS come from? Have we inherited genes from Neanderthals? How do plants use their internal clock? The genomic revolution in biology enables us to answer such questions. But the revolution would have been impossible without the support of powerful computational and statistical methods that enable us to exploit genomic data. Many universities are introducing courses to train the next generation of bioinformaticians: biologists fluent in mathematics and computer science, and data analysts familiar with biology. This readable and entertaining book, based on successful taught courses, provides a roadmap to navigate entry to this field. It guides the reader through key achievements of bioinformatics, using a hands-on approach. Statistical sequence analysis, sequence alignment, hidden Markov models, gene and motif finding and more, are introduced in a rigorous yet accessible way. A companion website provides the reader with Matlab-related software tools for reproducing the steps demonstrated in the book.
Download or read book Biocomputing 96 Proceedings Of The Pacific Symposium written by Klein Teri E and published by World Scientific. This book was released on 1995-12-15 with total page 776 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first Pacific Symposium on Biocomputing (PSB), will be held January 3-6, 1996 at the Ritz Carlton Hotel on the Big Island of Hawaii. PSB will bring together top researchers from North America, the Asian Pacific nations, Europe, and around the world, to exchange research results and address open issues in all aspects of computational biology. Replacing and extending the last three years of Biotechnology Computing Tracks at the Hawaiian International Conference on System Sciences, PSB will provide a forum for the presentation of work in databases, algorithms, interfaces, visualization, modelling and other computational methods, as applied to biological problems, with emphasis on applications in data-rich areas of molecular biology.The PSB is focussed into 4 tracks, 4 minitracks, 2 workshops and includes two invited keynote speakers, viz., Logical Simulation of Biomolecular Information Pathways (Minoru Kanehisa, Kyoto Univ.) and CEX and the Single Chemist (David Weimger, DAYLIGHT Chemical Info. Syst.)
Download or read book Robustness and Evolvability in Living Systems written by Andreas Wagner and published by Princeton University Press. This book was released on 2013-10-24 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt: All living things are remarkably complex, yet their DNA is unstable, undergoing countless random mutations over generations. Despite this instability, most animals do not grow two heads or die, plants continue to thrive, and bacteria continue to divide. Robustness and Evolvability in Living Systems tackles this perplexing paradox. The book explores why genetic changes do not cause organisms to fail catastrophically and how evolution shapes organisms' robustness. Andreas Wagner looks at this problem from the ground up, starting with the alphabet of DNA, the genetic code, RNA, and protein molecules, moving on to genetic networks and embryonic development, and working his way up to whole organisms. He then develops an evolutionary explanation for robustness. Wagner shows how evolution by natural selection preferentially finds and favors robust solutions to the problems organisms face in surviving and reproducing. Such robustness, he argues, also enhances the potential for future evolutionary innovation. Wagner also argues that robustness has less to do with organisms having plenty of spare parts (the redundancy theory that has been popular) and more to do with the reality that mutations can change organisms in ways that do not substantively affect their fitness. Unparalleled in its field, this book offers the most detailed analysis available of all facets of robustness within organisms. It will appeal not only to biologists but also to engineers interested in the design of robust systems and to social scientists concerned with robustness in human communities and populations.
Download or read book A Bibliography on Computational Molecular Biology and Genetics written by Sarah Barron and published by DIANE Publishing. This book was released on 1991 with total page 120 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides a definitive bibliographic review of the literature related to DNA mapping and sequence analysis, with a focus on computer and mathematical aspects of molecular biology and genetics. Over 2200 entries, arranged by author's name.
Download or read book Post translational Modifications in Plants written by N. H. Battey and published by Cambridge University Press. This book was released on 1993-03-18 with total page 334 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is about what happens to proteins once they have been synthesised within the plant cell.
Download or read book The Phylogenetic Handbook written by Philippe Lemey and published by Cambridge University Press. This book was released on 2009-03-26 with total page 763 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Phylogenetic Handbook is a broad, hands on guide to theory and practice of nucleotide and protein phylogenetic analysis. This second edition includes six new chapters, covering topics such as Bayesian inference, tree topology testing and the impact of recombination on phylogenies, as well as a detailed section on molecular adaptation. The book has a stronger focus on hypothesis testing than the previous edition, with more extensive discussions on recombination analysis, detecting molecular adaptation and genealogy-based population genetics. Many chapters include elaborate practical sections, which have been updated to introduce the reader to the most recent versions of sequence analysis and phylogeny software, including BLAST, FastA, Clustal, T-coffee, Muscle, DAMBE, Tree-puzzle, Phylip, MEGA, PAUP*, IQPNNI, CONSEL, ModelTest, Prottest, PAML, HYPHY, MrBayes, BEAST, LAMARC, SplitsTree, and RDP. Many analysis tools are described by their original authors, resulting in clear explanations that constitute an ideal teaching guide for advanced-level undergraduate and graduate students.
Download or read book Protein Structure Prediction written by David Webster and published by Springer Science & Business Media. This book was released on 2008-02-03 with total page 425 pages. Available in PDF, EPUB and Kindle. Book excerpt: The number of protein sequences grows each year, yet the number of structures deposited in the Protein Data Bank remains relatively small. The importance of protein structure prediction cannot be overemphasized, and this volume is a timely addition to the literature in this field. Protein Structure Prediction: Methods and Protocols is a departure from the normal Methods in Molecular Biology series format. By its very nature, protein structure prediction demands that there be a greater mix of theoretical and practical aspects than is normally seen in this series. This book is aimed at both the novice and the experienced researcher who wish for detailed inf- mation in the field of protein structure prediction; a major intention here is to include important information that is needed in the day-to-day work of a research scientist, important information that is not always decipherable in scientific literature. Protein Structure Prediction: Methods and Protocols covers the topic of protein structure prediction in an eclectic fashion, detailing aspects of pred- tion that range from sequence analysis (a starting point for many algorithms) to secondary and tertiary methods, on into the prediction of docked complexes (an essential point in order to fully understand biological function). As this volume progresses, the authors contribute their expert knowledge of protein structure prediction to many disciplines, such as the identification of motifs and domains, the comparative modeling of proteins, and ab initio approaches to protein loop, side chain, and protein prediction.
