Download or read book OECD Guidelines for the Testing of Chemicals Section 4 Test No 452 Chronic Toxicity Studies written by OECD and published by OECD Publishing. This book was released on 2018-06-27 with total page 18 pages. Available in PDF, EPUB and Kindle. Book excerpt: The objective of these chronic toxicity studies is to characterize the profile of a substance in a mammalian species (primarily rodents) following prolonged and repeated exposure. The Test Guideline focuses on rodents and oral administration. Both ...
Download or read book OECD Guidelines for the Testing of Chemicals Section 4 Test No 453 Combined Chronic Toxicity Carcinogenicity Studies written by OECD and published by OECD Publishing. This book was released on 2018-06-27 with total page 20 pages. Available in PDF, EPUB and Kindle. Book excerpt: The objective of a combined chronic toxicity/carcinogenicity study is to identify carcinogenic and the majority of chronic effects, and to determine dose-response relationships following prolonged and repeated exposure. The rat is typically used for ...
Download or read book OECD Guidelines for the Testing of Chemicals Section 4 Test No 484 Genetic Toxicology Mouse Spot Test written by OECD and published by OECD Publishing. This book was released on 1986-10-23 with total page 4 pages. Available in PDF, EPUB and Kindle. Book excerpt: The mouse spot test detects presumed somatic mutations in fetal cells following transplacental absorption of the test substance. This is an in vivo test in mice in which developing embryos are exposed to a chemical (solid, liquid, vapour or ...
Download or read book OECD Guidelines for the Testing of Chemicals Section 4 Test No 408 Repeated Dose 90 Day Oral Toxicity Study in Rodents written by OECD and published by OECD Publishing. This book was released on 2018-06-27 with total page 16 pages. Available in PDF, EPUB and Kindle. Book excerpt: This method provides information on health hazard likely to arise from exposure to test substance via oral administration. The determination of sub-chronic oral toxicity using repeated doses may be carried out after initial information on toxicity has been obtained from acute or repeated dose ...
Download or read book OECD Guidelines for the Testing of Chemicals Section 4 Test No 411 Subchronic Dermal Toxicity 90 day Study written by OECD and published by OECD Publishing. This book was released on 1981-05-12 with total page 9 pages. Available in PDF, EPUB and Kindle. Book excerpt: This study relates to the analysis, via dermal application, of the health hazards of solid or liquid test substance. It may be carried out after initial information obtained by acute testing. This method is composed of the main test and the limit ...
Download or read book OECD Guidelines for the Testing of Chemicals Section 4 Test No 409 Repeated Dose 90 Day Oral Toxicity Study in Non Rodents written by OECD and published by OECD Publishing. This book was released on 1998-09-21 with total page 9 pages. Available in PDF, EPUB and Kindle. Book excerpt: This method provides information on health hazard likely to arise from short-term exposure to test substance. The determination of sub-chronic oral toxicity using repeated doses may be carried out after initial information on toxicity has been ...
Download or read book OECD Guidelines for the Testing of Chemicals Section 4 Test No 413 Subchronic Inhalation Toxicity 90 day Study written by OECD and published by OECD Publishing. This book was released on 2018-06-27 with total page 23 pages. Available in PDF, EPUB and Kindle. Book excerpt: This revised Test Guideline has been designed to fully characterize test article toxicity by the inhalation route for a subchronic duration (90 days), and to provide robust data for quantitative inhalation risk assessments. Groups of 10 male and 10 ...
Download or read book OECD Guidelines for the Testing of Chemicals Section 4 Test No 407 Repeated Dose 28 day Oral Toxicity Study in Rodents written by OECD and published by OECD Publishing. This book was released on 2008-10-16 with total page 13 pages. Available in PDF, EPUB and Kindle. Book excerpt: This method provides information on health hazard likely to arise from exposure to test substance via oral administration. The method is based on the repeated oral administration of the substance of interest during one limited period (one dose level ...
Download or read book OECD Guidelines for the Testing of Chemicals Section 4 Test No 412 Subacute Inhalation Toxicity 28 Day Study written by OECD and published by OECD Publishing. This book was released on 2018-06-27 with total page 23 pages. Available in PDF, EPUB and Kindle. Book excerpt: This revised Test Guideline 412 (TG 412) has been designed to fully characterize test article toxicity by the inhalation route following repeated exposure for a limited period of time (28 days), and to provide data for quantitative inhalation risk ...
Download or read book OECD Guidelines for the Testing of Chemicals Section 4 Test No 423 Acute Oral toxicity Acute Toxic Class Method written by OECD and published by OECD Publishing. This book was released on 2002-02-08 with total page 14 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is a test guideline for testing for Acute Oral Tosxidity using the Acute Toxic Class Method.
Download or read book OECD Guidelines for the Testing of Chemicals Section 4 Test No 414 Prenatal Developmental Toxicity Study written by OECD and published by OECD Publishing. This book was released on 2018-06-27 with total page 14 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Test Guideline for developmental toxicity testing is designed to provide general information concerning the effects of prenatal exposure on the pregnant test animal and on the developing organism. The test substance is normally administered to ...
Download or read book OECD Guidelines for the Testing of Chemicals Section 4 Test No 403 Acute Inhalation Toxicity written by OECD and published by OECD Publishing. This book was released on 2009-09-08 with total page 20 pages. Available in PDF, EPUB and Kindle. Book excerpt: This method provides information on health hazard likely to arise from short-term exposure to a test article (gas, vapour or aerosol/particulate test article) by inhalation. The revised Test Guideline describes two studies: a traditional LC50 ...
Download or read book OECD Guidelines for the Testing of Chemicals Section 4 Test No 420 Acute Oral Toxicity Fixed Dose Procedure written by OECD and published by OECD Publishing. This book was released on 2002-02-08 with total page 14 pages. Available in PDF, EPUB and Kindle. Book excerpt: A principle of the method is that in the main study only moderately toxic doses are used, and the administration of doses that are expected to be lethal should be avoided. This Guideline is intended primarily for use with rat. Groups of animals of a ...
Download or read book OECD Guidelines for the Testing of Chemicals Section 4 Test No 424 Neurotoxicity Study in Rodents written by OECD and published by OECD Publishing. This book was released on 1997-07-21 with total page 15 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Test Guideline has been designed to obtain the information necessary to confirm or to further characterise the potential neurotoxicity of chemicals in adult animals. This Test Guideline is designed for use with the rat. It specifically ...
Download or read book OECD Guidelines for the Testing of Chemicals Section 4 Test No 402 Acute Dermal Toxicity written by OECD and published by OECD Publishing. This book was released on 2017-10-09 with total page 13 pages. Available in PDF, EPUB and Kindle. Book excerpt: This method provides information on health hazard likely to arise from a short-term exposure to solid or liquid test substance by the dermal route. This Test Guideline is intended primarily for use with rodents (rat, rabbit or guinea pig may be ...
Download or read book OECD Guidelines for the Testing of Chemicals Section 4 Test No 425 Acute Oral Toxicity Up and Down Procedure written by OECD and published by OECD Publishing. This book was released on 2008-10-16 with total page 29 pages. Available in PDF, EPUB and Kindle. Book excerpt: The method permits estimation of an LD50 with a confidence interval and the results allow a substance to be classified for acute toxicity according to the Globally Harmonised System of classification and labelling of chemicals. It is easiest to ...
Download or read book OECD Guidelines for the Testing of Chemicals Section 4 Health Effects Test No 436 Acute Inhalation Toxicity Acute Toxic Class Method written by OECD and published by OECD Publishing. This book was released on 2009-09-08 with total page 27 pages. Available in PDF, EPUB and Kindle. Book excerpt: The method described by this Test Guideline provides information that allows hazard assessment for short-term exposure to a test article by inhalation, and allows the substance to be classified according to the Globally Harmonized System of ...
