Download or read book OECD Guidelines for the Testing of Chemicals Section 2 Test No 231 Amphibian Metamorphosis Assay written by OECD and published by OECD Publishing. This book was released on 2009-09-08 with total page 33 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Test Guideline describes an amphibian metamorphosis assay intended to screen substances which may interfere with the normal functioning of the hypothalamo-pituitary-thyroid axis. The assay was validated with the species Xenopus laevis, which is ...
Download or read book OECD Guidelines for the Testing of Chemicals Section 2 Test No 241 The Larval Amphibian Growth and Development Assay LAGDA written by OECD and published by OECD Publishing. This book was released on 2015-07-28 with total page 38 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Test Guideline describes the Medaka Extended One Generation Test (MEOGRT), which exposes fish over multiple generations to give data relevant to ecological hazard and risk assessment of chemicals, including suspected endocrine disrupting chemicals (EDCs). Exposure in the MEOGRT starts with ...
Download or read book OECD Guidelines for the Testing of Chemicals Section 2 Test No 235 Chironomus sp Acute Immobilisation Test written by OECD and published by OECD Publishing. This book was released on 2011-07-28 with total page 17 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Test Guideline describes an acute immobilisation assay on chronomids and is designed to complement existing Test Guidelines for chironomid chronic toxicity assays (TG 218, 219 and 233). The test method is based on TG 202: Daphnia sp. Acute ...
Download or read book OECD Guidelines for the Testing of Chemicals Section 2 Test No 202 Daphnia sp Acute Immobilisation Test written by OECD and published by OECD Publishing. This book was released on 2004-11-23 with total page 12 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Test Guideline describes an acute toxicity test to assess effects of chemicals towards daphnids (usually Daphnia magna Staus). Young daphnids, aged less than 24 hours at the start of the test, are exposed to the test substance at a range of ...
Download or read book OECD Guidelines for the Testing of Chemicals Section 2 Test No 223 Avian Acute Oral Toxicity Test written by OECD and published by OECD Publishing. This book was released on 2016-07-29 with total page 28 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Test Guideline describes procedures designed to estimate the acute oral toxicity of substances to birds, and it provides three testing options: (1) limit dose test, (2) LD50-slope test, and (3) LD50-only test. The LD50-slope and LD50-only options are sequential testing procedures.
Download or read book OECD Guidelines for the Testing of Chemicals Section 2 Test No 204 Fish Prolonged Toxicity Test 14 Day Study written by OECD and published by OECD Publishing. This book was released on 1984-04-04 with total page 9 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Test Guideline presents guidance for measurement of lethal and other observed effects in fish exposed to test substances. It may be used in place of Test Guideline 203 if a longer observation period is considered useful and appropriate and the ...
Download or read book OECD Guidelines for the Testing of Chemicals Section 2 Test No 215 Fish Juvenile Growth Test written by OECD and published by OECD Publishing. This book was released on 2000-01-21 with total page 16 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Test Guideline is designed to assess the effects of prolonged exposure to chemicals on the growth of juvenile fish. Juvenile fish in exponential growth phase are placed, after being weighed, in test chambers and are normally exposed to five ...
Download or read book OECD Guidelines for the Testing of Chemicals Section 2 Test No 210 Fish Early life Stage Toxicity Test written by OECD and published by OECD Publishing. This book was released on 2013-07-26 with total page 24 pages. Available in PDF, EPUB and Kindle. Book excerpt: The test method described in this Test Guideline, is intended to define the lethal and sub-lethal effects of chemicals on the early life stages of the species tested. The early-life stages of fish are exposed to five concentrations of the test ...
Download or read book OECD Guidelines for the Testing of Chemicals Section 2 Test No 211 Daphnia magna Reproduction Test written by OECD and published by OECD Publishing. This book was released on 2021-06-17 with total page 25 pages. Available in PDF, EPUB and Kindle. Book excerpt: The test method described in this Test Guideline assesses the effect of chemicals on the reproductive output of Daphnia magna Straus. To this end, young female Daphnia are exposed to the test substance added to water at a range of concentrations (at ...
Download or read book OECD Guidelines for the Testing of Chemicals Section 2 Test No 203 Fish Acute Toxicity Test written by OECD and published by OECD Publishing. This book was released on 2019-06-18 with total page 10 pages. Available in PDF, EPUB and Kindle. Book excerpt: The fish are exposed to the test substance preferably for a period of 96 hours. Mortalities are recorded at 24, 48, 72 and 96 hours and the concentrations which kill 50 per cent of the fish (LC50) are determined where possible. One or more species ...
Download or read book OECD Guidelines for the Testing of Chemicals Section 2 Test No 214 Honeybees Acute Contact Toxicity Test written by OECD and published by OECD Publishing. This book was released on 1998-09-21 with total page 7 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Test Guideline is a laboratory test method, designed to assess the acute contact toxicity of pesticides and other chemicals to adult worker honeybees. Anaesthetized adult worker honeybees are exposed to five doses in a geometric series of the ...
Download or read book OECD Guidelines for the Testing of Chemicals Section 2 Test No 212 Fish Short term Toxicity Test on Embryo and Sac Fry Stages written by OECD and published by OECD Publishing. This book was released on 1998-09-21 with total page 20 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this Short-term Toxicity Test on Fish Embryo and Sac-Fry Stages, the life stages from the newly fertilized egg to the end of the sac-fry stage are exposed. The embryo and sac-fry stages of fish are exposed to five concentrations of the test ...
Download or read book OECD Guidelines for the Testing of Chemicals Section 2 Test No 246 Bumblebee Acute Contact Toxicity Test written by OECD and published by OECD Publishing. This book was released on 2017-10-09 with total page 11 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Test Guideline describes a method to assess effects of a test chemical on the phagocytotic activity of activated sludge containing protozoan organisms under defined conditions in the presence of different concentrations of the test chemical. The principle of biological sewage-treatment ...
Download or read book OECD Guidelines for the Testing of Chemicals Section 2 Test No 213 Honeybees Acute Oral Toxicity Test written by OECD and published by OECD Publishing. This book was released on 1998-09-21 with total page 8 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Test Guideline is a laboratory test method, designed to assess the oral acute toxicity of pesticides and other chemicals, to adult worker honeybees. Adult worker honeybees are exposed to five doses in a geometric series of the test substance ...
Download or read book OECD Guidelines for the Testing of Chemicals Section 2 Test No 248 Xenopus Eleutheroembryonic Thyroid Assay XETA written by OECD and published by OECD Publishing. This book was released on 2019-06-18 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The purpose of the test is to measure the capacity of a chemical to activate or inhibit the transcription of a genetic construct (THb/ZIP-GFP X. laevis eleutheroembryos) either by binding to the thyroid hormone receptor or by modifying the amount of thyroid hormone available for transcription. The test is based on the use of a transgenic frog (possessing the genetic construction THb/ZIP-GFP) of the species X. laevis. GFP is a fluorescent protein that can be used to affirm the presence of the substance and to follow its action. This test is based on the quantification of fluorescence, and thus of the GFP protein, throughout the eleutheroembryo exposed to a test chemical. Indeed, if the fluorescence is > 12% by including the highest concentration of the test, the test is considered positive. Organisms are exposed in chemically inert cell culture plates (6 wells). Each well contains ten organisms in solution. In a run, 20 organisms are exposed to each test concentration. Tadpoles are exposed to the test chemical at NF stage 45 for a duration of 72 hours. A positive result of the XETA test indicates in vivo that a substance induces damage to the receptor and metabolization of the thyroid hormone. A negative result indicates that, under test conditions, the test substance does not induce detectable damage to the thyroid and its functioning.
Download or read book Medaka written by Kenji Murata and published by John Wiley & Sons. This book was released on 2019-10-07 with total page 478 pages. Available in PDF, EPUB and Kindle. Book excerpt: Explains the advantages of using medaka in experimental designs, to facilitate research, and to stimulate progress by adopting medaka as a model animal The second volume of Medaka: Biology, Management, and Experimental Protocols, together with the first volume, helps to familiarize scientists with the advantages of using medaka in experimental designs, to facilitate research using medaka, and to stimulate progress by adopting medaka as a model animal. The second edition expands on the first by providing additional information and current protocols that have been recently developed, or modified, to successfully raise medaka fish under stable culture conditions in the laboratory. This volume explores new technologies developed after 2009, using the fish as a molecular tool in the fields of life science, evolution, ecology, and toxicology. The authors—noted experts in the field—provide the latest information that spans the varied research disciplines and addresses the value to science of medaka's adoption as a model animal. This important book: Explores the advantages of using medaka in experimental designs, to facilitate research Details the most recent protocols to successfully raise medaka fish under stable conditions in the laboratory Explores the most recent developments in the field Provides step-by step specifics for each protocol, allowing researchers to adapt them for use in their own work Written for students and researchers in fish biology and aquaculture, Medaka: Biology, Management, and Experimental Protocols, Volume 2 introduces the cutting edge research in basic and applied biology using medaka as a model animal as well as descriptions of experimental methods and protocols.
Download or read book Hayes Principles and Methods of Toxicology written by A. Wallace Hayes and published by CRC Press. This book was released on 2023-07-03 with total page 2143 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hayes’ Principles and Methods of Toxicology has long been established as a reliable and informative reference for the concepts, methodologies, and assessments integral to toxicology. The new edition contains updated and new chapters with the addition of new authors while maintaining the same high standards that have made this book a benchmark resource in the field. Key Features: The comprehensive yet concise coverage of various aspects of fundamental and applied toxicology makes this book a valuable resource for educators, students, and professionals. Questions provided at the end of each chapter allow readers to test their knowledge and understanding of the material covered. All chapters have been updated and over 60 new authors have been added to reflect the dynamic nature of toxicological sciences New topics in this edition include Safety Assessment of Cosmetics and Personal Care Products, The Importance of the Dose/Rate Response, Novel Approaches and Alternative Models, Epigenetic Toxicology, and an Expanded Glossary. The volume is divided into 4 major sections, addressing fundamental principles of toxicology (Section I. "Principles of Toxicology"), major classes of established chemical hazards (Section II. "Agents"), current methods used for the assessment of various endpoints indicative of chemical toxicity (Section III. "Methods"), as well as toxicology of specific target systems and organs (Section IV. "Organ- and System-Specific Toxicology"). This volume will be a valuable tool for the audience that wishes to broaden their understanding of hazards and mechanisms of toxicity and to stay on top of the emerging methods and concepts of the rapidly advancing field of toxicology and risk assessment.
