Download or read book Nuclear Volume and Cellular Metabolism written by Reinhard Hildebrand and published by Springer. This book was released on 2011-11-23 with total page 56 pages. Available in PDF, EPUB and Kindle. Book excerpt: The application of morphometric techniques in biology and the development ofbioche mical methods for cytological-histological research have deepened substantially our knowledge and understanding of the structure, dynamics, and function of morphologi cal structures, thereby improving upon a purely descriptive presentation. Thus the limits between the individual disciplines in basic research have become blurred. With the development of suitable methods of measuring the size of nuclear volu mes, it has become possible to obtain data regarding the variable state and nucleo kinetic processes in the "genetic center of control" of the cell (Siebert 1967), and to evaluate these data statistically so as to make them verifiable. With the formulation of the "basic law of karyometry" by Palkovits and Fischer (1968), in a dynamic approach to "genetic" and "functional trends" in karyometry, i. e. , an attempt to relate nuclear volume changes exclusively to the size and number of chromosomes, and, on the other hand, to comprehend these changes as an expression of functional changes, successfully connected with one another and interpreted bio logically. The early function-oriented observation that a swelling of the nuclear volume is an expression of an increase in cellular function, while a decrease in the volume is an indication of a lowering of activity, provided a preliminary basis for estimating nu clear size as a statement about the functional state of a tissue or organ.
Download or read book Nuclear Volume and Cellular Metabolism written by R. Hildebrand and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 63 pages. Available in PDF, EPUB and Kindle. Book excerpt: The application of morphometric techniques in biology and the development ofbioche mical methods for cytological-histological research have deepened substantially our knowledge and understanding of the structure, dynamics, and function of morphologi cal structures, thereby improving upon a purely descriptive presentation. Thus the limits between the individual disciplines in basic research have become blurred. With the development of suitable methods of measuring the size of nuclear volu mes, it has become possible to obtain data regarding the variable state and nucleo kinetic processes in the "genetic center of control" of the cell (Siebert 1967), and to evaluate these data statistically so as to make them verifiable. With the formulation of the "basic law of karyometry" by Palkovits and Fischer (1968), in a dynamic approach to "genetic" and "functional trends" in karyometry, i. e. , an attempt to relate nuclear volume changes exclusively to the size and number of chromosomes, and, on the other hand, to comprehend these changes as an expression of functional changes, successfully connected with one another and interpreted bio logically. The early function-oriented observation that a swelling of the nuclear volume is an expression of an increase in cellular function, while a decrease in the volume is an indication of a lowering of activity, provided a preliminary basis for estimating nu clear size as a statement about the functional state of a tissue or organ.
Download or read book Molecular Biology of The Cell written by Bruce Alberts and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Heterogeneity of Cancer Metabolism written by Anne Le and published by Springer. This book was released on 2018-06-26 with total page 186 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genetic alterations in cancer, in addition to being the fundamental drivers of tumorigenesis, can give rise to a variety of metabolic adaptations that allow cancer cells to survive and proliferate in diverse tumor microenvironments. This metabolic flexibility is different from normal cellular metabolic processes and leads to heterogeneity in cancer metabolism within the same cancer type or even within the same tumor. In this book, we delve into the complexity and diversity of cancer metabolism, and highlight how understanding the heterogeneity of cancer metabolism is fundamental to the development of effective metabolism-based therapeutic strategies. Deciphering how cancer cells utilize various nutrient resources will enable clinicians and researchers to pair specific chemotherapeutic agents with patients who are most likely to respond with positive outcomes, allowing for more cost-effective and personalized cancer therapeutic strategies.
Download or read book Cell Biology by the Numbers written by Ron Milo and published by Garland Science. This book was released on 2015-12-07 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: A Top 25 CHOICE 2016 Title, and recipient of the CHOICE Outstanding Academic Title (OAT) Award. How much energy is released in ATP hydrolysis? How many mRNAs are in a cell? How genetically similar are two random people? What is faster, transcription or translation?Cell Biology by the Numbers explores these questions and dozens of others provid
Download or read book Metabolic Signaling written by Sarah-Maria Fendt and published by Humana. This book was released on 2018-10-13 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides protocols to quantify metabolism, to identify metabolic crosstalk, and to setup and develop tools and models to gain insight into metabolic signaling using experimental and computational approaches. Chapters detail protocols to quantify metabolism, identify metabolic crosstalk, and develop tools and models to gain a systems-level insight into metabolic signaling. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Metabolic Signaling: Methods and Protocols aims to provide researchers with methods to study, perturb, and functionally interpret metabolism and metabolic signaling from the sub-cellular to the whole-body level.
Download or read book Metabolism in Cancer written by Thorsten Cramer and published by Springer. This book was released on 2016-08-24 with total page 272 pages. Available in PDF, EPUB and Kindle. Book excerpt: This textbook presents concise chapters written by internationally respected experts on various important aspects of cancer-associated metabolism, offering a comprehensive overview of the central features of this exciting research field. The discovery that tumor cells display characteristic alterations of metabolic pathways has significantly changed our understanding of cancer: while the first description of tumor-specific changes in cellular energetics was published more than 90 years ago, the causal significance of this observation for the pathogenesis of cancer was only discovered in the post-genome era. The first 10 years of the twenty-first century were characterized by rapid advances in our grasp of the functional role of cancer-specific metabolism as well as the underlying molecular pathways. Various unanticipated interrelations between metabolic alterations and cancer-driving pathways were identified and currently await translation into diagnostic and therapeutic applications. Yet the speed, quantity, and complexity of these new discoveries make it difficult for researchers to keep up to date with the latest developments, an issue this book helps to remedy.
Download or read book Emerging Technologies for Nutrition Research written by Institute of Medicine and published by National Academies Press. This book was released on 1997-09-03 with total page 729 pages. Available in PDF, EPUB and Kindle. Book excerpt: The latest of a series of publications based on workshops sponsored by the Committee on Military Nutrition Research, this book's focus on emerging technologies for nutrition research arose from a concern among scientists at the U.S. Army Research Institute of Environmental Medicine that traditional nutrition research, using standard techniques, centered more on complex issues of the maintenance or enhancement of performance, and might not be sufficiently substantive either to measure changes in performance or to predict the effects on performance of stresses soldiers commonly experience in operational environments. The committee's task was to identify and evaluate new technologies to determine whether they could help resolve important issues in military nutrition research. The book contains the committee's summary and recommendations as well as individually authored chapters based on presentations at a 1995 workshop. Other chapters cover techniques of body composition assessment, tracer techniques for the study of metabolism, ambulatory techniques for the determination of energy expenditure, molecular and cellular approaches to nutrition, the assessment of immune function, and functional and behavioral measures of nutritional status.
Download or read book Computational Approaches to Nuclear Receptors written by Pietro Cozzini and published by Royal Society of Chemistry. This book was released on 2012-11-30 with total page 191 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nuclear receptors (NR) are ligand-induced activated transcription factors that are involved in numerous biological processes. Since the 1990's when the first structures were determined by means of X ray diffraction, the number of NR structures has increased considerably. Moreover several 'omics' projects (genomics, pharmcogenomics and proteomics) have opened up great opportunities for the discovery of new targets, the characterization of abnormal protein patterns, the selection of "tailored" drugs and the evaluation of drug efficacy even with a lack of structural data. Furthermore, structure-based drug design, computational methods for in silico screening and nanobiotechnology- based tools are simplifying this time-consuming and money-intensive research of lead compounds and, possibly, new drugs. Biological interactions such as those that occur between a protein and ligand are concerted events where flexible molecules interact. Thus understanding flexibility of large molecules or biological complexes is of primary importance to help define the right model to approximate the reality for drug discovery, virtual screening, food safety analysis, etc. NRs are known as flexible targets, with many structural similarities, in particular for their Ligand Binding Domain: these similarities could be assumed to share behavioural qualities that belong to this class of compounds. Thus to supply a possible, complete and exhaustive answer to questions about the behaviour of NRs, their interactions with new potential drugs, endocrine disruptors such as animal and human food toxins, food additives or industry residuals, it is mandatory to approach the problem from a different point of view: a molecular modelling approach, steered synthesis, and in vitro and in vivo tests, etc. The aim of this book is to provide a state of the art review on investigations into Nuclear Receptors.
Download or read book Modeling Brain Function written by D. J. Amit and published by Cambridge University Press. This book was released on 1989 with total page 528 pages. Available in PDF, EPUB and Kindle. Book excerpt: One of the most exciting and potentially rewarding areas of scientific research is the study of the principles and mechanisms underlying brain function. It is also of great promise to future generations of computers. A growing group of researchers, adapting knowledge and techniques from a wide range of scientific disciplines, have made substantial progress understanding memory, the learning process, and self organization by studying the properties of models of neural networks - idealized systems containing very large numbers of connected neurons, whose interactions give rise to the special qualities of the brain. This book introduces and explains the techniques brought from physics to the study of neural networks and the insights they have stimulated. It is written at a level accessible to the wide range of researchers working on these problems - statistical physicists, biologists, computer scientists, computer technologists and cognitive psychologists. The author presents a coherent and clear nonmechanical presentation of all the basic ideas and results. More technical aspects are restricted, wherever possible, to special sections and appendices in each chapter. The book is suitable as a text for graduate courses in physics, electrical engineering, computer science and biology.
Download or read book Health Risks from Exposure to Low Levels of Ionizing Radiation written by Committee to Assess Health Risks from Exposure to Low Levels of Ionizing Radiation and published by National Academies Press. This book was released on 2006-03-23 with total page 422 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is the seventh in a series of titles from the National Research Council that addresses the effects of exposure to low dose LET (Linear Energy Transfer) ionizing radiation and human health. Updating information previously presented in the 1990 publication, Health Effects of Exposure to Low Levels of Ionizing Radiation: BEIR V, this book draws upon new data in both epidemiologic and experimental research. Ionizing radiation arises from both natural and man-made sources and at very high doses can produce damaging effects in human tissue that can be evident within days after exposure. However, it is the low-dose exposures that are the focus of this book. So-called “late” effects, such as cancer, are produced many years after the initial exposure. This book is among the first of its kind to include detailed risk estimates for cancer incidence in addition to cancer mortality. BEIR VII offers a full review of the available biological, biophysical, and epidemiological literature since the last BEIR report on the subject and develops the most up-to-date and comprehensive risk estimates for cancer and other health effects from exposure to low-level ionizing radiation.
Download or read book Sports Endocrinology written by F. Lanfranco and published by Karger Medical and Scientific Publishers. This book was released on 2016-06-28 with total page 182 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is an up-to-date, extensive overview of the effects of physical activity and training on endocrine function. It gives insights into a complex relationship by describing effects with respect to exercise performance, growth, development, and ageing. It includes discussions of the endocrine response depending on exercise mode, intensity, and duration as well as on gender, age, and fitness level. Additionally the book deals with the impact of environmental and psychological factors on endocrine level. A substantial part of Sports Endocrinology is devoted to the 'hot topic' of hormonal doping in sports. The properties of androgens, growth hormone, erythropoietin, and dietary supplements are highlighted. The use and abuse among professional and recreational athletes is discussed and specific methods of detection are presented and explained. All contributors are well-known experts in sports medicine and endocrinology, endocrine physiology, pharmacology, and doping detection, so this book is a must-read for every professional involved in the field.
Download or read book Principles of Nuclear Structure and Function written by P. R. Cook and published by Wiley-Liss. This book was released on 2001-04-24 with total page 376 pages. Available in PDF, EPUB and Kindle. Book excerpt: The nucleus guides the life processes of the cell by directing cellular reproduction, differentiation during development, and metabolism. The study of the structure and function of the nucleus along with its genetic material serves as the foundation for the science of genetics. Principles of Nuclear Structure and Function provides a comprehensive overview of the cell nucleus by illustrating the connection between function and the architecture of the nucleus. Richly illustrated throughout, each chapter includes an overview, detailed examples, summary points, references, and callout boxes highlighting methods and cutting-edge technology. The appendix provides a useful list of related Web sites. Some of the subjects reviewed within Principles of Nuclear Structure and Function include: * Nuclear structure, replication, damage, and repair * Regulation of gene expression * The cell cycle * Meiosis and recombination This timely volume presents functional studies within their proper structural context and is an informative profile of the cell and molecular biology in nuclei and chromatin. For those studying cell biology, along with molecular and cell biologists, geneticists, and reproductive biologists, Principles of Nuclear Structure and Function is a definitive resource. Visit www.wiley.com/cook for supplementary information, including additional Web resources, downloadable figures, and discussion questions.
Download or read book Metabolic Flux Analysis in Eukaryotic Cells written by Deepak Nagrath and published by Humana. This book was released on 2021-01-15 with total page 370 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume explores the latest metabolic flux analysis (MFA) techniques that cover the analysis of cellular, organ level, and whole-body metabolism. The chapters in this book discuss topics such as deutrium tracing; isotopologue fractions using GC-TOF; non-targeted mass isotopolome analysis; large-scale profiling of cellular metabolic activities using deep 13C labeling medium; metastases in mice; SWATH; Exo-MFA; metabolic flux from time-course metabolomics; and thermodynamic approaches in flux analysis. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and comprehensive, Metabolic Flux Analysis in Eukaryotic Cells: Methods and Protocols is a valuable resource for both experts in MFA techniques and researchers getting involved in the role of quantitative studies to uncover the dysregulated pathways in human diseases.
Download or read book Autophagy Cancer Other Pathologies Inflammation Immunity Infection and Aging written by M. A. Hayat and published by Academic Press. This book was released on 2016-12-28 with total page 431 pages. Available in PDF, EPUB and Kindle. Book excerpt: Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging is an eleven volume series that discusses in detail all aspects of autophagy machinery in the context of health, cancer, and other pathologies. Autophagy maintains homeostasis during starvation or stress conditions by balancing the synthesis of cellular components and their deregulation by autophagy. This series discusses the characterization of autophagosome-enriched vaccines and its efficacy in cancer immunotherapy. Autophagy serves to maintain healthy cells, tissues, and organs, but also promotes cancer survival and growth of established tumors. Impaired or deregulated autophagy can also contribute to disease pathogenesis. Understanding the importance and necessity of the role of autophagy in health and disease is vital for the studies of cancer, aging, neurodegeneration, immunology, and infectious diseases. Comprehensive and forward-thinking, these books offer a valuable guide to cellular processes while also inciting researchers to explore their potentially important connections. Presents the most advanced information regarding the role of the autophagic system in life and death Examines whether autophagy acts fundamentally as a cell survivor or cell death pathway or both Introduces new, more effective therapeutic strategies in the development of targeted drugs and programmed cell death, providing information that will aid in preventing detrimental inflammation Features recent advancements in the molecular mechanisms underlying a large number of genetic and epigenetic diseases and abnormalities, including atherosclerosis and CNS tumors, and their development and treatment Includes chapters authored by leaders in the field around the globe—the broadest, most expert coverage available
Download or read book Regulation of Cell Metabolism written by Gordon Ethelbert Ward Wolstenholme and published by . This book was released on 1959 with total page 420 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book NBS Special Publication written by and published by . This book was released on 1976 with total page 570 pages. Available in PDF, EPUB and Kindle. Book excerpt:
