Download or read book NTP Technical Report on Toxicity Studies of Black Newsprint Inks Administered Topically to F344 N Rats and C3H Mice written by Joel F. Mahler and published by . This book was released on 1992 with total page 70 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book NTP Toxicity Study Reports written by and published by . This book was released on 1991 with total page 58 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Technical Report on Toxicology and Carcinogenesis Studies of Sodium Dichromate Dihydrate CAS No 7789 12 0 in F344 N Rats and B6C3F1 Mice Drinking Water Studies written by M. J. Hooth and published by DIANE Publishing. This book was released on 2009-02 with total page 200 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chromium is a metal that exists in a variety of valence states, depending on surrounding conditions and what other atoms it is bound to. The most stable forms are metallic chromium, trivalent chromium (chromium III), and hexavalent chromium (chromium VI). Chromium VI has been shown to cause cancer when inhaled in the air. Because compounds containing chromium VI occur as contaminants in drinking water, scientists studied the effects of sodium dichromate dihydrate (SDD) in drinking water on rats and mice to identify potential toxic or cancer-related hazards. Results showed that rats exposed to SDD had carcinomas of the mouth, but none occurred in the control rats. Mice receiving SDD had greatly increased rates of cancer of the small intestine. Illus.

Download or read book NTP Technical Report on the Toxicity Studies of Select Ionic Liquids 1 Ethyl 3 Methylimidazolium Chloride 1 Butyl 3 Methylimidazolium Chloride 1 Butyl 1 Methylpyrrolidinium Chloride and N Butylpyridinium Chloride Administered in Drinking Water to Sprague Dawley Hsd Sprague Dawley r SD r Rats and B6C3F1 N Mice written by and published by . This book was released on 2022 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ionic liquids (ILs) are synthetic solvents with applications in a variety of industrial and chemical industries. Human exposure to this diverse chemical class is primarily through dermal or oral routes. Research suggests toxicity may be associated with IL structural characteristics, including the type of cation base or alkyl chain substitutions associated with the cation. To further investigate this hypothesis, the National Toxicology Program (NTP) conducted 3-month toxicity studies in male and female Sprague Dawley (Hsd:Sprague Dawley(r) SD(r)) rats and B6C3F1/N mice (n\s=\s10/sex/exposure group; 3\sexposure concentrations per IL) to compare the relative toxicities of four ILs administered via drinking water--1-ethyl-3-methylimidazolium chloride (Emim-Cl),1-butyl-3-methylimidazolium chloride (Bmim-Cl), 1-butyl-1-methylpyrrolidinium chloride (Bmpy-Cl), and n-butylpyridinium chloride (NBuPy-Cl). To select exposure concentrations for the 3-month studies, 2-week drinking water studies in rats and mice were conducted to assess palatability and toxicity of each IL. Informed by the literature and preliminary palatability studies, exposure concentrations in the 2-week studies ranged from 0\sto 100\smg/mL. Clinical observations (e.g., thinness and ruffled fur), lower water consumption, and lower mean body weights were associated with higher IL exposure concentrations. At the end of the 2-week exposure period, a range of organ weight changes and histological lesions was observed in rats and mice exposed to ILs. These observations were considered secondary to body weight changes and/or stress, rather than a direct toxic effect from 2-week IL exposure. Exposure concentrations (ranging from 0\sto 30\smg/mL) were selected for the 3-month studies because of the observed relative decreases in mean body weight (≤10%) and water consumption (