Download or read book NTP Technical Report on Toxicity Studies of a Chemical Mixture of 25 Groundwater Contaminants Administered in Drinking Water to F344 N Rats and B6C3F 1 Mice written by and published by . This book was released on 1993 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Draft NTP Technical Report on Toxicity Studies of a Chemical Mixture of 25 Groundwater Contaminants written by and published by . This book was released on 1993 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book NTP Technical Report on Toxicity Studies of a Chemical Mixture of 25 Groundwater Contaminants Administered in Drinking Water to F344 N Rats and B6C3F1 Mice written by National Toxicology Program (U.S.) and published by . This book was released on 1993 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book NTP Technical Report on Toxicity Studies of a Chemical Mixture of 25 Groundwater Contaminants written by National Toxicology Program (U.S.) and published by . This book was released on 1993 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book NTP Technical Report on Toxicity Studies of Pesticide fertilizer Mixtures Administered in Drinking Water to F344 N Rats and B6C3F1 Mice written by National Toxicology Program (U.S.) and published by . This book was released on 1993 with total page 60 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Comprehensive Toxicology written by and published by Elsevier. This book was released on 2017-12-01 with total page 8639 pages. Available in PDF, EPUB and Kindle. Book excerpt: Comprehensive Toxicology, Third Edition, Fifteen Volume Set discusses chemical effects on biological systems, with a focus on understanding the mechanisms by which chemicals induce adverse health effects. Organized by organ system, this comprehensive reference work addresses the toxicological effects of chemicals on the immune system, the hematopoietic system, cardiovascular system, respiratory system, hepatic toxicology, renal toxicology, gastrointestinal toxicology, reproductive and endocrine toxicology, neuro and behavioral toxicology, developmental toxicology and carcinogenesis, also including critical sections that cover the general principles of toxicology, cellular and molecular toxicology, biotransformation and toxicology testing and evaluation. Each section is examined in state-of-the-art chapters written by domain experts, providing key information to support the investigations of researchers across the medical, veterinary, food, environment and chemical research industries, and national and international regulatory agencies. Thoroughly revised and expanded to 15 volumes that include the latest advances in research, and uniquely organized by organ system for ease of reference and diagnosis, this new edition is an essential reference for researchers of toxicology. Organized to cover both the fundamental principles of toxicology and unique aspects of major organ systems Thoroughly revised to include the latest advances in the toxicological effects of chemicals on the immune system Features additional coverage throughout and a new volume on toxicology of the hematopoietic system Presents in-depth, comprehensive coverage from an international author base of domain experts

Download or read book Toxicology in Risk Assessment written by Harry Salem and published by CRC Press. This book was released on 2000-02-17 with total page 344 pages. Available in PDF, EPUB and Kindle. Book excerpt: Toxicology is an integral part of the risk assessment process. In this book, investigators from the scientific and regulatory communities describe recent technical developments in risk assessment embracing toxicology and its allied sciences, risk qualification and characterisation, risk management, and risk communication. Case studies pertaining to current issues involving chemical and environmental risks, including military and industrial scenarios, are presented. Chapters describe value and ethical choices underlying toxicological decisions, economic and legal implications of regulations, understanding risk, and recommendations of the commission on risk assessment and risk management.

Download or read book Contaminated Water Supplies at Camp Lejeune written by National Research Council and published by National Academies Press. This book was released on 2009-09-06 with total page 338 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the early 1980s, two water-supply systems on the Marine Corps Base Camp Lejeune in North Carolina were found to be contaminated with the industrial solvents trichloroethylene (TCE) and perchloroethylene (PCE). The water systems were supplied by the Tarawa Terrace and Hadnot Point watertreatment plants, which served enlisted-family housing, barracks for unmarried service personnel, base administrative offices, schools, and recreational areas. The Hadnot Point water system also served the base hospital and an industrial area and supplied water to housing on the Holcomb Boulevard water system (full-time until 1972 and periodically thereafter). This book examines what is known about the contamination of the water supplies at Camp Lejeune and whether the contamination can be linked to any adverse health outcomes in former residents and workers at the base.

Download or read book NTP Technical Report on Toxicity Studies of Black Newsprint Inks Administered Topically to F344 N Rats and C3H Mice written by Joel F. Mahler and published by . This book was released on 1992 with total page 70 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book NTP Technical Report on Toxicity Studies of Pesticide fertilizer Mixtures written by and published by . This book was released on 1993 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book NTP Technical Report on Toxicity Studies of Pesticide Fertilizer Mixtures Administered in Drinking Water to F344 N Rats and B6C3F 1 Mice written by and published by . This book was released on 1993 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Human Biomonitoring for Environmental Chemicals written by National Research Council and published by National Academies Press. This book was released on 2006-10-30 with total page 316 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biomonitoring—a method for measuring amounts of toxic chemicals in human tissues—is a valuable tool for studying potentially harmful environmental chemicals. Biomonitoring data have been used to confirm exposures to chemicals and validate public health policies. For example, population biomonitoring data showing high blood lead concentrations resulted in the U.S. Environmental Protection Agency's (EPA's) regulatory reduction of lead in gasoline; biomonitoring data confirmed a resultant drop in blood lead concentrations. Despite recent advances, the science needed to understand the implications of the biomonitoring data for human health is still in its nascent stages. Use of the data also raises communication and ethical challenges. In response to a congressional request, EPA asked the National Research Council to address those challenges in an independent study. Human Biomonitoring for Environmental Chemicals provides a framework for improving the use of biomonitoring data including developing and using biomarkers (measures of exposure), research to improve the interpretation of data, ways to communicate findings to the public, and a review of ethical issues.

Download or read book EPA Publications Bibliography written by United States. Environmental Protection Agency and published by . This book was released on 1994 with total page 506 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book NTP Toxicity Study Reports written by and published by . This book was released on 1991 with total page 58 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Casarett Doull s Toxicology The Basic Science of Poisons Eighth Edition written by Curtis Klaassen and published by McGraw Hill Professional. This book was released on 2013-04-25 with total page 1473 pages. Available in PDF, EPUB and Kindle. Book excerpt: The most trusted all-in-one overview of the biomedical and environmental aspects of toxicology--NOW more complete, up-to-date, and in full color The world's leading and most authoritative textbook on poisons has more to offer students,toxicologists, and pharmacologists than ever before. Now in full color, and thoroughly revised, the eighth edition of Casarett & Doull's TOXICOLOGY: The Basic Science of Poisons not only delivers a comprehensive review of the essential components of toxicology, it offers the most up-to-date,revealing, and in-depth look at the systemic responses of toxic substance available anywhere. Combined with the latest thinking by the field's foremost scholars plus solid coverage of general principles, modes of action, and chemical-specific toxicity, this landmark text continues to set the standard for toxicology references. NEW to the Eighth Edition FULL-COLOR design to allow for a clearer interpretationof the basic components of toxicology featured throughout the text EXPANDED tables, illustrations, and other visuals areupdated with state-of-the-art standards that makes thisedition even more current and relevant DVD with image bank features all tables and illustrations from the text in presentation-ready format NEW CHAPTERS include "Toxic Effects of Calories"and "Toxic Effects of Nanoparticles"

Download or read book NTP Technical Report on the Toxicity Studies of O Chloropyridine CASRN 109 09 1 Administered Dermally and in Drinking Water to F344 N Rats and B6C3F1 N Mice written by and published by . This book was released on 2017 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: O-Chloropyridine is used as an intermediate in synthetic organic, pharmaceutical, and agricultural chemical (fungicides, herbicides) manufacture. It is also used as a catalyst for phase transfer and is a key intermediate in the manufacture of pyrithione-based biocides for use in cosmetics and various pharmaceutical products. o-Chloropyridine is available in purified (99%), technical (95%), or crude (80%) grades. o-Chloropyridine was nominated for testing by NTP based on increasing production and use as a site-limited pharmaceutical and agrochemical intermediate, the potential for occupational and environmental exposures during its manufacture, its persistence in the environment (lasting longer than 6 months), evidence of mutagenicity based on results of several short-term test systems, and suspicion of carcinogenicity based on effects associated with structurally related chemicals. Male and female F344/N rats and B6C3F1/N mice received o-chloropyridine (99% pure) dermally for 2 weeks or in drinking water for 3 months. Genetic toxicology studies were conducted in Salmonella typhimurium and mouse peripheral blood erythrocytes. In the 2-week dermal studies, groups of five male and five female rats and mice were administered o-chloropyridine in ethanol 5 days per week over a 16-day period (12 dose days) at doses of 0, 6.25, 12.5, 25, 50, or 100 mg o-chloropyridine/kg body weight. Vehicle control animals were administered ethanol alone. A constant concentration of test chemical per dose concentration was administered to each animal at volumes of 0.5 mL/kg body weight for rats and 2 mL/kg for mice. All dosed rats and mice survived to the end of the studies. The mean body weights of all dosed groups of rats and mice were similar to those of the vehicle control groups. Liver weights of 50 and 100 mg/kg male rats were significantly greater than those of the vehicle controls. No gross or microscopic lesions were considered related to o-chloropyridine administration. In the 3-month toxicity studies, groups of 10 male and 10 female F344/N rats and B6C3F1/N mice were exposed to o-chloropyridine in drinking water at concentrations of 0, 10, 30, 100, 300, or 1,000 ppm (equal to average daily doses of approximately 1, 3, 9, 25, and 65 mg o-chloropyridine/kg body weight to male rats, 1, 3, 9, 27, and 70 mg/kg to female rats, 1.5, 4.5, 15, 41, and 110 mg/kg to male mice, and 1.3, 4, 12, 38, and 92 mg/kg to female mice) for 3 months. Additional groups of 10 male and 10 female rats designated for clinical pathology testing were exposed to the same concentrations for 22 days. All rats survived to the end of the study. Mean body weights of male and female rats exposed to 1,000 ppm were significantly less than those of the controls. Water consumption by the 1,000 ppm rats was less than that by the control groups during the first week of the study. In the 1,000 ppm groups, thinness was noted in seven of 10 male rats and all female rats on day 8, likely due to dehydration, and also in five of 10 male rats on day 64. The absolute and relative (except 100 ppm) right kidney weights of all exposed groups of male rats and of groups of female rats (≥30 ppm) were greater than controls. Absolute and relative liver weights of male rats (≥100 ppm) and female rats (≥30 ppm) were significantly greater than those of the control groups. Epididymal sperm counts were significantly lower in male rats exposed to 1,000 ppm, indicating that o-chloropyridine exhibits the potential to be a reproductive toxicant. In the liver of male rats, the incidence of clear cell focus (1,000 ppm) and the incidences and severities of hepatocyte cytoplasmic vacuolization (≥300 ppm) were significantly higher. The incidence of hepatocyte cytoplasmic vacuolization was significantly greater in female rats also (1,000 ppm). There were also several low-magnitude histologic and hematologic responses in male and female rats suggesting an erythron effect characterized by a decreased erythron (≥300 ppm males and females) with a compensatory erythropoietic response: increased reticulocyte counts (≥300 ppm males, 1,000 ppm females) and hematopoietic cell proliferation in the spleen (≥300 ppm males, 1,000 ppm females). Splenic congestion (1,000 ppm males, 10 ppm and ≥100 ppm females) was also observed and may have been related to the erythron effect. There were no treatment-related deaths in either sex of mice. The final mean body weight and mean body weight gain of 1,000 ppm male mice were significantly less than those of the control group; the mean body weight gain of 300 ppm female mice was significantly greater than that of the controls. Water consumption by the 1,000 ppm groups was less than that of the control groups during the first week of the study. The liver weights of all exposed groups of male mice and of 300 and 1,000 ppm female mice and the kidney weights of 1,000 ppm males (relative) and females (absolute and relative) were significantly greater than those of the controls. The incidences of hepatocyte centrilobular hypertrophy were significantly increased in the 300 and 1,000 ppm groups of male and female mice, with exposure concentration-related increases in severity. An erythron effect, similar to that observed in rats, was observed in 1,000 ppm female mice only and was characterized by a small decrease in hematocrit value, hemoglobin concentration, and erythrocyte count; no accompanying erythropoietic response was observed in mice. o-Chloropyridine was mutagenic in S. typhimurium strains TA98 and TA100 when tested with exogenous metabolic activation enzymes from rat or hamster liver; no mutagenic activity was observed in the absence of metabolic activation. In vivo, no increases in the frequencies of micronucleated erythrocytes were observed in peripheral blood of male or female mice exposed to o-chloropyridine for 3 months in drinking water. Under the conditions of these 3-month drinking water studies, there were treatment-related organ weight changes and lesions in male and female rats and mice. The major target tissues in rats affected by o-chloropyridine exposure included the kidney, spleen, bone marrow, and liver; the major target organ in mice was the liver. The measurement most sensitive to o-chloropyridine exposure in male rats was increased absolute (all exposure groups) and relative (all exposure groups except 100 ppm) kidney weights in the absence of histopathologic changes [lowest-observed-effect level (LOEL) = 10 ppm]. In female rats, a LOEL of 10 ppm was based on splenic congestion, observed in all treated groups (except 30 ppm), with hematopoietic cell proliferation and pigmentation in the spleen, bone marrow hyperplasia, and hematological changes at higher exposure concentrations. This pattern of erythropoietic responses in the spleen and bone marrow and hematologic changes was also observed in male rats at 300 ppm or greater doses. In male mice, absolute and relative liver weights were significantly higher than controls in all treated groups (LOEL 10 ppm), with histologic changes (centrilobular hepatocyte hypertrophy) occurring at 300 ppm and 1,000 ppm. In female mice, absolute and relative liver weights were significantly higher than controls, with increased incidences of centrilobular hepatocyte hypertrophy occurring at similar exposure concentrations (LOEL 300 ppm). SYNONYMS: Alpha-chloropyridine; 2-chloro-(9Cl); 2-chloropyridine (8Cl); pyridines.

Download or read book Casarett Doull s Toxicology The Basic Science of Poisons Eighth Edition written by Louis J. Casarett and published by McGraw Hill Professional. This book was released on 2013-06-19 with total page 1474 pages. Available in PDF, EPUB and Kindle. Book excerpt: Accompanying DVD-ROM in pocket at the rear of book.