Download or read book Novel Uses of Isotope Effects to Elucidate Enzyme Reaction Mechanisms written by Jeffrey D. Hermes and published by . This book was released on 1983 with total page 506 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Enzyme Mechanism from Isotope Effects written by Paul F. Cook and published by CRC Press. This book was released on 1991-09-20 with total page 656 pages. Available in PDF, EPUB and Kindle. Book excerpt: Isotope effects have become one of the most powerful tools available to the enzymologist for probing enzymic mechanisms. Enzyme Mechanism from Isotope Effects presents the basic theory underlying isotope effects, including the latest findings on proton tunneling and coupled atomic notions. Specific theoretical applications are emphasized in regard to the types of information that can be obtained using isotope effects. The book also examines recent theoretical treatments of the product dependence of deuterium isotope effects, multiple isotope effects and isotope effects on intermediate partitioning. Other topics include a complete discussion of methods for measuring isotope effects, including a detailed description of the use of the isotope ratio mass spectrometer to obtain isotope effects, and a review of the literature regarding mechanistic information obtained from isotope effects for individual classes of enzyme-catalyzed reactions. Enzyme Mechanism from Isotope Effects is an excellent reference source for investigators using isotope effects in their research. The book is also valuable for reference libraries and instructors teaching courses in enzyme mechanism.

Download or read book The Use of Isotope Effects as a Probe of Enzyme Reaction Mechanisms written by Paul Martin Karl Weiss and published by . This book was released on 1987 with total page 290 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Determination of Isotope Effects to Elucidate Enzyme Mechanisms written by John Sears Blanchard and published by . This book was released on 1979 with total page 662 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Isotope Effects In Chemistry and Biology written by Amnon Kohen and published by CRC Press. This book was released on 2005-11-01 with total page 1092 pages. Available in PDF, EPUB and Kindle. Book excerpt: The field of isotope effects has expanded exponentially in the last decade, and researchers are finding isotopes increasingly useful in their studies. Bringing literature on the subject up to date, Isotope Effects in Chemistry and Biology covers current principles, methods, and a broad range of applications of isotope effects in the physical, biolo

Download or read book Measurement and Analysis of Kinetic Isotope Effects written by and published by Academic Press. This book was released on 2017-09-12 with total page 634 pages. Available in PDF, EPUB and Kindle. Book excerpt: Experimental Analysis of Enzyme Mechanism Using Isotope Effects, Volume 596, the latest release in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. Chapters in this comprehensive update include Measurement of enzyme binding isotope effects, Chemical ligation and isotope labeling to locate dynamic effects, Measurement of heavy enzyme isotope effects, Extracting kinetic isotope effects from a global analysis of reaction progress curves, KIE of metabolic flux and enzymes, Solvent and Primary KIE on Flavin Enzymes, and The Rapid Determination of Primary Deuterium Isotope Effects on Enzyme-Catalyzed Proton Transfer at Carbon in 50/50 HOH/DOD. Readers who are interested in applying or understanding this research will find useful methods currently used for measuring isotope effects on solution and enzyme reactions. Written by pioneers of modern isotope effect research Is the only collection of modern kinetic isotope effect methods currently available

Download or read book The Elucidation of Mechanism and Transition State Structure for Enzyme and Non enzyme Catalyzed Reactions with the Aid of Novel Methods for the Measurement of Oxygen 18 Isotope Effects written by Steven Rosenberg and published by . This book was released on 1978 with total page 692 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Isotope Effects on Enzyme catalyzed Reactions written by William Wallace Cleland and published by . This book was released on 1977 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Isotope Effects on Enzyme catalyzed Reactions written by William Wallace Cleland and published by . This book was released on 1977 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Use of Isotope Effects to Determine Enzymatic and Nonenzymatic Mechanisms written by Mark Alan Rishavy and published by . This book was released on 2000 with total page 182 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Diary of an Ex Deuterium Adduct written by David H. Ingbar and published by . This book was released on 1974 with total page 278 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Isotope Effects as a Probe Biologically Important Chemical Reaction Mechanisms written by William A. Edens and published by . This book was released on 1996 with total page 262 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Isotope Effects in Chemical Reactions written by Clair J. Collins and published by . This book was released on 1971 with total page 456 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Application of Kinetic Isotope Effects and Theoretical Calculations to the Study of Interesting Reaction Mechanisms written by Jennifer Sue Hirschi and published by . This book was released on 2010 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: A variety of biological and organic reaction mechanisms are studied using powerful tools from experimental and theoretical chemistry. These tools include the precise measurement of kinetic isotope effects (KIEs) and the use of theoretical calculations to predict KIEs as well as determine factors that contribute to reaction acceleration and selectivity. Theoretical analysis of the Swain-Schaad relationship involves the prediction of a large number of isotope effects and establishes the semiclassical boundaries of the relationship. Studies on the mechanism of oxidosqualene cyclase involve the determination of a large number of precise KIEs simultaneously. Transition state models for the Sharpless asymmetric epoxidation have been developed that explain the versatility, high selectivities, and ligand accelerated catalysis of the reaction. Theoretical predictions on the proposed enzymatic mechanism of flavin dependent amine oxidation suggest a hydride transfer mechanism and rules out mechanisms involving covalent intermediates. Finally, a theoretical analysis of Diels-Alder reactions successfully describes the unexpected exo selectivity in some of these reactions.

Download or read book The Elucidation of Mechanisms of Multicentered Organic Reactions by the Use of Kinetic Isotope Effects written by William Shakespeare Morrison and published by . This book was released on 1973 with total page 406 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book The Use of Isotope Effects to Determine the Chemical Mechanism of Oxidative Decarboxylases written by Charles Buell Grissom and published by . This book was released on 1985 with total page 338 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Deuterium Isotope Effects in Selected Reaction Mechanisms written by Thomas J. George and published by . This book was released on 1978 with total page 268 pages. Available in PDF, EPUB and Kindle. Book excerpt: