Download or read book Novel Therapeutic Targets and Emerging Treatments for Fibrosis written by Chrishan S. Samuel and published by Frontiers Media SA. This book was released on 2018-01-12 with total page 162 pages. Available in PDF, EPUB and Kindle. Book excerpt: For decades we have known that the overgrowth, hardening and scarring of tissues (so-called fibrosis) represents the final common pathway and best histological predictor of disease progression in most organs. Fibrosis is the culmination of both excess extracellular matrix deposition due to ongoing or severe injury, and a failure to regenerate. An inadequate wound repair process ultimately results in organ failure through a loss of function, and is therefore a major cause of morbidity and mortality in disease affecting both multiple and individual organs. Whilst the pathology of fibrosis and its significance are well understood, until recently we have known little about its molecular regulation. Current therapies are often indirect and non-specific, and only slow progression by a matter of months. The recent identification of novel therapeutic targets, and the development of new treatment strategies based on them, offers the exciting prospect of more efficacious therapies to treat this debilitating disorder. This Research Topic therefore compromises several up-to-date mini-reviews on currently known and emerging therapeutic targets for fibrosis including: the Transforming Growth Factor (TGF)-family; epigenetic factors; Angiotensin II type 2 (AT2) receptors; mineralocorticoid receptors; adenosine receptors; caveolins; and the sphingosine kinase/sphingosine 1-phosphate and notch signaling pathways. In each case, mechanistic insights into how each of these factors contribute to regulating fibrosis progression are described, along with how they can be targeted (by existing drugs, small molecules or other mimetics) to prevent and/or reverse fibrosis and its contribution to tissue dysfunction and failure. Two additional reviews will discuss various anti-fibrotic therapies that have demonstrated efficacy at the experimental level, but are not yet clinically approved; and the therapeutic potential vs limitations of stem cell-based therapies for reducing fibrosis while facilitating tissue repair. Finally, this Research Topic concludes with a clinical perspective of various anti-fibrotic therapies for cardiovascular disease (CVD), outlining limitations of currently used therapies, the pipeline of anti-fibrotics for CVD and why so many anti-fibrotic drugs have failed at the clinical level.
Download or read book Novel Therapeutic Targets and Emerging Treatments for Fibrosis written by and published by . This book was released on 2018 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: For decades we have known that the overgrowth, hardening and scarring of tissues (so-called fibrosis) represents the final common pathway and best histological predictor of disease progression in most organs. Fibrosis is the culmination of both excess extracellular matrix deposition due to ongoing or severe injury, and a failure to regenerate. An inadequate wound repair process ultimately results in organ failure through a loss of function, and is therefore a major cause of morbidity and mortality in disease affecting both multiple and individual organs.Whilst the pathology of fibrosis and its significance are well understood, until recently we have known little about its molecular regulation. Current therapies are often indirect and non-specific, and only slow progression by a matter of months. The recent identification of novel therapeutic targets, and the development of new treatment strategies based on them, offers the exciting prospect of more efficacious therapies to treat this debilitating disorder.This Research Topic therefore compromises several up-to-date mini-reviews on currently known and emerging therapeutic targets for fibrosis including: the Transforming Growth Factor (TGF)-family; epigenetic factors; Angiotensin II type 2 (AT2) receptors; mineralocorticoid receptors; adenosine receptors; caveolins; and the sphingosine kinase/sphingosine 1-phosphate and notch signaling pathways. In each case, mechanistic insights into how each of these factors contribute to regulating fibrosis progression are described, along with how they can be targeted (by existing drugs, small molecules or other mimetics) to prevent and/or reverse fibrosis and its contribution to tissue dysfunction and failure. Two additional reviews will discuss various anti-fibrotic therapies that have demonstrated efficacy at the experimental level, but are not yet clinically approved; and the therapeutic potential vs limitations of stem cell-based therapies for reducing fibrosis while facilitating tissue repair. Finally, this Research Topic concludes with a clinical perspective of various anti-fibrotic therapies for cardiovascular disease (CVD), outlining limitations of currently used therapies, the pipeline of anti-fibrotics for CVD and why so many anti-fibrotic drugs have failed at the clinical level.
Download or read book Fibrosis in Disease written by Monte S. Willis and published by Springer. This book was released on 2018-11-10 with total page 471 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fibroproliferative diseases are a broad spectrum of entities from organ-specific involvement (e.g., pulmonary, heart, liver, and kidney fibrosis) to multi-system diseases such as systemic sclerosis and sclerodermatous graft vs. host disease. These diseases also encompass pathophysiologies not readily recognizably related, such as macular degeneration and cancer metastasis. Fibroproliferative diseases are a leading cause of morbidity and mortality and can affect all tissues and organ systems. Remarkable progress in elucidating the pathogenesis of these common diseases with fibrotic components, including the critical roles of myofibroblasts and the molecular mechanisms driving the transcriptional activation involved in the induction of fibrosis. As the importance of these processes is realized in the long-term recovery and treatment of diseases, effective anti-fibrotic therapies targeting the underlying ongoing disease processes are lacking. The complexity of discovering and applying therapies to fibroproliferative disease may be due to the diversity of the systems the pathogenesis of disease itself involves. By nature, fibroproliferative diseases are interdisciplinary, involving multiple cell types (organ-specific epithelial cells), immune cells, endothelial cells, and fibroblasts. Bone marrow, cytokines, and organ-specific pathologies further speckle both the clinical and scientific disciplines in such a way that communication is often limited to the clinical or scientific tribes we live in, despite the greatest access to information known to man available today. Therefore, the primary focus of this text is to bring together authors from a diversity of both clinical, scientific, and therapeutic backgrounds for readers to more fully appreciate that fantastic platform that is available to build upon to lessen the isolation of the clinical and scientific disciplines. With advances in the discovery of pre-clinical therapeutic targets (at least 20+ to date) involving TGF-beta (and other cytokines), transcription factors, and downstream kinases, it’s important to both recognize the broader impact and potential opportunities that exist even today. This book will serve as a state-of-the-art resource for physicians and translational medical researchers alike who are interested in the rapidly evolving field of fibroproliferative diseases. The book will provide new insight into the fundamental mechanisms of classic fibrotic pathophysiologic processes like myocardial infarction, idiopathic pulmonary fibrosis, chronic kidney disease, wound healing, and systemic sclerosis. It will also highlight the many new areas of therapeutic investigation currently underway. Lastly, we will touch upon newly emerging fields investigating the role of fibrosis in macular degeneration and cancer metastasis. The chapters will be written by established experts in their fields, including clinicians (cardiologists, cardiovascular surgeons, pathologists, and general practitioners) and translational biomedical researchers in a wide range of disciplines. However, the material will certainly have a broader audience including medical residents, fellows, and general practitioners as well as M.D. or Ph.D. post-doctoral research fellows. While comprehensive, we'll attempt to present the material in a manner that simplifies the complex pathophysiologic mechanisms that underlie common fibroproliferative diseases while making it appealing to a broad audience.
Download or read book Non small Cell Lung Cancer written by and published by . This book was released on 2021-12-09 with total page 258 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Chronic Liver Disease New Targets and New Mechanisms written by Jinhang Gao and published by Frontiers Media SA. This book was released on 2022-08-16 with total page 186 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Inflammation and Fibrosis in the Gastrointestinal Tract and Liver Mechanisms and Targets written by Ralf Weiskirchen and published by Frontiers Media SA. This book was released on 2023-04-04 with total page 421 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book New insights into renal fibrosis and therapeutic effects of natural products volume II written by Dan-Qian Chen and published by Frontiers Media SA. This book was released on 2023-04-19 with total page 227 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Therapeutic Targets For Inflammation And Cancer Novel Therapies For Digestive Diseases written by Cho Chi-hin and published by World Scientific. This book was released on 2017-04-20 with total page 460 pages. Available in PDF, EPUB and Kindle. Book excerpt: This unique book deals with both inflammation and cancer in a single source of publication. They are seldom grouped together although it has been known that both diseases are closely associated, particularly in the gastrointestinal tract and liver. As the book touches on two such major areas of diseases in humans, it should be of interest to a wider audience of researchers and readers. It is noted that the book combines the effort of both basic scientists and clinicians from different countries with extensive experiences in molecular biology and clinical practice to unveil the most updated picture of the pathogenesis and therapeutic strategies in the treatment of inflammation and cancer in the digestive tract. In this regard, potential pathogenic modulators and also therapeutic options are widely discussed. These types of information would definitely broaden our knowledge in better understanding these diseases. Contents:General Introduction to Inflammation and Cancer in the Digestive Tract (Ming Xing Li and Chi Hin Cho)Inflammation and Therapeutics in the Digestive Tract:Brain–Gut Relationship on Mucosal Inflammation in the Gastrointestinal Tract (Klara Gyires and Ágnes Fehér)Nesfatin-1: The Novel Appetite Peptide with Therapeutic Efficacy to Prevent Acute Hemorrhagic Gastric Lesions and Accelerate Gastric Ulcer Healing (Aleksandra Szlachcic, Jolanta Majka, and Tomasz Brzozowski)Chemoprophylaxis in Inflammatory Bowel Disease (Nikola Mitrev, Aladdin Alswaifi, and Rupert W Leong)Targeting the Nuclear Receptor HNF4α as a Potential Therapy for Gut Inflammation and Cancer (Jean-Philippe Babeu and François Boudreau)Established Therapies and New Therapeutic Strategies in Alcoholic Liver Disease (Helmut Karl Seitz and Sebastian Mueller)Carcinogenesis and Therapeutic Targets in the Gastrointestinal Tract:Targets of Tumor Epigenetics and Its Microenvironment in Gastrointestinal Cancer (Ssu-Yin Yen, Hong-Meng Chuang, Mao-Hsuan Huang, Sheng-Feng Tsai, Tzyy-Wen Chiou, Hong-Lin Su, Li-Ing Ho, Shinn-Zong Lin, and Horng-Jyh Harn)Esophageal Cancer: From Bench to Bedside (Gang Ma and Zhihua Liu)Angiogenesis and Lymphangiogenesis in Gastric MALT Lymphoma: Relation of VEGF and VASH2 (Masahiko Nakamura, Anders Øverby, and Hidenori Matsui)NF-κB as a Potential Molecular Target for Therapy of Gastrointestinal Cancers (Nathan Palmer, Muthu K Shanmugam, Gautam Sethi, and Philipp Kaldis)Hypoxia-Inducible Factor-1κ Modulation in Colorectal Carcinogenesis (Francesco Mariani, Stefano Mancini, Paola Sena, and Luca Roncucci)Therapeutic Approaches Targeting the Serrated Pathway of Colorectal Cancer Characterized by Mutation in the BRAF Gene and Overexpression of GTPase Rac1b (Paulo Matos, Vânia Gonçalves, and Peter Jordan)The "Yin" and "Yang" of Target-Oriented Anticancer Phytochemicals Derived from Herbal Medicines (Kathy K Auyeung and Joshua K S Ko)The Degradation System of Prostaglandin E2 in Gastrointestinal Cancer (Tetsuya Tanigawa, Toshio Watanabe, Shogo Takeda, Hiroshi Tatsuwaki, Masatsugu Shiba, Kazunari Tominaga, Yasuhiro Fujiwara, and Tetsuo Arakawa)Prostaglandin and Its Receptors: Potential Targets for Gastrointestinal Inflammation and Cancer (Vivian Y Shin and Ava Kwong)Autophagy and microRNAs as the Therapeutic Targets in Gastrointestinal Cancers:Modulation of Autophagy as a Potential Therapeutic Target for Gastrointestinal Cancers: Promises and Uncertainties (Li Ma)microRNAs as Therapeutic Targets for Gastric Cancer (Takatsugu Ishimoto and Hideo Baba)microRNA-based Novel Therapeutic Development in Gastrointestinal Cancer (Andrew Fesler and Jingfang Ju)Unraveling the Relationship between Autophagy and microRNA in Gastrointestinal Cancer (Yuanyuan Yin, Peiqi Wang, Yaxin Zheng, Yi Chen, and Jinhui Wang) Readership: Basic and clinical researchers in the fields of inflammation, hepatology, pathology, pharmacology, oncology and gastroenterology. Can be used as a reference for their research and clinical practice in academic and industrial sectors.
Download or read book Pulmonary Fibrosis One Manifestation Various Diseases written by Barbara Ruaro and published by Frontiers Media SA. This book was released on 2022-11-21 with total page 154 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Mechanisms of Chronic Liver Diseases Identifying New Therapeutic Targets written by Gianfranco Danilo Alpini and published by Frontiers Media SA. This book was released on 2022-01-25 with total page 279 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Molecular Mechanisms and New Therapeutic Targets in Epithelial to Mesenchymal Transition EMT and Fibrosis written by Cecilia Battistelli and published by Frontiers Media SA. This book was released on 2020-02-10 with total page 219 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Emerging Therapeutic Approaches for Cystic Fibrosis written by Miquéias Lopes-Pacheco and published by Frontiers Media SA. This book was released on 2020-01-27 with total page 281 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Hepatitis C Virus Advances in Research and Treatment 2012 Edition written by and published by ScholarlyEditions. This book was released on 2012-12-26 with total page 129 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hepatitis C Virus—Advances in Research and Treatment: 2012 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about Hepatitis C Virus in a concise format. The editors have built Hepatitis C Virus—Advances in Research and Treatment: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Hepatitis C Virus in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Hepatitis C Virus—Advances in Research and Treatment: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Download or read book Handbook of Cancer Treatment Related Symptoms and Toxicities written by Vamsidhar Velcheti and published by Elsevier Health Sciences. This book was released on 2021-01-28 with total page 355 pages. Available in PDF, EPUB and Kindle. Book excerpt: Early recognition and management of adverse effects of cancer treatments are essential for optimal care of patients with cancer, and drastically different approaches are required for different physiologic reactions. Handbook of Cancer Treatment-Related Symptoms and Toxicities is a focused, one-stop resource that enables clinicians to quickly find up-to-date, reliable information needed at the point of care. The high-yield approach prioritizes the most common toxicities associated with cancer treatment, and concise, templated chapters offer fast access to information needed in day-to-day practice. Presents a user-friendly overview of cancer treatment-related symptoms and toxicities management in a practical, easy-to-use format, allowing you to quickly find information in one convenient, concise resource. Covers systemic and radiation therapies, including chemotherapy, immunotherapy, targeted therapies, and radiation therapy, detailing symptoms of each toxicity to confirm your diagnosis. Overviews pharmacologic and non-pharmacologic approaches to symptom management. Offers recommendations for mitigating toxicities in high-risk patients. Discusses key topics such as management of infusion reactions, when the need for biopsy is warranted, and the unique challenges posed by novel immunotherapies.
Download or read book Textbook of Vascular Medicine written by Rhian M. Touyz and published by Springer. This book was released on 2019-08-02 with total page 503 pages. Available in PDF, EPUB and Kindle. Book excerpt: This textbook focuses on the vascular biology and physiology that underlie vascular disorders in clinical medicine. Vascular biomedicine is a rapidly growing field as new molecular mechanisms of vascular health and disease are unraveled. Many of the major cardiovascular diseases including coronary artery disease, heart failure, stroke and vascular dementia are diseases of the vasculature. In addition vascular injury underpins conditions like kidney failure and cardiovascular complications of diabetes. This field is truly multidisciplinary involving scientists in many domains such as molecular and vascular biology, cardiovascular physiology and pharmacology and immunology and inflammation. Clinically, specialists across multiple disciplines are involved in the management of patients with vascular disorders, including cardiologists, nephrologists, endocrinologists, neurologists and vascular surgeons. This book covers a wide range of topics and provides an overview of the discipline of vascular biomedicine without aiming at in-depth reviews, but rather offering up-to-date knowledge organized in concise and structured chapters, with key points and pertinent references. The structure of the content provides an integrative and translational approach from basic science (e.g. stem cells) to clinical medicine (e.g. cardiovascular disease). The content of this book is targeted to those who are new in the field of vascular biology and vascular medicine and is ideal for medical students, graduate and postgraduate students, clinical fellows and academic clinicians with an interest in the vascular biology and physiology of cardiovascular disease and related pathologies.
Download or read book Kidney Inflammation Injury and Regeneration written by Patrick C. Baer and published by MDPI. This book was released on 2020-04-03 with total page 496 pages. Available in PDF, EPUB and Kindle. Book excerpt: Acute kidney injury (AKI) is still associated with high morbidity and mortality incidence rates, and also bears an elevated risk of subsequent chronic kidney disease. Although the kidney has a remarkable capacity for regeneration after injury and may recover completely depending on the type of renal lesions, the options for clinical intervention are restricted to fluid management and extracorporeal kidney support. The development of novel therapies to prevent AKI, to improve renal regeneration capacity after AKI, and to preserve renal function is urgently needed. The Special Issue covers research articles that investigated the molecular mechanisms of inflammation and injury during different renal pathologies, renal regeneration, diagnostics using new biomarkers, and the effects of different stimuli like medication or bacterial components on isolated renal cells or in vivo models. The Special Issue contains important reviews that consider the current knowledge of cell death and regeneration, inflammation, and the molecular mechanisms of kidney diseases. In addition, the potential of cell-based therapy approaches that use mesenchymal stromal/stem cells or their derivates is summarized. This edition is complemented by reviews that deal with the current data situation on other specific topics like diabetes and diabetic nephropathy or new therapeutic targets.
Download or read book Organ Fibrosis Pathogenesis Biomarkers and Therapeutic Targets written by Henricus A. M. (Rick) Mutsaers and published by Frontiers Media SA. This book was released on 2022-01-05 with total page 144 pages. Available in PDF, EPUB and Kindle. Book excerpt:
