Download or read book Novel Therapeutic Strategies for the Treatment of Parkinson s Disease written by Stephen J. Crocker and published by . This book was released on 2000 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Parkinson s Disease written by Sarat Chandra Yenisetti and published by BoD – Books on Demand. This book was released on 2018-05-30 with total page 128 pages. Available in PDF, EPUB and Kindle. Book excerpt: Parkinson's disease (PD) is the second most common neurodegenerative disorder results due to loss of dopamine producing brain cells. Knowledge relating to PD condition has been known since 5000BC, however no effective therapeutic strategies are available till today. Therefore it is important for neurobiologists to work further by taking advantage of modern scientific methods and develop appropriate therapeutic strategies. Efforts in this direction are worthy as they will reduce the burden of PD among elderly, who are already burdened with age related systemic degenerative processes. This book is a humble effort in that progressive direction. It has chapters covering multiple aspects relating to etiology, pathophysiology of PD, available and futuristic therapeutics strategies. Therefore it will be of interest to common man, biomedical researchers and clinicians. This is one small step in a direction "to reduce the burden of neurological disease."
Download or read book Novel Therapeutic Approaches to the Treatment of Parkinson s Disease written by Corey R. Hopkins and published by Springer. This book was released on 2016-06-23 with total page 158 pages. Available in PDF, EPUB and Kindle. Book excerpt: Medicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for improving the quality of life. The art of medicinal chemistry continues to challenge its practitioners with the need for both intuition and experience to discover new drugs. Hence sharing the experience of drug research is uniquely beneficial to the field of medicinal chemistry. Drug research requires interdisciplinary team-work at the interface between chemistry, biology and medicine. Therefore, the topic-related series Topics in Medicinal Chemistry covers all relevant aspects of drug research, e.g. pathobiochemistry of diseases, identification and validation of (emerging) drug targets, structural biology, drugability of targets, drug design approaches, chemogenomics, synthetic chemistry including combinatorial methods, bioorganic chemistry, natural compounds, high-throughput screening, pharmacological in vitro and in vivo investigations, drug-receptor interactions on the molecular level, structure-activity relationships, drug absorption, distribution, metabolism, elimination, toxicology and pharmacogenomics. In general, special volumes are edited by well known guest editors.
Download or read book The New Parkinson s Disease Treatment Book written by J. Eric Ahlskog, , and published by Oxford University Press, USA. This book was released on 2015 with total page 545 pages. Available in PDF, EPUB and Kindle. Book excerpt: 2015 marks the ten-year anniversary since the First Edition of The Parkinson's Disease Treatment Book was published. This completely updated Second Edition represents a major revision with even more directed treatment guidelines, updated discussions relating to the possible cause(s), and assessments of the current and future role of surgical and innovative strategies.
Download or read book Rethinking Parkinson s Disease written by John C Coleman and published by Hybrid Publishers. This book was released on 2020-10-08 with total page 417 pages. Available in PDF, EPUB and Kindle. Book excerpt: John Coleman was diagnosed with Parkinson's disease while studying to be a naturopath, and banished all the frustrating symptoms of this cruel condition from his body ... naturally! His new book equips those diagnosed with the knowledge needed to reverse their Parkinson's disease symptoms and even recover, using completely natural means. Rethinking Parkinson's Disease traces known pathways leading to a diagnosis of Parkinson's disease, together with strategies to reverse each pathway. It includes the best evidence from Western allopathic medicine and complementary/alternative medicine in discovering how and why people with Parkinson's develop symptoms, the diagnostic process, standard treatments and prognoses offered by expert practitioners, and ongoing research. The book presents strategies that have been shown, clinically or in research, to improve the health of people with Parkinson's, with the possibility of reversing symptoms. A major section of this work details strategies to create wellness, many available to patients at little or no cost. There are sections on symptom control, complementary medical treatments and therapies to avoid. The book is aimed primarily at people with Parkinson's, families and supporters, and may be used as a self-help book, including advice on building a team of supportive practitioners. There are also suggestions and advice for both Western allopathic medicine and complementary/alternative medicine practitioners to enhance their care of patients with a Parkinson's disease diagnosis, so it may be used as a handbook for practitioners wishing to move away from the standard conservative view of Parkinson's disease as an "incurable" disease.
Download or read book Parkinson s Disease Animal Models Current Therapies and Clinical Trials written by Sarat Chandra Yenisetti and published by BoD – Books on Demand. This book was released on 2023-12-20 with total page 252 pages. Available in PDF, EPUB and Kindle. Book excerpt: Despite being described about 200 years ago, the pathophysiology of Parkinson’s disease (PD) is not well understood due to its complex etiology and heterogeneity of symptoms and progression. Animal models provide a great opportunity to follow the progression of neurodegeneration and to screen potent therapeutic molecules, knowledge of which can be critical for different levels of clinical trials. Contemporary health technologies are coming in handy to accelerate the pace of developing novel and refined therapeutic strategies for PD. This book, Parkinson’s Disease - Animal Models, Current Therapies and Clinical Trials, provides a comprehensive overview of PD, presenting information on animal models of PD and contemporary therapeutic strategies, health technologies, clinical trials, and their influence on the quality of life of patients with PD.
Download or read book Therapy of Parkinson s Disease Third Edition written by Rajesh Pahwa and published by CRC Press. This book was released on 2004-04-19 with total page 592 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive review of current tactics in the therapeutic management of Parkinson's disease, this volume offers summaries of salient research findings as well as contemporary attitudes and practical advice from field specialists. The well-timed Third Edition is expanded and topically reorganized to register trends and progress in anti-parkinsonian medications, ablative surgical options, deep brain stimulation, nonmotor symptom treatments, nonmedical strategies, and investigational therapies.
Download or read book Levodopa pharmacokinetics from stomach to brain written by Maria Nord and published by Linköping University Electronic Press. This book was released on 2019-01-07 with total page 72 pages. Available in PDF, EPUB and Kindle. Book excerpt: Parkinson’s disease (PD) is one of the most common neurodegenerative disorders and it is caused by a loss of dopamine (DA) producing neurons in the basal ganglia in the brain. The PD patient suffers from motor symptoms such as tremor, bradykinesia and rigidity and treatment with levodopa (LD), the precursor of DA, has positive effects on these symptoms. Several factors affect the availability of orally given LD. Gastric emptying (GE) is one factor and it has been shown to be delayed in PD patients resulting in impaired levodopa uptake. Different enzymes metabolize LD on its way from the gut to the brain resulting in less LD available in the brain and more side effects from the metabolites. By adding dopa decarboxylase inhibitors (carbidopa or benserazide) or COMT-inhibitors (e.g. entacapone) the bioavailability of LD increases significantly and more LD can pass the blood-brain-barrier and be converted to DA in the brain. It has been considered of importance to avoid high levodopa peaks in the brain because this seems to induce changes in postsynaptic dopaminergic neurons causing disabling motor complications in PD patients. More continuously given LD, e.g. duodenal or intravenous (IV) infusions, has been shown to improve these motor complications. Deep brain stimulation of the subthalamic nucleus (STN DBS) has also been proven to improve motor complications and to make it possible to reduce the LD dosage in PD patients. In this doctoral thesis the main purpose is to study the pharmacokinetics of LD in patients with PD and motor complications; in blood and subcutaneous tissue and study the effect of GE and PD stage on LD uptake and the effect of continuously given LD (CDS) on LD uptake and GE; in blood and cerebrospinal fluid (CSF) when adding the peripheral enzyme inhibitors entacapone and carbidopa to LD infusion IV; in brain during STN DBSand during oral or IV LD treatment. To conclude, LD uptake is more favorable in PD patients with less severe disease and GE is delayed in PD patients. No obvious relation between LD uptake and GE or between GE and PD stage is seen and CDS decreases the LD levels. Entacapone increases the maximal concentration of LD in blood and CSF. This is more evident with additional carbidopa and important to consider in avoiding high LD peaks in brain during PD treatment. LD in brain increases during both oral and IV LD treatment and the DA levels follows LD well indicating that PD patients still have capacity to metabolize LD to DA despite probable pronounced nigral degeneration. STN DBS seems to increase putaminal DA levels and together with IV LD treatment also increases LD in brain possibly explaining why it is possible to decrease LD medication after STN DBS surgery. Parkinsons sjukdom (PS) är en av de vanligaste s.k. neurodegenerativasjukdomarna och orsakas av förlust av dopamin(DA)producerande nervceller i hjärnan. Detta orsakar motoriska symptom såsom skakningar, stelhet och förlångsammade rörelser. Levodopa (LD) är ett ämne, som kan omvandlas till DA i hjärnan och ge symptomlindring och det är oftast förstahandsval vid behandling av patienter med PS. Flera faktorer påverkar tillgängligheten av LD, bl.a. den hastighet som magsäcken tömmer sig med och denna verkar förlångsammad hos personer med PS vilket ger sämre tillgänglighet av LD i blodet och därmed i hjärnan. LD bryts även ner i hög grad av olika enzym ute i kroppen vilket leder till mindre mängd LD som hamnar i hjärnan och till fler nedbrytningsprodukter som orsakar biverkningar. Tillägg av enzymhämmare leder till ökad mängd LD som kan nå hjärnan och omvandlas till DA. Det anses viktigt att undvika höga toppar av LD i hjärnan då dessa verkar bidra till utvecklandet av besvärliga motoriska komplikationer hos patienter med PS. Om LD ges mer kontinuerligt, exempelvis som en kontinuerlig infusion in i tarmen eller i blodet, så minskar dessa motoriska komplikationer. Inopererande av stimulatorer i vissa delar av hjärnan (DBS) har också visat sig minska dessa motoriska komplikationer och även resultera i att man kan minska LD-dosen. Huvudsyftet med den här avhandlingen är att studera LD hos patienter med PS; i blod och fettvävnad då LD ges i tablettform och se om det finns något samband med LD-upptag och hastigheten på magsäckstömningen (MT) och om kontinuerligt given LD påverkar LD-upptaget eller MT; i blod och i ryggmärgsvätska då enzymhämmarna entakapon och karbidopa tillsätts LD; i hjärna vid behandling med DBS och då LD ges både som tablett och som infusion i blodet. Sammanfattningsvis kan vi se att LD-upptaget är mer gynnsamt hos patienter med PS i tidigare skede av sjukdomens komplikationsfas. MT är förlångsammad hos patienter med PS och det är inget tydligt samband mellan LD-upptag och MT eller mellan MT och sjukdomsgrad. Kontinuerligt given LD minskar LDnivåerna. Enzymhämmaren entakapon ökar den maximala koncentrationen av LD i blod och ryggmärgsvätska och effekten är mer tydlig vid tillägg av karbidopa vilket är viktigt att ta i beaktande vid behandling av PS för att undvika höga toppar av LD i hjärnan. LD ökar i hjärnan då man behandlar med LD i tablettform och som infusion i blodet och DA-nivåerna i hjärnan följer LD väl vilket visar på att patienter med PS fortfarande kan omvandla LD till DA trots trolig uttalad brist av de DA-producerande nervcellerna i hjärnan. DBS verkar öka DA i vissa områden i hjärnan och tillsammans med LD-infusion i blodet verkar det även öka LD i hjärnan och det kan förklara varför man kan sänka LDdosen efter DBS-operation.
Download or read book Handbook of Parkinson s Disease Fifth Edition written by Rajesh Pahwa and published by CRC Press. This book was released on 2013-05-09 with total page 622 pages. Available in PDF, EPUB and Kindle. Book excerpt: Highly Commended, BMA Medical Book Awards 2014 This volume has long prevailed as one of the leading resources on Parkinson's disease (PD). Fully updated with practical and engaging chapters on pathology, neurochemistry, etiology, and breakthrough research, this source spans every essential topic related to the identification, assessment, and treatment of PD. Reflecting the many advances that have taken place in the management of PD, this volume promotes a multidisciplinary approach to care and supplies new sections on the latest pharmacologic, surgical, and rehabilitative therapies, as well as essential diagnostic, imaging, and nonmotor management strategies. New to this edition: • Early identification of premotor symptoms • Potential disease modification agents • Physical and occupational therapy
Download or read book Handbook of Parkinson s Disease Fourth Edition written by Rajesh Pahwa and published by CRC Press. This book was released on 2007-03-23 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This blue-ribbon guide has long prevailed as one of the leading resources on Parkinson's Disease (PD). Fully updated with practical and engaging chapters on pathology, neurochemistry, etiology, and breakthrough research, this source spans every essential topic related to the identification, assessment, and treatment of PD. Reflecting the many advances that have taken place in the management of PD, this source promotes a multidisciplinary approach to care and supplies new sections on the latest pharmacologic, surgical, and rehabilitative therapies, as well as essential diagnostic, imaging, and nonmotor management strategies for PD.
Download or read book Novel Therapeutic Approaches Targeting Oxidative Stress written by Pawan Kumar Maurya and published by Academic Press. This book was released on 2022-02-18 with total page 294 pages. Available in PDF, EPUB and Kindle. Book excerpt: Novel Therapeutic Approaches Targeting Oxidative Stress investigates the role of oxidative stress in disease and explores the latest methods and approaches to targeting oxidative stress for treatment and diagnosis. The book begins with an introduction to oxidative stress and its significance. Subsequent sections cover biochemical methods for detecting free radicals and novel therapeutic approaches for targeting oxidative stress in a number of different diseases. This includes age-related illnesses, neuropsychiatric disorders such as schizophrenia and bipolar disorder, and neurodegenerative diseases like Alzheimer's and Parkinson's disease. Novel approaches for targeting oxidative stress in cancer and cardiovascular diseases are also explored. The book then moves on to discuss advances in drug delivery systems and detecting oxidative stress biomarkers using biosensors. It concludes with case studies that illustrate the targeting of oxidative stress and future perspectives. - Explores oxidative stress in a variety of diseases, including neurological disorders, cardiovascular diseases, age-related diseases, and cancer - Covers a range of therapeutic approaches to target oxidative stress - Includes chapters on the application of novel drug delivery systems and diagnostic biosensors to oxidative stress - Features case studies illustrating the targeting of oxidative stress
Download or read book Therapy of Parkinson s Disease written by William C. Koller and published by CRC Press. This book was released on 1995 with total page 640 pages. Available in PDF, EPUB and Kindle. Book excerpt: This work offers a comprehensive and fully updated overview of supportive patient management strategies, highlighting therapeutic approaches other that dopaminergic agents and conventional antiparkinsonian drugs. This second edition: reviews the neuroprotective effects of selegiline on Parkinson's disease; investigates ways of enhancing the effectiveness of levodopa-based therapy; presents methods of speech therapy with well-documented short- and long-term efficacy; and more.
Download or read book Diagnosis and Treatment of Parkinson s Disease written by Cindy Levine and published by Department of Health and Human Services Pu Ncy for Healthcare Res. This book was released on 2003-01-01 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Living Well with Parkinson s written by Glenna Wotton Atwood and published by Wiley. This book was released on 2005-03-23 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The long-awaited update to the definitive guide to successfully living with Parkinson's disease Known for its upbeat, informative, and inspirational guidance, Living Well with Parkinson's includes a wealth of up-to-date medical information for Parkinson's sufferers, who number over 1 million in the U.S. alone. Combined with the author's poignant personal account of her own struggles with the disease, this new edition features coverage of pallidotomy (a new surgical technique), the dramatic implications of recent genetic research, and new drugs and therapies. The book also includes tips on dealing with social services and elder law, maintaining a positive attitude, handling issues with spouses and children, and finding support groups. Glenna Wotton Atwood, a former home economics teacher from Maine, lived with Parkinson's for over two decades until her death in 1998. Lila Green Hunnewell (Rockaway, NJ) is a freelance writer and editor. Roxanne Moore Saucier (Bangor, ME) is a journalist with the Bangor Daily News.
Download or read book Breakthroughs in Parkinsons Therapy written by Karen Brach and published by Independently Published. This book was released on 2024-03-20 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Breakthroughs in Parkinson's Therapy: Neurodegenerative Insights and Treatment Strategies" emerges as an essential guide for countless individuals navigating the complexities of Parkinson's disease (PD), offering a beacon of hope through innovative therapy options and groundbreaking research insights.At the heart of this transformative work is an exploration of the latest advancements in Parkinson's therapy, including cutting-edge neurodegenerative insights and treatment strategies that have shown significant promise in altering the disease's trajectory. Despite these advances, there remains a critical gap in awareness and application among healthcare professionals, leaving many patients without access to potentially life-changing treatments. Designed with both individuals living with Parkinson's and their healthcare providers in mind, this book delves deep into the scientific underpinnings of novel therapeutic approaches. It presents a comprehensive overview of the current research landscape, exploring the mechanisms through which these new treatments exert their effects on the brain and offering a clear protocol for those interested in integrating these strategies into their care regimen. The urgency for neurologists, general practitioners, and Parkinson's specialists to familiarize themselves with these emerging therapies cannot be overstated. With Parkinson's disease continuing to challenge those it affects, the introduction of immediate, accessible, and innovative treatment options represents a pivotal shift towards improving the quality of life for many. Following the legacy of pioneers who have pushed the boundaries of Parkinson's research and treatment, "Breakthroughs in Parkinson's Therapy" not only sheds light on their groundbreaking work but also calls upon the medical community to embrace and further investigate these novel strategies. It underscores the necessity for ongoing research and funding to bring these therapies from the fringes of experimental medicine to the forefront of mainstream clinical practice. In a landscape yearning for hope and substantive progress, this book stands as a testament to the resilience of those affected by Parkinson's and the relentless pursuit of a future where managing and overcoming this neurodegenerative disease is within reach.
Download or read book Navigating Life with Parkinson Disease written by Sotirios Parashos and published by Oxford University Press. This book was released on 2012-11-20 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt: Here is a marvelous guide for anyone affected by Parkinson's disease--patients, caregivers, family members, and friends. Containing the most up-to-date information on the disease, one of the most common neurological disorders, it discusses the available treatments and provides practical advice on how to manage the disease in the long term. Emphasizing life-style adjustments that will provide a better quality of life and moderate the burden for patients and their loved ones, the book answers many questions and clarifies misunderstandings regarding the disease. Written by two experts on Parkinson's disease and a freelance journalist, the book is approachable and easily understandable. Question and answer sections are provided, while "hot topics" are highlighted for easy visibility. The authors have also included true patient stories that will both inspire and instruct, and they have addressed several topics often not mentioned in physician-directed disease management, such as how to talk to family and friends about one's life with Parkinson's.
Download or read book Parkinson s Disease written by National Collaborating Centre for Chronic Conditions (Great Britain) and published by Royal College of Physicians. This book was released on 2006 with total page 243 pages. Available in PDF, EPUB and Kindle. Book excerpt:
