Download or read book Novel Strategies of Anti Tumor Vaccines written by Roberto S. Accolla and published by Frontiers Media SA. This book was released on 2020-02-14 with total page 170 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Novel Strategies for Anti Tumor Vaccines written by Roberto S. Accolla and published by . This book was released on 2020 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.

Download or read book Approaches to Advance Cancer Vaccines to Clinical Utility written by An M. T. Van Nuffel and published by Frontiers Media SA. This book was released on 2019-12-27 with total page 196 pages. Available in PDF, EPUB and Kindle. Book excerpt: Although cancer vaccines have yielded promising results both in vitro and in animal models, their translation into clinical application has not been very successful so far. Through the success of immune checkpoint inhibitors, the tumor immunotherapy field revived and led to important new insights. A better understanding of the functional capacity of different dendritic cell (DC) subsets and the immunogenicity of tumor antigens, more particularly of neoantigens, have important implications for the improvement of cancer vaccines. These insights can guide the development of novel strategies, to enhance the clinical utility of cancer vaccines. The aim of this Research Topic is therefore to provide a comprehensive overview of current issues regarding cancer vaccine development with an emphasis on novel approaches toward enhancing their efficacy.

Download or read book Novel Approaches and Strategies for Biologics Vaccines and Cancer Therapies written by Manmohan Singh and published by Academic Press. This book was released on 2014-12-30 with total page 520 pages. Available in PDF, EPUB and Kindle. Book excerpt: Novel Approaches and Strategies for Biologics, Vaccines and Cancer Therapies takes a look at the current strategies, successes and challenges involved with the development of novel formulations of biologics, vaccines and cancer therapy. This thorough reference on the latest trends in the development of diverse modalities will appeal to a broad community of scientists, students and clinicians. Written by leading authors across academia and industry, this book covers important topics such as unique drug delivery devices, non-parenteral delivery trends, novel approaches to the treatment of cancer, immunotherapy and more. It includes real-world cases and examples which highlight formulations with therapeutic proteins, monoclonal antibodies, peptides and biobetters, as well as cases on novel vaccines formulations including evolving pathogens, novel modalities of vaccines, universal vaccines. This book is a thorough and useful resource on the development of novel biologics, vaccines and cancer therapies. Provides strategies for the development of safe and efficacious novel formulations for various modalities of biologics, vaccines and for cancer therapy Highlights novel cases from current clinical trials as well as marketed products Reviews overall successes and challenges in the development of novel formulations, including new molecular targets for the treatment of diseases, design of target-specific therapies, regulatory considerations, individualized therapies

Download or read book Cancer Vaccination and Challenges written by Rishabha Malviya and published by CRC Press. This book was released on 2024-11-22 with total page 442 pages. Available in PDF, EPUB and Kindle. Book excerpt: Volume 1: Strategies for Therapeutic Cancer Vaccine Development deals with different strategies of cancer vaccine development, focusing on techniques for the development of therapeutic cancer vaccines and the roles of tumor antigens, proteins/peptides, microbial genes, and stem cells for the development of vaccines for cancer management. Volume 2: Delivery Strategies for Cancer Vaccine and Immunotherapy in Management of Various Carcinomas covers delivery strategies of cancer vaccines for the management of various forms of carcinoma, examining the prospects of delivering immuno-oncology therapies, focusing specifically on the effective drug delivery strategies for treatment of lung, prostate, and pancreatic carcinomas.

Download or read book Novel Technologies for Vaccine Development written by Igor S Lukashevich and published by Springer. This book was released on 2014-11-13 with total page 393 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents a detailed overview of the development of new viral vector-based vaccines before discussing two major applications: preventive vaccines for infectious diseases and therapeutic cancer vaccines. Viral vector-based vaccines hold a great potential for development into successful pharmaceutical products and several examples at the advanced pre-clinical or clinical stage are presented. Nevertheless, the most efforts were focused on novel and very innovative technologies for new generation of vector-based vaccines. Furthermore, specific topics such as delivery and adjuvant and protection strategies for cell-mediated-based vaccines are presented. Given its scope, the book is a “must read” for all those involved in vaccine development, both in academia and industrial vaccine development.

Download or read book Cancer Vaccines as Immunotherapy of Cancer written by Luigi Buonaguro and published by Academic Press. This book was released on 2021-09-15 with total page 150 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer Vaccines as Immunotherapy of Cancer provides extensive and state-of-the-art information about the meaning, relevance and limitation of therapeutic cancer vaccines. It covers all the aspects involved in the vaccine research and development (identification of optimal target antigens, formulations, delivery strategies, adjuvants among others) as well as their use in combination with other immunomodulatory approaches. The book discusses topics such as identification of tumor associated and specific antigens, proteogenomic for identification of novel target tumor antigens, antigen-specific T cells, and Peptide and RNA based vaccines. Additionally, it covers oncolytic viruses for antigen delivery, cancer vaccine targeting viral antigens and combinatorial immunotherapy strategies. Written by leading experts worldwide, this is a valuable resource for cancer researchers, oncologists and members of biomedical field who wants to understand in depth the recent findings in the field of cancer vaccines. Describes the state-of-the-art of the research and development of therapeutic cancer vaccines Presents detailed diagrams to help the reader understand the functionality of each type of vaccine discussed Encompasses recent findings in the field through chapters written by leading experts worldwide

Download or read book Novel Vaccination Strategies written by Stefan H. E. Kaufmann and published by John Wiley & Sons. This book was released on 2006-01-24 with total page 672 pages. Available in PDF, EPUB and Kindle. Book excerpt: The protection mode of most available vaccines is based on antibody responses. Since efficient immune responses to many pathogens rely on activating all arms of the immune system, traditional vaccine development does not provide efficient protection against many diseases. Novel vaccination strategies need to allow presentation of antigens that activate the full array of the immune response in the right composition and should prevent pathogen entry by mobilizing the mucosal immune response. New technological advances optimize the immunogenicity of 'live' and sub-unit vaccines. This book offers an interdisciplinary overview on research and future strategies for rational vaccine design based on recent developments in molecular biology and immunology. It covers new aspects of the immunological interplay between prokaryotic and eukaryotic systems as well as achievements in the development of novel vaccine candidates. Chapters on edible vaccines, on vaccines against bioterror agents and on economical and safety aspects of novel vaccine development round off this title.

Download or read book Handbook of Cancer Vaccines written by Michael A. Morse and published by Springer Science & Business Media. This book was released on 2004-01-28 with total page 626 pages. Available in PDF, EPUB and Kindle. Book excerpt: Morse offers this text to introduce this field of study to seasoned researchers and those new to the field. The book is well laid out into four sections including a Basic Science Background, General Vaccine and Immunotherapy Strategies, Tumor Specific Vaccines Being Developed and closing with a final section on General Background of Clinical Trials and Immune Analysis.

Download or read book Combinational Immunotherapy of Cancer Novel Targets Mechanisms and Strategies written by Xuyao Zhang and published by Frontiers Media SA. This book was released on 2024-01-15 with total page 537 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer immunotherapy, including immune checkpoint inhibitors (ICIs) and chimeric antigen receptor T-cell (CAR-T) therapy, has revolutionized the paradigm in cancer treatment. However, the clinical outcome of immunotherapy varies considerably among patients and only a minority of patients achieve long-term clinical benefits. This is largely attributed to the fact that existing cancer immunotherapies, which concentrate on several classical targets (CTAL-4, PD-1/PD-L1, etc.) and limited types of immune cell populations (T cells), are insufficient to cope with the complexity of highly heterogeneous tumor microenvironment (TME). This calls for more efforts to not only expand our toolbox for manipulating anticancer immunity but also diversify our combinational strategies. To this end, it is urgent to deeper our understanding of cancer immunotherapy by using both experimental and computational methodologies from multi-scale perspectives: 1) novel targets from either tumor cells or non-tumor cells within TME (e.g., tumor intrinsic resistance drivers, new immune checkpoints, neoantigens), 2) in-depth characterization of more immune cell populations (e.g., macrophages, Tregs, B cells) and their interactions and dynamics within TME, 3) landscape of actionable targets in patient populations for combination design. These efforts will open the avenue of rational design of combinational immunotherapies, allowing researchers and clinicians to design novel targeting therapeutics or to optimally orchestrate combinatory strategies aiming to surmount resistance mechanisms and improve clinical outcomes.

Download or read book Enhancing the Systemic Anti tumor Efficacy of in situ Vaccines Against Advanced Tumors written by Alexander Anthony Pieper and published by . This book was released on 2021 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Despite advancements in our ability to diagnosis and treat cancer, cancer progression still occurs in many patients. Disease progression at sites other than the treated tumor remains an obstacle for improved patient outcomes. In-situ cancer vaccine strategies use immunotherapeutics to increase antigen processing and adaptive cell priming at one site of disease, and their objective is to have this adaptive response mediate tumor cell killing at the local, treated tumor and at distant, untreated sites of disease. The Sondel lab has developed an effective in-situ vaccine strategy that combines local external beam radiation therapy (RT) with intratumoral injections of immunocytokine, which is a fusion protein comprised of interleukin 2 (IL-2) attached to a monoclonal antibody. In the weakly immunogenic B78 melanoma model, this in-situ vaccine can cure mice of established tumors and generate an adaptive, tumor-specific memory response. If the B78 model is made more difficult to treat by adding a second untreated tumor to the model or allowing the tumors to grow larger in size before treatment, RT combined with immunocytokine demonstrates reduced anti-tumor efficacy. The goal of this thesis was to explore mechanisms to improve our in-situ vaccination strategies, with a particular emphasis geared towards improving the strength of in-situ vaccines under model conditions that are deemed "hard-to-treat." Research with a different in-situ vaccine, local injections of CpG oligodeoxynucleotide combined with an OX40 agonist antibody (CpG+OX40), has shown the combination synergizes to cure mice bearing multiple A20 lymphoma tumors. In these studies, however, the tumors were relatively small at the time treatment was initiated. Additionally, the A20 lymphoma model is considered relatively immunogenic. By evaluating the efficacy of this in-situ vaccine in both the B78 and A20 models, these studies demonstrate CpG+OX40 is an effective in-situ vaccination strategy against relatively small tumors. However, as tumor burden increases through the addition of a second untreated tumor or allowing tumors to grow larger before treatment is initiated, these studies show the efficacy of CpG+OX40 is reduced. In the A20 model, there are tumor phenotypic changes that develop in these larger tumors, which correlate with the reduced efficacy of this T cell dependent in-situ vaccine against larger tumors. Radiation therapy (RT) has been studied for its ability to turn a weakly immunogenic tumor into one that is more immunogenic. The Sondel and Morris labs have utilized these immune modulating capabilities in their research, demonstrating that local radiation can make a weakly immunogenic tumor more responsive to immunotherapy. Chapter 3 of this dissertation presents data demonstrating that local radiation prior to in-situ vaccination with CpG+OX40 can render a tumor, which was previously unlikely to respond to immunotherapy, more likely to shrink and go away. The data suggest RT is functioning to improve the anti-tumor response with CpG+OX40 by increasing antigen presentation and T cell activation. Though the in-situ vaccine regimen RT+CpG+OX40 can cure some mice of established B78 tumors, the cure rate of this regimen was reduced compared to the historical data of combining RT with immunocytokine. In an effort to improve the efficacy of our in-situ vaccine strategies, studies were performed investigating if RT could be combined with a different immunotherapeutic, a novel IL-2 receptor agonist Bempegaldesleukin, to activate a strong T cell mediated anti-tumor immune response. This combination, RT combined with Bempegaldesleukin, was capable of curing mice of B78 tumors that have historically been less responsive to RT combined with immunocytokine. Additionally, these studies demonstrated that addition of checkpoint blockade to this combination of RT with Bempegaldesleukin can further enhance the anti-tumor response in model conditions that more closely mimic the disease characteristics in patients. The preclinical laboratory development of this in-situ vaccine regimen, RT combined with Bempegaldesleukin and checkpoint blockade, contributed to the design and initiation of a clinical trial that is now opening to accrual.

Download or read book Vaccines for Cancer Immunotherapy written by Nima Rezaei and published by Academic Press. This book was released on 2018-10-17 with total page 198 pages. Available in PDF, EPUB and Kindle. Book excerpt: Therapeutic cancer vaccines represent a type of active cancer immunotherapy. Clinicians, scientists, and researchers working on cancer treatment require evidence-based and up-to-date resources relating to therapeutic cancer vaccines. Vaccines for Cancer Immunotherapy provides a reference for cancer treatment for clinicians and presents a well-organized resource for determining high-potential research areas. The book considers that this promising modality can be made more feasible as a treatment for cancer. Chapters cover cancer immunology, general approaches to cancer immunotherapy, vaccines, tumor antigens, the strategy of allogeneic and autologous cancer vaccines, personalized vaccines, whole-tumor antigen vaccines, protein and peptide vaccines, dendritic cell vaccines, genetic vaccines, candidate cancers for vaccination, obstacles to developing therapeutic cancer vaccines, combination therapy, future perspectives and concluding remarks on therapeutic cancer vaccines. Introduces the feasible immunotherapeutic vaccines for patients with different types of cancer Presents the status of past and current vaccines for cancer treatment Considers advantages and disadvantages of different therapeutic cancer vaccines Looks at the combination of vaccines and other modalities, including immunotherapeutic and conventional methods Analyzes obstacles to development of therapeutic cancer vaccines Gives a view on future perspectives in the application of therapeutic cancer vaccines

Download or read book Cancer Vaccines and Immunotherapy written by Peter L. Stern and published by Cambridge University Press. This book was released on 2000-08-17 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt: Rapid progress in the definition of tumor antigens, and improved immunization methods, bring effective cancer vaccines within reach. In this wide-ranging survey, leading clinicians and scientists review therapeutic cancer vaccine strategies against a variety of diseases and molecular targets. Intended for an interdisciplinary readership, their contributions cover the rationale, development, and implementation of vaccines in human cancer treatment, with specific reference to cancer of the cervix, breast, colon, bladder, and prostate, and to melanoma and lymphoma. They review target identification, delivery vectors and clinical trial design. The book begins and ends with lucid overviews from the editors, that discuss the most recent developments.

Download or read book Development of New Strategies in Anti tumor Vaccination by Targeting Recombinant Bacteria to Dendritic Cells in Vivo written by Gianluca Rotta and published by . This book was released on 2005 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Novel Anticancer Strategies Volume II written by Hassan Bousbaa and published by Mdpi AG. This book was released on 2023-03-15 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Novel Anticancer Strategies (Volume II) reviews important findings and updates within the cancer therapy field of great interest to those in academic research studying the development and validation of novel anticancer approaches. The Editor invited preeminent specialists to contribute to original and review articles devoted to key areas of major progress and expectations. Key Features: Nanoparticle-based drug delivery in cancer therapy; Nanoerythrosomes; Cancer immunotherapy; Therapeutic vaccines; Oncogenic and tumor suppressive components of the cell cycle; Antimitotics in cancer clinical trials; Multifunctional enzymes as anti-cancer drug targets; Targeting undruggable proteins and non-coding RNAs; Cell-penetrating peptides; Repurposed cancer drugs in clinical trials; Circulating tumour cells.

Download or read book Cancer Immunology and Immunotherapy written by Mansoor M. Amiji and published by Elsevier. This book was released on 2021-08-27 with total page 548 pages. Available in PDF, EPUB and Kindle. Book excerpt: Delivery Technologies for Immuno-Oncology: Volume 1: Delivery Strategies and Engineering Technologies in Cancer Immunotherapy examines the challenges of delivering immuno-oncology therapies. Immuno-oncology (IO) is a growing field of medicine at the interface of immunology and cancer biology leading to development of novel therapeutic approaches, such as chimeric antigen receptor T-cell (CAR-T) and immune checkpoint blockade antibodies, that are clinically approved approaches for cancer therapy. Although currently approved IO approaches have shown tremendous promise for select types of cancers, broad application of IO strategies could even further improve the clinical success, especially for diseases such as pancreatic cancer, brain tumors where the success of IO so far has been limited. Nanotechnology-based targeted delivery strategies could improve the delivery efficiency of IO agents as well as provide additional avenues for novel therapeutic and vaccination strategies. Additionally, a number of locally-administered immunogenic scaffolds and therapeutic strategies, such as the use of STING agonist, could benefit from rationally designed biomaterials and delivery approaches. Delivery Technologies for Immuno-Oncology: Volume 1: Delivery Strategies and Engineering Technologies in Cancer Immunotherapy creates a comprehensive treaty that engages the scientific and medical community who are involved in the challenges of immunology, cancer biology, and therapeutics with possible solutions from the nanotechnology and drug delivery side. Comprehensive treaty covering all aspects of immuno-oncology (IO) Novel strategies for delivery of IO therapeutics and vaccines Forecasting on the future of nanotechnology and drug delivery for IO

Download or read book Nanotherapeutics in Cancer Vaccination and Challenges written by Mahfoozur Rahman and published by Academic Press. This book was released on 2022-03-03 with total page 496 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nanotherapeutics in Cancer Vaccination and Challenges consolidates the current research on cancer nanomedicine and therapeutic cancer vaccination to explore the most effective and promising avenues. The book covers cancer vaccines before exploring nanotherapeutics, DNA and mRNA vaccines in cancer treatment. Finally, it considers regulatory and industrial perspectives on cancer vaccination and nanotherapeutics. This resource will be useful for pharmaceutical scientists and researchers focused on biomedical engineering, chemical engineering, vaccine development, and cancer immunotherapy, along with advanced students in these subjects. Cancer is arguably the most complex and challenging disease known to mankind. Over the last two-decades, significant advancements have been made in new and novel concepts of cancer nanomedicines. Therapeutic cancer vaccines may be utilized to inhibit further growth of advanced cancers and/or relapsed tumors that are refractory to conventional therapies, such as surgery, radiation therapy and chemotherapy. Presents the progress made in cancer medicines from conventional to targeted therapy Covers the present state-of-the-art of cancer nanomedicines and upcoming therapeutic cancer vaccination Contains a focus on advanced nanomaterials that are utilized for encapsulation of nucleic acid, mRNA, DNA, siRNA