Download or read book Novel Pharmacological Inhibitors for Bacterial Protein Toxins written by Holger Barth and published by . This book was released on 2017 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Novel Pharmacological Inhibitors for Bacterial Protein Toxins written by Holger Barth and published by MDPI. This book was released on 2018-07-09 with total page 125 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a printed edition of the Special Issue "Novel Pharmacological Inhibitors for Bacterial Protein Toxins" that was published in Toxins

Download or read book Uptake and Trafficking of Protein Toxins written by Holger Barth and published by Springer. This book was released on 2017-12-01 with total page 261 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume focuses on the transport of medically relevant bacterial protein toxins into mammalian cells, and on novel pharmacological strategies to inhibit toxin uptake. The first chapters review our current understanding of the cell-surface receptors and cellular transport processes of Clostridium botulinum neurotoxins, Clostridium botulinum C3 toxin, Clostridium difficile toxins, binary clostridial enterotoxins, anthrax toxins and diphtheria toxin. In brief, specific binding/transport (B) subunits deliver the enzyme (A) subunits into the cytosol, where the latter modify their substrates, producing cytotoxic effects and the characteristic toxin-associated diseases. Key mechanisms for the transport of the A subunits from endosomes into the cytosol and the role of trans-membrane pores formed by the B subunits and host cell chaperones for this process are reviewed. The book’s closing chapters focus on compounds which inhibit the transport of the A subunits from endosomes into the cytosol and therefore might lead to novel therapeutic strategies for toxin-associated diseases. These substances include pharmacological inhibitors of the host cell chaperones involved, as well as multivalent and heterocyclic molecules that specifically block the toxins’ translocation channels. This volume offers an up-to-date resource for scientists.

Download or read book The Comprehensive Sourcebook of Bacterial Protein Toxins written by Joseph E. Alouf and published by Academic Press. This book was released on 2015-05-29 with total page 1201 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Comprehensive Sourcebook of Bacterial Protein Toxins, Fourth Edition, contains chapters written by internationally known and well-respected specialists. This book contains chapters devoted to individual toxins, as well as chapters that consider the different applications of these toxins. Considerable progress has been made in understanding the structure, function, interaction and trafficking into cells, as well as mechanism of action of toxins. Bacterial toxins are involved in the pathogenesis of many bacteria, some of which are responsible for severe diseases in human and animals, but can also be used as tools in cell biology to dissect cellular processes or used as therapeutic agents. Novel recombinant toxins are already proposed in the treatment of some diseases, as well as new vaccines. Alternatively, certain toxins are also considered as biological weapons or bioterrorism threats. Given the multifaceted aspects of toxin research and the multidisciplinary approaches adopted, toxins are of great interest in many scientific areas from microbiology, virology, cell biology to biochemistry and protein structure. This new edition is written with a multidisciplinary audience in mind and contains 5 new chapters that reflect the latest research in this area. Other chapters have been combined, deleted and fully revised as necessary to deliver relevant and valuable content. - Descriptions of relevant toxins as well as representative toxins of the main bacterial toxin families to allow for a better comparison between them - Focused chapters on toxin applications and common properties or general features of toxins

Download or read book Bacterial Toxins written by Klaus Aktories and published by John Wiley & Sons. This book was released on 2008-09-26 with total page 334 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is a survey of well characterized and recently discovered bacterial protein toxins. Leading investigators of the respective toxins review the various molecular mechanisms of action, ranging from toxin-induced ADP-ribosylation up to membrane perforation by pore-forming toxins. Thy also describe the consequences on host physiology before focusing on potential applications as cell biological and pharmacological tools for research and medical applications. Detailed descriptions of the methodology include the engineering and use of modified and chimeric toxins for better performance. A solid introduction to toxin structure and functions, as well as a valuable source of methodology for researchers in molecular biology, pharmacology and experimental medicine.

Download or read book Bacterial Protein Toxins written by K. Aktories and published by Springer Science & Business Media. This book was released on 2013-03-14 with total page 713 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years remarkable progress has been accomplished with respect to our knowledge about bacterial protein toxins. This refers especially to structural aspects of protein toxins but also holds true for genetics, molecular biology and biochemical mechanisms underlying the action of toxins. This volume covers the very current and exciting aspects of up-to-date bacterial toxicology and comprehensively reviews the most important bacterial protein toxins such as the intracellular acting toxins which exhibit enzyme activity, as well as those toxins that interact with cell plasma membranes by damaging the membranes (pore formation) or stimulating cell receptors (superantigens). This is the most current reference work on these important bacterial protein toxins, which are presented from the point of view of different disciplines such as pharmacology, microbiology, cell biology and protein chemistry.

Download or read book Bacterial Protein Toxins V3 written by Thomas C. Montie and published by Elsevier. This book was released on 2013-09-11 with total page 569 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bacterial Protein Toxins V3

Download or read book Guidebook to Protein Toxins and Their Use in Cell Biology written by Rino Rappuoli and published by OUP Oxford. This book was released on 1997-05-29 with total page 278 pages. Available in PDF, EPUB and Kindle. Book excerpt: Many bacteria, animals, and plants produce toxins that can prove lethal to other organisms. Toxins are a form of "biological warfare" that helps their producer to survive and so confer an evolutionary advantage. They display an extraordinary range of complexity, from the formic acid provided by ants to bacterial proteins composed of thousands of amino acids. This Guidebook considers the more complex protein and peptide toxins and groups them according to their mode of action. Topics covered include: membrane-permeabilizing toxins; toxins affecting signal transduction and protein synthesis; cytoskeleton-affecting toxins; toxins affecting the immune and inflammatory response. This class of biomolecules will be of interest to a wide range of researchers in cell biology, neuroscience, and toxicology.

Download or read book Discovery of Novel Inhibitors of the Bacterial Cell Division Protein FtsZ by Computational Drug Screening Coupled with Bioassays written by Fung-yi Chan and published by . This book was released on 2011 with total page 476 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Antimicrobial Chemotherapy written by Roger Finch and published by OUP Oxford. This book was released on 2012-01-05 with total page 409 pages. Available in PDF, EPUB and Kindle. Book excerpt: Antimicrobial agents are essential for the treatment of life-threatening infections and for managing the burden of minor infections in the community. In addition, they play a key role in organ and bone marrow transplantation, cancer chemotherapy, artificial joint and heart valve surgery. Unlike other classes of medicines, they are vulnerable to resistance from mutations in target microorganisms, and their adverse effects may extend to other patients (increased risk of cross-infection). As a consequence, there is a constant requirement for new agents, as well as practices that ensure the continued effective prescribing of licensed agents. Public awareness and concerns about drug resistant organisms has led to widespread publicity and political action in the UK, Europe and worldwide. The control of drug resistance and the implementation of good prescribing practice are now legal requirements in the UK as a result of the UK Health Act (2008). These fundamental changes underscore the need for a thorough understanding of the advantages and risks associated with specific antibiotic choices. This sixth edition of Antimicrobial Chemotherapy continues to be a valuable resource for undergraduates and graduates requiring a thorough grounding in the scientific basis and clinical application of these drugs. This new edition is updated to include the most recently licensed agents, notably in the treatment of viral infections including HIV/AIDS, and contains new guidance on prescribing practice and infection control practices that limit the development and spread of resistant organisms.

Download or read book Molecular Genetics Genomics and Biotechnology of Crop Plants Breeding written by Søren K. Rasmussen and published by MDPI. This book was released on 2020-05-27 with total page 238 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Special Issue on molecular genetics, genomics, and biotechnology in crop plant breeding seeks to encourage the use of the tools currently available. It features nine research papers that address quality traits, grain yield, and mutations by exploring cytoplasmic male sterility, the delicate control of flowering in rice, the removal of anti-nutritional factors, the use and development of new technologies for non-model species marker technology, site-directed mutagenesis and GMO regulation, genomics selection and genome-wide association studies, how to cope with abiotic stress, and an exploration of fruit trees adapted to harsh environments for breeding purposes. A further four papers review the genetics of pre-harvest spouting, readiness for climate-smart crop development, genomic selection in the breeding of cereal crops, and the large numbers of mutants in straw lignin biosynthesis and deposition.

Download or read book Exocytosis and Endocytosis written by Andrei I. Ivanov and published by Springer Science & Business Media. This book was released on 2008 with total page 407 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this book, skilled experts provide the most up-to-date, step-by-step laboratory protocols for examining molecular machinery and biological functions of exocytosis and endocytosis in vitro and in vivo. The book is insightful to both newcomers and seasoned professionals. It offers a unique and highly practical guide to versatile laboratory tools developed to study various aspects of intracellular vesicle trafficking in simple model systems and living organisms.

Download or read book Microbial Toxins written by P. Gopalakrishnakone and published by Springer. This book was released on 2018-03-14 with total page 502 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years, the field of Toxinology has expanded substantially. On the one hand it studies venomous animals, plants and micro organisms in detail to understand their mode of action on targets. While on the other, it explores the biochemical composition, genomics and proteomics of toxins and venoms to understand their three interaction with life forms (especially humans), development of antidotes and exploring their pharmacological potential. Therefore, Toxinology has deep linkages with biochemistry, molecular biology, anatomy and pharmacology. In addition, there is a fast developing applied subfield, clinical toxinology, which deals with understanding and managing medical effects of toxins on human body. Given the huge impact of toxin-based deaths globally, and the potential of venom in generation of drugs for so-far incurable diseases (for example, Diabetes, Chronic Pain), the continued research and growth of the field is imminent. This has led to the growth of research in the area and the consequent scholarly output by way of publications in journals and books. Despite this ever growing body of literature within biomedical sciences, there is still no all-inclusive reference work available that collects all of the important biochemical, biomedical and clinical insights relating to Toxinology. The Handbook of Toxinology aims to address this gap and cover the field of Toxinology comprehensively.

Download or read book Lehne s Pharmacology for Nursing Care E Book written by Jacqueline Rosenjack Burchum and published by Elsevier Health Sciences. This book was released on 2023-12-14 with total page 1499 pages. Available in PDF, EPUB and Kindle. Book excerpt: **Selected for Doody's Core Titles® 2024 in Pharmacology** Master an understanding of pharmacology — and apply that understanding to nursing practice! With an engaging approach that actually makes learning nursing pharmacology enjoyable, Lehne's Pharmacology for Nursing Care, 12th Edition makes it easier to understand difficult pharmacologic principles and the clinical use of drugs. The book discusses physiology and pathophysiology for each of the major drug families, using drug prototypes to simplify learning. What's more, it focuses your attention on the most important content, limiting discussions of drug interactions and adverse effects to those that matter most. Written by nursing educators Jacqueline Rosenjack Burchum and Laura D. Rosenthal, this text emphasizes the understanding of drugs and drug therapy as opposed to simply memorizing drug facts. - Clear, engaging writing style simplifies complex concepts, making difficult pharmacology content not only understandable but actually enjoyable. - Prototype Drugs approach focuses on representative agents that characterize all members of a given drug group, so that you can apply your understanding to related drugs that are currently available and those that will be released in the future. - Nursing implications of drug therapy are integrated throughout to show the relationship between drug therapy and nursing care, and also recapped in Summary of Major Nursing Implications sections. - Special Interest Topic boxes examine the everyday impact of pharmacology with engaging vignettes such as Vaping and Severe Acute Respiratory Syndrome Coronavirus-2 (COVID-19) Vaccine. - Safety Alerts call out important safety concerns related to contraindications, adverse effects, and more. - Concise drug summary tables present key information for individual drugs, including drug class, generic and trade names, dosages, routes, and indications. - Person-Centered Care Across the Life Span tables summarize safe and appropriate care for patients from infancy to older adulthood. - NEW! Updated drug content includes the latest FDA drug approvals, withdrawals, and therapeutic uses, along with updated nursing content. - NEW Transgender Health chapter covers gender-affirming hormone treatment for transgender patients. - NEW! The six cognitive skills of NCSBN's Clinical Judgment Measurement Model are integrated into the Application of Pharmacology in Nursing Practice chapter and in Summary of Major Nursing Considerations tables. - NEW! Enhanced emphasis on diversity, equity, and inclusion features updated gender-neutral language. - NEW! Updated COVID-19 content addresses the latest vaccination information and pharmacotherapeutic implications. - NEW coverage of CBD and expanded coverage of medical marijuana discusses the growing use of these substances. - NEW resources for the Next-Generation NCLEX® Examination (NGN) are included on the Evolve website and in the companion Study Guide.

Download or read book Introduction to Clinical Pharmacology E Book written by Constance G Visovsky and published by Elsevier Health Sciences. This book was released on 2021-01-04 with total page 418 pages. Available in PDF, EPUB and Kindle. Book excerpt: - NEW! Get Ready for the Next Generation NCLEX® Examination! section includes key points, review questions, and case studies with Next Generation NCLEX-format questions to prepare students for the new licensure examination. - NEW! Reorganized chapters break up lengthy content and more logically present pharmacological content by body system or major disorder. - UPDATED! Coverage of newly approved and updated pharmaceutical treatments and drugs prepares students for practice.

Download or read book Brody s Human Pharmacology E Book written by Lynn Wecker and published by Elsevier Health Sciences. This book was released on 2024-02-02 with total page 798 pages. Available in PDF, EPUB and Kindle. Book excerpt: Brody's Human Pharmacology is a well-established and much-loved textbook that guides students of medicine, pharmacology and other health professions through pharmacology from both basic and clinical perspectives. What can be a very difficult and complex topic is divided into easily digestible chapters, each of which is clearly structured from a therapeutic overview to mechanisms of action, relationships to clinical responses, pharmacokinetics, pharmacovigilance, new developments, and clinical relevance for all health professionals. - Contains all the essential aspects of pharmacology – suitable for exam preparation - Full color illustrations explain important processes and color-coded boxes enhance understanding - Therapeutic overviews, clinical problems and trade names – everything you need to know - Self-assessment questions and further reading to reinforce learning - Current developments for each class of drugs and how information relates to students in the healthcare professions bring learning to life - Updated content throughout - Pharmacodynamics chapter revised to include discussions of positive and negative allosteric modulators, as well as biased agonism - Pharmacogenetics chapter considers genetic variations and their relationship to drug responses - Section on cancer drugs revised to reflect major advances - New chapter on immunological and cell-based therapies

Download or read book Applied Microbiology and Infection Control Practices for Nurses E Book written by I DR. KANNAN and published by Elsevier Health Sciences. This book was released on 2023-07-03 with total page 355 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book primarily fulfils the content needs of Applied Microbiology and Infection Control Practices for Third Semester of B.Sc. Nursing students. Further, the book contains contents that help the nurses in profession to hone their microbiology knowledge used in their day-to-day practice. It contains all the updated vital aspects of infection control practices and the details of various infections suggested by WHO. The book provides the nursing interventions in the various areas of applied microbiology that will help them to sharpen their nursing skills. • All microbiology information needed for the undergraduate nursing students put in a systematic manner. • Concepts explained in lucid language for easy understanding by nursing students. • Content presented as bulleted lists for quick grasp of the subject matter. • Appropriate WHO guidelines and latest recommendations of infection control practices included. • Multicolour photographs, illustrations are used to explain complex microbiology concepts. • Content is completely based on the revised INC Syllabus with focus on Applied Microbiology • The content has been divided into two sections. Part A covers Applied Microbiology and Part B covers Infection Control & Safety • New! Content related to Infection Control and Safety has been added as a separate section. • New! Role of Infection Control Nurse in prevention of Healthcare-associated Infections (HAIs) has been added. • New! 7 new chapters have been added to this edition namely: ? Clinical Specimen Collection Techniques ? Healthcare-associated Infections (HAIs) ? Isolation Precautions and Other Infection Control Practices (Infection control practices including hand hygiene) ? Patient Safety Indicators ? International Patient Safety Goals (IPSG) ? Clinical Safety Protocol ? Hospital Employee Safety Indicators (HESI)