Download or read book Novel Oxylipins and Other Bioactive Metabolites from Marine Algae written by Dale George Nagle and published by . This book was released on 1994 with total page 430 pages. Available in PDF, EPUB and Kindle. Book excerpt: I have participated in a drug discovery program designed to screen marine algae for inhibitors of cancer-related enzymes, antitumor compounds, antiinflammatory substances, and other agents of potential pharmaceutical utility. Over 1,500 lipid and aqueous extracts of marine plants and animals were surveyed for biomedical potential. Assays designed to screen extracts for new types of marine toxins have served to guide the isolation and identification of biologically active compounds. Extracts of the Oregon marine alga Constantinea simplex were found to contain a mixture of constanolactones, and lactonized cyclopropyl-containing oxylipin metabolites that logically derive from arachidonic and eicosapentaenoic acids. Spectroscopic analysis and chiroptical measurements of the natural products and various synthetically produced derivatives afforded the structures of seven structurally related compounds. Nakienones A-C and nakitriol, a series of reactive cytotoxic metabolites, were isolated from dead and necrotic branches of stony coral (Acropora sp.) which were completely covered with a gray-black mat of cyanobacteria (Synechocystis sp.). Their structures were determined spectroscopically by interpretation of 2D-NMR experiments, including heteronuclear multiple-bond coherence spectroscopy (HMBC) and 2-D nuclear Overhauser exchange spectroscopy (NOESY), and by comparison with model compounds. Bioassay-guided fractionation of the organic extract of a Curacao Lyngbya majuscula organic extract led to the isolation of an extremely potent brine shrimp toxin with antiproliferative activity. The structure of this new thiazoline ring-containing lipid, curacin A, was deduced from spectroscopic information and comparison of products obtained from chemical degradation of the natural product with the same substances prepared by synthesis. Curacin A is an antimitotic agent that inhibits microtubule assembly and the binding of colchicine to tubulin. In addition to curacin A, a potent new ichthyotoxic depsipeptide (antillatoxin), a new malyngamide derivative, and an unusual molluscicidal compound have been isolated from this alga.
Download or read book Dissertation Abstracts International written by and published by . This book was released on 1995 with total page 778 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Environmental Metabolomics written by Diana Alvarez-Munoz and published by Elsevier. This book was released on 2020-05-19 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: Environmental Metabolomics Applications in Field and Laboratory Studies: From the Exposome to the Metabolome presents an overview of the current state of aquatic environments and problems caused by human pressure and daily life. The presence of contaminants in nature and their effects are evaluated, along with recommendations for preservation. This book not only shows readers how to implement techniques, it also guides them through the process. As metabolomics becomes a more routine technique for environmental studies and future perspectives, a guide for validation and globalization of current approaches is needed. Presents relevant and reliable information on the use of different analytical techniques for establishing the environmental metabolomics of polluted systems Includes a critical review of each central topic in every chapter, together with a bibliography and future trends Provides, for the first time, a global opinion and guide for achieving standardized results
Download or read book Natural Products From Marine Algae written by Dagmar B. Stengel and published by Humana. This book was released on 2016-10-13 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides a fundamental overview of the current state of the art in natural products from marine algae, linking the complex and diverse natural resource with recent developments in extraction, analytical and bioactivity testing methodologies. Natural Products from Marine Algae: Methods and Protocols guides readers through protocols and techniques on algal biotechnology, metabolites, Solid-Liquid Extraction (SLE), Microwave Assisted Extraction (MAE), Liquid Chromatography, Gas Chromatography, Nuclear Magnetic Resonance Spectroscopy, Infra-red spectroscopy and Raman Spectroscopy. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Natural Products from Marine Algae: Methods and Protocols hopes to aid scientists unravel and quantify algal chemical diversity and support further marine biotechnological developments.
Download or read book Handbook of Marine Macroalgae written by Se-Kwon Kim and published by John Wiley & Sons. This book was released on 2011-11-04 with total page 871 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Handbook of Macroalgae: Biotechnology and Applied Phycology describes the biological, biotechnological and the industrial applications of seaweeds. Vast research into the cultivation of seaweeds is currently being undertaken but there is a lack of methodological strategies in place to develop novel drugs from these sources. This book aims to rectify this situation, providing an important review of recent advances and potential new applications for macroalgae. Focusing on the chemical and structural nature of seaweeds the book brings the potentially valuable bioactive nature to the fore. Novel compounds isolated from seaweeds are reviewed to provide an invaluable reference for anyone working in the field.
Download or read book American Doctoral Dissertations written by and published by . This book was released on 1994 with total page 800 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Calmodulin Antagonists and Cellular Physiology written by Hiroyoshi Hidaka and published by Elsevier. This book was released on 2012-12-02 with total page 569 pages. Available in PDF, EPUB and Kindle. Book excerpt: Calmodulin Antagonists and Cellular Physiology focuses on the biochemistry of calmodulin antagonists as regulators of cellular physiology. Emphasis is placed on the use of calmodulin antagonists as an indicator of calmodulin function. The mechanism of action of calmodulin antagonists and their interactions with calmodulin are explored. This book is comprised of 33 chapters and begins with an introduction to the biochemical aspects of calmodulin as well as its distribution and functions, followed by a discussion on how calmodulin antagonists and other agents modulate Ca2+-dependent regulatory systems. The next section is devoted to the mechanism of action of calmodulin antagonists and includes chapters that examine the interaction of various drugs with calmodulin and the structure-activity relationships of calmodulin antagonists. The effects of calmodulin antagonists on cell proliferation and growth are then discussed. The remaining chapters deal with the role of calmodulin antagonists in cell function and the contractile process, along with their effect on protein kinase C. This monograph will be a useful resource for biochemists as well as students and researchers in biochemistry.
Download or read book Chemical Abstracts written by and published by . This book was released on 1995-09-11 with total page 1720 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Marine Chemical Ecology written by James B. McClintock and published by CRC Press. This book was released on 2001-06-13 with total page 626 pages. Available in PDF, EPUB and Kindle. Book excerpt: The interdisciplinary field of marine chemical ecology is an expanding and dynamic science. It is no surprise that the breadth of marine organisms studied expanded in concert with developments in underwater technology. With its up-to-date subject reviews by experts, Marine Chemical Ecology is the most current, comprehensive book on the subject. The
Download or read book Functional Ingredients from Algae for Foods and Nutraceuticals written by Herminia Dominguez and published by Elsevier. This book was released on 2013-09-30 with total page 766 pages. Available in PDF, EPUB and Kindle. Book excerpt: Algae have a long history of use as foods and for the production of food ingredients. There is also increasing interest in their exploitation as sources of bioactive compounds for use in functional foods and nutraceuticals. Functional ingredients from algae for foods and nutraceuticals reviews key topics in these areas, encompassing both macroalgae (seaweeds) and microalgae.After a chapter introducing the concept of algae as a source of biologically active ingredients for the formulation of functional foods and nutraceuticals, part one explores the structure and occurrence of the major algal components. Chapters discuss the chemical structures of algal polysaccharides, algal lipids, fatty acids and sterols, algal proteins, phlorotannins, and pigments and minor compounds. Part two highlights biological properties of algae and algal components and includes chapters on the antioxidant properties of algal components, anticancer agents derived from marine algae, anti-obesity and anti-diabetic activities of algae, and algae and cardiovascular health. Chapters in part three focus on the extraction of compounds and fractions from algae and cover conventional and alternative technologies for the production of algal polysaccharides. Further chapters discuss enzymatic extraction, subcritical water extraction and supercritical CO2 extraction of bioactives from algae, and ultrasonic- and microwave-assisted extraction and modification of algal components. Finally, chapters in part four explore applications of algae and algal components in foods, functional foods and nutraceuticals including the design of healthier foods and beverages containing whole algae, prebiotic properties of algae and algae-supplemented products, algal hydrocolloids for the production and delivery of probiotic bacteria, and cosmeceuticals from algae.Functional ingredients from algae for foods and nutraceuticals is a comprehensive resource for chemists, chemical engineers and medical researchers with an interest in algae and those in the algaculture, food and nutraceutical industries interested in the commercialisation of products made from algae. Provides an overview of the major compounds in algae, considering both macroalgae (seaweeds) and microalgae Discusses methods for the extraction of bioactives from algae Describes the use of algae and products derived from them in the food and nutraceutical industries
Download or read book Catalysis and Enzyme Action written by Myron L. Bender and published by McGraw-Hill Companies. This book was released on 1973 with total page 232 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Marine Bioactive Compounds written by Maria Hayes and published by Springer Science & Business Media. This book was released on 2011-11-19 with total page 239 pages. Available in PDF, EPUB and Kindle. Book excerpt: The aim and scope of this book is to highlight the sources, isolation, characterization and applications of bioactive compounds from the marine environment and to discuss how marine bioactive compounds represent a major market application in food and other industries. It discusses sustainable marine resources of macroalgal origin and gives examples of bioactive compounds isolated from these and other resources, including marine by-product and fisheries waste streams. In addition, it looks at the importance of correct taxonomic characterization.
Download or read book Bioactive Components written by Monika Thakur and published by Springer Nature. This book was released on 2022-12-01 with total page 609 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book compiles updated information about the role and health benefits of various bioactives in food. Different chapters are contributed by academicians, food scientists, technologists, and medical practitioners. The book addresses both theoretical and applied aspects of bioactive components and provides exhaustive knowledge about bioactive components. It comprises 27 chapters organized into 4 major sections covering topics in food science and technology, functional foods, and nutraceuticals. It provides perspectives for innovation, sources, applications, and sustainability in bioactive component research. The first section starts with introduction of bioactive components consisting of seven different chapters primarily focusing on the bioactive components and their sources with respective health benefits. The second section, comprising five different chapters, deals with different technological trends, regulations, and safety aspects of bioactive components. With eight chapters, the third section covers the role of bioactive components in human health and the role of functional foods in combating various health-related issues. The fourth section reviews functional foods through six chapters that cover the use of bioactive components in various food products. The book will prove useful to advanced food technology graduate and undergraduate students and research scholars, practicing food technologists in food and related industries, entrepreneurs, food-pharma researchers, and other scientists seeking information about smart and sustainable processes as well as information needed to design and develop these processes.
Download or read book Drug Discovery Handbook written by Shayne Cox Gad and published by John Wiley & Sons. This book was released on 2005-06-24 with total page 1494 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Drug Discovery Handbook gives professionals a tool to facilitate drug discovery by bringing together, for the first time in one resource, a compendium of methods and techniques that need to be considered when developing new drugs. This comprehensive, practical guide presents an explanation of the latest techniques and methods in drug discovery, including: Genomics, proteomics, high-throughput screening, and systems biology Summaries of how these techniques and methods are used to discover new central nervous system agents, antiviral agents, respiratory drugs, oncology drugs, and more Specific approaches to drug discovery, including problems that are encountered, solutions to these problems, and limitations of various methods and techniques The thorough coverage and practical, scientifically valid problem-solving approach of Drug Discovery Handbook will serve as an invaluable aid in the complex task of developing new drugs.
Download or read book Algae written by Nooruddin Thajuddin and published by BoD – Books on Demand. This book was released on 2016-06-29 with total page 344 pages. Available in PDF, EPUB and Kindle. Book excerpt: Algae - Organisms for Imminent Biotechnology will be useful source of information on basic and applied aspects of algae for post graduate students, researchers, scientists, agriculturists, and decision makers. The book comprises a total of 12 chapters covering various aspects of algae particularly on microalgal biotechnology, bloom dynamics, photobioreactor design and operation of microalgal mass cultivation, algae used as indicator of water quality, microalgal biosensors for ecological monitoring in aquatic environment, carbon capture and storage by microalgae to enhancing CO2 removal, synthesis and biotechnological potentials of algal nanoparticles, biofilms, silica-based nanovectors, challenges and opportunities in marine algae, and genetic identification and mass propagation of economically important seaweeds and seaweeds as source of new bioactive prototypes.
Download or read book Diatoms written by Joseph Seckbach and published by John Wiley & Sons. This book was released on 2019-07-01 with total page 657 pages. Available in PDF, EPUB and Kindle. Book excerpt: The aim of this new book series (Diatoms: Biology and Applications) is to provide a comprehensive and reliable source of information on diatom biology and applications. The first book of the series, Diatoms Fundamentals & Applications, is wide ranging, starting with the contributions of amateurs and the beauty of diatoms, to details of how their shells are made, how they bend light to their advantage and ours, and major aspects of their biochemistry (photosynthesis and iron metabolism). The book then delves into the ecology of diatoms living in a wide range of habitats, and look at those few that can kill or harm us. The book concludes with a wide range of applications of diatoms, in forensics, manufacturing, medicine, biofuel and agriculture. The contributors are leading international experts on diatoms. This book is for a wide audience researchers, academics, students, and teachers of biology and related disciplines, written to both act as an introduction to diatoms and to present some of the most advanced research on them.
Download or read book Taste and Odour in Source and Drinking Water written by Tsair-Fuh Lin and published by IWA Publishing. This book was released on 2018-03-15 with total page 322 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides an updated evaluation of the characterization and management of taste and odour (T&O) in source and drinking waters. Authored by international experts from the IWA Specialist Group on Off-flavours in the Aquatic Environment, the book represents an important resource that synthesizes current knowledge on the origins, mitigation, and management of aquatic T&O problems. The material provides new knowledge for an increasing widespread degradation of source waters and global demand for high quality potable water. Key topics include early warning, detection and source-tracking, chemical, sensory and molecular diagnosis, treatment options for common odorants and minerals, source management, modelling and risk assessment, and future research directions. Taste and Odour in Source and Drinking Water is directed towards a wide readership of scientists, engineers, technical operators and managers, and presents both practical and theoretical material, including an updated version of the benchmark Drinking Water Taste and Odour Wheel and a new biological wheel to provide a practical and informative tool for the initial diagnosis of the chemical and biological sources of aquatic T&O.
