Download or read book Novel Insights into the Treatment of HCC and Liver Tumors written by Alessandro Vitale and published by Frontiers Media SA. This book was released on 2022-05-03 with total page 447 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Liver Cancer written by Ahmed Lasfar and published by BoD – Books on Demand. This book was released on 2018-11-21 with total page 188 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book offers remarkable coverage of liver cancer from etiology to prevention and treatment. It provides an updated and new vision of this major cancer that continues to affect hundreds of thousands of people and remains one of the leading causes of cancer deaths around the world. To ensure the high quality of this book, important insights are included and rigorously discussed in a simple and authentic way. The book includes detailed and updated descriptions of the main causes of liver cancer and also the prevention and treatment of this disease. This book is a relevant source of knowledge, very useful for researchers, medical doctors, medical residents, students, healthcare providers, public health decision makers, and all individuals interested in the prevention of this disease.

Download or read book Liver Cancer in the Middle East written by Brian I. Carr and published by Springer Nature. This book was released on 2021-09-22 with total page 408 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book aims to illuminate the causes, incidence, and treatments of Hepatocellular Carcinoma(HCC) or liver cancer in the politically important and societally diverse region of the Middle East. Taking a flexible and inclusive view, it examines the influences of geography, crops and diet, ethnicity, and local behavior on both diagnosis and outcomes of this disease. Understanding the different causes of liver cancer enables effective strategies for both prevention and early diagnosis while knowledge of the different treatment modalities, their uses and limitations, availability and costs, works to inform rational treatment provision and selection. Divided into four sections, this book considers the causes and clinical syndromes associated with HCC, provides a detailed overview of clinical HCC and treatment modalities, describes country-specific clinical HCC experience and practice, and considers future needs and the potential for HCC collaborations across the region. Liver Cancer in the Middle East is a useful resource for clinicians seeking insight into the second highest cause of death from cancer worldwide, governments planning social and medical services for their peoples, as well as for international aid agencies prioritizing donations.

Download or read book Hepatocellular Carcinoma written by Yujin Hoshida and published by Springer. This book was released on 2019-08-05 with total page 366 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive overview of the current limitations and unmet needs in Hepatocellular Carcinoma (HCC) diagnosis, treatment, and prevention. It also provides newly emerging concepts, approaches, and technologies to address challenges. Topics covered include changing landscape of HCC etiologies in association with health disparities, framework of clinical management algorithm, new and experimental modalities of HCC diagnosis and prognostication, multidisciplinary treatment options including rapidly evolving molecular targeted therapies and immune therapies, multi-omics molecular characterization, and clinically relevant experimental models. The book is intended to assist collaboration between the diverse disciplines and facilitate forward and reverse translation between basic and clinical research by providing a comprehensive overview of relevant areas, covering epidemiological trend and population-level patient management strategies, new diagnostic and prognostic tools, recent advances in the standard care and novel therapeutic approaches, and new concepts in pathogenesis and experimental approaches and tools, by experts and opinion leaders in their respective fields. By thoroughly and concisely covering whole aspects of HCC care, Hepatocellular Carcinoma serves as a valuable reference for multidisciplinary readers, and promotes the development of personalized precision care strategies that lead to substantial improvement of disease burden and patient prognosis in HCC.

Download or read book Hepatobiliary Cancers Translational Advances and Molecular Medicine written by and published by Elsevier. This book was released on 2022-08-15 with total page 466 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hepatobiliary cancer refers to primary malignant tumors originating in cells of the liver, bile ducts, and gallbladder. Globally, primary liver cancer, which includes hepatocellular carcinoma (~75 % of all cases) and intrahepatic biliary cancer or cholangiocarcinoma (~10-15 % 0f all cases) is the 6th most commonly diagnosed cancer and 3rd leading cause of cancer deaths worldwide. The vast majority of these highly malignant cancers are diagnosed at an advanced stage where treatment options are limited and patient survival outcomes are poor. The biological and therapeutic challenges posed by hepatobililiary cancers such as hepatocellular carcinoma (HCC) and cholangiocarcinoma (CCA) are daunting, emphasizing a critical need to review and assess current and evolving basic, translational, and clinical research focused on addressing the critical obstacles that continue to limit progress towards achieving significant improvements in HCC and CCA clinical management and patient survival outcomes. Towards this goal, this special edition of Advances in Cancer Research is focused on providing a comprehensive, timely and authoritative reviews covering such topics of significant scientific and clinical relevance, including hepatobiliary cancer risk mechanisms and risk-predictive molecular biomarkers; causes and functional intricacies of inter- and intratumor heterogeneity; novel insights into the role of tumor microenvironment and key signaling pathways in promoting hepatobiliary cancer progression, therapeutic resistance and immunosuppression; emerging biomarkers of HCC and CCA prognosis; advances in molecular genomics for personalizing tumor classification and targeted therapies; innovative preclinical cell culture modeling for hepatobiliary cancer drug discovery; and current and emerging trends in hepatobiliary cancer molecular therapeutic targeting and immunotherapies. Up-to date review of hepatobiliary cancers molecular genetics, novel predictive molecular biomarkers, and distinct mechanisms of inter-and intratumor heterogeneity Novel insights into the role of tumor microenvironment as a promoter of hepatobiliary cancer progression and therapeutic resistance, as well as an emerging therapeutic target Current and emerging approaches and strategies for advancing personalized molecular therapeutic targeting and immunotherapy of hepatobiliary cancers

Download or read book Clinical and Molecular Insights Into Primary Pediatric Liver Cancer written by Víola Benedicte Weeda and published by . This book was released on 2016 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This thesis aims to give insight into the clinical status quo of primary pediatric liver tumors and investigate signaling pathways that may be of importance for liver tumorigenesis. The most recent series of the International Childhood Liver Tumors Strategy Group (SIOPEL) of hepatocellular carcinoma (HCC) and its distinct variant fibrolamellar hepatocellular carcinoma (FL-HCC) are discussed. For both tumors, complete resection is at present the only curative option. FL-HCC does not have a better prognosis than HCC. A potential role for the Delta-Notch signaling pathway in hepatoblastoma is explored and although this cannot be detected, interestingly, tissue-specific Notch 2 deletion is found to lead to bile duct agenesis. The role of the DCUN1D1-5 proteins and the neddylation and ubiquitination signaling pathways in hepatotumorigenesis was studied. The paralogues DCUN1D3 and DCUN1D5 were characterized; DCUN1D3 is shown to function as a tumor suppressor, whereas DCUN1D5 functions as an oncogene exhibiting an oncogene addiction phenotype. DCUN1D paralogue expression is found to correlate with function in liver cancer tissue and increased function correlates with low LD50 and IC50 of the neddylation inhibiting compound MLN4924. The oncogene addiction phenotype observed for several paralogues may thus be exploited to select liver tumors for treatment with such a drug..

Download or read book Liver Cancers written by Tim Cross and published by Springer. This book was released on 2018-12-12 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book explores in detail the primary liver cancers of hepatocellular carcinoma and cholangiocarcinoma examining the pathogenesis of disease along with diagnosis and current management options together with exploration of future treatment strategies and areas of controversy. Furthermore, the book highlights management of the common secondary malignancies and touches on benign liver tumours and how to best manage these. Written in a clear and didactic style, this volume includes summaries of the key learning points and questions so that the reader can gauge their knowledge and understanding. This book is aimed to broaden the knowledge base of primary care physicians, general physicians along with specialists in hepatology, oncology and hepato-biliary surgery

Download or read book Myeloid Derived Suppressor Cells as Disease Modulators written by Olivera J. Finn and published by Frontiers Media SA. This book was released on 2020-05-06 with total page 162 pages. Available in PDF, EPUB and Kindle. Book excerpt: Myeloid Derived Suppressor Cells (MDSCs) are a heterogeneous population of immature myeloid cells that can suppress the function of multiple immune cells and in particular, T cells, through various mechanisms. MDSCs can be divided into two major subtypes based on their cell surface phenotype and morphology: polymorphonuclear MDSC (PMN-MDSC or G-MDSC) and monocytic MDSC (M-MDSC). Additional subtypes have been proposed, such as the early MDSC (e-MDSC) that lack both macrophage and granulocyte markers. There is still considerable ambiguity about the phenotype of these cells that corresponds to their immunosuppressive function and there are on-going challenges on how to identify, purify and/or potentially generate and expand these cells in vitro. MDSCs were first discovered in cancer patients where they have been most extensively studied as components of the immunosuppressive tumor microenvironment. In the last several years, however, the importance of their immunomodulatory role in many other disease and clinical settings has emerged. Acknowledgments We acknowledge the initiation and support of this Research Topic by the International Union of Immunological Societies (IUIS). We hereby state publicly that the IUIS has had no editorial input in articles included in this Research Topic, thus ensuring that all aspects of this Research Topic are evaluated objectively, unbiased by any specific policy or opinion of the IUIS.

Download or read book Immunotherapy of Hepatocellular Carcinoma written by Tim F. Greten and published by Springer. This book was released on 2018-08-22 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this book we provide insights into liver – cancer and immunology. Experts in the field provide an overview over fundamental immunological questions in liver cancer and tumorimmunology, which form the base for immune based approaches in HCC, which gain increasing interest in the community due to first promising results obtained in early clinical trials. Hepatocellular carcinoma (HCC) is the third most common cause of cancer related death in the United States. Treatment options are limited. Viral hepatitis is one of the major risk factors for HCC, which represents a typical “inflammation-induced” cancer. Immune-based treatment approaches have revolutionized oncology in recent years. Various treatment strategies have received FDA approval including dendritic cell vaccination, for prostate cancer as well as immune checkpoint inhibition targeting the CTLA4 or the PD1/PDL1 axis in melanoma, lung, and kidney cancer. Additionally, cell based therapies (adoptive T cell therapy, CAR T cells and TCR transduced T cells) have demonstrated significant efficacy in patients with B cell malignancies and melanoma. Immune checkpoint inhibitors in particular have generated enormous excitement across the entire field of oncology, providing a significant benefit to a minority of patients.

Download or read book Diseases of the Abdomen and Pelvis 2018 2021 written by Juerg Hodler and published by Springer. This book was released on 2018-03-20 with total page 262 pages. Available in PDF, EPUB and Kindle. Book excerpt: This open access book deals with imaging of the abdomen and pelvis, an area that has seen considerable advances over the past several years, driven by clinical as well as technological developments. The respective chapters, written by internationally respected experts in their fields, focus on imaging diagnosis and interventional therapies in abdominal and pelvic disease; they cover all relevant imaging modalities, including magnetic resonance imaging, computed tomography, and positron emission tomography. As such, the book offers a comprehensive review of the state of the art in imaging of the abdomen and pelvis. It will be of interest to general radiologists, radiology residents, interventional radiologists, and clinicians from other specialties who want to update their knowledge in this area.

Download or read book Hepatocellular Carcinoma written by W. Y. Lau and published by World Scientific. This book was released on 2008-01-01 with total page 864 pages. Available in PDF, EPUB and Kindle. Book excerpt: 1. Epidemiology / Trishe Y.-M. Leong and Anthony S.-Y. Leong -- 2. Liver terminology and anatomy / Steven M. Strasberg -- 3. Assessment of liver function / Darren V. Mann -- 4. Prevention / Michael C. Kew -- 5. Screening / Morris Sherman -- 6. Presentation and diagnosis / Dario Ribero, Gareth Morris-Stiff and Jean-Nicolas Vauthey -- 7. Tumor markers / John Y. H. Chan and Zhi Wang -- 8. Imaging / Simon S. M. Ho and Simon C. H. Yu -- 9. Pathology / Anthony S.-Y. Leong, Trishe Y.-M. Leong and Pongsak Wannakrairot -- 10. Molecular aspects / John Y. H. Chan, Kenneth K. H. Lee, Yiu-Loon Chui and Macus T. Kuo -- 11. Staging / Justin M. Burns and Frederick L. Greene -- 12. Selection of patients for liver resection / Eric C. H. Lai, W. Y. Lau and Darren V. Mann -- 13. Problems associated with liver resection in cirrhotic patients / Cheng-Chung Wu -- 14. Preoperative portal vein embolization / Takuya Hashimoto and Masatoshi Makuuchi -- 15. Intraoperative ultrasound / Guido Torzilli and Henri Bismuth -- 16. Surgical treatment / Jacques Belghiti -- 17. Anterior approach using the hanging technique / Jacques Belghiti and Barbara Alkofer -- 18. Segment-based liver resection / W. Y. Lau and Eric C. H. Lai -- 19. Intrahepatic glissonian approach / Bernard Launois and Khoon Hean Tay -- 20. Ultrasonically guided segmentectomy and subsegmentectomy / Taku Aoki, Norihiro Kokudo and Masatoshi Makuuchi -- 21. Isolated caudate lobe resection (resection of couinaud segment 1) / Shu-You Peng -- 22. Laparoscopic Liver Resection / Rong Liu -- 23. Techniques of vascular control and protective strategies for parenchymal transection / Markus K. Müller, Henrik Petrowsky and Pierre-Alain Clavien -- 24. Techniques of liver transection / Eric T. Castaldo and C. Wright Pinson -- 25. Radiofrequency-assisted liver resection / Long R. Jiao and Nagy A. Habib -- 26. Cytoreductive (tumor-debulking) surgery / Eric C. H. Lai and W. Y. Lau -- 27. Cryosurgery / George Petrou and David L. Morris -- 28. Liver transplantation / Chao-Long Chen and Allan M. Concejero / 29. Local ablative therapy / Tito Livraghi -- 30. Regional therapy / W. Y. Lau and Eric C. H. Lai -- 31. Systemic chemotherapy / Thomas W. T. Leung -- 32. Neoadjuvant/adjuvant/chemoprevention therapy and tumor downstaging / W. Y. Lau and Eric C. H. Lai -- 33. Management of portal vein tumor thrombus / W. Y. Lau, Eric C. H. Lai and Simon C. H. Yu -- 34. Palliative care / Winnie Yeo and Anthony T. C. Chan -- 35. Management of specific complications / Eric C. H. Lai and W. Y. Lau -- 36. Management of acute liver failure / A. R. Nitin Rao -- 37. Extracorporeal energy therapy / Eric C. H. Lai and W. Y. Lau

Download or read book Novel Insights into the Comorbidities and Mortality in Patients with Diabetes written by Sen Li and published by Frontiers Media SA. This book was released on 2024-04-19 with total page 144 pages. Available in PDF, EPUB and Kindle. Book excerpt: Diabetes is a metabolic disorder of chronic hyperglycemia that causes numerous complications. The International Diabetes Federation and World Health Organization report that approximately 537 million people worldwide have diabetes in 2021, which may increase to 700 million by 2045. Diabetes and its complications significantly lower the quality of life of patients and cause more than 4 million deaths yearly. Diabetes and its complications also increase premature mortality, increasing society's economic burden. Numerous studies reveal that the chronic multisystem injury and dysfunction can be caused by diabetes, including cardiac and cerebral vascular lesions, nephropathy, retinopathy and neuropathy. In addition, diabetes usually co-occurs with other diseases that may have certain risk factors in common. For example, patients with diabetes are more likely to have hypertension, chronic obstructive pulmonary disease, or asthma. However, there is still a lack of knowledge on the relationship between diabetes and other potential comorbidities such as hepatitis infection, hearing impairment and periodontal disease. Furthermore, common risk factors contributing to the pathogenesis of diabetes and comorbidities are far from fully understood. Several comorbidities (e.g., cardiovascular and cerebrovascular diseases) raise the extra chances of death in patients with diabetes, but the association between diabetes and mortality of other diseases, such as endometrial or kidney cancer, is inconsistent. Further research is still needed to reveal the excess mortality associated with diabetic comorbidities.

Download or read book The Liver written by Irwin M. Arias and published by John Wiley & Sons. This book was released on 2020-03-09 with total page 1156 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bridging the gap between basic scientific advances and the understanding of liver disease — the extensively revised new edition of the premier text in the field. The latest edition of The Liver: Biology and Pathobiology remains a definitive volume in the field of hepatology, relating advances in biomedical sciences and engineering to understanding of liver structure, function, and disease pathology and treatment. Contributions from leading researchers examine the cell biology of the liver, the pathobiology of liver disease, the liver’s growth, regeneration, metabolic functions, and more. Now in its sixth edition, this classic text has been exhaustively revised to reflect new discoveries in biology and their influence on diagnosing, managing, and preventing liver disease. Seventy new chapters — including substantial original sections on liver cancer and groundbreaking advances that will have significant impact on hepatology — provide comprehensive, fully up-to-date coverage of both the current state and future direction of hepatology. Topics include liver RNA structure and function, gene editing, single-cell and single-molecule genomic analyses, the molecular biology of hepatitis, drug interactions and engineered drug design, and liver disease mechanisms and therapies. Edited by globally-recognized experts in the field, this authoritative volume: Relates molecular physiology to understanding disease pathology and treatment Links the science and pathology of the liver to practical clinical applications Features 16 new “Horizons” chapters that explore new and emerging science and technology Includes plentiful full-color illustrations and figures The Liver: Biology and Pathobiology, Sixth Edition is an indispensable resource for practicing and trainee hepatologists, gastroenterologists, hepatobiliary and liver transplant surgeons, and researchers and scientists in areas including hepatology, cell and molecular biology, virology, and drug metabolism.

Download or read book Primary Liver Cancer written by Jianren Gu and published by Springer Science & Business Media. This book was released on 2012-12-02 with total page 479 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Primary Liver Cancer: Challenges and Perspectives" presents the recent progress in basic and clinical research in Primary Liver Cancer (PLC) in China and around the world. PLC patients in China make up more than 50% of the total patients worldwide. By contributing to the book, the leading experts in the field of liver cancer in China as well as in the US share with readers their new concepts, practices, and experiences from bench to bed, from population study to individual survey, from molecular search to clinical practice, and from early diagnosis to treatment. The book is intended for researchers in the fields of epidemiology, molecular genetics, cell biology, immunology of HCC and other cancers, and clinical oncology in primary liver cancer. Jianren Gu is a Professor of molecular oncology at the Shanghai Cancer Institute, Shanghai Jiao Tong University School of Medicine and Academician of Chinese Academy of Engineering.

Download or read book 100 Questions and Answers about Liver Cancer written by Ghassan K. Abou-Alfa and published by Jones & Bartlett Publishers. This book was released on 2011-12-15 with total page 137 pages. Available in PDF, EPUB and Kindle. Book excerpt: 100 Questions & Answers About Liver Cancer is a quick and practical reference guide containing all aspects of the diagnosis and therapy of hepatocellular carcinoma (HCC), prognostic and staging systems, clinical management, molecular biology, current controversies, and future insights. Organized into a condensed, bulleted format, this concise reference offers precise and up-to-date information on the epidemiology, classification, diagnosis, treatment, and risk factors for cancers of the liver.

Download or read book Stereotactic Body Radiation Therapy written by Simon S. Lo and published by Springer Science & Business Media. This book was released on 2012-08-28 with total page 433 pages. Available in PDF, EPUB and Kindle. Book excerpt: Stereotactic body radiation therapy (SBRT) has emerged as an important innovative treatment for various primary and metastatic cancers. This book provides a comprehensive and up-to-date account of the physical/technological, biological, and clinical aspects of SBRT. It will serve as a detailed resource for this rapidly developing treatment modality. The organ sites covered include lung, liver, spine, pancreas, prostate, adrenal, head and neck, and female reproductive tract. Retrospective studies and prospective clinical trials on SBRT for various organ sites from around the world are examined, and toxicities and normal tissue constraints are discussed. This book features unique insights from world-renowned experts in SBRT from North America, Asia, and Europe. It will be necessary reading for radiation oncologists, radiation oncology residents and fellows, medical physicists, medical physics residents, medical oncologists, surgical oncologists, and cancer scientists.

Download or read book RNA Modification in Human Cancers Roles and Therapeutic Implications written by You Zhou and published by Frontiers Media SA. This book was released on 2022-04-26 with total page 514 pages. Available in PDF, EPUB and Kindle. Book excerpt: