Download or read book Novel Functionalized and Patterned Surfaces for Cardiovascular Applications written by Romain Schieber and published by . This book was released on 2018 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book 2D Functionalized Films and 3D Direct Printed Patterned PLLA Stents for Cardiovascular Applications written by Santiago Raymond Llorens and published by . This book was released on 2016 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Functionalized CoCr Surfaces with Adhesive Molecules to Improve Endothelialization written by Maria Isabel Castellanos Arboleda and published by . This book was released on 2017 with total page 69 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cobalt-chromium (CoCr) alloys are widely used as biomaterials for coronary stents due to their excellent mechanical properties, biocompatibility and corrosion resistance. However, these materials are bioinert, retarding the complete endothelialization and resulting in a higher risk of restenosis, narrowing of the artery, and late-stent thrombosis. Therefore, the improvement of implants surface endothelialization has acquired importance in the last years. Immobilization of cell adhesive biomolecules onto biomaterials surface is a well-known strategy to control cell response. However, the strategy of immobilization, the optimal combination or the appropriate spatial presentation of the bioactive sequences to enhance endothelialization for cardiovascular applications, remains to be elucidated. The present PhD thesis focused on the development of a new biofunctionalized CoCr alloy surfaces in order to improve the endothelialization. To that end, elastin-like recombinamers (ELR) genetically modified with an REDV (Arg-Glu-Asp-Val) sequence and short synthetized peptides RGDS (Arg-Gly-Asp-Ser), REDV, YIGSR (Tyr-Ile-Gly-Ser-Arg) and their equimolar combination, were attached by physisorption and covalent bonding onto CoCr alloy surfaces and thoroughly characterized physico-chemically and evaluated in vitro with human umbilical vein endothelial cells (HUVECs), coronary artery smooth muscle cells (CASMCs) and platelets from blood donors. First, biofunctionalized surfaces with ELR were developed and optimized by evaluating different surface activation treatments, oxygen plasma and sodium hydroxide etching, and different binding strategies, physisorption and covalent bonding. The functionalized surfaces demonstrated a higher cell adhesion and spreading of HUVEC cells, this effect is emphasized as increases the amount of immobilized biomolecules and directly related to the immobilization technique: covalent bonding. Nevertheless, the silanization process was not completely effective since a mixture of covalent and physisorption behavior was observed probably due to the use of big molecules that decreased the control of the bonding between the biomolecule and the surface. Secondly, it was synthetized immobilized RGDS, REDV, YIGSR and their equimolar combination peptides onto the different surfaces. Cell studies demonstrated that the covalent functionalization of CoCr surfaces with an equimolar combination of RGDS/YIGSR represented the most powerful strategy to enhance the early stages of HUVECs adhesion, proliferation and migration, indicating a positive synergistic effect between the two peptide motifs. Besides, gene expression and platelet adhesion studies showed that surfaces silanized with the combination RGDS/YIGSR improved anti-thrombogenicity compared to non-modified surfaces. Finally, cell co-cultures of HUVECs/CASMCs found that functionalization increased the amount of adhered HUVECs onto modified surfaces compared to plain CoCr, independently of the used peptide and the strategy of immobilization. Overall, the present thesis offer a comprehensive view of the effectiveness of immobilizing cell adhesive molecules onto CoCr alloy surfaces to enhance endothelialization while preventing restenosis and thrombosis for cardiovascular applications.

Download or read book Nanoscale Engineering of Biomaterials Properties and Applications written by Lalit M. Pandey and published by Springer Nature. This book was released on 2022-02-16 with total page 696 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive overview of the latest advances in a wide range of biomaterials for the development of smart and advanced functional materials. It discusses the fundamentals of bio-interfacial interactions and the surface engineering of emerging biomaterials like metals and alloys, polymers, ceramics, and composites/nanocomposites. In turn, the book addresses the latest techniques and approaches to engineering material surfaces/interfaces in, e.g., implants, tissue engineering, drug delivery, antifouling, and dentistry. Lastly, it summarizes various challenges in the design and development of novel biomaterials. Given its scope, it offers a valuable source of information for students, academics, physicians and particularly researchers from diverse disciplines such as material science and engineering, polymer engineering, biotechnology, bioengineering, chemistry, chemical engineering, nanotechnology, and biomedical engineering for various commercial and scientific applications.

Download or read book Zipes and Jalife s Cardiac Electrophysiology From Cell to Bedside written by Jose Jalife and published by Elsevier Health Sciences. This book was released on 2021-12-16 with total page 1709 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fully updated from cover to cover, Zipes and Jalife’s Cardiac Electrophysiology: From Cell to Bedside, 8th Edition, provides the comprehensive, multidisciplinary coverage you need—from new knowledge in basic science to the latest clinical advances in the field. Drs. José Jalife and William Gregory Stevenson lead a team of global experts who provide cutting-edge content and step-by-step instructions for all aspects of cardiac electrophysiology. Packs each chapter with the latest information necessary for optimal basic research as well as patient care. Covers new technologies such as CRISPR, protein research, improved cardiac imaging, optical mapping, and wearable devices. Contains significant updates in the areas of molecular biology and genetics, iPSCs (induced pluripotent stem cells), embryonic stem cells, precision medicine, antiarrhythmic drug therapy, cardiac mapping with advanced techniques, and ablation technologies including stereotactic radioablation. Includes 47 new standalone chapters that are organized into discrete topics for improved access. Discusses extensive recent progress in the understanding, diagnosis, and management of arrhythmias, including new clinical insights on atrial fibrillation and stroke prevention, new advances in the understanding of ventricular arrythmias in genetic disease, and advances in implantable devises and infection management. Features 1,600 high-quality photographs, anatomic and radiographic images, electrocardiograms, tables, algorithms, and more., with additional figures, tables, and videos online. Recipient of a 2018 Highly Commended award from the British Medical Association.

Download or read book Nanostructured Thin Films and Surfaces written by and published by John Wiley & Sons. This book was released on 2010-03-08 with total page 453 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book series Nanomaterials for the Life Sciences, provides an in-depth overview of all nanomaterial types and their uses in the life sciences. Each volume is dedicated to a specific material class and covers fundamentals, synthesis and characterization strategies, structure-property relationships and biomedical applications. The series brings nanomaterials to the Life Scientists and life science to the Materials Scientists so that synergies are seen and developed to the fullest. Written by international experts of various facets of this exciting field of research, the series is aimed at scientists of the following disciplines: biology, chemistry, materials science, physics, bioengineering, and medicine, together with cell biology, biomedical engineering, pharmaceutical chemistry, and toxicology, both in academia and fundamental research as well as in pharmaceutical companies. VOLUME 5 - Nanostructured Thin Films and Surfaces

Download or read book Cardiac Electrophysiology From Cell to Bedside E Book written by Douglas P. Zipes and published by Elsevier Health Sciences. This book was released on 2017-05-13 with total page 1429 pages. Available in PDF, EPUB and Kindle. Book excerpt: Rapid advancements in cardiac electrophysiology require today’s health care scientists and practitioners to stay up to date with new information both at the bench and at the bedside. The fully revised 7th Edition of Cardiac Electrophysiology: From Cell to Bedside, by Drs. Douglas Zipes, Jose Jalife, and William Stevenson, provides the comprehensive, multidisciplinary coverage you need, including the underlying basic science and the latest clinical advances in the field. An attractive full-color design features color photos, tables, flow charts, ECGs, and more. All chapters have been significantly revised and updated by global leaders in the field, including 19 new chapters covering both basic and clinical topics. New topics include advances in basic science as well as recent clinical technology, such as leadless pacemakers; catheter ablation as a new class I recommendation for atrial fibrillation after failed medical therapy; current cardiac drugs and techniques; and a new video library covering topics that range from basic mapping (for the researcher) to clinical use (implantations). Each chapter is packed with the latest information necessary for optimal basic research as well as patient care, and additional figures, tables, and videos are readily available online. New editor William G. Stevenson, highly regarded in the EP community, brings a fresh perspective to this award-winning text. Expert Consult eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, images, videos (including video updates), glossary, and references from the book on a variety of devices.

Download or read book Racing for the Surface written by Bingyun Li and published by Springer Nature. This book was released on 2020-02-28 with total page 808 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers the key basics of tissue engineering as well as the latest advances in the integration of both antimicrobial and osteoinductive properties. Topics covered include osteoconductive and osteoinductive biomaterials (calcium phosphate, bone morphogenetic protein, peptides, antibodies, bioactive glasses, nanomaterials, etc.) and scaffolds. Research integrating both antimicrobial/biofilm-inhibiting and osteoinductive/osteoconductive properties and their co-delivery is detailed and their roles in clinical success are discussed. Combined with its companion volume, Racing for the Surface: Antimicrobial and Interface Tissue Engineering, this book bridges the gap between infection and tissue engineering, and is an ideal book for academic researchers, clinicians, industrial engineers and scientists, governmental representatives in national laboratories, and advanced undergraduate students and post-doctoral fellows who are interested in tissue engineering and regeneration, infection, and biomaterials and devices.

Download or read book Kaplan s Cardiac Anesthesia E Book written by Joel A. Kaplan and published by Elsevier Health Sciences. This book was released on 2023-06-09 with total page 1236 pages. Available in PDF, EPUB and Kindle. Book excerpt: Current, comprehensive, and evidence-based, Kaplan's Cardiac Anesthesia: Perioperative and Critical Care Management, 8th Edition, offers practical guidance from today’s international leaders in cardiac anesthesiology, helping you to optimize perioperative outcomes, avoid complications, and ensure maximum patient safety. Dr. Joel A. Kaplan, along with an expert team of associate editors, guides you through today’s clinical challenges, including expanded coverage of critical care, the newest approaches to perioperative assessment and management, state-of-the art diagnostic techniques, and cardiovascular and coronary physiology. Covers the full spectrum of contemporary cardiothoracic anesthesia practice, including preoperative assessment, physiology, pharmacology, monitoring, transesophageal echocardiography, coagulation, specific cardiac procedures, extracorporeal circulation, postoperative pain treatment, and management of the complex patient with cardiac disease. Includes expanded coverage of critical care topics, reflecting the increased perioperative care now provided by anesthesiologists in the ICU. Contains new chapters on Structural Heart Disease Procedures; Cardiorespiratory Effects of COVID-19; Critical Care Ultrasound; Intensive Unit Management of Patients on Mechanical Circulatory Support; and Postoperative Care of the Heart and Lung Transplant Patient. Features more than 900 full-color illustrations, decision trees, charts, and graphs (over one-third are new) that aid in visual understanding of complex topics. Provides access to over 120 videos, including a range of echocardiography clips. Contains balanced, dependable, and updated content on all aspects of the anesthetic management of cardiac surgical procedures, as well as cardiology procedures performed in catheterization and electrophysiologic laboratories. Places new emphasis on cardiac devices requiring perioperative care, including cardiac implanted electrical devices and ventricular assist devices.

Download or read book Clinical Cardiac Pacing Defibrillation and Resynchronization Therapy E Book written by Kenneth A. Ellenbogen and published by Elsevier Health Sciences. This book was released on 2011-09-08 with total page 1106 pages. Available in PDF, EPUB and Kindle. Book excerpt: Clinical Cardiac Pacing, Defibrillation and Resynchronization Therapy, 4th Edition, by Drs. Kenneth A. Ellenbogen, Bruce L. Wilkoff, G. Neal Kay, and Chu-Pak Lau, helps you deliver superior clinical outcomes using the latest, most successful cardiac electrophysiology techniques. Expertly and practically incorporate today’s technical developments in device and ablation therapies into your practice, and stay on the edge of this rapidly advancing field. Strengthen your skills in challenging new areas like ICD therapy in hereditary arrhythmias, interventional techniques for device implantation, implantable cardiovascular monitors, leadless pacing, and the biologic pacemaker. Watch experts perform these cutting-edge procedures online at www.expertconsult.com to help maximize your efficiency and solve a broader range of heart rhythm challenges than ever before. Manage more patients and handle a broader range of conditions by following the newest standards in pacing, defibrillation, and resynchronization technologies. Apply the latest procedures with guidance from world authorities who contribute fresh perspectives on the challenging clinical area of cardiac electrophysiology. Confidently treat your patients with the newest, state-of-the-art techniques for atrial and ventricular pacing modes; ICD therapy in hereditary arrhythmias; interventional techniques for device implantation; guidelines for managing device and lead advisories; implantable cardiovascular monitors; leadless pacing and ICDs; and the biologic pacemaker. Mirror the performance of the experts as they perform step-by-step procedures in intervention, implantation, and ablation therapies in the online videos. Search the complete contents online, link to PubMed, download the image gallery, review practice guidelines, and view all of the videos at www.expertconsult.com.

Download or read book Functional Imaging and Modelling of the Heart written by Mihaela Pop and published by Springer. This book was released on 2017-05-22 with total page 524 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book constitutes the refereed proceedings of the 9th International Conference on Functional Imaging and Modeling of the Heart, held in Toronto, ON, Canada, in June 2017. The 48 revised full papers were carefully reviewed and selected from 63 submissions. The focus of the papers is on following topics: novel imaging and analysis methods for myocardial tissue characterization and remodeling; advanced cardiac image analysis tools for diagnostic and interventions; electrophysiology: mapping and biophysical modeling; biomechanics and flow: modeling and tissue property measurements.

Download or read book Breath Figures written by Juan Rodríguez-Hernández and published by Springer Nature. This book was released on 2020-08-31 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book offers a complete and concise overview of the different strategies used to prepare microstructured surfaces employing information regarding surface instabilities and physical processes. Based upon the concept of the remarkably uniform layer of water vapor that is applied when one simply breathes onto a surface in cold temperatures, the book presents a comprehensive treatise addressing chemical and physical fundamentals, fabrication, and applications of the breath figures approach to surface wetting, coating, and modification (breath figures self-assembly) of various materials. The main topics of the book are divided into six parts: the control of surface properties in polymer blends; block copolymer design with the aim of providing order at different lengths; combination of block copolymer blends with the breath figures (BFs); dynamic templating; the breath figures method; biorecognition; and alternative approaches for surface structuring and functionalization. Discusses various physical processing methods in preparing microstructured surfaces; Describes relevant aspects of micro- and nanostructured surfaces from fabrication to final applications, including additive manufacturing, bacterial adhesion and entrapment, optical and electro-optical applications, and membrane technology; Details the breath figures approach to surface structuring while discussing alternative strategies that tie morphology to functionality of materials.

Download or read book Biomaterials in Translational Medicine written by Lei Yang and published by Academic Press. This book was released on 2018-11-30 with total page 358 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biomaterials in Translational Medicine delivers timely and detailed information on the latest advances in biomaterials and their role and impact in translational medicine. Key topics addressed include the properties and functions of these materials and how they might be applied for clinical diagnosis and treatment. Particular emphasis is placed on basic fundamentals, biomaterial formulations, design principles, fabrication techniques and transitioning bench-to-bed clinical applications. The book is an essential reference resource for researchers, clinicians, materials scientists, engineers and anyone involved in the future development of innovative biomaterials that drive advancement in translational medicine. Systematically introduces the fundamental principles, rationales and methodologies of creating or improving biomaterials in the context of translational medicine Includes the translational or commercialization status of these new biomaterials Provides the reader with enough background knowledge for a fundamental grip of the difficulties and technicalities of using biomaterial translational medicine Directs the reader on how to find other up-to-date sources (i.e. peer reviewed journals) in the field of translational medicine and biomaterials

Download or read book Braunwald s Heart Disease E Book written by Douglas P. Zipes and published by Elsevier Health Sciences. This book was released on 2018-01-09 with total page 2040 pages. Available in PDF, EPUB and Kindle. Book excerpt: Trusted by generations of cardiologists for the latest, most reliable guidance in the field, Braunwald’s Heart Disease, 11th Edition, remains your #1 source of information on rapidly changing clinical science, clinical and translational research, and evidence-based medicine. This award-winning text has been completely updated, providing a superior multimedia reference for every aspect of this fast-changing field, including new material about almost every topic in cardiology.

Download or read book 3D Printing in Medicine written by Deepak M. Kalaskar and published by Woodhead Publishing. This book was released on 2022-10-18 with total page 424 pages. Available in PDF, EPUB and Kindle. Book excerpt: 3D Printing in Medicine, Second Edition examines the rapidly growing market of 3D-printed biomaterials and their clinical applications. With a particular focus on both commercial and premarket tools, the book looks at their applications within medicine and the future outlook for the field. The chapters are written by field experts actively engaged in educational and research activities at the top universities in the world. The earlier chapters cover the fundamentals of 3D printing, including topics such as materials and hardware. The later chapters go on to cover innovative applications within medicine such as computational analysis of 3D printed constructs, personalized 3D printing - including 3D cell and organ printing and the role of AI - with a subsequent look at the applications of high-resolution printing, 3D printing in diagnostics, drug development, 4D printing, and much more. This updated new edition features completely revised content, with additional new chapters covering organs-on-chips, bioprinting regulations and standards, intellectual properties, and socio-ethical implications of organs-on-demand. Reviews a broad range of biomedical applications of 3D printing biomaterials and technologies Provides an interdisciplinary look at 3D printing in medicine, bridging the gap between engineering and clinical fields Includes completely updated content with additional new chapters, covering topics such as organs-on-chips, bioprinting regulations, intellectual properties, medical standards in 3D printing, and more

Download or read book How Tobacco Smoke Causes Disease written by United States. Public Health Service. Office of the Surgeon General and published by . This book was released on 2010 with total page 728 pages. Available in PDF, EPUB and Kindle. Book excerpt: This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.

Download or read book Fabrication and Functionalization of Advanced Tubular Nanofibers and their Applications written by Baoliang Zhang and published by Elsevier. This book was released on 2023-01-27 with total page 362 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fabrication and Functionalization of Advanced Tubular Nanofibers and their Applications describes the synthesis, preparation and characterization of carbon-based tubular nanofibers and their applications in environmental protection and new energy sources. The book explores novel strategies for the preparation of carbon tubular nanofibers and explains how they have been used to great effect in a range of applications, including energy and healthcare. The processing-structure-property relationship in functional inorganic/organic materials is examined at the nano-level, explaining where interesting electronic, magnetic, optical, mechanical or catalytic and therapeutic properties are derived. Covering everything from the basics to their use in practice, including the synthetic procedure and characterization, this book is the perfect guide for anyone interested in the design of nanomaterials for advanced applications. Nanomaterial science is a relatively young and rapidly developing discipline that includes aspects of physics, chemistry and biology and is finding applications in some of mankind’s greatest current challenges. Describes how to produce superior tubular nanofiber performance in one or more characteristics Addresses important advances in the synthesis, processing and surface modification of new materials Explains innovative applications of tubular nanofibers in environmental and biotechnology applications