Download or read book Novel Approaches to the Visualization of Cell Specific Gene Expression Patterns written by Chuba Benson Odimegwu Oyolu and published by Stanford University. This book was released on 2011 with total page 191 pages. Available in PDF, EPUB and Kindle. Book excerpt: The fate of a cell is largely determined by the unique patterns of gene expression found within it. Complex biological machinery exists within each cell to manipulate chromatin state, and ultimately control gene expression. Developmental processes such as cellular differentiation require very specific chemical signals and environmental conditions. These serve as triggers to put the chromatin modification schemes that produce the resultant patterns of differential gene expression into action, leading to the formation of the cell type of interest. My thesis work is an in depth study of the link between chromatin modification, gene expression, and the unique genetic signatures that characterize distinct cells on unicellular and multi-cellular levels. On the multi-cellular level, I have examined histone modification patterns for their effects on gene activation and repression during human embryonic stem cell differentiation. On the unicellular level, I have worked with a variety of cell types to ascertain the degree of individuality that exists between single members of relatively homogenous cell groups while simultaneously looking for housekeeping gene expression signatures that can be used to classify each cell type into a unique group. To further elucidate the patterns of gene expression found within cell groups and the single cells that comprise them, I have worked to develop new computational methods that produce visual aids to elucidate gene expression signatures of single cells and cell groups.
Download or read book Data Analysis and Visualization in Genomics and Proteomics written by Francisco Azuaje and published by John Wiley & Sons. This book was released on 2005-06-24 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt: Data Analysis and Visualization in Genomics and Proteomics is the first book addressing integrative data analysis and visualization in this field. It addresses important techniques for the interpretation of data originating from multiple sources, encoded in different formats or protocols, and processed by multiple systems. One of the first systematic overviews of the problem of biological data integration using computational approaches This book provides scientists and students with the basis for the development and application of integrative computational methods to analyse biological data on a systemic scale Places emphasis on the processing of multiple data and knowledge resources, and the combination of different models and systems
Download or read book Neuroanatomy and transgenic technologies written by Laurent Gautron and published by Frontiers Media SA. This book was released on 2015-04-21 with total page 140 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neuroanatomists increasingly rely on techniques enabling them to manipulate genes in defined brain cell populations. In particular, engineered transgenes, which encode a variety of fluorescent reporter proteins can be inserted into the genome or delivered into desired brain regions using viral vectors, thereby allowing the labeling of molecularly-defined populations of neurons and/or glial cells. Transgenic technology can also be used to selectively delete genes in targeted neuronal populations or bi-directionally modulate their electrical excitability using optogenetic or chemogenetic techniques. One of the primary advantages of using transgenic reagents is to simplify the identification and tracing of targeted population of brain cells, which can be laborious using traditional techniques in neuroanatomy. In this research topic, we assembled up-to-date reviews and original articles that demonstrate the versatility and power of transgenic tools in advancing our knowledge of the nervous system, with a special emphasis on the application of transgenic technology to neuroanatomical questions.
Download or read book Biomedical Data Visualization Methods and Applications written by Guangchuang Yu and published by Frontiers Media SA. This book was released on 2022-05-24 with total page 146 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Visualization in Medicine and Life Sciences written by Lars Linsen and published by Springer Science & Business Media. This book was released on 2007-12-27 with total page 335 pages. Available in PDF, EPUB and Kindle. Book excerpt: Visualization technology is becoming increasingly important for medical and biomedical data processing and analysis. The interaction between visualization and medicine is one of the fastest expanding fields, both scientifically and commercially. This book discusses some of the latest visualization techniques and systems for effective analysis of such diverse, large, complex, and multi-source data.
Download or read book Index Medicus written by and published by . This book was released on 2004 with total page 2036 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.
Download or read book Head and Neck Cancer written by Jacques Bernier and published by Springer Science & Business Media. This book was released on 2011-06-15 with total page 700 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years, great advances in translational research have led to new paradigms in the treatment of cancers of the head and neck. Written by leading international physicians and investigators, this innovative multi-disciplinary book presents the most up-to-date research and clinical approaches. Coverage is given to progress in a variety of clinical settings, including programs of organ and function preservation, curative treatments, unresectable disease, adjuvant treatments in high-risk patients, and recurrent/metastatic disease. Complementary to the techniques of surgery, radiotherapy, and systemic treatments, the authors present data on epidemiology, molecular pathology, normal tissue complications, rehabilitation, palliative care, and treatment in the elderly. State-of-the-art functional imaging is elucidated; and the latest developments in high precision techniques in irradiation, sequencing of chemo- and radiotherapy, as well as the integration of biomolecular therapies into cytotoxic treatments are explored.
Download or read book Cumulated Index Medicus written by and published by . This book was released on 1996 with total page 1354 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book New Approach Methods in Immunology written by Jeffrey John Bajramovic and published by Frontiers Media SA. This book was released on 2024-09-27 with total page 258 pages. Available in PDF, EPUB and Kindle. Book excerpt: Currently, the assessment of functional immunological relevance is mainly done in animal models. Motivation to work on non-animal methods, or new approach methods (NAM), stems from economical and ethical considerations, and is supported by public pressure. Importantly, the translational gap between results obtained in animal studies and clinical trials in humans (the ‘valley of death’), combined with the reproducibility crisis in science, also provide strong scientific arguments to work on novel, robust, human-based methodology. The field of immunology confronts NAM scientists with specific challenges. Firstly, immunological responses require several cell types in different locations for proper development and take considerable time to develop. Secondly, immunological responses in outbred humans are characterized by genetic and functional variability. Still, the development and application of NAM are increasing rapidly, and the field is moving at such a fast pace that a special issue is timely. Our goal is to provide an overview of the current state-of-the-art regarding new approach methods or non-animal methods (NAM) in immunology. These should be inspired by the desire to mimic in vivo biology and describe e.g. challenges in mimicking immunological structures (like lymph nodes, bone marrow, local immune structures), immunological responses (systemic and local, innate and adaptive, B cells and T cells) and/or immunological processes (like maturation, trafficking, extravasation, immunotoxicity, affinity maturation).
Download or read book GeNeDis 2020 written by Panayiotis Vlamos and published by Springer Nature. This book was released on 2022-01-01 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt: The 4th World Congress on Genetics, Geriatrics and Neurodegenerative Diseases Research (GeNeDis 2020) focuses on the latest major challenges in scientific research, new drug targets, the development of novel biomarkers, new imaging techniques, novel protocols for early diagnosis of neurodegenerative diseases, and several other scientific advances, with the aim of better, safer, and healthier aging. Computational methodologies for implementation on the discovery of biomarkers for neurodegenerative diseases are extensively discussed. This volume focuses on the sessions from the conference regarding computational biology and bioinformatics.
Download or read book New Technologies for Glutamate Interaction written by Maria Kukley and published by Springer Nature. This book was released on 2024 with total page 378 pages. Available in PDF, EPUB and Kindle. Book excerpt: Zusammenfassung: This volume explores the latest technologies used to study the co-existence of neuronal and neuron-glia synapses in the brain. The chapters in this volume are organized into three parts. Part One covers recent advancements in the technical approaches for studying glutamatergic signalling between neurons. Part Two highlights approaches to study the functional role of astrocytes at neuronal synapses. Part Three focuses on fast signalling at neuron-glia synapses, and highlights relevant methods for investigating these unusual synapses, including slice electrophysiology and in vivo gene delivery techniques. In the Neuromethods series style, all chapters contain key advices from experts in the field that are valuable for performing successful experiments on the topic in your laboratory. Cutting-edge and thorough, New Technologies for Glutamate Interactions: Neurons and Glia is a valuable resource for both neuronal and glial physiologists who are interested in learning about and developing new methods to further understand neuronal and neuron-glia synaptic transmission
Download or read book Meiotic Recombination and DNA Repair New Approaches to Solve Old Questions in Model and Non Model Plant Species written by Christophe Lambing and published by Frontiers Media SA. This book was released on 2022-10-05 with total page 272 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Molecular Pathology written by William B. Coleman and published by Academic Press. This book was released on 2017-11-09 with total page 805 pages. Available in PDF, EPUB and Kindle. Book excerpt: As the molecular basis of human disease becomes better characterized, and the implications for understanding the molecular basis of disease becomes realized through improved diagnostics and treatment, Molecular Pathology, Second Edition stands out as the most comprehensive textbook where molecular mechanisms represent the focus. It is uniquely concerned with the molecular basis of major human diseases and disease processes, presented in the context of traditional pathology, with implications for translational molecular medicine. The Second Edition of Molecular Pathology has been thoroughly updated to reflect seven years of exponential changes in the fields of genetics, molecular, and cell biology which molecular pathology translates in the practice of molecular medicine. The textbook is intended to serve as a multi-use textbook that would be appropriate as a classroom teaching tool for biomedical graduate students, medical students, allied health students, and others (such as advanced undergraduates). Further, this textbook will be valuable for pathology residents and other postdoctoral fellows that desire to advance their understanding of molecular mechanisms of disease beyond what they learned in medical/graduate school. In addition, this textbook is useful as a reference book for practicing basic scientists and physician scientists that perform disease-related basic science and translational research, who require a ready information resource on the molecular basis of various human diseases and disease states. - Explores the principles and practice of molecular pathology: molecular pathogenesis, molecular mechanisms of disease, and how the molecular pathogenesis of disease parallels the evolution of the disease - Explains the practice of "molecular medicine and the translational aspects of molecular pathology - Teaches from the perspective of "integrative systems biology - Enhanced digital version included with purchase
Download or read book Transcriptome and Single Cell Sequencing Analyses to Classify Immune Subtypes Uncover Novel Biomarkers and Assess Immunotherapeutic Responses in Cancer written by Hongda Liu and published by Frontiers Media SA. This book was released on 2024-07-24 with total page 242 pages. Available in PDF, EPUB and Kindle. Book excerpt: According to the most recent projections of the International Agency for Research on Cancer (IARC), there would be around 19.3 million new cases of cancer and 10 million cancer-related deaths globally in 2022. Cancer research has never halted. In particular, research into the cancer immunological microenvironment is gaining popularity.
Download or read book Introduction to Bioinformatics written by Stephen A. Krawetz and published by Springer Science & Business Media. This book was released on 2003-01-31 with total page 776 pages. Available in PDF, EPUB and Kindle. Book excerpt: CD-ROM contains: chapter illustrations -- full and trial versions of programs.
Download or read book Mammalian and Avian Transgenesis New Approaches written by Shirley Pease and published by Springer Science & Business Media. This book was released on 2007-07-31 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mammalian and Avian Transgenesis presents a collection of novel methods for the production of a wide range of transgenic animals. The manual focuses largely on mice, but also contains protocols for successful transgenesis in rats, cows, pigs and birds. The manual provides detailed, step-by-step protocols covering all aspects of the production of transgenic animals, including the use of lentiviral vectors in gene transfer, intracytoplasmic sperm injection, nuclear transfer, large insert transgenesis, conditional gene expression systems, the use of reporter genes in transgenesis and transgenesis in large animals and birds. The text is supplemented by superb color photos. While the focus is on newly established techniques, the fundamental methods of transgenesis are also covered for those new to the field. Thus this manual is perfectly suited for those wishing to adopt new technologies in transgenesis.
Download or read book Photonic Devices and Algorithms for Computing written by and published by . This book was released on 2006 with total page 254 pages. Available in PDF, EPUB and Kindle. Book excerpt:
