Download or read book Nouvelles mol cules immunomodulatrices dans l immunoth rapie des cancers written by Anne-Clémence Quintin and published by . This book was released on 2015 with total page 121 pages. Available in PDF, EPUB and Kindle. Book excerpt: L'immunité induite par les cellules cancéreuses est capable, pendant un temps, de limiter la croissance de la tumeur. Mais différents facteurs liés, soit au microenvironnement, soit à la cellule tumorale, soit à la réponse immunitaire elle-même, vont permettre au cancer de se développer. Les molécules membranaires de régulation négative CTLA-4 et PD-1 jouent un rôle majeur dans l'échappement de la tumeur face aux défenses anti-tumorales. Les anticorps anti CTLA-4, anti PD-1, anti PD-L1 inhibent ces voies suppressives. Ils sont à l'origine d'une révolution de la thérapie du cancer principalement dans la lutte contre les tumeurs solides. Avec un recul de 10 ans les oncologues ont constaté une guérison chez 25% des patients présentant un mélanome avancé considéré incurable. L'efficacité de ces traitements est durable mais elle est associée à une toxicité réelle d'origine immunitaire. Cependant, ces pathologies secondaires sont gérables à l'aide des traitements à base de corticoïdes. De nombreuses études néanmoins sont en cours concernant la toxicité, les démarches méthodologiques et surtout la validation de marqueurs prédictifs d'efficacité, afin d'optimiser ces thérapies immunomodulatrices. De nombreux essais cliniques suggèrent que ces thérapies sont souvent plus efficaces lorsqu'elles sont associées entre elles ou à d'autres approches thérapeutiques conventionnelles.

Download or read book Regulatory T Cells in Health and Disease written by and published by Academic Press. This book was released on 2015-11-26 with total page 301 pages. Available in PDF, EPUB and Kindle. Book excerpt: Regulatory T Cells in Health and Disease focuses on the mechanism by which T cells become regulatory T cells, the processes which control the number of regulatory T cells in the blood and tissue, and the ways in which regulatory T cell prevent autoimmune disease and interact with infections and cancer. Contains contributions from leading authorities in the field of regulatory T cell biology Informs and updates on all the latest developments in the field Explores the processes which control the number of regulatory T cells in the blood and tissue, and the ways in which regulatory T cell prevent autoimmune disease and interact with infections and cancer

Download or read book Treatment of Ovarian Cancer written by A. P. Bardos and published by Nova Publishers. This book was released on 2005 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new volume presents the latest research on therapies for ovarian cancer. Ovarian cancer is cancer that begins in the cells that constitute the ovaries, including surface epithelial cells, germ cells, and the sex cord-stromal cells. Cancer cells that metastasize from other organ sites to the ovary (most commonly breast or colon cancers) are not then considered ovarian cancer. According to the American Cancer Society, ovarian cancer accounts for 4 percent of all cancers among women and ranks fifth as a cause of their deaths from cancer. The American Cancer Society statistics for ovarian cancer estimate that there will be 25,400 new cases and 14,300 deaths in 2003. The death rate for this disease has not changed much in the last 50 years. Unfortunately, almost 70 percent of women with the common epithelial ovarian cancer are not diagnosed until the disease is advanced in stage -- i.e., has spread to the upper abdomen (stage III) or beyond (stage IV). The 5-year survival rate for these women is only 15 to 20 percent, whereas the 5-year survival rate for stage I disease patients approaches 90 percent and for stage II disease patients approaches 70 percent. Ovarian tumors are named according to the type of cells the tumor started from and whether the tumor is benign or cancerous. The three main types of ovarian tumors are: Epithelial Tumors, Germ Cell Tumors and Stromal Tumors.

Download or read book Strategies to Enhance the Therapeutic Ratio of Radiation as a Cancer Treatment written by Mitchell S. Anscher and published by Springer. This book was released on 2018-07-05 with total page 305 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume will describe recent progress and future directions in radiation oncology and biology research, focusing on strategies designed to improve disease control and reduce the risk of long-term adverse effects on patients. As more and more patients are becoming long-term survivors, this strategy will become increasingly important--in radiation oncology and throughout the field of oncology.