Download or read book Notch Regulation of the Immune System written by Freddy Radtke and published by Springer Science & Business Media. This book was released on 2012-09-13 with total page 192 pages. Available in PDF, EPUB and Kindle. Book excerpt: Notch signaling regulates many cell fate decision and differentiation processes during embryonic development and tissue homeostasis. Moreover, disregulation of the pathway is associated with human disorders and cancer. In the last 15 years it became evident that Notch plays important roles in the hematopoietic system as well as in the regulation of immune responses. This special issue on Notch regulation of the immune system summarizes recent advances and covers multiple aspects of Notch signaling within the hematopoietic and the immune system. This issue covers subjects including Notch function in embryonic and adult hematopoietic stem cells, lymphocyte development and function as well as in T cell leukemia.
Download or read book Notch Regulation of the Immune System written by Freddy Radtke and published by Springer. This book was released on 2012-09-14 with total page 184 pages. Available in PDF, EPUB and Kindle. Book excerpt: Notch signaling regulates many cell fate decision and differentiation processes during embryonic development and tissue homeostasis. Moreover, disregulation of the pathway is associated with human disorders and cancer. In the last 15 years it became evident that Notch plays important roles in the hematopoietic system as well as in the regulation of immune responses. This special issue on Notch regulation of the immune system summarizes recent advances and covers multiple aspects of Notch signaling within the hematopoietic and the immune system. This issue covers subjects including Notch function in embryonic and adult hematopoietic stem cells, lymphocyte development and function as well as in T cell leukemia.
Download or read book Notch Signaling written by Koji Yasutomo and published by Springer. This book was released on 2017-08-02 with total page 106 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers the broad area related to Notch-mediated regulation of the immune system and tumorigenesis. Notch signaling was originally identified as a crucial pathway to regulate cell fate choice. Subsequent studies, however, have revealed that Notch regulates many steps of immune cell differentiation or development as well as tumorigenesis of cells. Although there are still many controversial issues regarding the functions or regulatory mechanism of Notch, it is important to summarize all data together in one volume to help facilitate this research area. Also, the studies regarding the functions of Notch in immune cells and tumor cells have motivated researchers and pharmaceutical companies to develop drugs for treating immune-mediated diseases and tumors. Therefore, this book covering the broad area of Notch in immunology and tumorigenesis will be attractive to many researchers including faculty members and postdoctoral fellows in academia and researchers in the pharmaceutical industry.
Download or read book Hematopoietic Stem Cell Development written by Isabelle Godin and published by Springer Science & Business Media. This book was released on 2010-05-27 with total page 188 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book collects articles on the biology of hematopoietic stem cells during embryonic development, reporting on fly, fish, avian and mammalian models. The text invites a comparative overview of hematopoietic stem cell generation in the different classes, emphasizing conserved trends in development. The book reviews current knowledge on human hematopoietic development and discusses recent breakthroughs of relevance to both researchers and clinicians.
Download or read book Signaling and Gene Expression in the Immune System written by and published by CSHL Press. This book was released on 1999 with total page 656 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides a dialogue on the nature of the membrane signals and intracytoplasmic events that provoke immunity. The debate ranges over biochemistry, physiology, molecular genetics, as well as classical cellular immunology. Input came from over 70 of the world's leading investigators.
Download or read book Molecular Mechanisms of Notch Signaling written by Tilman Borggrefe and published by Springer. This book was released on 2018-07-20 with total page 417 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes the Notch signaling pathway with a focus on molecular mechanisms. The Notch signaling pathway is a seemingly simple pathway that does not involve any second messenger. Upon ligand binding two consecutive proteolytic cleavages of the NOTCH receptor release the Notch intracellular domain from the membrane. The Notch intracellular domain migrates into the nucleus and activates gene expression. Recently, new technologies allowed us to better understand this pivotal signaling cascade and revealed new regulatory mechanisms. The different chapters cover many aspects of the Notch signaling focusing on the mechanisms governing the receptor/ligand interaction as well as on the downstream intracellular signaling events. Aspects of both canonical and non-canonical signaling are discussed and the function of Notch signaling in physiological and pathological contexts are elucidated. This book is not only intended for experts but it should also be a useful resource for young, sprouting scientists or interested scientists from other research areas, who may use this book as a stimulating starting point for further discoveries and developments.
Download or read book Analysis of Notch driven Regulation of Dendritic Cell Function written by Alborz Borjian and published by . This book was released on 2015 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: "An effective immune response against pathogens or cancer requires proper guidance of the immune system. Being the first responders in innate immunity, Dendritic Cells (DCs) provide essential and differentiation cues to T cells, guiding them down specific effector lineages. Cell-cell communication through Notch signaling is initiated by trans-binding of receptor and ligand on neighboring cells to guide various cell fate decisions. However, recently it has been shown that cis-interaction of Notch receptor and Delta ligand in mammalian cells can result in inhibition of Notch signaling. DCs are known to express both Notch ligands and receptors. We have previously shown that DCs differentially express Notch ligands in response to stimuli associated with specific TH lineages. These findings suggest that relative abundance of Notch ligands to receptors may lead the cell to adopt a phenotype associated with signaling through either Notch ligand or receptor. Thereby, we hypothesize that the Notch signaling directly regulates DC function and therefore indirectly modulates T-cell polarization. To observe Notch signaling associated with different states of DC activation, we measured expression of components of Notch signal transduction in response to the Toll-like receptor (TLR) ligand lipopolysaccharide (LPS) and Leishmania parasites. Activation of DCs with TH1-directing LPS maintains the low Notch1 levels, but increases Notch2 expression. DCs infected with Leishmania remain immature, even if exposed to LPS subsequently, show higher Notch1 levels. Analysis of Notch1-deficient DCs, illustrated that Notch1 expression negatively regulates DC activation. Similarly, DCs stimulated with TH1-inducing agents maintain low Notch1 levels but have increased Delta4 expression. On the other hand, Notch2 expression positively regulates DC activation. Induced Notch2 expression leads to increased expression of co-stimulatory molecule CD86 and proinflammatory cytokine Interleukin 12 (IL-12). The increased Notch2 expression in DCs stimulated with LPS is, however, accompanied by a reduction in Jagged2 expression. Accordingly, Jagged2 is shown to negatively regulate IL-12 secretion. Such pattern of expression among Notch ligands and receptors (i.e. mutually exclusive expression of Notch1/Delta4 or Notch2/Jagged2) supports the evidence for cis-inhibition, a mechanism by which Notch receptors and ligands expressed on the same cell reciprocally inhibit one another. Such cis-interaction results in removal of the receptors and ligands from the cell surface and their subsequent proteolysis. All in all, our results propose that relative levels of Notch receptor and ligands can directly alter DC phenotype." --
Download or read book Genetic Regulation of the Immune Response written by Vivian Siegel and published by . This book was released on 2002 with total page 148 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Molecular Biology of the Cell written by and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Notch Negative Regulatory Region Mutations and Mechanisms written by Michael John Malecki and published by . This book was released on 2007 with total page 156 pages. Available in PDF, EPUB and Kindle. Book excerpt: Notch signaling is a developmentally conserved pathway involved in cell fate determination. One development program in which Notch signaling plays a prominent role is in the development of the immune system, where Notch1, one of four mammalian Notch receptors, guides the choice of T-cell fate. However, mutations leading to aberrant increases in Notch1 signaling are associated with T-cell Acute Lymphoblastic Leukemia (T-ALL), indicating the importance of regulation in modulating the timing and strength of Notch1 signals. Notch receptors are synthesized as single-chain type-I transmembrane proteins. During transit through the trans -golgi, Notch receptors are typically cleaved by a furin-like protease, resulting in two subunits that are non-covalently associated through a subunit heterodimerization (HD) domain. The majority of leukemia-associated mutations in human Notch1, which are found in about 40% of T-ALLs, lie in this HD domain.
Download or read book Cancer Immune Therapy written by Gernot Stuhler and published by John Wiley & Sons. This book was released on 2002-12-03 with total page 448 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cure or life with cancer? What can be achieved by cancer immune therapy? The past decade has seen substantial advancements in tumor immunology. Much of the new knowledge has been translated into new strategies for cancer treatment and into clinical trials. Some of these trials herald future breakthroughs, others have been disappointing and have prompted intensive search for alternatives.Major contributors to the field summarize the knowledge on the molecular and cellular mechanisms of tumorigenesis, critically review the instruments of the immune system that might be exploited for therapy, and discuss the clinical experiences with the different immune therapy concepts. Researchers in the fields of immunology, tumor biology and medicine will highly appreciate this up-to-date volume for evaluating future research activities.
Download or read book The Theory of the Gene written by Thomas Hunt Morgan and published by . This book was released on 1926 with total page 392 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Signaling Mechanisms Regulating T Cell Diversity and Function written by Jonathan Soboloff and published by CRC Press. This book was released on 2017-03-27 with total page 258 pages. Available in PDF, EPUB and Kindle. Book excerpt: T cells play a vital role mediating adaptive immunity, a specific acquired resistance to an infectious agent produced by the introduction of an antigen. There are a variety of T cell types with different functions. They are called T cells, because they are derived from the thymus gland. This volume discusses how T cells are regulated through the operation of signaling mechanisms. Topics covered include positive and negative selection, early events in T cell receptor engagement, and various T cell subsets.
Download or read book Anatomy and Physiology written by J. Gordon Betts and published by . This book was released on 2013-04-25 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book How Notch and Wnt Make T cells Tick written by and published by . This book was released on 2013 with total page 150 pages. Available in PDF, EPUB and Kindle. Book excerpt: "This dissertation shows that the ancient Wnt and Notch signaling modules have been coopted by the immune system to direct T-cell responses. Notch has turned out to be particularly dedicated to induction of effector cell differentiation and function. Lack of Notch activation may predispose cells to less terminally differentiated fates, as most prominently suggested by our results on CD8+ T-cells. A more restricted role seems to be played by Wnt, which selectively controls survival of a subset of effector cells. With these studies, we have identified some of the cogwheels and springs that control the inner workings of the immune system."--Samenvatting auteur.
Download or read book Canonical Notch Signaling Positively Regulates MiR 155 Transcription in a NFkB dependent Manner written by Joe Torres and published by . This book was released on 2018 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: MicroRNA-155 (miR-155) is an important pro-inflammatory molecule that controls immune responses in both physiological and pathological settings. Although miR-155 is well studied, little is known about its transcriptional regulation in T cells. We sought to further understand the mechanisms by which miR-155 transcription is induced following T cell activation. We found that miR-155 transcription is dependent on the activity of the Notch and NFkB signaling pathways. It was determined that the canonical Notch signaling pathway was involved in this regulation and that it was dependent upon the activation of NFkB. Additional work confirmed that both NFkB and Notch1 directly bind to the promoter of miR-155. These results support a model by which the canonical Notch signaling pathway cooperates with NFkB to directly promote the transcription of miR-155 following T cell activation. In conclusion, we have identified a novel mechanism of miR-155 regulation that will contribute to a greater understanding of its role in the immune system.
Download or read book Immunological Tolerance written by Paul J. Fairchild and published by Boom Koninklijke Uitgevers. This book was released on 2007 with total page 982 pages. Available in PDF, EPUB and Kindle. Book excerpt: Immunological Tolerance: Methods and Protocols is a comprehensive guide to the techniques currently used for culturing and characterising the cell types responsible for imposing self-tolerance and the experimental models employed to study their function both in vitro and in vivo. This guide is aimed at AIDS researchers, immunologists, transplant surgeons/specialists, and biotechnologists.
