Download or read book Not Vital written by Olivier Renaud-Clément and published by Hauser & Wirth. This book was released on 2020 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Not Vital: SCARCH is a survey of sculptural architect Not Vital's career, published on the occasion of a January 2020 exhibition at Hauser & Wirth Somerset. Vital has created and installed responsive works that are integrated into habitats and communities around the globe: in the Engadine region of his native Switzerland and across Europe, Africa, South America, and Asia. Edited and with texts by Olivier Renaud-Clément and Giorgia von Albertini, the book features Vital's prose and poems, and additional essays by Philip Jodidio and Tilla Theus. The book brings together the far-flung locations where the artist's works are situated and envisioned, and his projects and typologies are introduced by geographic groupings. Exhibition: Hauser & Wirth Somerset, Bruton, UK (25.01.-04.05.2020).
Download or read book Organic Cation Transporter 1 OCT1 Not Vital for Life but of Substantial Biomedical Relevance written by Jurgen Brockmoller and published by Frontiers Media SA. This book was released on 2022-01-12 with total page 145 pages. Available in PDF, EPUB and Kindle. Book excerpt: Around one third of all biologically relevant small molecules are organic cations. These include endogenous substances like catecholamines and other neurotransmitters, toxins and drugs designed to affect signaling processes. The organic cation transporter 1 (OCT1) is among the strongest expressed membrane transporters at the sinusoidal (blood-facing) side of liver cells and contributes substantially to the clearance of the blood from numerous organic cations. A most striking feature of OCT1 is its pronounced genetic diversity. Between 1 and 10% of all human populations have little to no OCT1 activity. With several of the OCT1 substrates up to 10% of Europeans are functionally OCT1 deficient. Apparently, the lack of OCT1 do not lead to apparent substantial pathological changes in these individuals. It thus appears that this transporter is not essential to human life, but does it means that OCT1 is irrelevant? In the last 25 years since the first cloning of this transporter, data on its pharmacological and physiological relevance is steadily accumulating. Numerous clinically relevant drugs (e.g. metformin, morphine, fenoterol, sumatriptan, tramadol and tropisetron) have been shown to be substrates of OCT1, and OCT1 deficiency has been shown to affect the pharmacokinetics, efficacy, or toxicity of these drugs. Also vitamin B1 has been shown to be a substrate of OCT1, and in genetically modified mice OCT1 substantially modulated hepatic lipid metabolism, total body fat and systemic glucose and lipid concentrations. Still, numerous important questions remain unsolved: For which drugs, toxins, or other endogenous or exogenous substances is OCT1 relevant? How can we predict the relevance of OCT1 from in vitro studies? What determines the substrate selectivity of OCT1 in comparison to other transporters or transport processes for organic cations? What regulates the expression of OCT1 in the liver and possibly in other tissues? What is the impact of OCT1 variation in different areas of medicine, including the therapies for cancer as well as for pulmonary, cardiovascular, or neurological diseases? How can evolutionary biology contribute to a better understanding of the roles of OCT1? And, importantly, what types of research are likely to significantly further the knowledge on OCT1 in the next decades?
Download or read book Theatre of the Unimpressed written by Jordan Tannahill and published by Coach House Books. This book was released on 2015-05-11 with total page 161 pages. Available in PDF, EPUB and Kindle. Book excerpt: How dull plays are killing theatre and what we can do about it. Had I become disenchanted with the form I had once fallen so madly in love with as a pubescent, pimple-faced suburban homo with braces? Maybe theatre was like an all-consuming high school infatuation that now, ten years later, I saw as the closeted balding guy with a beer gut he’d become. There were of course those rare moments of transcendencethat kept me coming back. But why did they come so few and far between? A lot of plays are dull. And one dull play, it seems, can turn us off theatre for good. Playwright and theatre director Jordan Tannahill takes in the spectrum of English-language drama – from the flashiest of Broadway spectacles to productions mounted in scrappy storefront theatres – to consider where lifeless plays come from and why they persist. Having travelled the globe talking to theatre artists, critics, passionate patrons and the theatrically disillusioned, Tannahill addresses what he considers the culture of ‘risk aversion’ paralyzing the form. Theatre of the Unimpressed is Tannahill’s wry and revelatory personal reckoning with the discipline he’s dedicated his life to, and a roadmap for a vital twenty-first-century theatre – one that apprehends the value of ‘liveness’ in our mediated age and the necessity for artistic risk and its attendant failures. In considering dramaturgy, programming and alternative models for producing, Tannahill aims to turn theatre from an obligation to a destination. ‘[Tannahill is] the poster child of a new generation of (theatre? film? dance?) artists for whom "interdisciplinary" is not a buzzword, but a way of life.’ —J. Kelly Nestruck, Globe and Mail ‘Jordan is one of the most talented and exciting playwrights in the country, and he will be a force to be reckoned with for years to come.’ —Nicolas Billon, Governor General's Award–winning playwright (Fault Lines)
Download or read book Engadin Art Talks written by Cristina Bechtler and published by Jrp Ringier. This book was released on 2013 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume compiles ideas and projects from well-known artists, architects, designers, filmmakers and researchers on mountainous regions not only in Switzerland, but worldwide. It includes writings by Vito Acconci, Doug Aitken, Ron Arad, Nairy Baghramian and Jan von Brevern, as well as a discussion on architect Bruno Taut's "Crystal Chain Letters."
Download or read book It s Not Just You written by Tori Tsui and published by Simon and Schuster. This book was released on 2023-07-06 with total page 177 pages. Available in PDF, EPUB and Kindle. Book excerpt: ‘The world is in desperate need of this book’ - Greta Thunberg 'It's Not Just You is a galvanising breath of fresh air' - Mikaela Loach 'Tori Tsui is changing the conversation around mental health and the climate crisis' - Vogue ‘A must-read for anyone who would love to understand the intersections of mental health and the climate crisis’ - Vanessa Nakate ------------------------ It’s not just you. The climate crisis is making us all unwell. But not just you. The climate crisis is affecting certain communities disproportionately. And it’s not just the climate crisis… The term ‘eco-anxiety’ has been popularised as a way to talk about the negative impact of the climate emergency on our wellbeing. In It’s Not Just You, activist Tori Tsui reframes eco-anxiety as the urgent mental health crisis it clearly is. Drawing on the wisdom of environmental advocates from around the globe, Tori looks to those on the frontlines of eco-activism to demonstrate that the current climate-related mental health struggle goes beyond the climate itself. Instead, it is a struggle that encompasses many injustices and is deeply entrenched in systems such as racism, sexism, ableism and, above all, capitalism. Because of this, climate injustice disproportionately affects most marginalised communities, who are often excluded from narratives on mental health. Tori argues that we can only begin to tackle both the climate and mental health crisis by diversifying our perspectives and prioritising community-led practices. In essence, reminding us that It’s Not Just You. Tackling this increasingly urgent crisis requires looking both inwards and outwards, embracing individuality over individualism and championing climate justice. Only then can we start to build better futures for both people and the planet.
Download or read book The Vital Question written by Nick Lane and published by . This book was released on 2016 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: A game-changing book on the origins of life, called the most important scientific discovery 'since the Copernican revolution' in The Observer.
Download or read book Vital Forces Teleology and Organization written by Andrea Gambarotto and published by Springer. This book was released on 2017-10-03 with total page 137 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book offers a comprehensive account of vitalism and the Romantic philosophy of nature. The author explores the rise of biology as a unified science in Germany by reconstructing the history of the notion of “vital force,” starting from the mid-eighteenth through the early nineteenth century. Further, he argues that Romantic Naturphilosophie played a crucial role in the rise of biology in Germany, especially thanks to its treatment of teleology. In fact, both post-Kantian philosophers and naturalists were guided by teleological principles in defining the object of biological research. The book begins by considering the problem of generation, focusing on the debate over the notion of “formative force.” Readers are invited to engage with the epistemological status of this formative force, i.e. the question of the principle behind organization. The second chapter provides a reconstruction of the physiology of vital forces as it was elaborated in the mid- to late-eighteenth century by the group of physicians and naturalists known as the “Göttingen School.” Readers are shown how these authors developed an understanding of the animal kingdom as a graded series of organisms with increasing functional complexity. Chapter three tracks the development of such framework in Romantic Naturphilosophie. The author introduces the reader to the problem of classification, showing how Romantic philosophers of nature regarded classification as articulated by a unified plan that connects all living forms with one another, relying on the idea of living nature as a universal organism. In the closing chapter, this analysis shows how the three instances of pre-biological discourse on living beings – theory of generation, physiology and natural history – converged to form the consolidated disciplinary matrix of a general biology. The book offers an insightful read for all scholars interested in classical German philosophy, especially those researching the philosophy of nature, as well as the history and philosophy of biology.
Download or read book Healthside written by and published by . This book was released on 1846 with total page 444 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Vital Center written by Arthur M. Schlesinger, Jr. and published by Transaction Large Print. This book was released on 2014-09-30 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Vital Center is an eloquent and incisive defense of liberal democracy against its rivals to the left and to the right, communism and fascism. Originally published in 1949, it shows how the failures of free society led to the disenchantment of the masses with democracy, and sharpened the appeal of totalitarian solutions. The book calls for a radical reconstruction of the democratic polity based on a realistic understanding of human limitations and frailties.
Download or read book Against Empathy written by Paul Bloom and published by HarperCollins. This book was released on 2016-12-06 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt: New York Post Best Book of 2016 We often think of our capacity to experience the suffering of others as the ultimate source of goodness. Many of our wisest policy-makers, activists, scientists, and philosophers agree that the only problem with empathy is that we don’t have enough of it. Nothing could be farther from the truth, argues Yale researcher Paul Bloom. In AGAINST EMPATHY, Bloom reveals empathy to be one of the leading motivators of inequality and immorality in society. Far from helping us to improve the lives of others, empathy is a capricious and irrational emotion that appeals to our narrow prejudices. It muddles our judgment and, ironically, often leads to cruelty. We are at our best when we are smart enough not to rely on it, but to draw instead upon a more distanced compassion. Basing his argument on groundbreaking scientific findings, Bloom makes the case that some of the worst decisions made by individuals and nations—who to give money to, when to go to war, how to respond to climate change, and who to imprison—are too often motivated by honest, yet misplaced, emotions. With precision and wit, he demonstrates how empathy distorts our judgment in every aspect of our lives, from philanthropy and charity to the justice system; from medical care and education to parenting and marriage. Without empathy, Bloom insists, our decisions would be clearer, fairer, and—yes—ultimately more moral. Brilliantly argued, urgent and humane, AGAINST EMPATHY shows us that, when it comes to both major policy decisions and the choices we make in our everyday lives, limiting our impulse toward empathy is often the most compassionate choice we can make.
Download or read book In Vital Harmony written by Karen Glass and published by . This book was released on 2019-11-11 with total page 186 pages. Available in PDF, EPUB and Kindle. Book excerpt: Charlotte Mason looked at the world and saw that it was governed by universal laws, such as the law of gravity. Then she wondered. What if there were similar laws that governed the way people learn? If we knew what those laws were, we'd be able to pursue education along the most promising lines . She devoted her life to finding the key principles of education and then developing methods to make the most of them. The result is a comprehensive picture of living and learning that breathes life into education at every level--from babyhood to the adult years. It's not a rote system, but a flexible set of ideas that keep education in focus. These principles are for everyone concerned with teaching and learning. They are no more difficult to implement than the principle of gravity which allows you to walk, run, and even--when you know what you are doing--to soar.
Download or read book Vital Decomposition written by Kristina M. Lyons and published by Duke University Press. This book was released on 2020-04-17 with total page 147 pages. Available in PDF, EPUB and Kindle. Book excerpt: In Colombia, decades of social and armed conflict and the US-led war on drugs have created a seemingly untenable situation for scientists and rural communities as they attempt to care for forests and grow non-illicit crops. In Vital Decomposition Kristina M. Lyons presents an ethnography of human-soil relations. She follows state soil scientists and peasants across labs, greenhouses, forests, and farms and attends to the struggles and collaborations between farmers, agrarian movements, state officials, and scientists over the meanings of peace, productivity, rural development, and sustainability in Colombia. In particular, Lyons examines the practices and philosophies of rural farmers who value the decomposing layers of leaves, which make the soils that sustain life in the Amazon, and shows how the study and stewardship of the soil point to alternative frameworks for living and dying. In outlining the life-making processes that compose and decompose into soil, Lyons theorizes how life can thrive in the face of the violence, criminalization, and poisoning produced by militarized, growth-oriented development.
Download or read book Dictionary of Practical Surgery etc written by Samuel COOPER (Senior Surgeon to University College Hospital.) and published by . This book was released on 1809 with total page 772 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Vital and Health Statistics written by and published by . This book was released on 1963 with total page 324 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Not Vital written by Aitor Ortiz and published by . This book was released on 2014 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Not Vital by Aitor Ortiz brings the two artists together in a unique publication in which Ortiz photographs Vital's art in the very landscape that inspired it. A single phrase runs through the publication, weaving through its pages as if guiding us through the mountainous Swiss terrain. With the harsh beauty of the Engadin Valley as backdrop, Basque photographer Aitor Ortiz's dramatic black-and-white images capture the stark contrasts inherent to Vital's work.
Download or read book The Collected Works of Witness Lee 1993 volume 2 written by Witness Lee and published by Living Stream Ministry. This book was released on 2021-05-28 with total page 395 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Collected Works of Witness Lee, 1993, volume 2, contains messages given by Brother Witness Lee from May 28 through December 17, 1993. During the first eight months of 1993 Brother Lee was in Anaheim, California. At the beginning of September he visited Seattle, Washington, for one week, after which he returned to Anaheim and remained there until the end of the year. The contents of this volume are divided into nine sections, as follows: 1. Seven messages given in Anaheim, California, on May 28 through 30. These messages were previously published, along with the speaking of forty-six brothers from throughout Southern California, in a book entitled 1993 Blending Conference Messages concerning the Lord's Recovery and Our Present Need and are included in this volume under the same title. Only the outlines of the conference and the portions spoken by Brother Lee are included in The Collected Works of Witness Lee. 2. A message given in Anaheim, California, on May 28. This message is included in this volume as chapter 1 of the previous section entitled 1993 Blending Conference Messages concerning the Lord's Recovery and Our Present Need. Portions of this message were combined with other various writings by Brother Lee concerning the Triune God, and the compilation was previously published in a book entitled The Crucial Points of the Major Items of the Lord's Recovery Today. The contents of this book are included in this volume under the same title. 3. A message given in Anaheim, California, on July 3. This message was divided into two chapters and is included in this volume under the title Remaining in Life and Keeping the One Accord. 4. Four messages given in Anaheim, California, on August 13 through 15. These messages were previously published in a book entitled The Problems Causing the Turmoils in the Church Life and are included in this volume under the same title. 5. Fifteen messages given in Anaheim, California, on August 28 through December 17. These messages were previously published in a fourteen-chapter book entitled The Spirit with Our Spirit and are included in this volume under the same title. 6. Fourteen messages given in Anaheim, California, on September 1 through December 15. These messages were previously published in a thirteen-chapter book entitled The Training and the Practice of the Vital Groups and are included in this volume under the same title. 7. Six messages given in Seattle, Washington, on September 3 through 6. These messages were previously published in a book entitled The Organic Union in God's Relationship with Man and are included in this volume under the same title. 8. A message given in Seattle, Washington, on September 6. This message is included in this volume under the title Knowing and Experiencing the Organic Union in God's Relationship with Man. 9. Six messages given in Anaheim, California, on November 25 through 28. These messages were previously published in a seven-chapter book entitled The Issue of the Dispensing of the Processed Trinity and the Transmitting of the Transcending Christ and are included in this volume under the same title.
Download or read book Putting Defense Back into U S Defense Policy written by Ivan Eland and published by Bloomsbury Publishing USA. This book was released on 2001-09-30 with total page 254 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book examines the implications of counterinsurgency wars for U.S. defense policy and makes the compelling argument that the United States' default position on counterinsurgency wars should be to avoid them. In this compelling study, Eland questions the core assumptions of the American foreign policy and defense establishments that call for military interventions around the world and high and increasing defense budgets at home. He outlines a security policy more appropriate to the sober realities of the post-Cold War era. This is an approach that calls for military restraint overseas, taking advantage of the already secure U.S. geostrategic position, while safeguarding vital national interests. Eland details the military force structure needed for this new role and calculates the reduced defense budget required to pay for these forces. This book is a timely wake-up call to those who make American foreign and defense policies. It demands a badly needed re-thinking of America's national interests. In the author's view, America's natural geostrategic position places it at a natural advantage, rendering unnecessary a forward defense posture. A non-interventionist foreign policy would save money by requiring lower defense budgets. An America less willing to get involved in complex overseas disputes unrelated to U.S vital interests would also be less likely to make enemies around the world.
