Download or read book Nonpolar Matrices for Matrix Assisted Laser Desportion Ionization Time of Flight Mass Spectrometry written by and published by . This book was released on 2005 with total page 105 pages. Available in PDF, EPUB and Kindle. Book excerpt: Matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) has been used extensively for the characterization of large biomolecules, synthetic polymers and small molecules. Typically, low molecular weight acidic matrices have been used in MALDI-MS for such analyses. Here, the use of low molecular weight nonpolar matrices for MALDI-MS is investigated. In particular, the analytical and physical properties of this class of matrices are studied. The effect of instrumental factors on nonpolar matrix behavior was investigated. Two different MALDI target substrates, stainless steel and poly(methylmethacrylate) (PMMA), were used. The radical molecular ion abundance of nonpolar analyte ions analyzed in the presence of various nonpolar matrices, such as anthracene and 9-cyanoanthracene, were determined as a function of the MALDI target substrate. It was found that PMMA MALDI target substrates yielded higher radical molecular ion abundances for nonpolar analyte ions than stainless steel MALDI target substrates. This difference is attributed to the absence of photoelectrons which reduce charged species in the plume. To determine whether the desorption process for nonpolar matrices is different than the desorption process for polar, acidic matrices, matrix initial ion velocities were measured in MALDI-MS. The relative initial ion velocities of the nonpolar matrices, anthracene, 9-cyanoanthracene, pyrene, and acenapthene and were investigated and compared to the relative initial ion velocities for 2,5-dihydroxybenzoic acid (DHB), sinapinic acid (SA), and all-trans retinoic acid (RTA), polar matrices. It was found that DHB has a greater relative initial ion velocity than the nonpolar matrices. It does not appear that the desorption process is different between nonpolar and polar matrices based upon these results. In addition, when using any matrix, polar or nonpolar, to analyze nonpolar polymers, the addition of a metal salt increased the relative initial ion velocity of the matrix, suggesting a different desorption mechanism in these cases. To illustrate an application of nonpolar matrices for analytical MALDI-MS, an atmospheric resid crude oil fraction was characterized. The MALDI mass spectral data for this sample was difficult to interpret when a polar matrix, 3-indole acrylic acid, was used, due to fragmentation and matrix clustering in the analyte molecular weight distribution range. The nonpolar matrices anthracene and 9-cyanoanthracene were found to be very suitable for the analysis of this sample in either linear or reflectron mode time-of-flight mass spectrometry. These matrices did not lead to fragmentation or clustering, and identification and characterization of the analyte peaks were straightforward.

Download or read book Development and Application of Novel Matrices Under Matrix assisted Laser Desorption ionization Time of flight MALDI TOF Mass Spectrometry Conditions written by Bharat R. Mankani and published by . This book was released on 2010 with total page 176 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book A Study of Silicon based Materials as Matrices for Matrix assisted Laser Desorption ionization time of flight Mass Spectrometry written by Sanela Martic and published by . This book was released on 2005 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Exploration of the Fundamentals of Matrix Assisted Laser Desorption ionization Time of flight Mass Spectrometry written by William Joseph Erb and published by . This book was released on 2007 with total page 203 pages. Available in PDF, EPUB and Kindle. Book excerpt: This thesis focuses on the study of different tools used for preparing samples for MALDI TOFMS and the utilization of these tools to study different ionization processes operating in the MALDI experiment.

Download or read book Matrix Assisted Laser Desorption Ionization Quadrupole Time of flight Mass Spectrometry of Poly 2 vinylpyridine written by Donna M. Smith and published by . This book was released on 2005 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book The Quantitative Aspects of Matrix assisted Laser Desorption ionization Time of flight Mass Spectrometry written by Russell R. Hensel and published by . This book was released on 1996 with total page 264 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book The Development of Matrix Assisted Laser Desorption Ionization Time of Flight Mass Spectrometry and Its Application to the Study of Polymers and Biopolymers written by Sajid Bashir and published by . This book was released on 2001 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Study of Matrix assisted Laser Desorption ionization Time of Flight Mass Spectrometry for Polymer Analysis written by Hassan Rashidzadeh and published by . This book was released on 1999 with total page 230 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Complex Mixture Analysis by Matrix assisted Laser Desorption ionization Time of flight Mass Spectrometry written by Michael Z. Wang and published by . This book was released on 2003 with total page 308 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Infrared Matrix Assisted Laser Desorption Ionization Mass Spectrometry with Liquid and Ice Matrices written by Steven J. Lawson and published by . This book was released on 2001 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Matrix Assisted Laser Desorption ionization Orthogonal Acceleration Time of flight Mass Spectrometry written by David Sean Selby and published by . This book was released on 2002 with total page 364 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Improved Matrix assisted Laser Desorption ionization Linear Time of flight Mass Spectrometry of Oligonucleotides and Nucleic Acids Via Matrix Additvies and Sample Preparatory Technique written by Tracey Arlene Simmons and published by . This book was released on 2001 with total page 252 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Matrix assisted Laser Desorption ionization Time of flight Mass Spectrometry MALDI TOF MS of C methyl Calix 4 Resorcinarene written by Fenglan He and published by . This book was released on 1999 with total page 102 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Matrix assisted Laser Desorption ionization Time of flight Mass Spectrometry for Small Molecule Analysis in Foods written by Suzanne Lorraine Frison and published by . This book was released on 2003 with total page 226 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Chemical Approaches to the Stabilization of Non covalent Complexes in Matrix assisted Laser Desorption ionization Mass Spectrometry written by Anne Marie Distler and published by . This book was released on 2003 with total page 456 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Matrix assisted Laser Desorption Ionization Time of flight Mass Spectrometry written by Ricky Dale Edmondson and published by . This book was released on 1998 with total page 314 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Electrospray and MALDI Mass Spectrometry written by Richard B. Cole and published by John Wiley & Sons. This book was released on 2011-09-26 with total page 900 pages. Available in PDF, EPUB and Kindle. Book excerpt: Discover how advances in mass spectrometry are fueling new discoveries across a broad range of research areas Electrospray and MALDI Mass Spectrometry brings both veteran practitioners and beginning scientists up to date with the most recent trends and findings in electrospray ionization and matrix-assisted laser desorption/ionization (MALDI) mass spectrometry. In particular, this Second Edition highlights how advances in electrospray and MALDI mass spectrometry are supporting important discoveries in new and emerging fields such as proteomics and metabolomics as well as in traditional areas of chemistry and physics research. Electrospray AND MALDI Mass Spectrometry, SECOND EDITION is divided into five parts: Part A, Fundamentals of ES, explains the fundamental phenomena underlying the electrospray process, including selectivity in ionization and inherent electrochemistry, and concludes with a chapter offering a comparative inventory of source hardware Part B, Fundamentals of MALDI, confronts ionization mechanisms, instrument development, and matrix selection, and includes a final chapter that explores the special application of MALDI to obtain two-dimensional images of spatial distributions of compounds on surfaces Part C, ES and MALDI Coupling to Mass Spectrometry Instrumentation, examines the coupling of these ionization techniques to various mass analyzers, including quadrupole ion trap, time-of-flight, Fourier transform ion cyclotron resonance, and ion mobility mass spectrometers Part D, Practical Aspects of ES and MALDI, investigates analytical issues including quantification, charge-state distributions, noncovalent interactions in solution that are preserved as gas-phase ions, and various means of ion excitation in preparation for tandem mass spectrometry, and offers a guide to the interpretation of even-electron mass spectra Part E, Biological Applications of ES and MALDI, examines the role of mass spectrometry in such areas as peptide and protein characterization, carbohydrate analysis, lipid analysis, and drug discovery Written by a team of leading experts, the book not only provides a critical review of the literature, but also presents key concepts in tutorial fashion to help readers take full advantage of the latest technological breakthroughs and applications. As a result, Electrospray and MALDI Mass Spectrometry will help researchers fully leverage the power of electrospray and MALDI mass spectrometry. The judicious compartmentalization of chapters, and the pedagogic presentation style throughout, render the book highly suitable for use as a text for graduate-level courses in advanced mass spectrometry.