Download or read book Noninvasive Diagnostic Techniques for the Detection of Skin Cancers written by U. S. Department of Health and Human Services and published by CreateSpace. This book was released on 2013-04-11 with total page 68 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancers of the skin are the most common forms of cancer in men and women, and account for nearly half of all malignancies. In 2009, more than 1 million cases were expected in the United States. Basal cell carcinoma (BCC) and squamous cell carcinoma (SCC), two types of nonmelanomatous lesions associated with aging and sun exposure, are responsible for more than 800,000 cases per year. Recent studies have also linked nonmelanoma skin cancer (NMSC) to prior cancer therapy, especially radiation therapy. While NMSC is rarely lethal, these lesions are associated with other malignancies (including hematologic and respiratory tract cancers). In contrast, melanoma accounts for approximately 4 percent of all skin cancer cases, but causes the majority of skin cancer deaths. One study found that melanoma incidence rates had doubled in all socioeconomic groups over a 10-year period. Another study found that melanoma incidence rates have increased by 3 percent per year in white Hispanic and white non-Hispanic populations, and both white Hispanic and Black populations had more advanced disease at presentation. Melanoma is associated with significant morbidity, and late stage melanoma with significant mortality due to the likelihood of metastatic spread. Therefore, timely diagnosis and treatment are critical to reducing rates of morbidity and mortality of all skin cancers. However, suboptimal diagnostic accuracy of current methods of lesion assessment (such as visual inspection) may lead to misleading false positives or conversely missed diagnoses, and the existing protocol of excisional biopsy of suspected lesions is an invasive, costly, and time-intensive procedure. Newer noninvasive screening and diagnostic modalities are available that may provide more precise imaging of suspected lesions and more accurate detection, thereby improving in vivo diagnosis. These newer technologies may, therefore, assist with earlier detection, eliminate unnecessary biopsies, and reduce costs and patient time spent in the physician's office. Several groups in Europe, North America, Australia, and New Zealand have developed guidelines for the screening and prevention of skin cancer. According to a 2009 Guideline Synthesis, while there is general agreement that there is insufficient evidence to support screening of the general population for skin cancer, increased surveillance for individuals at higher risk is generally recommended. The objectives of this technical brief are to provide a description of the state of the science of noninvasive imaging modalities in diagnosing cancerous tumors of the skin, proffer an analytic framework for assessing the applications of the devices, provide a summary of ongoing research, and to delineate future research needs. Three principal forms of skin cancer will be considered: basal cell carcinoma (BCC) and squamous cell carcinoma (SCC), the more prevalent forms of skin cancer, and melanoma, among the most virulent. While the focus of this brief will be on modalities currently in general or limited clinical use and/or FDA approved or cleared, we also will consider investigational technologies based on available data and input from our key informants particularly the potential importance of these technologies and where they might fit into the care process.
Download or read book Noninvasive Diagnostic Techniques for the Detection of Skin Cancers written by and published by . This book was released on with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Noninvasive Diagnostic Techniques for the Detection of Skin Cancers written by and published by . This book was released on 2011 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: BACKGROUND: Cancers of the skin are the most common forms of cancer. Timely diagnosis and treatment are critical to reducing the rates of morbidity and mortality. Newer noninvasive imaging technologies may assist with earlier detection. OBJECTIVE: To provide an objective description of noninvasive imaging modalities in diagnosing cancerous tumors of the skin, to proffer an analytic framework for assessing the applications of the imaging modalities, to summarize the state of ongoing research, and to delineate future research needs. METHODS: We searched the MEDLINE(r) database for English-language literature published between 1990 and March 2011 for selected noninvasive imaging technologies. We included all publications types and study designs. We extracted data solely from relevant abstracts. Our search also included grey literature (manufacturers' Web sites, Food and Drug Administration's relevant databases, and ClinicalTrials.gov), and incorporated expert input from our key informants. Devices were classified as in general clinical use, limited clinical use, or investigational use, based on all available information. FINDINGS: We screened in 629 abstracts that were relevant to the noninvasive imaging technologies of interest. Only 11 abstracts were on randomized controlled trials. Of the devices in general clinical use, we found a total of 51 abstracts on photography and 433 on dermoscopy. Of note, only one abstract reported clinical outcomes. None of the abstracts reported adverse events. Photography is principally used in specialty and subspecialty settings (i.e., oncology) and while widely used by dermatologists, dermoscopy is still not used in primary care. We did not identify any consistent guidelines for the assessment of suspicious skin lesions. Devices in limited clinical use are principally used in research settings. Available literature was limited for these devices as well as those still considered investigational. SUMMARY: A review of the literature reveals predominant use of noninvasive devices by dermatologists with limited diffusion of this technology in primary care. When compared with the use of biopsy, future research is needed to evaluate the test accuracies, clinical impact, and the potential adverse events associated with the use of noninvasive imaging technologies.
Download or read book Non Invasive Diagnostic Techniques in Clinical Dermatology written by Enzo Berardesca and published by Springer Science & Business Media. This book was released on 2013-12-02 with total page 464 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a comprehensive but compact guide to the latest technical and technological developments in the growing field of non invasive diagnosis in clinical dermatology. Information is provided on the practical and technical characteristics of a wide range of equipment and methods for in vivo measurements that aid in the investigation of skin function, the evaluation of topically applied products and the monitoring of skin disease. Individual sections are devoted to imaging techniques, skin analysis, superficial skin analysis, skin mechanics, water and stratum corneum hydration and erythema and blood flow. All of the authors are experts in the field, with detailed knowledge of the techniques they describe. Non Invasive Diagnostic Techniques in Clinical Dermatology will be of value for all dermatologists, whether they are engaged in delivering patient care or in research programs, for cosmetic scientists and for biologists involved in skin research and product assessment.
Download or read book Non Invasive Technologies for the Diagnosis and Management of Skin Cancer E Book written by Darrell S. Rigel and published by Elsevier Health Sciences. This book was released on 2017-09-16 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This issue of Dermatologic Clinics, guest edited by Drs. Darrell S. Rigel and Aaron S. Farberg, is devoted to Non-Invasive Technologies for the Diagnosis of Skin Cancer. Articles in this issue include: Current state and issues of clinical inspection; Tele-dermatology applications in skin cancer diagnosis; Enhancing skin cancer diagnosis with dermoscopy; Mole Mapping for management of pigmented skin lesions; Temporal image comparison (Serial Imaging) in assessing pigmented lesions; Multispectral digital skin lesion imaging and analysis; Using reflectance confocal microscopy in skin cancer diagnosis; Optical Coherence Tomography in the diagnosis of skin cancer; Electrical impedance spectroscopy in skin cancer diagnosis; The use of Raman Spectroscopy to detect and diagnose skin cancer; Applying high frequency ultrasound in the diagnosis of skin cancer; Proteomic mass spectrometery imaging for skin cancer diagnosis; Assessing skin cancer using epidermal genetic information retrieved by tape stripping; Smartphone-based applications for skin monitoring and melanoma detection; Detection of aberrations in cellular DNA in diagnosis and assessment of skin cancer; Assessing genetic expression profiles in melanoma diagnosis; Assessing genetic expression profiles in melanoma prognosis; and Integrating skin cancer related technologies into clinical practice.
Download or read book Dermoscopy in General Dermatology written by Aimilios Lallas and published by CRC Press. This book was released on 2018-09-03 with total page 719 pages. Available in PDF, EPUB and Kindle. Book excerpt: This lavishly illustrated guide from experts will enable practitioners to get the most out of dermoscopy for investigations and treatments in general dermatology.
Download or read book Non Invasive Technologies for the Diagnosis and Management of Skin Cancer an Issue of Dermatologic Clinics written by Darrell S. Rigel and published by Elsevier. This book was released on 2017-09-19 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This issue of Dermatologic Clinics, guest edited by Drs. Darrell S. Rigel and Aaron S. Farberg, is devoted to Non-Invasive Technologies for the Diagnosis of Skin Cancer. Articles in this issue include: Current state and issues of clinical inspection; Tele-dermatology applications in skin cancer diagnosis; Enhancing skin cancer diagnosis with dermoscopy; Mole Mapping for management of pigmented skin lesions; Temporal image comparison (Serial Imaging) in assessing pigmented lesions; Multispectral digital skin lesion imaging and analysis; Using reflectance confocal microscopy in skin cancer diagnosis; Optical Coherence Tomography in the diagnosis of skin cancer; Electrical impedance spectroscopy in skin cancer diagnosis; The use of Raman Spectroscopy to detect and diagnose skin cancer; Applying high frequency ultrasound in the diagnosis of skin cancer; Proteomic mass spectrometery imaging for skin cancer diagnosis; Assessing skin cancer using epidermal genetic information retrieved by tape stripping; Smartphone-based applications for skin monitoring and melanoma detection; Detection of aberrations in cellular DNA in diagnosis and assessment of skin cancer; Assessing genetic expression profiles in melanoma diagnosis; Assessing genetic expression profiles in melanoma prognosis; and Integrating skin cancer related technologies into clinical practice.
Download or read book Imaging in Dermatology written by Michael R. Hamblin and published by Academic Press. This book was released on 2016-07-29 with total page 560 pages. Available in PDF, EPUB and Kindle. Book excerpt: Imaging in Dermatology covers a large number of topics in dermatological imaging, the use of lasers in dermatology studies, and the implications of using these technologies in research. Written by the experts working in these exciting fields, the book explicitly addresses not only current applications of nanotechnology, but also discusses future trends of these ever-growing and rapidly changing fields, providing clinicians and researchers with a clear understanding of the advantages and challenges of laser and imaging technologies in skin medicine today, along with the cellular and molecular effects of these technologies. Outlines the fundamentals of imaging and lasers for dermatology in clinical and research settings Provides knowledge of current and future applications of dermatological imaging and lasers Coherently structured book written by the experts working in the fields covered
Download or read book Recent Developments in Therapies and Diagnostic Tools for Melanoma and Non melanoma Skin Cancer written by Taku Fujimura and published by Frontiers Media SA. This book was released on 2021-04-13 with total page 129 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Dermatologic Ultrasound with Clinical and Histologic Correlations written by Ximena Wortsman and published by Springer Science & Business Media. This book was released on 2013-07-02 with total page 620 pages. Available in PDF, EPUB and Kindle. Book excerpt: Significant technological advances have produced equipment that allows imaging of the skin with variable frequency ultrasound in previously unseen detail and provides a range of dynamic data that is currently unmatched by any other technology. Dermatologic Ultrasound with Clinical and Histologic Correlations is a comprehensive introduction to ultrasonography of the skin, nails, and scalp as it relates to the assessment and diagnosis of dermatologic diseases. It provides radiologists, sonographers, dermatologists, and physicians with interest in skin imaging with a concise understanding of the diagnosis of dermatologic conditions through extensive high-resolution gray scale and color Doppler ultrasound images and presents classical correlations of clinical dermatologic lesions with sonographic and histologic findings. Featuring more than 1700 images, this text-atlas provides an excellent starting point in learning about this topic. Featuring contributions from world-renowned authorities in the field of superficial ultrasound imaging, the book reviews the technical considerations relating to color Doppler ultrasound of the skin; surveys the dermatologic entities that can be visualized with ultrasound imaging, such as cutaneous tumors, inflammatory diseases, hemangiomas and vascular malformations, melanoma, nail tumors, scalp diseases and cosmetic conditions; shows common simulators of cutaneous diseases; and discusses protocols for assessing common dermatologic conditions. Inclusion of clinical overviews, tips, and pitfalls enables a better understanding of the pathologies of the disorders and the methodological approach in assessing these entities.
Download or read book Image Guided Dermatologic Treatments written by Robert L. Bard and published by Springer Nature. This book was released on 2019-11-05 with total page 147 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book showcases the latest digital skin imaging, optical/laser systems and advanced immunologic therapies including topics ranging from the basic dermatologic sciences to advanced microscopic and laser optics. The addition of radiologic breakthroughs serves as comprehensive source for the dermatologic community, helping them access sonographic, CT, MRI and nuclear medicine procedures refined for dermatologic and subcutaneous pathologies. In addition, it assists radiologists determine the appropriate imaging technologies for specific clinical dermal disorders. A detailed and up-to-date overview of image-guided treatments is provided. The initial chapters on benign and inflammatory diseases are precursors to advanced chapters on hidradenitis suppurativa and pigmented lesion analysis. A dedicated chapter on melanoma skin cancer and malignant melanoma is followed by updated concepts of melanoma treatment, including genetic markers and PET/CT to monitor therapeutic success. Further chapters address such topics as dermal trauma from foreign bodies and burns, scar imaging, fillers complications and podiatric imaging. Chapters on optical coherence tomography and reflectance confocal microscopy complete the coverage. All chapters were written by dermatologists trained in ultrasound diagnosis, interventional radiologists, dermatopathologists and specialists in advanced optical and microscopic dermatologic analysis, providing a reference guide to noninvasive diagnosis techniques and image guided minimally invasive treatment options. As such, Image Guided Dermatologic Treatments will be an invaluable asset for clinicians in medical and allied fields where dermatologic diagnosis using the least invasive option is required.
Download or read book Pathology and Genetics of Skin Tumours written by International Academy of Pathology and published by IARC. This book was released on 2006 with total page 364 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pathology and Genetics of Skin Tumours is the latest volume in the new WHO series on histological and genetic typing of human tumours. This publication, offers an authorative and concise reference book, providing an international standard for dermatologists, pathologists and oncologists and will serve as an indispensable guide for use in the design of studies monitoring response to therapy and clinical outcome. Diagnostic criteria, pathological features, and associated genetic alterations are described in strictly disease-oriented manner. Sections on all WHO-recognized neoplasms and their variants include ICD-O codes, incidence, age and sex distribution, location, clinical signs and symptoms, pathology, genetics, and predictive factors. The book, prepared by more than 150 authors from 20 countries, contains 648 colour photographs, clinical images and charts, amd more than 2600 references. This volume covers keratinocytic, melanocytic, appendageal, haematopoietic, soft tissue and neural tumours, as well as inherited tumour syndromes. Each entity is extensively discussed with information on clinicopathological, epidemiological, immunophenotypic and genetic aspects of these diseases.
Download or read book Spectral Diagnosis of Skin Cancer written by Narasimhan Rajaram and published by . This book was released on 2010 with total page 224 pages. Available in PDF, EPUB and Kindle. Book excerpt: The number of skin cancer cases reported in the United States is increasing every year and nearly equals the total cancer cases detected from every other part of the body. Current detection strategies of skin cancers include a visual examination followed by a tissue biopsy. This procedure is subjective, invasive and time-consuming. Therefore, considering the number of cancer cases reported and the number biopsies performed, there is a critical need for a non-invasive diagnostic aid to help clinicians reduce the significantly large numbers of unnecessary biopsies. This dissertation presents a quantitative method based on optical spectroscopy for performing a non-invasive 'optical biopsy' of melanoma and non-melanoma skin cancers. We have developed the hardware, software and optical algorithms necessary to implement such a device. First, we present a novel lookup table-based model for determining the optical properties of tissue that is valid for fiber-based probe geometries with close source-detector separations and in highly absorbing tissue. These optical properties are quantitative parameters that can be correlated with the physiology of tissue. Second, we present experimental validation of the effects of microvasculature pigment packaging on diffuse reflectance spectra. We have conducted experiments using microfluidic devices over a physiologically relevant range of optical properties and blood vessel sizes. Third, we present the development of a probe-based portable and clinically compatible instrument capable of in vivo spectral measurements. The instrument combines two modalities -- diffuse reflectance and intrinsic fluorescence spectroscopy -- to provide complementary information regarding tissue morphology, function and biochemical composition. Finally, we present the results of a pilot clinical study using our portable instrument to determine the accuracy of spectral diagnosis of non-melanoma skin cancers. Our results show that the mean optical properties and fluorophore contributions of normal skin and non-melanoma skin cancers are significantly different from each other and can potentially be used as biomarkers for non-invasive diagnosis of skin cancer.
Download or read book Non Surgical Treatment of Keratinocyte Skin Cancer written by Gregor Jemec and published by Springer Science & Business Media. This book was released on 2009-10-13 with total page 218 pages. Available in PDF, EPUB and Kindle. Book excerpt: Books mark the progress of Man since they were invented. Through them we are able to gain insight into the minds of our predecessors better than through any other medium. They describe how the delicate interplay between practice and ideal, which is better known as evolution, has brought forward the societies in which we now live. A book marks the synthesis of knowledge in a different way from individual papers. A certain maturity and volume of understanding and knowledge is necessary before the material is suitable for a book. The timing of the cognitive and analytical synt- sis represented by a book is therefore crucial; too soon and it is lost in speculation, too late and it is old news. Non-melanoma skin cancer is common; it causes morbidity, it causes a burden on society, and treatment has been traditionally almost exclusively surgical. Decades of medical science have however now brought forward a number of techniques which may help both the diagnosis and treatment of skin cancer without physically removing it, either alone or in combination in treatment programs tailored to the individual patients.
Download or read book Atlas of Skin Cancers written by Ali Hendi and published by Springer. This book was released on 2016-08-23 with total page 124 pages. Available in PDF, EPUB and Kindle. Book excerpt: The incidence of skin cancer has risen rapidly in recent decades, and patients often present initially to practitioners in many different specialties. Because skin cancer can vary in clinical appearance, even dermatologists may experience difficulty in reaching a clinical diagnosis. For primary care physicians and physician extenders (physician assistants, nurses, and nurse practitioners), who have had very little or no formal training in dermatology, the task can be still more daunting. In this atlas, the authors set out to provide a practical resource that will help improve the 'visual vocabulary' of physicians and physician extenders, helping them identify lesions that should be biopsied. Hundreds of high-quality color images are included to assist the reader in the task of recognition and identification. All of the common cutaneous malignancies are illustrated, with a number of examples of each entity and of common mimickers. In addition, biopsy techniques and treatment options are presented in step-by step detail with the use of high resolution clinical images, and potential complications of treatment are discussed. This atlas is ideal for all providers who wish to sharpen their clinical acumen and gain confidence in identifying skin cancers.
Download or read book High Risk Cutaneous Squamous Cell Carcinoma written by Chrysalyne D. Schmults and published by Springer. This book was released on 2016-04-29 with total page 261 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a cutting-edge resource that provides clinicians with the up-to-date practical knowledge required in order to manage SCC patients optimally. It summarizes newly available information relating to the definition of high-risk SCC, its pathophysiologic underpinnings, and its management. New prognostic information and staging systems are summarized that enable high-risk tumors to be defined more precisely than ever before. Many helpful tips are provided on the practical management of challenging cases, including multiple tumors/field cancerization, high-risk tumors, nodal metastases, and unresectable disease. The authors are all acknowledged experts in the emerging field of high-risk and advanced SCC.
Download or read book Ultrasound in Dermatology written by Peter Altmeyer and published by Springer. This book was released on 1992 with total page 480 pages. Available in PDF, EPUB and Kindle. Book excerpt:
