Download or read book NK3 written by Michael Tolkin and published by Atlantic Books. This book was released on 2017-09-07 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: A panoramic vision - suspenseful, comedic, prophetic - set in a near-future California that has been devastated by NK3, a memory-destroying virus from North Korea. The H LYW OD sign presides over a Los Angeles devastated by a weaponized microbe that has been accidentally spread around the globe, deleting human identity. In post-NK3 Los Angeles, a sixty-foot-tall fence surrounds the hills where the rich used to live, but the mansions have been taken over by those with the only power that matters: the power of memory. Inside the Fence, life for the new aristocracy, a society of the partially rehabilitated who call themselves the Verified, is a perpetual party. Outside the Fence, in downtown Los Angeles, the Verified use an invented mythology to keep control over the mindless Drifters, Shamblers and Bottle Bangers who serve the gift economy until no longer needed. The ruler, Chief, takes his guidance from gigantic effigies of a man and a woman in the heart of the Fence. They warn him of trouble to come, but who is the person to watch: the elusive Eckmann, holed up with the last functioning plane at LAX; Shannon Squier, the chisel-wielding pop superstar from the pre-NK3 world, pulled from the shambling masses; a treacherous member of Chief's inner circle; or Hopper, the uncommon Drifter compelled by an inner voice to search for a wife whose name and face he doesn't know? Each threatens to upset the delicate power balance in this fragile world. In deliciously dark prose, Tolkin winds a noose-like plot around this melee of despots, prophets and rebels as they struggle for command and survival in a town that still manages to exert a magnetic force, even as a ruined husk.
Download or read book Extracellular Vesicles as Next Generation Therapeutics written by Sylwia Bobis-Wozowicz and published by Frontiers Media SA. This book was released on 2022-06-02 with total page 163 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Tachykinins written by Peter Holzer and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 574 pages. Available in PDF, EPUB and Kindle. Book excerpt: The tachykinins represent one of the most thoroughly investigated family of neuropeptides, whose members and receptors have been characterized at the genetic and molecular level and whose pharmacology has now been advanced to the first clinical application. These exciting accomplishments and prospects are reviewed and discussed in this volume in an authoritative manner. Particular emphasis is laid on the development of selective non-peptide antagonists for all 3 tachykinin receptors and their potential as novel drugs in a variety of diseases. The approval of the first tachykinin receptor antagonist as an antiemetic drug is particularly highlighted, and the utility of tachykinin receptor antagonists in affective disorders, chronic obstructive airway disease and irritable bowel syndrome, to name a few indications, is extensively considered.
Download or read book Class Field Theory written by Nancy Childress and published by Springer Science & Business Media. This book was released on 2008-10-28 with total page 230 pages. Available in PDF, EPUB and Kindle. Book excerpt: Class field theory brings together the quadratic and higher reciprocity laws of Gauss, Legendre, and others, and vastly generalizes them. This book provides an accessible introduction to class field theory. It takes a traditional approach in that it attempts to present the material using the original techniques of proof, but in a fashion which is cleaner and more streamlined than most other books on this topic. It could be used for a graduate course on algebraic number theory, as well as for students who are interested in self-study. The book has been class-tested, and the author has included lots of challenging exercises throughout the text.
Download or read book Tachykinin Receptors Advances in Research and Application 2012 Edition written by and published by ScholarlyEditions. This book was released on 2012-12-26 with total page 41 pages. Available in PDF, EPUB and Kindle. Book excerpt: Tachykinin Receptors—Advances in Research and Application: 2012 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about Tachykinin Receptors in a concise format. The editors have built Tachykinin Receptors—Advances in Research and Application: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Tachykinin Receptors in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Tachykinin Receptors—Advances in Research and Application: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Download or read book Rod Opsins Advances in Research and Application 2012 Edition written by and published by ScholarlyEditions. This book was released on 2012-12-26 with total page 54 pages. Available in PDF, EPUB and Kindle. Book excerpt: Rod Opsins—Advances in Research and Application: 2012 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about Rod Opsins in a concise format. The editors have built Rod Opsins—Advances in Research and Application: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Rod Opsins in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Rod Opsins—Advances in Research and Application: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Download or read book Frontiers in CNS Drug Discovery written by Atta-ur Rahman and published by Bentham Science Publishers. This book was released on 2011-08-12 with total page 653 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Frontiers in CNS Drug Discovery" is an Ebook series devoted to publishing the latest and the most important advances in Central Nervous System (CNS) drug design and discovery. Eminent scientists write contributions on all areas of rational drug design an
Download or read book Handbook of Biologically Active Peptides written by Abba Kastin and published by Elsevier. This book was released on 2011-04-28 with total page 1682 pages. Available in PDF, EPUB and Kindle. Book excerpt: Peptides play a crucial role in many physiological processes including actions as neurotransmitters, hormones, and antibiotics. Research has shown their importance in such fields as neuroscience, immunology, pharmacology, and cell biology. The Handbook of Biologically Active Peptides presents, for the first time, this tremendous body of knowledge in the field of biologically active peptides in one single reference. The section editors and contributors represent some of the most sophisticated and distinguished scientists working in basic sciences and clinical medicine. The Handbook of Biologically Active Peptides is a definitive, all-encompassing reference that will be indispensable for individuals ranging from peptide researchers, to biochemists, cell and molecular biologists, neuroscientists, pharmacologists, and to endocrinologists. Chapters are designed to be a source for workers in the field and will enable researchers working in a specific area to examine other related areas with which they would not ordinarily be familiar.*Chapters are designed to be a source for workers in the field and will enable researchers working in a specific area to examine other related areas that they would not ordinarily be familiar.*Fascinating relationships described in the book include the presence of some peptides originally found in frog skin that persist in the human human and brain where they can affect food intake and obesity.
Download or read book Targets and Emerging Therapies for Schizophrenia written by Jeffrey S. Albert and published by John Wiley & Sons. This book was released on 2012-06-06 with total page 565 pages. Available in PDF, EPUB and Kindle. Book excerpt: New and emerging directions in pharmaceutical research to better treat schizophrenia Although the dopamine hypothesis has been the cornerstone of schizophrenia therapeutics, it is clear that dopamine-based approaches do not treat all aspects of the disease. Moreover, many schizophrenia patients fail to respond to current antipsychotics. Integrating chemistry, biology, and pharmacology, this book explores emerging directions in pharmaceutical research for drug targeting and discovery in order to find more effective treatments for schizophrenia, one of the most serious and widespread psychiatric diseases. Targets and Emerging Therapies for Schizophrenia presents the basics of schizophrenia, drug targets for the disease, and potential new drugs and therapeutics. It begins with a discussion of prevalence and etiology. Then, it describes therapies such as dopamine agonists and phosphodiesterase (PDE) inhibitors as well as growing research aimed at addressing untreated symptoms. Next, the authors discuss receptor modulators, inhibitors, and targeting strategies for drug discovery. Both the neurobiological and chemical aspects of all major pharmacological targets are examined. With contributions from an international team of pioneering pharmaceutical researchers, this book compiles the current knowledge in the field, setting the stage for new breakthroughs in the treatment of schizophrenia. Targets and Emerging Therapies for Schizophrenia: Provides a comprehensive resource for neuro-drug discovery and the development of molecular targets for schizophrenia treatment Draws from chemistry, biology, and pharmacology for more effective drug targeting and discovery Explores a wide range of receptors and molecular targets, including dopamine, PDEs, and neuropeptides With Targets and Emerging Therapies for Schizophrenia as their guide, drug discovery and development scientists have the information they need to advance their own research so that new, more effective treatments for schizophrenia will soon be a reality.
Download or read book Encyclopedia of Neuroscience Volume 1 written by Larry R. Squire and published by Academic Press. This book was released on 2009-06-12 with total page 12505 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Encyclopedia of the Neuroscience explores all areas of the discipline in its focused entries on a wide variety of topics in neurology, neurosurgery, psychiatry and other related areas of neuroscience. Each article is written by an expert in that specific domain and peer reviewed by the advisory board before acceptance into the encyclopedia. Each article contains a glossary, introduction, a reference section, and cross-references to other related encyclopedia articles. Written at a level suitable for university undergraduates, the breadth and depth of coverage will appeal beyond undergraduates to professionals and academics in related fields.
Download or read book Progress in Medicinal Chemistry written by and published by Elsevier. This book was released on 1998-07-03 with total page 268 pages. Available in PDF, EPUB and Kindle. Book excerpt: Eminent scientists at the cutting edge of pharmacology and medicinal chemistry research provide us with yet another excellent addition to this famous series. The focus on bacterial resistance mechanisms serves to highlight an important area of unmet medical need requiring the attention of medicinal chemists. Five topical subjects are reviewed: the biosynthesis, metabolism and function of Vitamin D3 and the potential application of its analogues in bone disorders and immune-related diseases; the therapeutic potential of neurokinin antagonists; opioid receptor antagonists; the mechanisms of bacterial resistance; and a survey of recent advances in cannabinoid research. This volume will deservedly take its place in clinical and industrial pharmaceutical libraries, and will prove invaluable to medicinal chemists.
Download or read book Progress in Medicinal Chemistry written by F.D. King and published by Gulf Professional Publishing. This book was released on 2005-06-14 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt: Annotation The complex and multidisciplinary nature of modern drug discovery is well illustrated in the six chapters of this volume that describe exciting developments in both newly emerging and mature areas of medicinal chemistry. Chapter 1 provides a comprehensive review of therapeutic applications of ligands for peroxisome proliferator-activated receptor gamma PPAR?, a key regulator of glucose and lipid homeostasis. Progress over the last decade on ligands that bind to central nicotinic acetylcholine receptors is timely reviewed in Chapter 2, with the emphasis on the a4ß2 subtype. Chapter 3 reviews inhibitors of PARP-1, the founding member of the family, with the focus on their therapeutic potential in ischaemia related CNS injuries. Chapter 4 describes the structure-activity relationships of some semi-synthetic analogues including promising new compounds in development. Chapter 5 describes selective, first generation, non-peptidic neuropeptide Y1 and Y2 antagonists and their actions and evaluates their potential therapeutic application in cardiovascular disorders, with the emphasis on NPY1 antagonists. Chapter 6 is an extensive review of the considerable progress that has been achieved in developing Cathepsin K inhibitors and evaluates their potential for treating arthritis and atherosclerosis.
Download or read book Annual Reports in Medicinal Chemistry written by Annette M. Doherty and published by Academic Press. This book was released on 2003-09-10 with total page 484 pages. Available in PDF, EPUB and Kindle. Book excerpt: Annual Reports in Medicinal Chemistry provides timely and critical reviews of important topics in medicinal chemistry together with an emphasis on emerging topics in the biological sciences, which are expected to provide the basis for entirely new future therapies. Sections I-IV are disease-orientated and generally report on specific medicinal agents. Sections V-VI continue to emphasize important topics in medicinal chemistry, biology and drug design. In addition to the chapter reviews, a comprehensive set of indices has been included to enable the reader to easily locate topics in Volumes 1-38 of this series.
Download or read book Molecular Biology of Membrane Bound Complexes in Phototrophic Bacteria written by Gerhart Drews and published by Springer Science & Business Media. This book was released on 2013-11-27 with total page 484 pages. Available in PDF, EPUB and Kindle. Book excerpt: A selection of 56 papers from a symposium in Breisgan, Germany, in August 1989. Treats the structure and regulation of genes coding for pigment-binding membrane proteins and enzymes for bacteriochlorophyll, carotenoid, and cytochrome synthesis under the control of oxygen and light gradients. Discussions of the composition, structure, organization,
Download or read book Neurogenic Inflammation in Health and Disease written by and published by Newnes. This book was released on 2008-11-11 with total page 371 pages. Available in PDF, EPUB and Kindle. Book excerpt: Morphological and functional studies revealed a complex system of primary sensory neurons that parallels the autonomic nervous system not only in its extent, but probably also in its significance. Neuropeptides released from activated nociceptive afferent nerves play a pivotal role in inflammatory reactions and pain, significantly modulate cardiac, vascular, respiratory, gastrointestinal and immune functions and influence the protective, restorative and trophic functions of somatic and visceral tissues. Several chapters of the book deal with the therapeutic potential of a new class of putative pain relieving agents acting through TRPV1, the capsaicin/vanilloid receptor, a specific ion channel that transmits pain. - Neurogenic inflammation in historical perspective - Cardiac protection by nociceptive afferents - Molecular mechanisms of nociception - Sensory mechanisms in migraine pathophysiology - Vagal signaling of visceral inflammation - Neurogenic mechanisms in arthritis - Therapeutic implications of vanilloid-type compounds
Download or read book Lymphocyte Activation and Differentiation written by J. C. Mani and published by Walter de Gruyter GmbH & Co KG. This book was released on 2019-07-08 with total page 984 pages. Available in PDF, EPUB and Kindle. Book excerpt: No detailed description available for "Lymphocyte Activation and Differentiation".
Download or read book Neuropeptide Technology written by P. Michael Conn and published by Academic Press. This book was released on 2013-10-22 with total page 589 pages. Available in PDF, EPUB and Kindle. Book excerpt: Methods in Neurosciences, Volume 5: Neuropeptide Technology: Gene Expression and Neuropeptide Receptors discusses procedures and tools of assay useful for the identification, purification, and quantification of neuropeptides and their receptors. This volume is divided into two sections—neuropeptide gene expression and neuropeptide receptors. In these sections, this book specifically discusses the assays for peptide products of somatostatin gene expression; molecular assays for rat thyrotropin-releasing hormone gene; and structure, expression, and chromosomal localization of human gene. The gastrin-releasing peptide or mammalian bombesin; semiquantitative analysis of cellular somatostatin mRNA Levels; and atrial natriuretic factor receptor assays are also elaborated. This text likewise covers the receptors for opioid peptides in brain and autoradiography of somatostatin receptors in rat cerebellum. This publication is beneficial to neuroscientists and students intending to acquire knowledge of gene expression and neuropeptide receptors.
