Download or read book New Insights into the Complexity of Tumor Immunology in B cell Malignancies Tumor Immunology and Immunotherapy written by Jérôme Paggetti and published by Frontiers Media SA. This book was released on 2022-03-02 with total page 191 pages. Available in PDF, EPUB and Kindle. Book excerpt: Topic Editor MS received funding from Bayer AG.
Download or read book New Insights into the Complexity of Tumor Immunology in B cell Malignancies Disease Biology and Signaling written by Jérôme Paggetti and published by Frontiers Media SA. This book was released on 2022-01-31 with total page 164 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book New Insights into the Complexity of Tumor Immunology in B cell Malignancies Prognostic and Predictive Biomarkers and Therapy written by Jérôme Paggetti and published by Frontiers Media SA. This book was released on 2022-06-23 with total page 127 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Advances in Tumor Immunology and Immunotherapy written by Joseph D. Rosenblatt and published by Springer Science & Business Media. This book was released on 2013-10-25 with total page 369 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent advances in understanding of fundamental immunology have created new insights into the dynamic interactions between tumors and the immune system. This includes new understanding of T- and B-cell interaction, immune inhibitory mechanisms including the biology of T regulatory cells, myeloid suppressor cells, and dendritic cell subsets. Enhanced understanding of mechanisms underlying T-cell anergy such as arginine deprivation, immunosuppressive cytokines, defective innate and interferon response pathways, and NKG2D downregulation have all provided new insight into suppression of anti-tumor immunity and tumor evasion. In addition to emerging understanding of tumor evasion, new immune targets such as CTLA4 blockade, NK stimulatory receptors, manipulation of the antigen processing and presentation, cytokine and costimulatory responses all provide new possibilities for enhancing anti-tumor immunity even in tumors previously felt to be resistant to immune attack. Several of these strategies have already been realized in the clinic. The volume will explore evolving paradigms in antigen presentation, dendritic cell biology, the innate response and immunosuppressive mechanisms, and emerging strategies for manipulation of the immune system for therapeutic benefit that have realized success in neuroblastoma, leukemia, melanoma, lung cancer, and allogeneic transplantation. Early successes as well as failures will be highlighted to provide a snapshot of the state of clinical immunotherapy with an eye to future possibilities such as combination therapies, adoptive T-cell transfer, and the retargeting of immune cells via T-cell receptor engineering.
Download or read book Tumor Immunology and Immunotherapy written by Robert C. Rees and published by OUP Oxford. This book was released on 2014-05-29 with total page 496 pages. Available in PDF, EPUB and Kindle. Book excerpt: Patients are beginning to benefit from antibody based, cellular and vaccine approaches that are effective against genetically diverse and therapy-resistance cancers. BCG immunotherapy is now being used as a first line treatment for human bladder cancer and the introduction of prophylactic vaccination against Hepatitis B and HPV cancers is starting to show positive results. Following recent FDA approval for a vaccination against prostate cancer, and optimistic results in clinical trials for a vaccine targeting cancer antigens in lung cancer, cancer immunotherapy is now significantly impacting patient clinical management. Tumor Immunology and Immunotherapy provides an up-to-date and comprehensive account of cancer immunity and immunotherapy. It discusses our adaptive and innate immunity to cancer, the mechanisms underpinning our immune response, current approaches to cancer immunotherapy, and how tumour and host responses can circumvent effective anti-cancer immunity. The book examines recent results, publications and current areas of interest including 'immune editing' and the specific issues that are affecting the research and development of vaccines, providing insight into how these problems may be overcome, as viewed by world leaders in the field. Tumor Immunology and Immunotherapy will appeal to clinicians working in oncology and cancer immunotherapy, and research scientists including PhD and masters students, post-doctoral researchers and senior investigators.
Download or read book Lymphocyte Updates written by Gheorghita Isvoranu and published by BoD – Books on Demand. This book was released on 2017-07-12 with total page 194 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book represents a synergic effort of an international team of specialists in immunology to expand the scientific achievements in the field of lymphocytes. It offers important and specific updated information to researchers, students, teachers, and medical professionals. Moreover, considering the remarkable dynamics of immunology and immunotherapy, this book "Lymphocyte Updates - Cancer, Autoimmunity, and Infection" aims to represent a significant source of concise scientific data and advancement of knowledge in this field. The chapters offer new insights into the latest scientific progress on lymphocyte roles in protective immunity, as well as their involvement in pathogenesis of various disorders.
Download or read book Cancer Immunology and Immunotherapy written by Glenn Dranoff and published by Springer Science & Business Media. This book was released on 2011-04-11 with total page 313 pages. Available in PDF, EPUB and Kindle. Book excerpt: The interplay between tumors and their immunologic microenvironment is complex, difficult to decipher, but its understanding is of seminal importance for the development of novel prognostic markers and therapeutic strategies. The present review discusses tumor-immune interactions in several human cancers that illustrate various aspects of this complexity and proposes an integrated scheme of the impact of local immune reactions on clinical outcome. Current active immunotherapy trials have shown durable tumor regressions in a fraction of patients. However, clinical efficacy of current vaccines is limited, possibly because tumors skew the immune system by means of myeloid-derived suppressor cells, inflammatory type 2 T cells and regulatory T cells (Tregs), all of which prevent the generation of effector cells. To improve the clinical efficacy of cancer vaccines in patients with metastatic disease, we need to design novel and improved strategies that can boost adaptive immunity to cancer, help overcome Tregs and allow the breakdown of the immunosuppressive tumor microenvironment.
Download or read book Tumor Immunology written by A. G. Dalgleish and published by Cambridge University Press. This book was released on 2010-11-25 with total page 374 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume reviews advances in the field of human tumor immunology, particularly in relation to the potential for immune intervention in preventing or treating tumors. The editors and contributors, all leading workers in the field, survey advances in the understanding of the relationship between the cancer cell and the immune response. Chapters review in depth the function of immune surveillance and mechanisms of tumor immunity, the role of T lymphocytes and oncogenes in the immune response to cancer, and the potential for immunotherapy of cancer. New areas of tumor immunology are presented, including recent progress in the development of tumor vaccines with particular reference to melanoma.
Download or read book Immune Checkpoint Inhibitors written by Afsheen Raza and published by BoD – Books on Demand. This book was released on 2023-03-08 with total page 214 pages. Available in PDF, EPUB and Kindle. Book excerpt: Immune Checkpoint Inhibitors - New Insights and Recent Progress explores a vast array of subjects related to immune checkpoint inhibitors and presents novel insights in this emerging field. Chapters address such topics as mechanistic approaches of emerging immune checkpoint inhibitors, their role in clinical and pre-clinical trials, the manipulation of the system by immune-related adverse events that hinder the utility of these immune molecules, and the predictive and prognostic aspects of these molecules as biomarkers of response in immunotherapy. The book is useful for students, clinicians, and scientists to gain updated information on managing patients treated with immune checkpoint inhibitors.
Download or read book New insights into innate immune cell based immunotherapies in cancer written by Mary Poupot-Marsan and published by Frontiers Media SA. This book was released on 2024-04-17 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Cancer Immunotherapy written by George C. Prendergast and published by Elsevier Inc. Chapters. This book was released on 2013-06-04 with total page 684 pages. Available in PDF, EPUB and Kindle. Book excerpt: Immunological thought is exerting a growing effect in cancer research, correcting a divorce that occurred in the mainstream of the field decades ago as cancer genetics began to emerge as a dominant movement. During the past decade, a new general consensus has emerged among all cancer researchers that inflammation and immune escape play crucial causal roles in the development and progression of malignancy. This consensus is now driving a new synthesis of thought with great implications for cancer treatments of the future. This book introduces new concepts and practices that will dramatically affect oncology by adding new immune modalities to present standards of care in surgery, radiotherapy and chemotherapy. Its aim is to cross-fertilize ideas in the new area of immunochemotherapy, which strives to develop new combinations of immunological and pharmacological agents as cancer therapeutics. Specifically, our goals are to (1) highlight novel principles of immune suppression in cancer, which represent the major salient breakthroughs in the field of cancer immunology the last decade, and to (2) discuss the latest thinking in how immunotherapeutic and chemotherapeutic agents might be combined, not only to defeat mechanisms of tumoral immune suppression but also to reprogram the inflammatory microenvironment of tumor cells to enhance the long-term outcomes of clinical intervention. Many immune-based therapies have focused on activating the immune system. However, it is now clear that these therapies are often thwarted by the ability of cancers to erect barricades that evade or suppress the immune system. Mechanistic insights into these barricades have enormous medical implications, not only to treat cancer but also many chronic infectious and age-associated diseases where relieving pathogenic immune tolerance is a key challenge. In this book, contributors with a wide diversity of perspectives and experience provide an introductory overview to the immune system; how tumors evolve to evade the immune system; the nature of various approaches used presently to treat cancer in the oncology clinic; and how these approaches might be enhanced by inhibiting important mechanisms of tumoral immune tolerance and suppression. The overarching aim of this treatise is to provide a conceptual foundation to create a more effective all-out attack on cancer. This chapter offers a historical perspective on the development of immunological thought in cancer, a discussion of some of the fundamental challenges to be faced, and an overview of the chapters which frame and address these challenges.
Download or read book Cancer Immunotherapy written by George C. Prendergast and published by Academic Press. This book was released on 2013-06-04 with total page 679 pages. Available in PDF, EPUB and Kindle. Book excerpt: There has been major growth in understanding immune suppression mechanisms and its relationship to cancer progression and therapy. This book highlights emerging new principles of immune suppression that drive cancer, and it offers radically new ideas about how therapy can be improved by attacking these principles. Following work that firmly establishes immune escape as an essential trait of cancer, recent studies have now defined specific mechanisms of tumor immune suppression. It also demonstrates how attacking tumors with molecular targeted therapeutics or traditional chemotherapeutic drugs can produce potent anti-tumor effects in preclinical models. This book provides basic, translational, and clinical cancer researchers with an indispensable overview of immune escape as a critical trait in cancer and how applying specific combinations of immunotherapy and chemotherapy to attack this trait may radically improve the treatment of advanced disease. Offers a synthesis of concepts that are useful to cancer immunologists and pharmacologists, who tend to work in disparate fields with little cross-communication Drs. Prendergast and Jaffee are internationally recognized leaders in cancer biology and immunology who have created a unique synthesis of fundamental and applied concepts in this important new area of cancer research Summarizes the latest insights into how immune escape defines an essential trait of cancer Includes numerous illustrations, including how molecular-targeted therapeutic drugs or traditional chemotherapy can be combined with immunotherapy to improve anti-tumor efficacy and how reversing immune suppression by the tumor can cause tumor regression
Download or read book The Tumor Immunoenvironment written by Michael R Shurin and published by Springer Science & Business Media. This book was released on 2013-03-19 with total page 745 pages. Available in PDF, EPUB and Kindle. Book excerpt: Analysis of multidirectional immunological responses at the tumor site allows forming a new concept of The Tumor Immunoenvironment, which is introduced and discussed in the present book with a particular focus on the role of immune cells in controlling the tumor microenvironment at different stages of cancer development. The main goal of this publication is to provide an overview of the current knowledge on the complex and unique role of the immune system, tumor-associated inflammation and tumor-mediated immunomodulation in cancer progression in a way that allows understanding the logistics of cellular and molecular interactions in the tumor lesions.
Download or read book Tumor Immunology and Cancer Therapy written by R. H. Goldfarb and published by CRC Press. This book was released on 2020-07-24 with total page 346 pages. Available in PDF, EPUB and Kindle. Book excerpt: Based on a Tumor Immunology Symposium held in Pittsburgh, this work provides comprehensive coverage of the most important aspects of tumor immunology. It reveals novel approaches to the immunotherapy of cancer and presents complex issues in an accessible manner.
Download or read book Tumor Induced Immune Suppression written by Dmitry I. Gabrilovich and published by Springer Science & Business Media. This book was released on 2014-02-10 with total page 471 pages. Available in PDF, EPUB and Kindle. Book excerpt: Tumor-Induced Immune Suppression - Prospects and Progress in Mechanisms and Therapeutic Reversal presents a comprehensive overview of large number of different mechanisms of immune dysfunction in cancer and therapeutic approaches to their correction. This includes the number of novel mechanisms that has never before been discussed in previous monographs. The last decades were characterized by substantial progress in the understanding of the role of the immune system in tumor progression. Researchers have learned how to manipulate the immune system to generate tumor specific immune response, which raises high expectations for immunotherapy to provide breakthroughs in cancer treatment. It is increasingly clear that tumor-induced abnormalities in the immune system not only hampers natural tumor immune surveillance, but also limits the effect of cancer immunotherapy. Therefore, it is critically important to understand the mechanisms of tumor-induced immune suppression to make any progress in the field and this monograph provides these important insights.
Download or read book General Principles of Tumor Immunotherapy written by Howard L. Kaufman and published by Springer Science & Business Media. This book was released on 2007-10-12 with total page 502 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book brings together the world’s leading authorities on tumor immunology. This book describes the basic immunology principles that form the foundation of understanding how the immune system recognizes and rejects tumor cells. The role of the innate and adaptive immune responses is discussed and the implications of these responses for the design of clinical strategies to combat cancer are illustrated.
Download or read book Cancer Vaccines and Tumor Immunity written by Rimas Orentas and published by John Wiley & Sons. This book was released on 2007-10-26 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer Vaccines and Tumor Immunity offers a review of the basic scientific discoveries that have moved forward into clinical trials. Presented in the context of real-world human research and experimentation, these major scientific advances demonstrate how our understanding of immune activation, T-regulatory cells, and autoimmunity will impact cancer vaccine design. The authors also explain how vaccination in the context of bone marrow transplantation will open new avenues for clinical study in the future.
