Download or read book New Frontiers and Applications of Synthetic Biology written by Vijai Singh and published by Academic Press. This book was released on 2022-01-12 with total page 487 pages. Available in PDF, EPUB and Kindle. Book excerpt: New Frontiers and Applications of Synthetic Biology presents a collection of chapters from eminent synthetic biologists across the globe who have established experience and expertise working with synthetic biology. This book offers several important areas of synthetic biology which allow us to read and understand easily. It covers the introduction of synthetic biology and design of promoter, new DNA synthesis and sequencing technology, genome assembly, minimal cells, small synthetic RNA, directed evolution, protein engineering, computational tools, de novo synthesis, phage engineering, a sensor for microorganisms, next-generation diagnostic tools, CRISPR-Cas systems, and more. This book is a good source for not only researchers in designing synthetic biology, but also for researchers, students, synthetic biologists, metabolic engineers, genome engineers, clinicians, industrialists, stakeholders and policymakers interested in harnessing the potential of synthetic biology in many areas. - Offers basic understanding and knowledge in several aspects of synthetic biology - Covers state-of-the-art tools and technologies of synthetic biology, including promoter design, DNA synthesis, DNA sequencing, genome design, directed evolution, protein engineering, computational tools, phage design, CRISPR-Cas systems, and more - Discusses the applications of synthetic biology for smart drugs, vaccines, therapeutics, drug discovery, self-assembled materials, cell free systems, microfluidics, and more

Download or read book New Frontiers in Chemical Biology written by Mark E. Bunnage and published by Royal Society of Chemistry. This book was released on 2011 with total page 329 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book highlights the new frontiers in chemical biology and describes their impact and future potential in drug discovery.

Download or read book New Frontiers of Molecular Epidemiology of Infectious Diseases written by Serge Morand and published by Springer Science & Business Media. This book was released on 2011-09-08 with total page 335 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular epidemiology has recently broaden its focuses due to the development of molecular tools but also by incorporating advances of other fields such as mathematical epidemiology, molecular ecology, population genetics and evolution. Facing new risks of emerging and re-emerging infectious diseases that are threats for humans and their livestock, the objectives of molecular epidemiology include: - the development of molecular tools, genotyping and gene expression - the incorporation of concepts and results of population genetics of infectious diseases - the integration of recent advances in theoretical epidemiology and evolutionary ecology of diseases - a better understanding of transmission for the development of risk factors analyses. This book will demonstrate how the latest developments in molecular tools and in epidemiology can be integrated with studies of host-pathogen interactions. Besides a strong theoretical component, there will also be an emphasis on applications in the fields of epidemiology, public health, veterinary medicine, and health ecology. Students and researchers in the fields of epidemiology, animal and human health, evolutionary ecology, parasitology are the main potential readers of the book, as well as a broader audience from veterinary medicine and conservation.

Download or read book New Frontiers in Astrobiology written by Rebecca Thombre and published by Elsevier. This book was released on 2022-06-18 with total page 340 pages. Available in PDF, EPUB and Kindle. Book excerpt: New Frontiers in Astrobiology presents a simple and concise overview of the emerging field of astrobiology. Astrobiology studies the evolution, origin, and future of life on Earth and beyond. This book provides a brief overview of the current research and future status of this fascinating field. The book covers a wide range of topics from the history of astrobiology, the big bang, prebiotic chemistry, theories of the origin of life, extreme environments on Earth, and the quest for intelligent life in space. Currently, there is a critical gap in knowledge related to the future scope of astrobiology and its applications in science and society. The hallmark of the book is that it takes critical perspectives to analyze the new frontiers in astrobiology post Mars 2020/ExoMars missions that encompass the latestdevelopments in the detection of biosignatures and habitability beyond our Solar System (exomoons, exoplanets). The book will be a valuable resource for students, researchers, and scientists who seek greater insights into understanding the current status and future of astrobiology. - Explores the background and historical developments in astrobiology - Provides concise cutting-edge reviews on fundamental questions on origin and distribution of life on Earth, habitability beyond Earth, and future of life on Earth - Integrates contemporary and critical views in new frontiers in astrobiology

Download or read book Cell Molecular Biology of Prostate Cancer written by Heide Schatten and published by Springer. This book was released on 2018-09-18 with total page 135 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume covers classic and modern cell and molecular biology of prostate cancer, as well as novel biomarkers, inflammation, centrosome pathologies, microRNAs, cancer initiation novel biomarkers, inflammation, centrosome pathologies, microRNAs, cancer initiation and genetics, epigenetics, mitochondrial dysfunctions and apoptosis, cancer stem cells, angiogenesis and progression to metastasis, and treatment strategies including clinical trials related to prostate cancer. Cell & Molecular Biology of Prostate Cancer is one of two companion books comprehensively addressing the biology and clinical aspects of prostate cancer. Prostate Cancer: Molecular & Diagnostic Imaging and Treatment Stategies, the companion volume, discusses both classic and the most recent imaging approaches including analysis of needle biopsies, applications of nanoparticle probes and peptide-based radiopharmaceuticals for detection, early diagnosis and treatment of prostate cancer. Taken together, these volumes form one comprehensive and invaluable contribution to the literature.

Download or read book Proteome Research written by Marc R. Wilkins and published by Springer Science & Business Media. This book was released on 1997 with total page 270 pages. Available in PDF, EPUB and Kindle. Book excerpt: Introduction to the proteome (K. L. Williams, D. F. Hochstrasser). Two-dimensional electrophoresis: the state of the art and future directions (B. R. Herbert, J.-C. Sanchez, L. Bini). large-scale comparative protein modeling ( M. C. Peitsch, N. Guex); Clinical and biomedical applications of proteomics (D. F. Hochstrasser). Biological applications of proteomics (K. L. Williams, V. Pallini). Conclusions (D. F. Hochstrasser, L. Williams). Index.

Download or read book Frontiers and Advances in Molecular Spectroscopy written by Jaan Laane and published by Elsevier. This book was released on 2017-11-13 with total page 788 pages. Available in PDF, EPUB and Kindle. Book excerpt: Frontiers and Advances in Molecular Spectroscopy once again brings together the most eminent scientists from around the world to describe their work at the cutting-edge of molecular spectroscopy. Much of what we know about atoms, molecules and the nature of matter has been obtained using spectroscopy over the last one hundred years or so. Going far beyond the topics discussed in Jaan Laane's earlier book on the subject, these chapters describe new methodologies and applications, instrumental developments and theory, which are taking spectroscopy into still new frontiers. The robust range of topics once again demonstrates the wide utility of spectroscopic techniques. New topics include ultrafast spectroscopy of the transition state, SERS/far-uv spectroscopy, femtosecond coherent anti-Stokes Raman spectroscopy, high-resolution laser induced fluorescence spectroscopy, Raman spectroscopy and biosensors, vibrational optical activity, ultrafast two-dimensional spectroscopy, biology with x-ray lasers, isomerization dynamics and hydrogen bonding, single molecule imaging, spectra of intermediates, matrix isolation spectroscopy and more. - Covers spectroscopic investigations on the cutting edge of science - Written and edited by leading experts in their respective fields - Allows researchers to access a broad range of essential modern spectroscopy content from a single source rather than wading through hundreds of scattered journal articles

Download or read book Frontiers in Computational and Systems Biology written by Jianfeng Feng and published by Springer Science & Business Media. This book was released on 2010-06-14 with total page 411 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biological and biomedical studies have entered a new era over the past two decades thanks to the wide use of mathematical models and computational approaches. A booming of computational biology, which sheerly was a theoretician’s fantasy twenty years ago, has become a reality. Obsession with computational biology and theoretical approaches is evidenced in articles hailing the arrival of what are va- ously called quantitative biology, bioinformatics, theoretical biology, and systems biology. New technologies and data resources in genetics, such as the International HapMap project, enable large-scale studies, such as genome-wide association st- ies, which could potentially identify most common genetic variants as well as rare variants of the human DNA that may alter individual’s susceptibility to disease and the response to medical treatment. Meanwhile the multi-electrode recording from behaving animals makes it feasible to control the animal mental activity, which could potentially lead to the development of useful brain–machine interfaces. - bracing the sheer volume of genetic, genomic, and other type of data, an essential approach is, ?rst of all, to avoid drowning the true signal in the data. It has been witnessed that theoretical approach to biology has emerged as a powerful and st- ulating research paradigm in biological studies, which in turn leads to a new - search paradigm in mathematics, physics, and computer science and moves forward with the interplays among experimental studies and outcomes, simulation studies, and theoretical investigations.

Download or read book New Frontiers of Network Analysis in Systems Biology written by Avi Ma'ayan and published by Springer Science & Business Media. This book was released on 2012-06-25 with total page 204 pages. Available in PDF, EPUB and Kindle. Book excerpt: The rapidly developing field of systems biology is influencing many aspects of biological research and is expected to transform biomedicine. Some emerging offshoots and specialized branches in systems biology are receiving particular attention and are becoming highly active areas of research. This collection of invited reviews describes some of the latest cutting-edge experimental and computational advances in these emerging sub-fields of systems biology. In particular, this collection focuses on the study of mammalian embryonic stem cells; new technologies involving mass-spectrometry proteomics; single cell measurements; methods for modeling complex stochastic systems; network-based classification algorithms; and the revolutionary emerging field of systems pharmacology.

Download or read book Protein protein Recognition written by Colin Kleanthous and published by Frontiers in Molecular Biology. This book was released on 2000 with total page 370 pages. Available in PDF, EPUB and Kindle. Book excerpt: The purpose of Protein-Protein Recognition is to bring together concepts and systems pertaining to protein-protein interactions in a single unifying volume. In the light of the information from the genome sequencing projects and the increase in structural information it is an opportune time totry to make generalizations about how and why proteins form complexes with each other. The emphasis of the book is on heteromeric complexes (complexes in which each of the components can exist in an unbound state) and will use well-studied model systems to explain the processes of formingcomplexes. After an introductory section on the kinetics, thermodynamics, analysis, and classification of protein-protein interactions, weak, intermediate, and high affinity complexes are dealt with in turn. Weak affinity complexes are represented by electron transfer proteins and integrincomplexes. Anti-lysozyme antibodies, the MHC proteins and their interactions with T-cell receptors, and the protein interactions of eukaryotic signal transduction are the systems used to explain complexes with intermediate affinities. Finally, tight binding complexes are represented by theinteraction of protein inhibitors with serine proteases and by nuclease inhibitor complexes. Throughout the chapters common themes are the technologies which have had the greatest impact, how specificity is determined, how complexes are stabilized, and medical and industrial applications.

Download or read book Prokaryotic Gene Expression written by Simon Baumberg and published by OUP Oxford. This book was released on 1999-05-27 with total page 350 pages. Available in PDF, EPUB and Kindle. Book excerpt: Prokaryotic gene expression is not only of theoretical interest but also of highly practical significance. It has implications for other biological problems, such as developmental biology and cancer, brings insights into genetic engineering and expression systems, and has consequences for important aspects of applied research. For example, the molecular basis of bacterial pathogenicity has implications for new antibiotics and in crop development. Prokaryotic Gene Expression is a major review of the subject, providing up-to-date coverage as well as numerous insights by the prestigious authors. Topics covered include operons; protein recognition of sequence specific DNA- and RNA-binding sites; promoters; sigma factors, and variant tRNA polymerases; repressors and activators; post-transcriptional control and attenuation; ribonuclease activity, mRNA stability, and translational repression; prokaryotic DNA topology, topoisomerases, and gene expression; regulatory networks, regulatory cascades and signal transduction; phosphotransfer reactions; switch systems, transcriptional and translational modulation, methylation, and recombination mechanisms; pathogenicity, toxin regulation and virulence determinants; sporulation and genetic regulation of antibiotic production; origins of regulatory molecules, selective pressures and evolution of prokaryotic regulatory mechanisms systems. Over 1100 references to the primary literature are cited. Prokaryotic Gene Expression is a comprehensive and authoritative review of current knowledge and research in the area. It is essential reading for postgraduates and researchers in the field. Advanced undergraduates in biochemistry, molecular biology, and microbiology will also find this book useful.

Download or read book Frontiers of Molecular Spectroscopy written by Jaan Laane and published by Elsevier. This book was released on 2011-08-11 with total page 741 pages. Available in PDF, EPUB and Kindle. Book excerpt: Much of what we know about atoms, molecules, and the nature of matter has been obtained using spectroscopy over the last one hundred years or so. In this book we have collected together twenty chapters by eminent scientists from around the world to describe their work at the cutting edge of molecular spectroscopy. These chapters describe new methodology and applications, instrumental developments, and theory which is taking spectroscopy into new frontiers. The range of topics is broad. Lasers are utilized in much of the research, but their applications range from sub-femtosecond spectroscopy to the study of viruses and also to the investigation of art and archeological artifacts. Three chapters discuss work on biological systems and three others represent laser physics. The recent advances in cavity ringdown spectroscopy (CRDS), surface enhanced Raman spectroscopy (SERS), two-dimensional correlation spectroscopy (2D-COS), and microwave techniques are all covered. Chapters on electronic excited states, molecular dynamics, symmetry applications, and neutron scattering are also included and demonstrate the wide utility of spectroscopic techniques. - Provides comprehensive coverage of present spectroscopic investigations - Features 20 chapters written by leading researchers in the field - Covers the important role of molecular spectroscopy in research concerned with chemistry, physics, and biology

Download or read book Plant Signal Transduction written by Dierk Scheel and published by Oxford University Press, USA. This book was released on 2002 with total page 324 pages. Available in PDF, EPUB and Kindle. Book excerpt: The growth and differentiation of living organisms are continuously adjusted to a multitude of environmental factors, each of which underlies a perpetual variation. The sessile existence of plants further emphasizes the requirement for efficient adaptation and defence mechanisms. The changes in environmental factors may range from moderate to dramatic and can concern many components at the same time. They may be abiotic or biotic in nature and range from essential to toxic in their effects. Among the numerous abiotic factors are nutrients, light, oxygen, water, temperature, gravity, wind, touch and chemicals. Biotic factors are represented by other organisms involved in symbiotic, pathogenic or herbivorous interactions with plants. All of these environmental factors are independently and specifically recognized by plants. Perception and overall response are linked by signal transduction pathways at cellular, systemic and interorganismic levels. In order to guarantee proper adaptation to the environment, signals generated following perception of a multitude of environmental factors need to be integrated and evaluated according to their importance. Cross-talk between different signaling pathways within such networks appears to be the basis for the evaluation of the importance of incoming signals. Knowledge of these complex processes allows a better understanding of the molecular mechanisms underlying adaptation. Modulation of distinct signaling elements can generate plants with improved stress resistance. This book represents a comprehensive summary of the enormous amount of information that is now available on signal transduction processes involved in the communication of plants with abiotic and biotic elements of their environment.

Download or read book New Frontiers in Bryology written by Andrew J. Wood and published by Springer Science & Business Media. This book was released on 2013-03-20 with total page 208 pages. Available in PDF, EPUB and Kindle. Book excerpt: The mosses (Bryophatea, Musci) are a diverse and widely distributed group of land plants. Mosses are attractive experimental plants because they exhibit the traditional attributes of good model systems (Le. ease of growth & maintenance, fast generation time, and amenable genetics) with the added advantage of a haploid gametophyte that allowed developmental mutants to be recovered with relative ease. In addition, mosses with the ability to tolerate extreme environmental conditions offer realistic models for the analysis of environmental stress-tolerance; particularly when compared to tracheophytes such as Arabidopsis thaliana in which these important plant phenotypes are either not clearly expressed or entirely lacking. And, in one of the most exciting developments in Plant Biology, efficient homologous recombination occurs in the moss Physcomitrella patens. The ability to perform efficient homologous recombination (Le. gene knock-outs) in P. patens is at present unique amongst all plants and represents an extremely powerful technique for the functional analysis of many plant genes. Over the past 5 years, a world-wide community of moss researchers has evolved. A highly successful "Moss" conference has been held annually (l998-Mumbai, India; 1999-Carbondale, IL, USA; 2000-Villars, Switzerland; 200l-0kazaki, Japan; 2002-Ambleside, UK; 2003-St. Louis, MO, USA) with "Moss 2004" planned to be held in Frieburg Germany. These conferences have been instrumental in the creation & development of strong collaborative ties, and the free exchange of both ideas and materials.

Download or read book Frontiers in Biomedical Engineering written by Ned H.C. Hwang and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 563 pages. Available in PDF, EPUB and Kindle. Book excerpt: New Frontiers in Biomedical Engineering will be an edited work taken from the 1st Annual World Congress of Chinese Biomedical Engineers - Taipei, Taiwan 2002. As the economy develops rapidly in China and the Asian-Pacific population merges into the global healthcare system, many researchers in the West are trying to make contact with the Chinese BME scientists. At WCCBME 2002, invited leaders, materials scientists, bioengineers, molecular and cellular biologists, orthopaedic surgeons, and manufacturers from P.R. of China, Taiwan, Singapore and Hong Kong covered all five major BME domains: biomechanics, biomaterials and tissue engineering, medical imaging, biophotonics and instrumentation, and rehabilitation. This edited work taken from the World Congress proceedings will capture worldwide readership.

Download or read book DNA polymerases in Biotechnology written by Zvi Kelman and published by Frontiers Media SA. This book was released on 2015-03-18 with total page 147 pages. Available in PDF, EPUB and Kindle. Book excerpt: DNA polymerases are core tools for molecular biology including PCR, whole genome amplification, DNA sequencing and genotyping. Research has focused on discovery of novel DNA polymerases, characterization of DNA polymerase biochemistry and development of new replication assays. These studies have accelerated DNA polymerase engineering for biotechnology. For example, DNA polymerases have been engineered for increased speed and fidelity in PCR while lowering amplification sequence bias. Inhibitor resistant DNA polymerase variants enable PCR directly from tissue (i.e. blood). Design of DNA polymerases that efficiently incorporate modified nucleotide have been critical for development of next generation DNA sequencing, synthetic biology and other labeling and detection technologies. The Frontiers in Microbiology Research Topic on DNA polymerases in Biotechnology aims to capture current research on DNA polymerases and their use in emerging technologies.

Download or read book An Introduction to Molecular Medicine and Gene Therapy written by Thomas F. Kresina and published by John Wiley & Sons. This book was released on 2004-03-24 with total page 408 pages. Available in PDF, EPUB and Kindle. Book excerpt: An Introduction to Molecular Medicine and Gene Therapy Edited by Thomas F. Kresina, Ph.D. Gene therapy, or the use of genetic manipulation for disease treatment, is derived from advances in genetics, molecular biology, clinical medicine, and human genomics. Molecular medicine, the application of molecular biological techniques to disease treatment and diagnosis, is derived from the development of human organ transplantation, pharmacotherapy, and elucidation of the human genome. An Introduction to Molecular Medicine and Gene Therapy provides a basis for interpreting new clinical and basic research findings in the areas of cloning, gene transfer, and targeting; the applications of genetic medicine to clinical conditions; ethics and governmental regulations; and the burgeoning fields of genomics, biotechnology, and bioinformatics. By dividing the material into three sections - an introduction to basic science, a review of clinical applications, and a discussion of the evolving issues related to gene therapy and molecular medicine-this comprehensive manual describes the basic approaches to the broad range of actual and potential genetic-based therapies. In addition, An Introduction to Molecular Medicine and Gene Therapy: * Covers new frontiers in gene therapy, animal models, vectors, gene targeting, and ethical/legal considerations * Provides organ-based reviews of current studies in gene therapy for monogenetic, multifactoral or polygenic disorders, and infectious diseases * Includes bold-faced terms, key concepts, summaries, and lists of helpful references by subject in each chapter * Contains appendices on commercial implications and a review of the history of gene therapy This textbook offers a clear, concise writing style, drawing upon the expertise of the authors, all renowned researchers in their respective specialties of molecular medicine. Researchers in genetics and molecular medicine will all find An Introduction to Molecular Medicine and Gene Therapy to be an essential guide to the rapidly evolving field of gene therapy and its applications in molecular medicine.