Download or read book New Directions in Bioprocess Modeling and Control written by Michael A. Boudreau and published by ISA. This book was released on 2007 with total page 356 pages. Available in PDF, EPUB and Kindle. Book excerpt: Models offer benefits even before they are put on line. Based on years of experience, the authors reveal in New Directions in Bioprocess Modeling and Control that significant improvements can result from the process knowledge and insight that are gained when building experimental and first-principle models for process monitoring and control. Doing modeling in the process development and early commercialization phases is advantageous because it increases process efficiency and provides ongoing opportunities for improving process control. This technology is important for maximizing benefits from analyzers and control tool investments. If you are a process design, quality control, information systems, or automation engineer in the biopharmaceutical, brewing, or bio-fuel industry, this handy resource will help you define, develop, and apply a virtual plant, model predictive control, first-principle models, neural networks, and multivariate statistical process control. The synergistic knowledge discovery on bench top or pilot plant scale can be ported to industrial scale processes. This learning process is consistent with the intent in the Process Analyzer and Process Control Tools sections of the FDA_s Guidance for Industry PAT _ A Framework for Innovative Pharmaceutical Development, Manufacturing and Quality Assurance. It states in the Process Analyzer section of the FDA_s guidance: _For certain applications, sensor-based measurements can provide a useful process signature that may be related to the underlying process steps or transformations. Based on the level of process understanding these signatures may also be useful for the process monitoring, control, and end point determination when these patterns or signatures relate to product and process quality._
Download or read book New Directions in Bioprocess Modeling and Control written by Gregory McMillan and published by . This book was released on 2020-12-15 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Bioprocessing Technology for Production of Biopharmaceuticals and Bioproducts written by Claire Komives and published by John Wiley & Sons. This book was released on 2018-12-27 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written for industrial and academic researchers and development scientists in the life sciences industry, Bioprocessing Technology for Production of Biopharmaceuticals and Bioproducts is a guide to the tools, approaches, and useful developments in bioprocessing. This important guide: • Summarizes state-of-the-art bioprocessing methods and reviews applications in life science industries • Includes illustrative case studies that review six milestone bio-products • Discuses a wide selection of host strain types and disruptive bioprocess technologies
Download or read book PID Control in the Third Millennium written by Ramon Vilanova and published by Springer Science & Business Media. This book was released on 2012-02-03 with total page 600 pages. Available in PDF, EPUB and Kindle. Book excerpt: The early 21st century has seen a renewed interest in research in the widely-adopted proportional-integral-differential (PID) form of control. PID Control in the Third Millennium provides an overview of the advances made as a result. Featuring: new approaches for controller tuning; control structures and configurations for more efficient control; practical issues in PID implementation; and non-standard approaches to PID including fractional-order, event-based, nonlinear, data-driven and predictive control; the nearly twenty chapters provide a state-of-the-art resumé of PID controller theory, design and realization. Each chapter has specialist authorship and ideas clearly characterized from both academic and industrial viewpoints. PID Control in the Third Millennium is of interest to academics requiring a reference for the current state of PID-related research and a stimulus for further inquiry. Industrial practitioners and manufacturers of control systems with application problems relating to PID will find this to be a practical source of appropriate and advanced solutions.
Download or read book Tuning and Control Loop Performance Fourth Edition written by Gregory K. McMillan and published by Momentum Press. This book was released on 2014-12-18 with total page 754 pages. Available in PDF, EPUB and Kindle. Book excerpt: Tuning and Control Loop Performance, Fourth Edition provides the knowledge to eliminate the misunderstandings, realize the difference between theoretical and industrial application of PID control, address practical difficulties, improve field automation system design, use the latest PID features, and ultimately get the best tuning settings that enables the PID to achieve its full potential. The proportional-integral-derivative (PID) controller is the heart of every control system in the process industry. Given the proper setup and tuning, the PID has proven to have the capability and flexibility needed to meet nearly all of industry’s basic control requirements. However, the information to support the best use of these features has fallen behind the progress of improved functionality. Additionally, there is considerable disagreement on the tuning rules that largely stems from a misunderstanding of how tuning rules have evolved and the lack of recognition of the effect of automation system dynamics and the incredible spectrum of process responses, disturbances, and performance objectives.
Download or read book Biomass Now written by Miodrag Darko Matovic and published by BoD – Books on Demand. This book was released on 2013-04-30 with total page 556 pages. Available in PDF, EPUB and Kindle. Book excerpt: This two-volume book on biomass is a reflection of the increase in biomass related research and applications, driven by overall higher interest in sustainable energy and food sources, by increased awareness of potentials and pitfalls of using biomass for energy, by the concerns for food supply and by multitude of potential biomass uses as a source material in organic chemistry, bringing in the concept of bio-refinery. It reflects the trend in broadening of biomass related research and an increased focus on second-generation bio-fuels. Its total of 40 chapters spans over diverse areas of biomass research, grouped into 9 themes.
Download or read book Animal Cell Biotechnology written by Hansjörg Hauser and published by Walter de Gruyter GmbH & Co KG. This book was released on 2014-11-10 with total page 718 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book introduces fundamental principles and practical application of techniques used in the scalable production of biopharmaceuticals with animal cell cultures. A broad spectrum of subjects relevant to biologics production and manufacturing are reviewed, including the generation of robust cell lines, a survey of functional genomics for a better understanding of cell lines and processes, as well as advances in regulatory compliant upstream and downstream development. The book is an essential reference for all those interested in translational animal cell-based pharmaceutical biotechnology.
Download or read book Automation Applications in Bio pharmaceuticals written by George Buckbee (P.E.) and published by ISA. This book was released on 2008 with total page 324 pages. Available in PDF, EPUB and Kindle. Book excerpt: A guide for engineers and designers new to the field of bio-pharmaceutical process control. For the experienced automation professional, it outlines the unique design and application issues for the bio-pharmaceutical industry. For those already familiar with this industry, it provides specific advice for automating these processes.
Download or read book Handbook of PI and PID Controller Tuning Rules written by Aidan O'Dwyer and published by Imperial College Press. This book was released on 2009 with total page 623 pages. Available in PDF, EPUB and Kindle. Book excerpt: The vast majority of automatic controllers used to compensate industrial processes are PI or PID type. This book comprehensively compiles, using a unified notation, tuning rules for these controllers proposed from 1935 to 2008. The tuning rules are carefully categorized and application information about each rule is given. The book discusses controller architecture and process modeling issues, as well as the performance and robustness of loops compensated with PI or PID controllers. This unique publication brings together in an easy-to-use format material previously published in a large number of papers and books.This wholly revised third edition extends the presentation of PI and PID controller tuning rules, for single variable processes with time delays, to include additional rules compiled since the second edition was published in 2006.
Download or read book Control of Biological and Drug Delivery Systems for Chemical Biomedical and Pharmaceutical Engineering written by Laurent Simon and published by John Wiley & Sons. This book was released on 2012-11-27 with total page 388 pages. Available in PDF, EPUB and Kindle. Book excerpt: Enables readers to apply process dynamics and control theory to solve bioprocess and drug delivery problems The control of biological and drug delivery systems is critical to the health of millions of people worldwide. As a result, researchers in systems biology and drug delivery rely on process dynamics and control theory to build our knowledge of cell behavior and to develop more effective therapeutics, controlled release devices, and drug administration protocols to manage disease. Written by a leading expert and educator in the field, this text helps readers develop a deep understanding of process dynamics and control theory in order to analyze and solve a broad range of problems in bioprocess and drug delivery systems. For example, readers will learn how stability criteria can be used to gain new insights into the regulation of biological pathways and lung mechanics. They'll also learn how the concept of a time constant is used to capture the dynamics of diffusive processes. Readers will also master such topics as external disturbances, transfer functions, and input/output models with the support of the author's clear explanations, as well as: Detailed examples from the biological sciences and novel drug delivery technologies 160 end-of-chapter problems with step-by-step solutions Demonstrations of how computational software such as MATLAB and Mathematica solve complex drug delivery problems Control of Biological and Drug-Delivery Systems for Chemical, Biomedical, and Pharmaceutical Engineering is written primarily for undergraduate chemical and biomedical engineering students; however, it is also recommended for students and researchers in pharmaceutical engineering, process control, and systems biology. All readers will gain a new perspective on process dynamics and control theory that will enable them to develop new and better technologies and therapeutics to treat human disease.
Download or read book Essentials of Modern Measurements and Final Elements in the Process Industry written by Gregory K. McMillan and published by ISA. This book was released on 2010 with total page 593 pages. Available in PDF, EPUB and Kindle. Book excerpt: Aims to increase awareness of the opportunities afforded by measurement instruments and final elements. This title shows how to get maximum benefit from the revolution in smart technologies. It builds an understanding of the fundamental aspects of measurements, measurement instruments, and final elements for applications in the process industry.
Download or read book Control Loop Foundation written by Terrence L. Blevins and published by ISA. This book was released on 2011 with total page 425 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this in-depth book, the authors address the concepts and terminology that are needed to work in the field of process control. The material is presented in a straightforward manner that is independent of the control system manufacturer. It is assumed that the reader may not have worked in a process plant environment and may be unfamiliar with the field devices and control systems. Much of the material on the practical aspects of control design and process applications is based on the authors personal experience gained in working with process control systems. Thus, the book is written to act as a guide for engineers, managers, technicians, and others that are new to process control or experienced control engineers who are unfamiliar with multi-loop control techniques. After the traditional single-loop and multi-loop techniques that are most often used in industry are covered, a brief introduction to advanced control techniques is provided. Whether the reader of this book is working as a process control engineer, working in a control group or working in an instrument department, the information will set the solid foundation needed to understand and work with existing control systems or to design new control applications. At various points in the chapters on process characterization and control design, the reader has an opportunity to apply what was learned using web-based workshops. The only items required to access these workshops are a high-speed Internet connection and a web browser. Dynamic process simulations are built into the workshops to give the reader a realistic "hands-on" experience. Also, one chapter of the book is dedicated to techniques that may be used to create process simulations using tools that are commonly available within most distributed control systems. At various points in the chapters on process characterization and control design, the reader has an opportunity to apply what was learned using web-based workshops. The only items required to access these workshops are a high-speed Internet connection and a web browser. Dynamic process simulations are built into the workshops to give the reader a realistic "hands-on" experience. Also, one chapter of the book is dedicated to techniques that may be used to create process simulations using tools that are commonly available within most distributed control systems. As control techniques are introduced, simple process examples are used to illustrate how these techniques are applied in industry. The last chapter of the book, on process applications, contains several more complex examples from industry that illustrate how basic control techniques may be combined to meet a variety of application requirements. As control techniques are introduced, simple process examples are used to illustrate how these techniques are applied in industry. The last chapter of the book, on process applications, contains several more complex examples from industry that illustrate how basic control techniques may be combined to meet a variety of application requirements.
Download or read book Process Dynamics and Control written by Dale E. Seborg and published by John Wiley & Sons. This book was released on 2016-09-13 with total page 512 pages. Available in PDF, EPUB and Kindle. Book excerpt: The new 4th edition of Seborg’s Process Dynamics Control provides full topical coverage for process control courses in the chemical engineering curriculum, emphasizing how process control and its related fields of process modeling and optimization are essential to the development of high-value products. A principal objective of this new edition is to describe modern techniques for control processes, with an emphasis on complex systems necessary to the development, design, and operation of modern processing plants. Control process instructors can cover the basic material while also having the flexibility to include advanced topics.
Download or read book Control in Bioprocessing written by Pablo A. López Pérez and published by John Wiley & Sons. This book was released on 2020-03-03 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt: Closes the gap between bioscience and mathematics-based process engineering This book presents the most commonly employed approaches in the control of bioprocesses. It discusses the role that control theory plays in understanding the mechanisms of cellular and metabolic processes, and presents key results in various fields such as dynamic modeling, dynamic properties of bioprocess models, software sensors designed for the online estimation of parameters and state variables, and control and supervision of bioprocesses Control in Bioengineering and Bioprocessing: Modeling, Estimation and the Use of Sensors is divided into three sections. Part I, Mathematical preliminaries and overview of the control and monitoring of bioprocess, provides a general overview of the control and monitoring of bioprocesses, and introduces the mathematical framework necessary for the analysis and characterization of bioprocess dynamics. Part II, Observability and control concepts, presents the observability concepts which form the basis of design online estimation algorithms (software sensor) for bioprocesses, and reviews controllability of these concepts, including automatic feedback control systems. Part III, Software sensors and observer-based control schemes for bioprocesses, features six application cases including dynamic behavior of 3-dimensional continuous bioreactors; observability analysis applied to 2D and 3D bioreactors with inhibitory and non-inhibitory models; and regulation of a continuously stirred bioreactor via modeling error compensation. Applicable across all areas of bioprocess engineering, including food and beverages, biofuels and renewable energy, pharmaceuticals and nutraceuticals, fermentation systems, product separation technologies, wastewater and solid-waste treatment technology, and bioremediation Provides a clear explanation of the mass-balance–based mathematical modelling of bioprocesses and the main tools for its dynamic analysis Offers industry-based applications on: myco-diesel for implementing "quality" of observability; developing a virtual sensor based on the Just-In-Time Model to monitor biological control systems; and virtual sensor design for state estimation in a photocatalytic bioreactor for hydrogen production Control in Bioengineering and Bioprocessing is intended as a foundational text for graduate level students in bioengineering, as well as a reference text for researchers, engineers, and other practitioners interested in the field of estimation and control of bioprocesses.
Download or read book THE WBF BOOK SERIES ISA 88 and ISA 95 in the Life Science Industries written by The WBF and published by Momentum Press. This book was released on 2011-03-03 with total page 220 pages. Available in PDF, EPUB and Kindle. Book excerpt: THE WBF BOOK SERIES--ISA 88 and ISA 95 In Life Science Industries is a guide book to the ISA 88 and ISA 95 Manufacturing Protocols. The book features: -- How to set up a pharmaceutical module library using ISA 88 and how to implement ISA 88 across life Science Development Operations -- Understanding Product life cycle batches -- Case Studies on Risk-based engineering assessment and qualifications, a SCADA upgrade project, and more. The ISA (International Society of Automation) standards 88 and 95 are manufacturing standards established in the late 1990s and periodically updated by the governing bodies responsible for them -- the ISA and the WBF (World Batch Forum). The two standards set up protocols and uniform specifications for batch control systems, including types of control equipment, design of control systems and interpretation of batch control data. In Volume 1, ISA 88 and 95 are explained in the context of the pharmaceutical and medical industries. Examples of such batch processing procedures as fermentation, separation, and refinement are discussed and how the two standards affect the design of facilities and systems for performing these procedures. The ISA 88 and 95 standards have been around (and periodically updated) for nearly 20 years now, but little really helpful has been published on how to put those standards into use, particularly from a pragmatic, real-life experience point of view. The four books in this new series will do exactly that: explain to the manufacturing engineer, the controls engineers, and the industrial planner and manager alike how these standards translate into improved batch and continuous process operations -- and ultimately how those operations can be integrated and automated into general business operations (accounting, inventory, customer relations, product development) of the manufacturing concern.
Download or read book 15th European Workshop on Advanced Control and Diagnosis ACD 2019 written by Elena Zattoni and published by Springer Nature. This book was released on 2022-06-13 with total page 1441 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book, published in two volumes, embodies the proceedings of the 15th European Workshop on Advanced Control and Diagnosis (ACD 2019) held in Bologna, Italy, in November 2019. It features contributed and invited papers from academics and professionals specializing in an important aspect of control and automation. The book discusses current theoretical research developments and open problems and illustrates practical applications and industrial priorities. With a focus on both theory and applications, it spans a wide variety of up-to-date topics in the field of systems and control, including robust control, adaptive control, fault-tolerant control, control reconfiguration, and model-based diagnosis of linear, nonlinear and hybrid systems. As the subject coverage has expanded to include cyber-physical production systems, industrial internet of things and sustainability issues, some contributions are of an interdisciplinary nature, involving ICT disciplines and environmental sciences. This book is a valuable reference for both academics and professionals in the area of systems and control, with a focus on advanced control, automation, fault diagnosis and condition monitoring.
Download or read book Comprehensive Biotechnology written by and published by Elsevier. This book was released on 2019-07-17 with total page 4876 pages. Available in PDF, EPUB and Kindle. Book excerpt: Comprehensive Biotechnology, Third Edition, Six Volume Set unifies, in a single source, a huge amount of information in this growing field. The book covers scientific fundamentals, along with engineering considerations and applications in industry, agriculture, medicine, the environment and socio-economics, including the related government regulatory overviews. This new edition builds on the solid basis provided by previous editions, incorporating all recent advances in the field since the second edition was published in 2011. Offers researchers a one-stop shop for information on the subject of biotechnology Provides in-depth treatment of relevant topics from recognized authorities, including the contributions of a Nobel laureate Presents the perspective of researchers in different fields, such as biochemistry, agriculture, engineering, biomedicine and environmental science
