Download or read book New Avenues to Efficient Chemical Synthesis written by P.H. Seeberger and published by Springer Science & Business Media. This book was released on 2007-06-02 with total page 247 pages. Available in PDF, EPUB and Kindle. Book excerpt: In modern drug discovery and development, chemical synthesis is one of the key technologies. For the rapid preparation of new test compounds and drug development candidates, several innovative technologies with great potential have emerged. This book offers a compact overview of the current status of these technologies and includes many real-life examples from industry and academic institutions.
Download or read book Novel Process Windows written by Volker Hessel and published by John Wiley & Sons. This book was released on 2015-03-23 with total page 342 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book introduces the concept of novel process windows, focusing on cost improvements, safety, energy and eco-efficiency throughout each step of the process. The first part presents the new reactor and process-related technologies, introducing the potential and benefit analysis. The core of the book details scenarios for unusual parameter sets and the new holistic and systemic approach to processing, while the final part analyses the implications for green and cost-efficient processing. With its practical approach, this is invaluable reading for those working in the pharmaceutical, fine chemicals, fuels and oils industries.
Download or read book Flow Chemistry Applications written by Ferenc Darvas and published by Walter de Gruyter GmbH & Co KG. This book was released on 2014-10-15 with total page 345 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Flow Chemistry fills the gap in graduate education by covering chemistry and reaction principles along with current practice, including examples of relevant commercial reaction, separation, automation, and analytical equipment. The Editors of Flow Chemistry are commended for having taken the initiative to bring together experts from the field to provide a comprehensive treatment of fundamental and practical considerations underlying flow chemistry. It promises to become a useful study text and as well as reference for the graduate students and practitioners of flow chemistry." Professor Klavs Jensen Massachusetts Institute of Technology, USA Broader theoretical insight in driving a chemical reaction automatically opens the window towards new technologies particularly to flow chemistry. This emerging concept promotes the transformation of present day's organic processes into a more rapid continuous set of synthesis operations, more compatible with the envisioned sustainable world. These two volumes Fundamentals and Applications provide both the theoretical foundation as well as the practical aspects.
Download or read book New Synthetic Technologies in Medicinal Chemistry written by Elizabeth Farrant and published by Royal Society of Chemistry. This book was released on 2011-10-04 with total page 177 pages. Available in PDF, EPUB and Kindle. Book excerpt: The modern synthetic chemist applies all the tools available to identify the drug-like molecules with the best chances of becoming novel drugs. This book will act as a primer for graduates and postgraduates interested in a career in drug discovery. It covers both synthetic technologies currently impacting medicinal chemistry and emerging areas. The chapters focus on topics including: parallel medicinal chemistry; solid supported reagents; microwave assisted chemistry; flow synthesis, and high throughput reaction screening.
Download or read book Catalytic Arylation Methods written by Anthony J. Burke and published by John Wiley & Sons. This book was released on 2015-02-09 with total page 530 pages. Available in PDF, EPUB and Kindle. Book excerpt: This "hands-on" approach to the topic of arylation consolidates the body of key research over the last ten years (and up to around 2014) on various catalytic methods which involve an arylation process. Clearly structured, the chapters in this one-stop resource are arranged according to the reaction type, and focus on novel, efficient and sustainable processes, rather than the well-known and established cross-coupling methods. The entire contents are written by two authors with academic and industrial expertise to ensure consistent coverage of the latest developments in the field, as well as industrial applications, such as C-H activation, iron and gold-catalyzed coupling reactions, cycloadditions or novel methodologies using arylboron reagents. A cross-section of relevant tried-and-tested experimental protocols is included at the end of each chapter for putting into immediate practice, along with patent literature. Due to its emphasis on efficient, "green" methods and industrial applications of the products concerned, this interdisciplinary text will be essential reading for synthetic chemists in both academia and industry, especially in medicinal and process chemistry.
Download or read book Palladium Catalyzed Coupling Reactions written by Árpád Molnár and published by John Wiley & Sons. This book was released on 2013-02-14 with total page 531 pages. Available in PDF, EPUB and Kindle. Book excerpt: This handbook and ready reference brings together all significant issues of practical importance in selected topics discussing recent significant achievements for interested readers in one single volume. While covering homogeneous and heterogeneous catalysis, the text is unique in focusing on such important aspects as using different reaction media, microwave techniques or catalyst recycling. It also provides a comprehensive treatment of key issues of modern-day coupling reactions having emerged and matured in recent years and emphasizes those topics that show potential for future development, such as continuous flow systems, water as a reaction medium, and catalyst immobilization, among others. With its inclusion of large-scale applications in the pharmaceutical industry, this will equally be of great interest to industrial chemists. From the contents * Palladium-Catalyzed Cross-Coupling Reactions - A General Introduction * High-turnover Heterogeneous Palladium Catalysts in Coupling Reactions: the Case of Pd Loaded on Dealuminated Y Zeolites Palladium-Catalyzed Coupling Reactions with Magnetically Separable Nanocatalysts * The Use of Ordered Porous Solids as Support Materials in Palladium-Catalyzed Cross-Coupling Reactions * Coupling Reactions Induced by Polymer-Supported Catalysts * Coupling Reactions in Ionic Liquids * Cross-Coupling Reactions in Aqueous Media * Microwave-Assisted Synthesis in C-C and C-Heteroatom Coupling Reactions * Catalyst Recycling in Palladium-Catalyzed Carbon-Carbon Coupling Reactions * Nature of the True Catalytic Species in Carbon-Carbon Coupling Reactions with * Heterogeneous Palladium Precatalysts * Coupling Reactions in Continuous Flow Systems * Large-Scale Applications of Palladium-Catalyzed Couplings in the Pharmaceutical Industry
Download or read book Drugs written by Rick Ng and published by John Wiley & Sons. This book was released on 2011-09-20 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Concise and easy to read, the book quickly introduces basic concepts, then moves on to discuss target selection and the drug discovery process for both small and large molecular drugs." —Doody's Reviews, May 2009 "The second edition of a book that offers a user-friendly step-by-step introduction to all the key processes involved in bringing a drug to the market, including the performance of preclinical trials." —Chemistry World, February 2009 The new edition of this best-selling book continues to offer a user-friendly, step-by-step introduction to all the key processes involved in bringing a drug to the market, including the performance of pre-clinical studies, the conduct of human clinical trials, regulatory controls, and even the manufacturing processes for pharmaceutical products. Concise and easy to read, the book quickly introduces basic concepts, then moves on to discuss target selection and the drug discovery process for both small and large molecular drugs. This second edition features many key enhancements, including Key Points, Chapter Summary, and Review Questions in each chapter, Answers to Review Questions provided in a book-end appendix, and one or two carefully selected "mini" case studies in each chapter. Richly illustrated throughout with over ninety figures and tables, this important book also includes helpful listings of current FDA and European guidelines and a special section on regulatory authority and processes in China. It is an indispensable resource for pharmaceutical industry and academic researchers, pharmaceutical managers and executives, healthcare clinicians, policymakers, regulators, and lobbyists with an interest in drug development. It is also an excellent textbook for students in pharmacy, science, and medicine courses.
Download or read book Microreactors in Preparative Chemistry written by Wladimir Reschetilowski and published by John Wiley & Sons. This book was released on 2013-09-13 with total page 351 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the first book in the field to focus on these aspects, providing extremely valuable information unavailable elsewhere for anyone seeking the practical application of microreactor technology in preparative chemistry. The topics covered branch out in three different directions. To begin with, the knowledge necessary for the preparative chemistry concerning the influence of the so-called microeffects on the reaction procedure and on mass and heat transfer as well as the surface phenomena are provided in detail. Next, practical aspects of the synthesis of various basic chemicals and fine chemicals, polymers, bioproducts and nanoparticles are discussed, including important advice for both the researcher and industrial chemist. Finally, reaction examples in microreactors whose reaction guidance are best understood are given together with universally applicable correlations as well as modeling approaches and transfer potential on related reaction systems. With its specific instructions, tips and experimental procedures for product syntheses as well as the inclusion of both the technical and theoretical background this is a must-have for beginners and experts alike working in this emerging field.
Download or read book Discovering the Future of Molecular Sciences written by Bruno Pignataro and published by John Wiley & Sons. This book was released on 2014-05-05 with total page 538 pages. Available in PDF, EPUB and Kindle. Book excerpt: The European Young Chemist Award has now been awarded four times (2006, 2008, 2010 and 2012). The authors of the previous books based on the competition have become some of the leading scientists in Europe. These books truly provide a glimpse into the future research landscape of European chemistry. Fifteen top contributions have been selected for this single volume covering areas of chemistry and materials science. The broad range of themes is presented in an approachable and readable manner equally appropriate for non-specialists on the topic. The overview of intriguing topics includes chemical synthesis and advanced methodologies as well as materials, nanoscience and nanotechnologies.
Download or read book Immunotherapy in 2020 written by Andreas Radbruch and published by Springer Science & Business Media. This book was released on 2007-06-22 with total page 116 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume features contributions from participants of the ESRF symposium on Immunotherapy in 2020—Visions and Trends for Targeting Inflammatory Diseases held in Potsdam near Berlin, Germany, in October 2006. The symposium presentations covered the main mechanisms of immunoregulation.
Download or read book Progestins and the Mammary Gland written by Orla M. Conneely and published by Springer Science & Business Media. This book was released on 2008-03-27 with total page 211 pages. Available in PDF, EPUB and Kindle. Book excerpt: Progestins play a key role in reproductive endocrinology and as pharmaceutical drugs for contraception and in combined hormone therapy. To further our understanding of progestin action in the mammary gland, an international symposium, attended by leading researchers from academia and industry, was held in Berlin, 21–23 March 2007. Genetic mouse models helped to elucidate the role of progestins, both in normal breast development and in disease. Mechanistic molecular studies inspired the design of new progestins with improved tissue selectivity. In addition, the clinical impact of progesterone receptor agonists and antagonists for the prevention and treatment of breast cancer was discussed.
Download or read book Organocatalysis written by Manfred Reetz and published by Springer Science & Business Media. This book was released on 2008-05-27 with total page 348 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides an excellent overview on state-of-the-art of modern organocatalysis. It presents the contributions from leading experts, with backgrounds in academia and industry, to an Ernst Schering Research Foundation Symposium held in April 2007. It will be of interest to those who want a general overview of the topic, but also to those who want to learn more about the state-of-the-art, current trends and perspectives in this highly dynamic field of research.
Download or read book Oncogenes Meet Metabolism written by Guido Kroemer and published by Springer Science & Business Media. This book was released on 2008-07-25 with total page 275 pages. Available in PDF, EPUB and Kindle. Book excerpt: In 1920s, Otto Warburg described the phenomenon of ‘aerobic glycolysis’, the ability of tumour cells to convert glucose to lactate in the presence of normal oxygen conditions. Warburg’s hypothesis of an altered metabolism in cancer cells found no immediate acceptance, though it was latter confirmed for most human tumours. With the advent of molecular biology the focus in tumour research has shifted towards the search for oncogenes. However, the interest in cancer molecular profiling eventually led to a renaissance of the Warburg effect trying to combine genetic alterations with effects on metabolism with the help of modern analytic technologies to rapidly analyze broad varieties of metabolites in various tissues and bodyfluids (metabonomics).
Download or read book Green Chemical Synthesis with Microwaves and Ultrasound written by Dakeshwar Kumar Verma and published by John Wiley & Sons. This book was released on 2024-03-25 with total page 421 pages. Available in PDF, EPUB and Kindle. Book excerpt: Green Chemical Synthesis with Microwaves and Ultrasound A guide to the efficient and sustainable synthesis of organic compounds Chemical processes and the synthesis of compounds are essential aspects of numerous industries, and particularly central to the creation of drug-like structures. Their often significant environmental biproducts, however, have driven substantial innovations in the areas of green and organic synthesis, which have the potential to drive efficient, solvent-free synthesis and create more sustainable chemical processes. The use of microwaves and ultrasounds in chemical synthesis has proven an especially fruitful area of research, with the potential to produce a more sustainable industrial future. Green Chemical Synthesis with Microwaves and Ultrasound provides a comprehensive overview of recent advances in microwave- and ultrasound-driven synthesis and their cutting-edge applications. Green Chemical Synthesis with Microwaves and Ultrasound readers will also find: Introduction to the key equipment and tools of green chemical synthesis Detailed discussion of methods including ultrasound irradiation, metal-catalyzed reactions, enzymatic reactions, and many more An authorial team with immense experience in environmentally friendly organic chemical production Green Chemical Synthesis with Microwaves and Ultrasound is ideal for chemists, organic chemists, chemical engineers, biochemists, and any researchers or industry professionals working on the synthesis of chemicals and/or organic compounds.
Download or read book Fundamentals of Chemical Reactor Engineering written by Timur Dogu and published by John Wiley & Sons. This book was released on 2021-10-07 with total page 356 pages. Available in PDF, EPUB and Kindle. Book excerpt: FUNDAMENTALS OF CHEMICAL REACTOR ENGINEERING A comprehensive introduction to chemical reactor engineering from an industrial perspective In Fundamentals of Chemical Reactor Engineering: A Multi-Scale Approach, a distinguished team of academics delivers a thorough introduction to foundational concepts in chemical reactor engineering. It offers readers the tools they need to develop a firm grasp of the kinetics and thermodynamics of reactions, hydrodynamics, transport processes, and heat and mass transfer resistances in a chemical reactor. This textbook describes the interaction of reacting molecules on the molecular scale and uses real-world examples to illustrate the principles of chemical reactor analysis and heterogeneous catalysis at every scale. It includes a strong focus on new approaches to process intensification, the modeling of multifunctional reactors, structured reactor types, and the importance of hydrodynamics and transport processes in a chemical reactor. With end-of-chapter problem sets and multiple open-ended case studies to promote critical thinking, this book also offers supplementary online materials and an included instructor’s manual. Readers will also find: A thorough introduction to the rate concept and species conservation equations in reactors, including chemical and flow reactors and the stoichiometric relations between reacting species A comprehensive exploration of reversible reactions and chemical equilibrium, including the thermodynamics of chemical reactions and different forms of the equilibrium constant Practical discussions of chemical kinetics and analysis of batch reactors, including batch reactor data analysis In-depth examinations of ideal flow reactors, CSTR, and plug flow reactor models Ideal for undergraduate and graduate chemical engineering students studying chemical reactor engineering, chemical engineering kinetics, heterogeneous catalysis, and reactor design, Fundamentals of Chemical Reactor Engineering is also an indispensable resource for professionals and students in food, environmental, and materials engineering.
Download or read book Chemical Catalysts for Biomass Upgrading written by Mark Crocker and published by John Wiley & Sons. This book was released on 2020-03-09 with total page 634 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive reference to the use of innovative catalysts and processes to turn biomass into value-added chemicals Chemical Catalysts for Biomass Upgrading offers detailed descriptions of catalysts and catalytic processes employed in the synthesis of chemicals and fuels from the most abundant and important biomass types. The contributors?noted experts on the topic?focus on the application of catalysts to the pyrolysis of whole biomass and to the upgrading of bio-oils. The authors discuss catalytic approaches to the processing of biomass-derived oxygenates, as exemplified by sugars, via reactions such as reforming, hydrogenation, oxidation, and condensation reactions. Additionally, the book provides an overview of catalysts for lignin valorization via oxidative and reductive methods and considers the conversion of fats and oils to fuels and terminal olefins by means of esterification/transesterification, hydrodeoxygenation, and decarboxylation/decarbonylation processes. The authors also provide an overview of conversion processes based on terpenes and chitin, two emerging feedstocks with a rich chemistry, and summarize some of the emerging trends in the field. This important book: -Provides a comprehensive review of innovative catalysts, catalytic processes, and catalyst design -Offers a guide to one of the most promising ways to find useful alternatives for fossil fuel resources -Includes information on the most abundant and important types of biomass feedstocks -Examines fields such as catalytic cracking, pyrolysis, depolymerization, and many more Written for catalytic chemists, process engineers, environmental chemists, bioengineers, organic chemists, and polymer chemists, Chemical Catalysts for Biomass Upgrading presents deep insights on the most important aspects of biomass upgrading and their various types.
Download or read book Bioelectrosynthesis written by Aijie Wang and published by John Wiley & Sons. This book was released on 2020-07-02 with total page 420 pages. Available in PDF, EPUB and Kindle. Book excerpt: Introduces basic principles and mechanisms, covers new developments, and provides a different view of the main facets of bioelectrosynthesis Bioelectrosynthesis represents a promising approach for storing renewable energy or producing target chemicals in an energy-sustainable and low-cost way. This timely and important book systemically introduces the hot issues surrounding bioelectrosynthesis, including potential value-added products via bioelectrochemical system, reactor development of bioelectrosynthesis, and microbial biology on biofilm communities and metabolism pathways. It presents readers with unique viewpoints on basic principles and mechanisms along with new developments on reactor and microbial ecology. Beginning with a principle and products overview of bioelectrosynthesis, Bioelectrosynthesis: Principles and Technologies for Value-Added Products goes on to offer in-depth sections on: biogas production and upgrading technology via bioelectrolysis; organic synthesis on cathodes; chemical products and nitrogen recovery; external electron transfer and electrode material promotion; and the microbiology of bioelectrosynthesis. Topics covered include: hydrogen production from waste stream with microbial electrolysis cell; microbial electrolysis cell; inorganic compound synthesis in bioelectrochemical system; microbial growth, ecological, and metabolic characteristics in bioelectrosynthesis systems; microbial metabolism kinetics and interactions in bioelectrosynthesis system; and more. * Comprehensively covers all of the key issues of biolelectrosynthesis * Features contributions from top experts in the field * Examines the conversion of organic wastes to methane via electromethanogenesis; methane production at biocathodes; extracellular electron transport of electroactive biofilm; and more Bioelectrosynthesis: Principles and Technologies for Value-Added Products will appeal to chemists, electrochemists, environmental chemists, water chemists, microbiologists, biochemists, and graduate students involved in the field.
