Download or read book New Approaches for Flavin Catalysis written by and published by Academic Press. This book was released on 2019-05-07 with total page 564 pages. Available in PDF, EPUB and Kindle. Book excerpt: New Approaches for Flavin Catalysis, Volume 620, a new volume in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. Topics covered in this update include Anaerobiosis and Methods for Reduction, Reduction Potentials, Anaerobic Stopped-Flow, No Glove-Box, Anaerobic Stopped-Flow, in a Glove-Box, Chemical Quenching, Oxygen Reactions, Double-mixing Stopped-Flow, Kinetic Isotope Effects and Viscosity Effects, Heavy Enzymes Synthetic Flavins & Linear Free Energy Relationships, Vibrational Spectroscopy, Stark Spectroscopy, EPR and Related Methods, Molecular Dynamics, Phylogenetic Relationships/Superfamilies, O2 and Superoxide Analogs, and more. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Methods in Enzymology series Updated release includes the latest information on New Approaches for Flavin Catalysis

Download or read book Flavin based Catalysis written by Radek Cibulka and published by Wiley-VCH. This book was released on 2021-09-07 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book gives a unique overview of this rapidly developing research field, presenting structures and properties of flavin derivatives as well as their proven application as bioinspired catalysts in various organocatalytic, biocatalytic, and photocatalytic reactions.

Download or read book Flavin Based Catalysis written by Radek Cibulka and published by John Wiley & Sons. This book was released on 2021-06-10 with total page 393 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book gives a unique overview of this rapidly developing research field, presenting structures and properties of flavin derivatives as well as their proven application as bioinspired catalysts in various organocatalytic, biocatalytic, and photocatalytic reactions.

Download or read book Flavin Dependent Enzymes Mechanisms Structures and Applications written by and published by Academic Press. This book was released on 2020-09-21 with total page 568 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Enzymes, Volume 47, highlights new advances in the field, with this new volume presenting interesting chapters on The Multipurpose Family of Oxidases, Vanillyl alcohol oxidase, Choline oxidases, Aryl alcohol oxidase, D- and L-amino acid oxidases, Sugar oxidases, Phenolic Compounds hydroxylases, Baeyer-Villiger Monooxygenases, Flavin-dependent halogenases, Flavin-dependent dehalogenases, Styrene Monooxygenases, Bacterial luciferases, Cellobiose Dehydrogenases, Prenylated flavoenzymes, Ene-reductases, Flavoenzymes in Biocatalysis. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in The Enzymes series

Download or read book Dynamics of Systems on the Nanoscale written by Ilia A. Solov'yov and published by Springer Nature. This book was released on 2022-06-03 with total page 554 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents the structure formation and dynamics of animate and inanimate matter on the nanometre scale. This is a new interdisciplinary field known as Meso-Bio-Nano (MBN) science that lies at the intersection of physics, chemistry, biology and material science. Special attention in the book is devoted to investigations of the structure, properties and dynamics of complex MBN systems by means of photonic, electronic, heavy particle and atomic collisions. This includes problems of fusion and fission, fragmentation, surfaces and interfaces, reactivity, nanoscale phase and morphological transitions, irradiation-driven transformations of complex molecular systems, collective electron excitations, radiation damage and biodamage, channeling phenomena and many more. Emphasis in the book is placed on the theoretical and computational physics research advances in these areas and related state-of-the-art experiments. Particular attention in the book is devoted to the utilization of advanced computational techniques and high-performance computing in studies of the dynamics of systems.

Download or read book New and Future Developments in Catalysis written by Steven L Suib and published by Newnes. This book was released on 2013-07-17 with total page 631 pages. Available in PDF, EPUB and Kindle. Book excerpt: New and Future Developments in Catalysis is a package of seven books that compile the latest ideas concerning alternate and renewable energy sources and the role that catalysis plays in converting new renewable feedstock into biofuels and biochemicals. Both homogeneous and heterogeneous catalysts and catalytic processes will be discussed in a unified and comprehensive approach. There will be extensive cross-referencing within all volumes.The various sources of environmental pollution are the theme of this volume. The volume lists all current environmentally friendly catalytic chemical processes used for environmental remediation and critically compares their economic viability. Offers in-depth coverage of all catalytic topics of current interest and outlines future challenges and research areas A clear and visual description of all parameters and conditions, enabling the reader to draw conclusions for a particular case Outlines the catalytic processes applicable to energy generation and design of green processes

Download or read book Design Synthesis and Applications of Biomimetic Flavin based Organocatalysts written by Mohammad Shawkat Hossain and published by . This book was released on 2019 with total page 439 pages. Available in PDF, EPUB and Kindle. Book excerpt: Oxidation reactions are one of the most important transformations in synthetic chemistry. Most commonly used oxidants are metal oxides, which are neither green nor selective towards multi-functional molecules. The efficiency of the reactions can be improved by the introduction of a catalyst by lowering the activation energy. In nature, oxidation reactions are highly specific and are controlled by enzymes, co-enzymes, and availability of a renewable terminal oxidant, molecular oxygen. Among the various enzymatic oxidative transformations, our research was inspired by the oxidations controlled by co-enzymes FMN or FAD in the presence of flavoproteins and molecular oxygen. Flavin mimics were often studied/used to oxidize heteroatoms; however, the goal of this research was initialy focused on mimicking other chemoselective oxidations of flavins, primarily at carbon centers. In chapter one, the function of natural flavins in nature and different approaches to perform nucleophilic and electrophilic oxidation using artificial flavin is described. In chapter two, flavin reactivity was extended to the Dakin oxidation of electron-rich benzaldehydes. This conversion of aryl aldehyde to phenol worked efficiently under mild conditions with either hydrogen peroxide or molecular oxygen as terminal oxidant. The mechanism was understood by various reaction rates studies. Substituent effects of catalysts and substrates aided in the identification of the rate determining step. The order of reagents and extensive pH studies reveal the various way flavin catalysts enable oxo-transfer under mild, more neutral conditions, by altering both the pKa of the active nucleophilic oxygen source, and by lowering the energy of the oxide leaving group, as previously hypothesized by Briuce and coworkers. In chapter three, pre-heteroaromatic compounds (initially investigated as possible reducing agents for flavin mimics) were transformed to their aromatic form aerobically using flavin catalyst in arguably the most mild methods described to date. Chapters four through six describe the preparation and function of various classes of flavins. Chapter four discussed the bioactivity of new flavin species against cancerous and normal breast cells. Chapter five details the preparation of water-soluble classes of flavins and their photochemical properties (O2 activation and Methyl Orange degredation). And Chapter six discusses the preparation of redox active flavins that were prepared for tethering to metal oxide photocatalyst and various electrode surfaces. Chapter seven describes a new preparation of 5-deazaflavin cofactors - deazariboflavin, 8-hydroxydeazariboflavin (an F420-precursor), and 10-methyl deazaflavin. An improved route to these species is described, and their redox activity were investigated in F420-dependent enzymes. Finally, chapter eight shows a new, concise and high yielding synthetic route explored for the synthesis of flavin catalysts, which includes the synthesis of different o-phenylenediamine derivatives and alloxan derivatives.

Download or read book New and Future Developments in Catalysis written by Ram Singh and published by Elsevier Inc. Chapters. This book was released on 2013-07-17 with total page 40 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Comprehensive Natural Products III written by and published by Elsevier. This book was released on 2020-07-22 with total page 4266 pages. Available in PDF, EPUB and Kindle. Book excerpt: Comprehensive Natural Products III, Third Edition, Seven Volume Set updates and complements the previous two editions, including recent advances in cofactor chemistry, structural diversity of natural products and secondary metabolites, enzymes and enzyme mechanisms and new bioinformatics tools. Natural products research is a dynamic discipline at the intersection of chemistry and biology concerned with isolation, identification, structure elucidation, and chemical characteristics of naturally occurring compounds such as pheromones, carbohydrates, nucleic acids and enzymes. This book reviews the accumulated efforts of chemical and biological research to understand living organisms and their distinctive effects on health and medicine and to stimulate new ideas among the established natural products community. Provides readers with an in-depth review of current natural products research and a critical insight into the future direction of the field Bridges the gap in knowledge by covering developments in the field since the second edition published in 2010 Split into 7 sections on key topics to allow students, researchers and professionals to find relevant information quickly and easily Ensures that the knowledge within is easily understood by and applicable to a large audience

Download or read book Origin of Life written by Y. Wolman and published by Springer Science & Business Media. This book was released on 1981-02-28 with total page 640 pages. Available in PDF, EPUB and Kindle. Book excerpt: Proceedings of the Third ISSOL Meeting and the Sixth ICOL Meeting, Jerusalem, 22-27 June 1980

Download or read book New Experimental Probes for Enzyme Specificity and Mechanism written by and published by Elsevier. This book was released on 2023-05-26 with total page 572 pages. Available in PDF, EPUB and Kindle. Book excerpt: New Experimental Probes for Enzyme Specificity and Mechanism, Volume 685, the latest release in the Methods of Enzymology series, highlights new advances in the field with this new volume presenting interesting chapters on a variety of topics including Subverting Hedgehog Protein Autoprocessing by Chemical Induction of Paracatalysis, New Mechanistic Probes to Identify Novel Substrates for N-Myristoyltransferases, Phosphonate and a Fluorophosphonate Analogues of D Glucose 6 Phosphate as Active-Site Probes of 1L-Myo-Inositol 1 phosphate Synthase, Kinetic Mechanism of Nicotine-Degrading Enzyme Probed by Stopped-Flow Kinetic Analyses, Kinetics and Mechanism for Enzyme-Catalyzed Reactions of Substrate Pieces, and more. Additional chapters cover Kinetics and Mechanism for Reactions of Enzyme Pieces, Evaluation of allostery for the bienzyme assembly of a 3-deoxy-D-arabino heptulosonate-7-phosphate synthase and chorismate mutase, Recognition and Catalysis of Reactions of Chiral Substrates by Mandelate Racemase, Innovative and emerging modalities of EGFR kinase inhibitors, Characterization of the Aminoacrylate Intermediate of Tyrosine Phenol-Lyases, and much more. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in Methods in Enzymology serials Updated release includes the latest information on New Experimental Probes for Enzyme Specificity and Mechanism

Download or read book Catalysis An Integrated Approach written by R.A. van Santen and published by Elsevier. This book was released on 2000-09-26 with total page 646 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book concentrates on industrially relevant reactions which are catalyzed by heterogeneous and homogeneous catalysts. Homogeneous catalysis by metal complexes is treated jointly with heterogeneous catalysis using metallic and non-metallic solids. In both areas the high degree of sophistication of spectroscopic techniques and theoretical modelling has led to an enormous increase in our understanding at the molecular level. This holds for the kinetics of the reactions and the reactivities of the catalysts, as well as for the syntheses of the catalytic materials. The development of catalysis science since the first edition of this book has necessitated a thorough revision, including special chapters on biocatalysis, catalyst characterization and adsorption methods. The multidisciplinary nature of catalysis is reflected in the choice of a novel combination of basic disciplines which will be refreshing and inspiring to readers.

Download or read book Redox and Non redox Reactions Catalyzed by Biomimetric Flavin based Organocatalysts and the Discovery of Selective Oxidation Methods for the Preparation of N Heterocycles written by Pawan Thapa and published by . This book was released on 2019 with total page 635 pages. Available in PDF, EPUB and Kindle. Book excerpt: In nature, flavoproteins (FMN and FAD) are known to catalyze several chemical transformations which play a vital role in the growth, development, and survival of organisms. They are involved in one-electron and two-electron transfer reactions, photo-induced electron transfer reactions, dehydrogenase reactions, oxidative atom transfer reactions and also rare non-redox reactions. Their enhanced stability and ability to turn over in presence of dioxygen has inspired synthetic chemists, including our group, to perform biomimetic transformations within a range of function of natural flavoproteins. In chapter 1, both intramolecular and intermolecular dehydrogenative coupling between the alpha carbon of tertiary amines and various nitrogen, phosphorus, and carbon-based nucleophilesare reported. This study signifies the flavin dependent oxidase type chemistry promoted by synthetic flavins, rendering the catalytic construction of some sophisticated heterocycles through an atom economical and aerobic approach. Mechanistic studies with different radical probes suggest the involvement of radical intermediates in the reaction cycle. Moreover, intramolecular kinetic isotope studies performed reveal possibility of Hydrogen atom abstraction being rate determining step. In chapter 2, a non-redox type of chemistry is disclosed. A subclass of riboflavin mimics was found to catalyze C-C bond formation by activating small molecules in a new manner. This approach was successfully applied to synthesize various industrially important dyes and chemical reagents. Additionally, the relationship discovered between molecular structure and catalytic function of riboflavin mimics in these new chemical reactions revealed a plausible explanation for the function of natural riboflavin-dependent hydroxynitrilase enzymes in biological system. Mechanistic studies using nuclear magnetic resonance (NMR) spectroscopy, UV-vis spectroscopy and electron paramagnetic resonance (EPR) spectroscopy showed a possible frustrated lewis-pair (FLP) type of interaction between aldehydes and flavin mimics. In chapter 3, studies on benzimidazole synthesis by iron catalysts will be discussed. 1,2-disubstituted benzimidazoles serve as important class of molecules in several area of chemistry including drug discovery, catalysis, etc. Our investigation in this area with redox active iron catalysts revealed N,N'-disubstituted-ortho-phenylenediamine substrates being superior to N,N disubstituted-ortho-phenylenediamines in generating 1,2-disubstituted benzimidazoles. Extensive UV-vis spectroscopy studies and kinetic studies have been performed in addition to EPR spectroscopy to understand the nature of mechanism. Both Lewis acid property and redox active property of iron trichloride are thought to play a significant role in catalysis. Smooth complex formation between N,N'-disubstituted-ortho-phenylenediamine substrates and iron catalyst provides the driving force for the electron transfer process to form productive iminiumintermediate.A simple method for chemo-selective oxidation of isoindolines to isoindolinones was also studied in chapter 4. This method utilizes no catalyst, no additive, mild condition and is highlighted as just solvent mediated transformation. Mechanistic investigation shows hydrogen atom abstraction process leading to isoindole intermediates which further binds to oxygen to give desired isoindolinones products.

Download or read book Comprehensive Chirality written by and published by Newnes. This book was released on 2012-12-31 with total page 5635 pages. Available in PDF, EPUB and Kindle. Book excerpt: Although many books exist on the subject of chiral chemistry, they only briefly cover chiral synthesis and analysis as a minor part of a larger work, to date there are none that pull together the background information and latest advances in one comprehensive reference work. Comprehensive Chirality provides a complete overview of the field, and includes chiral research relevant to synthesis, analytic chemistry, catalysis, and pharmaceuticals. The individual chapters in each of the 9 volumes provide an in depth review and collection of references on definition, technology, applications and a guide/links to the related literature. Whether in an Academic or Corporate setting, these chapters will form an invaluable resource for advanced students/researchers new to an area and those who need further background or answers to a particular problem, particularly in the development of drugs. Chirality research today is a central theme in chemistry and biology and is growing in importance across a number of disciplinary boundaries. These studies do not always share a unique identifying factor or subject themselves to clear and concise definitions. This work unites the different areas of research and allows anyone working or researching in chiral chemistry to navigate through the most essential concepts with ease, saving them time and vastly improving their understanding. The field of chirality counts several journals that are directly and indirectly concerned with the field. There is no reference work that encompasses the entire field and unites the different areas of research through deep foundational reviews. Comprehensive Chirality fills this vacuum, and can be considered the definitive work. It will help users apply context to the diverse journal literature offering and aid them in identifying areas for further research and/or for solving problems. Chief Editors, Hisashi Yamamoto (University of Chicago) and Erick Carreira (ETH Zürich) have assembled an impressive, world-class team of Volume Editors and Contributing Authors. Each chapter has been painstakingly reviewed and checked for consistent high quality. The result is an authoritative overview which ties the literature together and provides the user with a reliable background information and citation resource.

Download or read book Organochalcogen Compounds written by Eder João Lenardão and published by Elsevier. This book was released on 2022-05-17 with total page 341 pages. Available in PDF, EPUB and Kindle. Book excerpt: Organochalcogen compounds reviews the state of the art in new green protocols involving organochalcogen compounds (Se, S, and Te), including the use of nonconventional reaction media, alternative solvents, and solvent-free protocols to prepare these important compounds. Bringing together several leading researchers in organochalcogen chemistry, it provides an authoritative overview of the current state of the field and compiles recent advances in methodologies for the application of green chemistry principles in compound development. These include the use of organochalcogen compounds as intermediates, catalysts, or target products across a range of applications. The recent developments outlined in in the book reflect the efforts of the researchers in this area to move toward a more sustainable chemistry, giving the book the dual benefit of highlighting the latest developments in the field while also showing how the principles of green chemistry can effectively be included in active research projects. Thus it is a valuable reference for chemists, particularly those working in organic, green, and synthetic chemistry across both academia and industry. Highlights green synthetic methods with potential application in the synthesis of natural compounds or other biologically active scaffolds Explores the chemical modification of natural compounds by insertion of organochalcogen groups for the preparation of boosted bioactive semisynthetic molecules Discuss how redox catalysis and catalysis in flow conditions using eco-friendly oxidant can provide new opportunities for the synthesis of linear ad cyclic derivatives

Download or read book The Pyridine Nucleotide Coenzymes written by Johannes Everse and published by Elsevier. This book was released on 2012-12-02 with total page 426 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Pyridine Nucleotide Coenzymes provides a comprehensive discussion of the evolution, properties, and reactions of pyridine nucleotide coenzymes. The pyridine nucleotide coenzymes, NAD and NADP, appear to be among the most versatile of molecules with respect to their biological functions. In addition to their well-documented roles in a large number of oxidation-reduction reactions, these coenzymes are involved in many aspects of metabolic regulation. The book begins by tracing the evolution of coenzymes and pyridine nucleotide coenzymes. This is followed by separate chapters that deal with the static and dynamic properties of the pyridine nucleotide coenzymes; chemistry and solution conformation of the pyridine coenzymes; pyridine nucleotide analogs; and the three-dimensional structures of pyridine nucleotide binding enzymes. Subsequent chapters cover the synthesis and characterization of immobilized coenzymes and derivatives and their applications in affinity chromatography and enzyme reactors; the pathways to quinolinate, a major precursor of pyridine nucleotides; the role of pyridine nucleotides in phagocytosis; and non-oxidation-reduction reactions of pyridine nucleotides.

Download or read book Organic Chemistry of Enzyme Catalyzed Reactions Revised Edition written by Richard B. Silverman and published by Elsevier. This book was released on 2002-03-07 with total page 736 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Organic Chemistry of Enzyme-Catalyzed Reactions is not a book on enzymes, but rather a book on the general mechanisms involved in chemical reactions involving enzymes. An enzyme is a protein molecule in a plant or animal that causes specific reactions without itself being permanently altered or destroyed. This is a revised edition of a very successful book, which appeals to both academic and industrial markets. Illustrates the organic mechanism associated with each enzyme-catalyzed reaction Makes the connection between organic reaction mechanisms and enzyme mechanisms Compiles the latest information about molecular mechanisms of enzyme reactions Accompanied by clearly drawn structures, schemes, and figures Includes an extensive bibliography on enzyme mechanisms covering the last 30 years Explains how enzymes can accelerate the rates of chemical reactions with high specificity Provides approaches to the design of inhibitors of enzyme-catalyzed reactions Categorizes the cofactors that are appropriate for catalyzing different classes of reactions Shows how chemical enzyme models are used for mechanistic studies Describes catalytic antibody design and mechanism Includes problem sets and solutions for each chapter Written in an informal and didactic style