Download or read book Nevogenesis written by Ashfaq A. Marghoob and published by Springer Science & Business Media. This book was released on 2012-10-13 with total page 160 pages. Available in PDF, EPUB and Kindle. Book excerpt: The “Abtropfung” theory that nevi develop through the migration of nevus cells from the epidermis to the dermis prevailed for almost a century until the “Hochsteigerung” theory postulated the reverse pattern of migration. Most recently, however, new insights gained from epidemiology, cross-sectional and longitudinal studies of nevi, dermoscopy and confocal microscopy, and cellular and molecular studies have brought into question both of these theories. This book provides a comprehensive guide to current knowledge about nevogenesis by presenting these latest advances and in addition discusses issues yet to be resolved. It will assist practicing physicians in effectively managing patients with a variety of nevi and will also be of great value to researchers in the field. Importantly, since nevi are associated with an increased risk of melanoma, understanding nevogenesis may help to unravel some of the mysteries of melanomagenesis.

Download or read book The Pigmentary System written by James J. Nordlund and published by John Wiley & Sons. This book was released on 2008-04-15 with total page 1248 pages. Available in PDF, EPUB and Kindle. Book excerpt: The most comprehensive and integrated book on pigmentation The Pigmentary System, Second Edition, gathers into one convenient, all-inclusive volume a wealth of information about the science of pigmentation and all the common and rare clinical disorders that affect skin color. The two parts, physiology (science) and pathophysiology (clinical disorders), are complementary and annotated so that those reading one part can easily refer to relevant sections in the other. For the clinician interested in common or rare pigment disorders or the principles of teaching about such disorders, this book provides an immediate and complete resource on the biologic bases for these disorders. For the scientist studying the biology of melanocyte function, the book provides a list of disorders that are related to basic biological functions of melanocytes. New features of this Second Edition include: Completely new section on the basic science of pigmentation – explaining the integration of melanocyte functions with other epidermal cells and with various organ systems like the immune system New chapters on pigmentary disorders related to intestinal diseases, the malignant melanocyte, benign proliferations of melanocytes (nevi) and phototherapy with narrow band UV All clinical chapters include the latest genetic findings and advances in therapy More than 400 color images of virtually all clinical disorders The book is ideal for all dermatologists and especially those interested in disorders of pigmentation. It is of particular use for pediatric dermatologists and medical geneticists caring for patients with congenital and genetic pigmentary disorders. This authoritative volume will fill the gap for dermatology training programs that do not have local experts on pigmentation. Basic and cosmetic scientists studying pigmentation and melanocytes will find the science and clinical correlations very useful in showing human significance and relevance to the results of their studies.

Download or read book Precision Molecular Pathology of Dermatologic Diseases written by Victor G. Prieto and published by Springer. This book was released on 2015-08-10 with total page 142 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume is a concise yet comprehensive resource for physicians dealing with, and interested in, the field of molecular pathology in dermatopathology. The book includes descriptions of the techniques and their application to cutaneous diseases and describes possible future techniques and their use in dermatopathology. Special emphasis is also given to the practical application of these techniques to particular situations illustrated by demonstrative cases. Written by experts in their fields, Precision Molecular Pathology of Dermatologic Diseases is of great value to pathologists, dermatologists, resident and fellows, internists, and general practitioners who deal with dermatologic diseases.

Download or read book Issues in Dermatology and Cosmetic Medicine 2012 Edition written by and published by ScholarlyEditions. This book was released on 2013-01-10 with total page 166 pages. Available in PDF, EPUB and Kindle. Book excerpt: Issues in Dermatology and Cosmetic Medicine: 2012 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Dermatology. The editors have built Issues in Dermatology and Cosmetic Medicine: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Dermatology in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in Dermatology and Cosmetic Medicine: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Download or read book Dermoscopy an Issue of Dermatologic Clinics written by Giuseppe Argenziano and published by Elsevier Health Sciences. This book was released on 2013-10-28 with total page 214 pages. Available in PDF, EPUB and Kindle. Book excerpt: Viewing lesions using a dermatoscope helps the dermatologist distinguish between benign and malignant lesions. It is particularly useful in the early diagnosis of melanoma, which is the fastest growing cancer in the US and worldwide. This issue of the Dermatologic Clinics issue all of the important topics in dermoscopy, including differentiation of lesions, lesions in the young and older populations, and dermoscopy in general dermatology.

Download or read book Clinical Cases in Dermoscopy of Skin Cancers written by Danica Tiodorovic and published by Springer Nature. This book was released on 2020-01-01 with total page 225 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a practical guide to the clinical decision-making process used in the management of skin cancers with the use of dermoscopy. Clinical cases are examined to help the reader through the treatment of unusual skin cancers using best practice techniques. A variety of skin conditions are covered, including melanoma, basal cell carcinoma, squamous cell carcinoma, Bowen’s disease and actinic keratosis. Clinical Cases in Dermoscopy of Skin Cancers highlights evidence-based best practice through its multidisciplinary approach and is an important addition to the literature to help trainees and practicing dermatologists or any healthcare professional who manages these patients.

Download or read book Reflectance Confocal Microscopy of Cutaneous Tumors written by Salvador Gonzalez and published by CRC Press. This book was released on 2017-07-06 with total page 849 pages. Available in PDF, EPUB and Kindle. Book excerpt: Reflectance confocal microscopy enables lesions in skin to be examined without excision, but with improved diagnostic accuracy, assessment of dermoscopic-histologic correlation, assessment of surgical margins, as well as speed and convenience for the physician and patient. This extensively enlarged and updated text reviews the current and future state of the art for those involved with the diagnosis and treatment of skin tumors, with a greatly increased amount of material on the expected normal patterns of skin throughout life and on non-melanocytic tumors.

Download or read book Identification and clinical evaluation of senescence associated markers to distinguish melanocytic nevi from melanomas written by Kyriakos Orfanidis and published by Linköping University Electronic Press. This book was released on 2019-12-19 with total page 102 pages. Available in PDF, EPUB and Kindle. Book excerpt: Melanoma is a form of cancer that develops in melanocytes. While it represents only 5% of skin malignancies, it is the most aggressive and lethal. Benign proliferation of these cells form the melanocytic nevi. The definitive diagnosis of melanocytic nevi or melanoma lesions is histopathologic. However, it is estimated that a correct diagnosis is established by means of standard skin biopsy in only 83% of the melanocytic lesions; of the remaining cases 8% and 9% are overinterpreted (false positives) and under-interpreted (false negatives), respectively. This underscores the importance of additional diagnostic tests. Since cellular senescence is considered to be a tumor suppressive mechanism, immuno-histochemistry using senescence markers has been suggested for the evaluation of difficult melanocytic lesions; however, the routinely used senescence markers lack the ability to distinguish nevi from melanoma. The general aim of this thesis is therefore to identify novel senescence markers that may aid in melanoma diagnosis. In study I, we established a cellular model with nevus-mimicking characteristics consisting in primary melanocytes that become senescent. Transcriptomic analysis allowed expanding the set of senescence-associated markers that could distinguish nevi from melanoma and identifying tubulin ?-3 as a potential diagnostic marker. Depletion of tubulin ?-3 and pretreatment with tubulin destabilizing drugs in melanocytes and melanoma cells induced a senescence-like phenotype in vitro. In particular, reduced migration capacity and induction of cell cycle arrest in G2/M phase of the cell cycle was demonstrated. In study II, a potential inter-cellular signaling pathway between melanoma cells and stromal fibroblasts, that might facilitate melanoma invasion, was investigated. Ultraviolet (UV) radiation was shown, both in melanoma cells and fibroblasts, to promote the release and activation of TGF-?1 and subsequent increase in expression of the serine protease FAP-?, a protein that plays role in extracellular matrix degradation and therefore facilitates the invasion of melanoma cells. Such mechanism was not functional in senescent melanocytes. In study III, it was shown that tubulin ?-3 immunostaining aids in the diagnosis of nevi and melanomas. The diagnostic criterium was the tubulin ?-3 gradient within the melanocytic nevi that was no longer apparent in melanoma. Different patterns of tubulin ?-3 immunostaining in melanoma were described, dermoscopy-immunohistochemistry associations were found, specific dermoscopic features highlighted, and the prognostic value of this tubulin ?-3 marker was examined. The progression rate in patients whose melanomas had areas with loss of tubulin ?-3 was 4 times higher than in patients without this feature, although statistical significance could not be reached (p=0.06). In conclusion, transcriptomic analysis expanded the set of senescence-associated markers that could distinguish nevi from melanoma and identified tubulin ?-3 as novel immunohistochemistry marker shown to have diagnostic and probably prognostic value. From a mechanistical point of view, ultraviolet radiation was shown to promote not only the formation of melanoma but also its progression by increasing a cathepsin-TGF-?1-FAP-? pathway resulting in extracellular matrix degradation. Malignt melanom är en form av cancer som utvecklas i melanocyter, de celler i huden som bildar pigmentet melanin. Även om malignt melanom endast utgör 5% av alla hudcancrar, är den den mest aggressiva och dödliga. Godartad ansamling av melanocyter bildar en leverfläck eller ett sk nevus. Vid minsta misstanke om melanom, opereras nevuset bort och analyseras i mikroskop. Det uppskattas dock att en korrekt diagnos fastställs endast i 83% av de bortopererade lesionerna. Av de återstående fallen är 8% övertolkade och 9% undertolkade. Detta understryker vikten av att förbättra melanomdiagnostik. Melanocyter i nevi anses i motsats till melanom ha avtagande förmåga att föröka sig efter ett visst antal celldelningar på grund av cellåldrande. Påvisande av cellåldrande-markörer skulle därför kunna förbättra diagnostiken av svårbedömda lesioner. De idag rutinmässigt använda cellåldrande-markörerna saknar dock förmåga att skilja nevi från melanom. Det övergripande syftet med denna avhandling var därför att försöka identifiera nya cellåldrande-markörer för att förbättra melanom-diagnostiken. I studie I etablerade vi en cellmodell med nevus-efterliknande egenskaper bestående av melanocyter som åldras. Med genuttryck-analys studerades cellåldrande-markörer som kunde skilja nevi från melanom. Proteinet tubulin ?-3 identifierades som en potentiell diagnostisk markör. Minskning av tubulin ?-3 och förbehandling med tubulin-destabiliserande läkemedel i melanocyter visade sig inducera ett tillstånd som liknar cellåldrandet. I studie II undersöktes en signalväg mellan melanomceller och fibroblaster, som kan underlätta melanomcellers förmåga att infiltrera och aktivt förstöra omgivande vävnad. Fibroblaster är en typ av bindvävsceller i läderhuden som tillverkar ämnen som finns mellan celler, s.k. extracellulär matrix. Ultraviolett (UV)-strålning visade sig, både i melanomceller och fibroblaster, främja signalvägen som resulterar i ökat proteinuttryck av FAP-?, ett protein som bidrar till nedbrytning av extracellulär matrix vilket kan underlätta infiltration av melanomceller. En sådan signalväg var inte funktionell i åldrande melanocyter. I studie III visade vi att proteinet tubulin ?-3 är en markör som underlättar diagnostik av nevi respektive melanom. Det diagnostiska kriteriet var tubulin ?-3 gradienten som kunde ses i nevi men som ej var synligt i melanom. Olika mönster av tubulin ?-3 analys i melanom beskrevs, kliniska associationer hittades och värdet av denna markör för att förutsäga sjukdomens förlopp undersöktes. Melanompatienter, vars melanom hade områden med förlust av tubulin ?-3, hade fyra gånger högre progressionstakt av sjukdomen jämfört med patienter utan detta mönster. Sammanfattningsvis studerade vi cellåldrande-markörer som kunde skilja nevi från melanom och vi identifierade proteinet tubulin ?-3 som en markör med diagnostiskt och förmodligen prognostiskt värde. Vi visade att ultraviolett strålning inte bara främjar melanombildning utan också dess progression genom att öka en signalväg mellan melanomceller och fibroblaster som resulterar i extracellulär matrixnedbrytning.

Download or read book An Atlas of Dermoscopy written by Ashfaq Marghoob and published by CRC Press. This book was released on 2012-07-26 with total page 395 pages. Available in PDF, EPUB and Kindle. Book excerpt: Building on a successful first edition, this revised and extended Atlas of Dermoscopy demonstrates the state of the art of how to use dermoscopy to detect and diagnose lesions of the skin, with a special emphasis on malignant skin tumours. With well over 1,500 photographs, drawings, and tables, the book has extensive clinical correlation with dermo

Download or read book Pathology of Melanocytic Nevi and Melanoma written by Raymond L. Barnhill and published by Springer Science & Business Media. This book was released on 2014-02-18 with total page 654 pages. Available in PDF, EPUB and Kindle. Book excerpt: Highly acclaimed and considered the leading reference in the field, Pathology of Melanocytic Nevi and Malignant Melanoma has once again been fully revised and updated to reflect the most recent advances and techniques in the field of melanoma pathology. The successful focus and format of the previous editions have been preserved. Each lesion and diagnosis is clearly illustrated with the aid of a wealth of digitally enhanced full-color photomicrographs. A concise description of the clinical features, histopathology, differential diagnosis, and the most important characteristics of each lesion provides readers with a quick yet comprehensive overview of each topic covered. Pathology of Melanocytic Nevi and Malignant Melanoma is the essential reference for every practicing dermatopathologist, pathologist, dermatologist, and cancer research scientist today.

Download or read book Color Atlas of Dermoscopy written by Horacio Cabo and published by JP Medical Ltd. This book was released on 2017-07-17 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dermoscopy is a non-invasive, widely used diagnostic tool that aids the diagnosis of skin lesions and is proven to increase the accuracy of melanoma diagnosis. This colour atlas is a comprehensive guide to the diagnosis of skin lesions and melanomas using a dermoscope. Beginning with an introduction to the use of the dermascope, the following chapters teach clinicians how to recognise dermoscopic criteria, colours and patterns, how to diagnose different types of lesions and calculate diagnostic algorithms. The finals sections cover related topics including entomodermatoscopy, inflammatoscopy, trichoscopy and capilaroscopy. This highly useful resource is enhanced by more than 1000 clinical images and illustrations. Key points Comprehensive guide to diagnosis of skin lesions and melanomas using a dermoscope Teaches clinicians how to recognise dermoscopic criteria Covers related dermatoscopic topics Includes more than 1000 images and illustrations

Download or read book Cutaneous Oncology An Issue of Hematology Oncology Clinics of North America E Book written by David E. Fisher and published by Elsevier Health Sciences. This book was released on 2024-09-05 with total page 281 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this issue of Hematology/Oncology Clinics, guest editor Dr. David E. Fisher brings his considerable expertise to the topic of Cutaneous Oncology. Top experts first provide information on skin structure, function, and immunology, then offer overviews of the therapeutic state of the art for both melanoma and non-melanoma skin cancers. Discussions focus on unique clinical challenges and biological breakthroughs which have come to light in recent studies of cutaneous malignancies. - Contains 16 relevant, practice-oriented topics including high risk non-melanoma skin cancers; progress in immune checkpoints for melanoma therapy; targeted therapy innovations for melanoma; advances in vaccines for melanoma; microbiome and immunotherapy; Merkel cell carcinoma; and more. - Provides in-depth clinical reviews on cutaneous oncology, offering actionable insights for clinical practice. - Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

Download or read book Cancer New Insights for the Healthcare Professional 2011 Edition written by and published by ScholarlyEditions. This book was released on 2012-01-09 with total page 3939 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer: New Insights for the Healthcare Professional: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Cancer. The editors have built Cancer: New Insights for the Healthcare Professional: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Cancer in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Cancer: New Insights for the Healthcare Professional: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Download or read book Reflectance Confocal Microscopy for Skin Diseases written by Rainer Hofmann-Wellenhof and published by Springer Science & Business Media. This book was released on 2012-03-01 with total page 484 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on the use and significance of in vivo reflectance confocal microscopy (RCM) for non-invasive high-resolution imaging of the skin. All of the chapters in this hands-on guide are generously illustrated with numerous confocal images and structured in a reader-friendly way. The contents include detailed information on the most relevant and up-to-date aspects of RCM, schematic drawings summarizing and explaining the most important RCM criteria, and a chapter specifically devoted to bridging the gap between dermoscopy, RCM, and histopathology. At the end of each chapter, core messages recapitulate the most pertinent aspects. Reflectance Confocal Microscopy for Skin Diseases will be a valuable resource for all physicians involved in the diagnosis and treatment of neoplastic and inflammatory skin diseases.

Download or read book Holcomb and Ashcraft s Pediatric Surgery E Book written by George W. Holcomb and published by Elsevier Health Sciences. This book was released on 2019-04-14 with total page 1317 pages. Available in PDF, EPUB and Kindle. Book excerpt: Known for its readability, portability, and global perspectives, Holcomb and Ashcraft's Pediatric Surgery remains the most comprehensive, up-to-date, single-volume text in its field. As technology and techniques continue to evolve, the 7th Edition provides state-of-the-art coverage—both in print and on video—of the full range of general surgical and urological problems in infants, children, and adolescents, equipping you to achieve optimal outcomes for every patient. - Provides authoritative, practical coverage to help you implement today's best evidence-based open and minimally invasive techniques, with guidance from internationally recognized experts in the field. - Features more than 1,000 high-quality images depicting the visual nuances of surgery for the full range of pediatric and urologic conditions you're likely to see. - Delivers comprehensive updates throughout including the latest advances in managing Inguinal Hernias and Hydroceles; Imperforate Anus and Cloacal Malformations; Hirschsprung Disease; Duodenal and Intestinal Atresia and Stenosis; Esophageal Atresia; and more. - Offers access to more than 50 videos that help you improve and refine your surgical skills. New videos cover Fetal Endoluminal Tracheal Occlusion (FETO); Laparoscopic Inguinal Hernia Repair; Robotic Extravesical Ureteral Reimplantation; Laparoscopic Management of Ovarian Torsion; and Laparoscopic Sleeve Gastrectomy. - Enhanced eBook version included with purchase, which allows you to access all of the text, figures, and references from the book on a variety of devices

Download or read book Pediatric Nail Disorders written by Robert Baran and published by CRC Press. This book was released on 2016-10-26 with total page 401 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is a highly illustrated guide to the diagnosis and management of nail conditions in children. With new material on genetics and on developments such as dermoscopy, it will be invaluable as a reliable clinical reference for both dermatologists and pediatricians, as well as those in family practice.

Download or read book Essentials of Surgical Pediatric Pathology written by Marta C. Cohen and published by Cambridge University Press. This book was released on 2015-02-05 with total page 1225 pages. Available in PDF, EPUB and Kindle. Book excerpt: Essentials of Surgical Pediatric Pathology is a clear and practical yet comprehensive guide for trainee pediatric pathologists and non-pediatric pathologists. Each chapter corresponds to one of the main subspecialties, such as dermatopathology, head and neck pathology, and system pathology. Practical guidance is given on handling pediatric specimens and the authors highlight the ways in which common conditions present differently in adults and children. Other chapters cover conditions typical of childhood, including soft tissue tumors and blue round cell tumors. The chapters begin with a brief clinical presentation, followed by a clear macroscopical and histological description of the principal pathologies seen in children. Up-to-date genetic and immunohistochemical information is provided, and the book includes hundreds of high-quality color images. Written and edited by leading international experts in the field, this is an essential resource for trainee pediatric pathologists, as well as general pathologists who may encounter pediatric cases.