Download or read book The Neuronal Cytoskeleton Motor Proteins and Organelle Trafficking in the Axon written by and published by Academic Press. This book was released on 2016-01-12 with total page 534 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Neuronal Cytoskeleton, Motor Proteins, and Organelle Trafficking in the Axon, a new volume in the Methods in Cell Biology series continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers research methods in neuronal cells, and includes sections on such topics as actin transport in axons and neurofilament transport. Covers an increasingly appreciated field in cell biology Includes both established and new technologies Contributed by experts in the field
Download or read book The Neuronal Cytoskeleton written by Robert D. Burgoyne and published by Wiley-Liss. This book was released on 1991-02-27 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt: This text examines the organization and structure of cytoskeletal proteins, their regulation and precise roles in neuronal development and function. Using a wide range of techniques including ultrastructural, biochemical and molecular biological approaches, the chapters examine such particular components as microtubule-associated proteins, microtubules and microtubule assembly, actin and related proteins and neurofilaments. Also describes the functional importance of the neuronal cytoskeleton during neuronal development and in axonal transport and neurotransmitter release. Designed to stand alone as self-contained reviews of a particular aspect of the field, the chapters amount to a comprehensive view of the neuronal cytoskeleton and its functions.
Download or read book Shaping the Brain by Neuronal Cytoskeleton from Development to Disease and Regeneration written by C. Laura Sayas and published by Frontiers Media SA. This book was released on 2020-03-25 with total page 185 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Cytoskeleton of the Nervous System written by Ralph A. Nixon and published by Springer Science & Business Media. This book was released on 2011-02-04 with total page 775 pages. Available in PDF, EPUB and Kindle. Book excerpt: This monograph begins with a general description of the cytoskeleton in axonal development and pathology and then moves to more detailed descriptions of particular components, including microtubules and associated proteins, neurofilaments and interacting proteins, actin and its binding proteins, and glial fibrillary acidic protein. The later chapters focus on the functional significance of the neuronal cytoskeleton in axonal transport and its regulation in health and disease states. The Cytoskeleton of the Nervous System will encourage further development of unifying principles and stimulate new conceptual and technical approaches toward a better understanding of cytoskeleton functions in health and disease.
Download or read book Nanoneuroscience written by Nancy J. Woolf and published by Springer Science & Business Media. This book was released on 2009-12-04 with total page 290 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nanoneuroscience is the study of computationally relevant biomolecules found inside neurons. Because of recent technological advances at the nanometer scale, scientists have at their disposal increasingly better ways to study the brain and the biophysics of its molecules. This book describes how biomolecules contribute to the operations of synapses and perform other computationally relevant functions inside dendrites. These biomolecular operations considerably expand the brain-computer analogy - endowing each neuron with the processing power of a silicon-based multiprocessor. Amazingly, the brain contains hundreds of billions of neurons.
Download or read book Cytoskeleton of the Nervous System written by and published by . This book was released on 2011-04-11 with total page 792 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Neuronal Cytoskeleton written by Hirokawa and published by CRC Press. This book was released on 1994-01-12 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book discusses the primary functions of microtubule-associated proteins (MAPs) such as MAP2 and tau in neuronal morphogenesis, as well as relationships between neuronal differentiation and the expression of neuronal intermediate filaments (nestin, alpha internexin, and neurofilament triplet proteins). It emphasizes the importance of several cytoskeletal proteins for neuronal differentiation and morphogenesis, organelle transport, and synaptic functions. The book considers the involvement of tau MAPs in the formation of paired helical filaments in Alzheimer's disease, and it examines the mechanisms of organelle transports and molecular motors such as kinesin, braindynein, and kinesin superfamily proteins. Cytoskeletal proteins involved in synaptic formation and transmitter release and new synaptic junctional-associated proteins are explored as well.
Download or read book Molecular Biology of The Cell written by Bruce Alberts and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Alterations in the Neuronal Cytoskeleton in Alzheimer Disease written by George Perry and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 230 pages. Available in PDF, EPUB and Kindle. Book excerpt: The neuronal cytoskeleton is a complex structure responsive to both intrinsic and extrinsic factors. Defined populations of neurons in the brains of patients with Alzheimer and several other neurodegenerative diseases contain abnormal filamentous accumulations which share elements with the cytoskeleton. Although there is a general consensus that these abnormal filaments do contain cytoskeletal elements, much debate remains regarding which cytoskeletal elements are incorporated and whether the cytoskeletal rearrangement is primary or secondary to other cellular changes. In this book these questions are addressed in a historical perspect ive in light of new data that allows the reinterpretation of previously reported results. Contributions are based on many of the major tech niques of modern biology including biochemistry, molecular biology, electron microscopy and immunocytochemistry. In the view of the editor, this volume is being written at a time when our understanding of the cytopathology of Alzheimer disease is moving from predominantly descriptive to both analytical and mechanistic. I hope that this contribution will provide impetus to speed this transi tion. George Perry Cleveland, Ohio vii ACKNOWLEDGEMENT The support of the Fidia Pharmaceutic Corporation for the computer generated color figure on page 65 is gratefully acknowledged.
Download or read book The Cytoskeleton written by Rolf Dermietzel and published by Humana Press. This book was released on 2016-05-01 with total page 376 pages. Available in PDF, EPUB and Kindle. Book excerpt: This informative Neuromethods series book surveys the cytoskeleton, and offers detailed protocols on emerging techniques including in vivo and in vitro imaging and preparative strategies for isolation of cytoskeletal components of the central nervous system.
Download or read book Basic Neurochemistry written by R. Wayne Albers and published by Elsevier. This book was released on 2005-11-11 with total page 1020 pages. Available in PDF, EPUB and Kindle. Book excerpt: Basic Neurochemistry: Molecular, Cellular and Medical Aspects, a comprehensive text on neurochemistry, is now updated and revised in its Seventh Edition. This well-established text has been recognized worldwide as a resource for postgraduate trainees and teachers in neurology, psychiatry, and basic neuroscience, as well as for graduate and postgraduate students and instructors in the neurosciences. It is an excellent source of information on basic biochemical processes in brain function and disease for qualifying examinations and continuing medical education. Completely updated with 60% new authors and material, and entirely new chapters Over 400 fully revised figures in splendid color
Download or read book Neuronal Mechanics and Transport written by Daniel M. Suter and published by Frontiers Media SA. This book was released on 2016-05-26 with total page 214 pages. Available in PDF, EPUB and Kindle. Book excerpt: Understanding the underlying mechanisms of how axons and dendrites develop is a fundamental problem in neuroscience and a main goal of research on nervous system development and regeneration. Previous studies have provided a tremendous amount of information on signaling and cytoskeletal proteins regulating axonal and dendritic growth and guidance. However, relatively little is known about the relative contribution and role of cytoskeletal dynamics, transport of organelles and cytoskeletal components, and force generation to axonal elongation. Advancing the knowledge of these biomechanical processes is critical to better understand the development of the nervous system, the pathological progression of neurodegenerative diseases, acute traumatic injury, and for designing novel approaches to promote neuronal regeneration following disease, stroke, or trauma. Mechanical properties and forces shape the development of the nervous system from the cellular up to the organ level. Recent advances in quantitative live cell imaging, biophysical, and nanotechnological methods such as traction force microscopy, optical tweezers, and atomic force microscopy have enabled researchers to gain better insights into how cytoskeletal dynamics and motor-driven transport, membrane-dynamics, adhesion, and substrate rigidity influence axonal elongation. Given the complexity and mechanical nature of this problem, mathematical modeling contributes significantly to our understanding of neuronal mechanics. Nonetheless, there has been limited direct interaction and discussions between experimentalists and theoreticians in this research area. The purpose of this Frontiers Research Topic is to highlight exciting, and important work that is currently developing in the fields of neuronal cell biology, neuronal mechanics, intracellular transport, and mathematical modeling in the form of primary research articles, reviews, perspectives, and commentaries.
Download or read book Neuronal Growth Cones written by Phillip R. Gordon-Weeks and published by Cambridge University Press. This book was released on 2000-07-03 with total page 275 pages. Available in PDF, EPUB and Kindle. Book excerpt: 'I had the good fortune to behold for the first time that fantastic ending of the growing axon. In my sections of the spinal cord of the three day chick embryo, this ending appeared as a concentration of protoplasm of conical form, endowed with amoeboid movements. It could be compared with a living battering ram, soft and flexible, which advances, pushing aside mechanically the obstacles which it finds in its path, until it reaches the region of its peripheral termination. This curious terminal club, I christened the growth cone.' (Santiago Ramón y Cajal, Recollections of My Life, 1937). In Neuronal Growth Cones, Phillip Gordon-Weeks presents the molecular biology of the behavior of growth cones. The book covers the basic morphology and behavior of growth cones, motility and neurite extension via the growth cone cytoskeleton, pathfinding, intracellular signalling, and synaptogenesis. It is the first detailed, critical analysis of all aspects of growth cone biology.
Download or read book Cytoskeleton written by Jose C. Jimenez-Lopez and published by BoD – Books on Demand. This book was released on 2017-05-17 with total page 344 pages. Available in PDF, EPUB and Kindle. Book excerpt: The cytoskeleton is a highly dynamic intracellular platform constituted by a three-dimensional network of proteins responsible for key cellular roles as structure and shape, cell growth and development, and offering to the cell with "motility" that being the ability of the entire cell to move and for material to be moved within the cell in a regulated fashion (vesicle trafficking). The present edition of Cytoskeleton provides new insights into the structure-functional features, dynamics, and cytoskeleton's relationship to diseases. The authors' contribution in this book will be of substantial importance to a wide audience such as clinicians, researches, educators, and students interested in getting updated knowledge about molecular basis of cytoskeleton, such as regulation of cell vital processes by actin-binding proteins as cell morphogenesis, motility, their implications in cell signaling, as well as strategies for clinical trial and alternative therapies based in multitargeting molecules to tackle diseases, that is, cancer.
Download or read book Neurobiology of Actin written by Gianluca Gallo and published by Springer Science & Business Media. This book was released on 2010-11-04 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt: This text is an introduction to the interface between the actin cytoskeleton and the myriad of issues fundamental to the understanding of the nervous system. It covers the neurobiology of actin ranging from basic cellular organization and function to the roles of actin in the health and disease states of the nervous system. Its opening chapter presents the fundamental concepts required to appreciate the details of the molecular machinery that regulates actin in a cellular context, setting the stage for the first part of the book which reviews the neurobiology of actin at the cellular level. The latter section of the book then discusses the functions of actin in the context of neurobiological issues ranging from early development to synaptic function and disease states of the nervous system. This text is intended for neuroscientists interested in investigating the actin cytoskeleton in the context of their particular neuroscience research program, and its chapters are cross-referenced in order to assist readers in finding relevant information that is covered in greater depth in other chapters.
Download or read book The Microtubule Cytoskeleton written by Jens Lüders and published by Springer. This book was released on 2016-04-08 with total page 189 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides an overview on the organization and function of the microtubule cytoskeleton, which is essential to many cellular processes and profoundly linked to a range of human diseases. Covering basic concepts as well as molecular details, the book discusses how microtubules are nucleated and organized into ordered arrays, at different cell cycle stages and in distinct cell types. In addition, the book highlights how defects in the microtubule cytoskeleton are linked to diseases such as neurodevelopmental disorders. The book is intended for students, graduates and more senior researchers in cell and developmental biology as well as for medical doctors.
Download or read book Neuronal Cell Death written by Arezu Jahani-Asl and published by Springer Nature. This book was released on 2022-07-01 with total page 359 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume covers comprehensive methods on ways to assess structural and ultrastructural changes in the mitochondria, cytoskeleton, and microglia using state-of-the-art microscopy techniques including super-resolution imaging, electron microscopy, and ultra-high field MRI. The chapters in this book cover topics such as analysis of neurodegeneration in the post-mortem characterization of preclinical animal models, in vivo modeling in cell death in different model systems and brain organoids, single cell clonal analysis using Mosaic Analysis with Double Markers in genetic mouse models, and genome and proteomic methods for analysis of mRNA dynamics and quantitation of targeted peptides. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and thorough, Neuronal Cell Death: Methods and Protocols is a valuable resource for any scientist and researcher interested in learning more about this developing field.
