Download or read book Neuroinflammation in Vascular Dementia written by Gary Rosenberg and published by Academic Press. This book was released on 2022-09-07 with total page 233 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neuroinflammation in Vascular Dementia describes the molecular mechanisms that drive this transition to mixed pathology, along with the newer lifestyle and pharmacological approaches that can reduce the incidence of dementia. The book describes the practical aspects of neuroimaging methods, along with novel neuroimaging methods, using MRI, that are becoming important clinically. The author also discusses how the diagnosis of dementias will be greatly aided by biomarkers from neuroimaging, blood and CSF biochemistry and neuropsychological testing in the future. This information will be used in precision medicine to design treatment strategies based on the most likely causes of the disease. Dementia research has undergone dramatic growth driven by current and projected increases in the aging of the population, and thus leading to a larger number of patients with dementia by 2050. Hence, advances in neuroimaging, brain chemistry, and genetics have accelerated our understanding of diseases that lead to cognitive decline. - Reviews the clinical aspects and subtypes of dementia - Explains molecular pathways involved in brain inflammation - Includes the role of CSF and blood in diagnosis - Covers established and novel neuroimaging methods - Discusses established and developing treatment strategies - Identifies future directions, such as machine learning and precision medicine
Download or read book Vascular Inflammation in Aging and Neurodegeneration written by Donghui Zhu and published by Frontiers Media SA. This book was released on 2022-11-16 with total page 154 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Inflammation Vascular Factors and Risk of Dementia written by Marieke van Oijen and published by . This book was released on 2007 with total page 171 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Type 2 Diabetes and Dementia written by Velandai Srikanth and published by Academic Press. This book was released on 2018-02-09 with total page 322 pages. Available in PDF, EPUB and Kindle. Book excerpt: Type 2 Diabetes and Dementia details the relationship between diabetes, dementia and the future of medicine and therapeutics. Chapters range from epidemiology, clinical features, neuroimaging biomarkers, neuropathology, macrostructural and molecular mechanisms, risk assessment and prevention strategies, and the application of therapeutics. The book reflects the translational aspects of the current science in the field, with an emphasis on the display of neuroimaging and neuropathology. It contains contributions from world experts, and is ideal for clinicians and researchers in the fields of neurology, neuroscience, geriatric medicine and endocrinology. - Presents a comprehensive overview that details the relationship between diabetes, dementia and the future of medicine and therapeutics - Written for researchers and clinicians in neurology, neuroscience, geriatric medicine and endocrinology - Includes topics ranging from epidemiology, clinical features, neuroimaging biomarkers, neuropathology, macrostructural and molecular mechanisms, risk assessment, prevention strategies and therapeutic applications
Download or read book Quality Control of Cellular Protein in Neurodegenerative Disorders written by Uddin, Md. Sahab and published by IGI Global. This book was released on 2020-02-14 with total page 515 pages. Available in PDF, EPUB and Kindle. Book excerpt: Protein misfolding and aggregation are hallmarks of several neurodegenerative proteinopathies. Though multiple factors like aging, oxidative stress, mitochondrial dysfunction, proteotoxic insults, genetic inconsistency, etc. are responsible for the dysfunction of the neuronal protein quality control system, targeting protein quality control has become an auspicious approach to halt the propagation of neurodegeneration. Quality Control of Cellular Protein in Neurodegenerative Disorders provides diverse aspects exploring the role of the protein quality control in neurodegenerative disorders and potential therapeutic strategies to combat the development and propagation of neurodegeneration. Featuring coverage on a broad range of topics such as molecular chaperones, protein misfolding, and stress signaling, this book is ideally designed for neurobiologists, neuropsychologists, neurophysiologists, medical professionals, neuropathologists, researchers, academicians, students, and practitioners engaged in studies of the protein quality control system in neuronal cells.
Download or read book Vascular Dementia written by Robert H. Paul and published by Springer Science & Business Media. This book was released on 2007-11-17 with total page 344 pages. Available in PDF, EPUB and Kindle. Book excerpt: A multidisciplinary survey of our current understanding of the biological and clinical aspects of vascular disease. The authors describe its basic mechanisms, its clinical characteristics, its pharmacological management, and the use of neuroimaging methods to investigate it. The complex relationship between VaD and AD is also fully explored with chapters on how these processes interact and how one disease may lower the threshold for clinical expression of the other.
Download or read book Infection Inflammation Cardiovascular diseases and Neurodegeneration written by Deng-Feng Zhang and published by Frontiers Media SA. This book was released on 2021-10-25 with total page 153 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Death Receptors and Cognate Ligands in Cancer written by Holger Kalthoff and published by Springer Science & Business Media. This book was released on 2010-03-12 with total page 286 pages. Available in PDF, EPUB and Kindle. Book excerpt: Death receptors play a central role in directing apoptosis in mammalian cells. This process of active cell death is important for a number of biological processes, e.g. for the regulation of the immune system. Death receptors are cell surface receptors that transmit apoptotic signals initiated by corresponding death ligands. Many complex signaling pathways are activated and apoptosis is the final result of a complex biochemical cascade of events. Besides their role in the induction of cell death, evidence now exists that death receptors are able to activate several non-apoptotic signaling pathways which, depending on cellular context, may lead to apoptosis resistance, secretion of pro-inflammatory proteins, proliferation and invasive growth of cancer cells. This book looks at the molecular basis of death receptor signaling and the role of death receptors in cancer development.
Download or read book Mechanisms of Neuroinflammation and Inflammatory Neurodegeneration in Acute Brain Injury written by Arthur Liesz and published by Frontiers Media SA. This book was released on 2015-11-13 with total page 286 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mechanisms of brain-immune interactions became a cutting-edge topic in systemic neurosciences over the past years. Acute lesions of the brain parenchyma, particularly, induce a profound and highly complex neuroinflammatory reaction with similar mechanistic properties between differing disease paradigms like ischemic stroke, intracerebral hemorrhage (ICH) and traumatic brain injury (TBI). Resident microglial cells sense tissue damage and initiate inflammation, activation of the endothelial brain-immune interface promotes recruitment of systemic immune cells to the brain and systemic humoral immune mediators (e.g. complements and cytokines) enter the brain through the damaged blood-brain barrier. These cellular and humoral constituents of the neuroinflammatory reaction to brain injury contribute substantially to secondary brain damage and neurodegeneration. Diverse inflammatory cascades such as pro-inflammatory cytokine secretion of invading leukocytes and direct cell-cell-contact cytotoxicity between lymphocytes and neurons have been demonstrated to mediate the inflammatory ‘collateral damage’ in models of acute brain injury. Besides mediating neuronal cell loss and degeneration, secondary inflammatory mechanisms also contribute to functional modulation of neurons and the impact of post-lesional neuroinflammation can even be detected on the behavioral level. The contribution of several specific immune cell subpopulations to the complex orchestration of secondary neuroinflammation has been revealed just recently. However, the differential vulnerability of specific neuronal cell types and the molecular mechanisms of inflammatory neurodegeneration are still elusive. Furthermore, we are only on the verge of characterizing the control of long-term recovery and neuronal plasticity after brain damage by inflammatory pathways. Yet, a more detailed but also comprehensive understanding of the multifaceted interaction of these two supersystems is of direct translational relevance. Immunotherapeutic strategies currently shift to the center of translational research in acute CNS lesion since all clinical trials investigating direct neuroprotective therapies failed. To advance our knowledge on brain-immune communications after brain damage an interdisciplinary approach covered by cellular neuroscience as well as neuroimmunology, brain imaging and behavioral sciences is crucial to thoroughly depict the intricate mechanisms.
Download or read book Neurological and Neuroscientific Evidence in Aged COVID 19 Patients written by Thomas Wisniewski and published by Frontiers Media SA. This book was released on 2021-12-21 with total page 231 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Cerebral Circulation written by Marilyn J. Cipolla and published by Biota Publishing. This book was released on 2016-07-28 with total page 82 pages. Available in PDF, EPUB and Kindle. Book excerpt: This e-book will review special features of the cerebral circulation and how they contribute to the physiology of the brain. It describes structural and functional properties of the cerebral circulation that are unique to the brain, an organ with high metabolic demands and the need for tight water and ion homeostasis. Autoregulation is pronounced in the brain, with myogenic, metabolic and neurogenic mechanisms contributing to maintain relatively constant blood flow during both increases and decreases in pressure. In addition, unlike peripheral organs where the majority of vascular resistance resides in small arteries and arterioles, large extracranial and intracranial arteries contribute significantly to vascular resistance in the brain. The prominent role of large arteries in cerebrovascular resistance helps maintain blood flow and protect downstream vessels during changes in perfusion pressure. The cerebral endothelium is also unique in that its barrier properties are in some way more like epithelium than endothelium in the periphery. The cerebral endothelium, known as the blood-brain barrier, has specialized tight junctions that do not allow ions to pass freely and has very low hydraulic conductivity and transcellular transport. This special configuration modifies Starling's forces in the brain microcirculation such that ions retained in the vascular lumen oppose water movement due to hydrostatic pressure. Tight water regulation is necessary in the brain because it has limited capacity for expansion within the skull. Increased intracranial pressure due to vasogenic edema can cause severe neurologic complications and death.
Download or read book Neuroinflammation in Alzheimer s Disease and Vascular Cognitive Impairment written by Erica Marie Weekman and published by . This book was released on 2017 with total page 161 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Neuroinflammation From Bench to Bedside written by H. Kettenmann and published by Springer Science & Business Media. This book was released on 2002-05-15 with total page 260 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book deals with the subject of neuroinflammation and attempts to take the reader on a journey from the bench to the bedside. The microglia and their response to brain injury as well as the importance of the chemokine family are discussed. The relevance of neuroinflammation in experimental models of BSE, scrapie and vCJD as well as Alzheimer's disease, stroke and multiple sclerosis is investigated before proceeding to clinical aspects of neuroinflammation and its involvement in human disease pathophysiology. The book provides an excellent introduction to the field of neuroinflammation and its involvement in human neurodegenerative disease.
Download or read book Neuroinflammation and its Resolution From Molecular Mechanisms to Therapeutic Perspectives written by Morena Zusso and published by Frontiers Media SA. This book was released on 2020-07-14 with total page 282 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Neuroinflammation written by Paul L. Wood and published by Springer Science & Business Media. This book was released on 1997-10-24 with total page 372 pages. Available in PDF, EPUB and Kindle. Book excerpt: An unprecedented review of our current knowledge of the neuroinflammatory mediators and cells involved in neurodegenerative diseases. Beginning with a detailed review of our current concepts of which biochemical mediators are involved in neuronal loss and the mechanisms of cell death, the distinguished contributors critically examine those areas of current research involved in the design of specific pharmacological agents to inhibit at defined points in the neuroinflammatory cascade. They also address the molecular, cellular, and disease model actions of first-generation agents, as well as the potential clinical relevance to AIDS-related dementia, Alzheimer's disease, amyotropic lateral sclerosis (ALS), Down's syndrome, Huntington's disease, multiple sclerosis, Parkinson's disease, and stroke.
Download or read book Vascular Dementia written by John Meyer and published by Wiley-Blackwell. This book was released on 2001-01-17 with total page 310 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vascular dementia (VAD) accounts for one-third of all dementias in today''s aging population, second only to Alzheimer's disease (DAT). Fortunately, current imaging techniques allow clinicians to view specific lesions in the brain, classify them by etiology and anatomical location, and assess changes using serial imaging, while at the same time correlating those changes with signs and symptoms of VAD or DAT. In 17 chapters, this book summarizes new concepts concerning the epidemiology, etiology, risk factors, neuropathology and pathogenesis of VAD and DAT, and mixtures of the two, and reviews their multiple causes, including microvascular and hemorrhagic lesions, and ischemic and inflammatory changes affecting both white and gray matter.
Download or read book Neuroinflammation and Behaviour written by Luba Sominsky and published by Frontiers Media SA. This book was released on 2015-07-21 with total page 138 pages. Available in PDF, EPUB and Kindle. Book excerpt: The brain and immune system are involved in an intricate network of bidirectional communication. This relationship is vital for optimal physiological and psychological development and functioning but can also result in unwanted outcomes. In particular, this interaction plays an important role in cognition, mood and behaviour. Neuroinflammation is known to contribute to neurological and affective disorders including impaired learning and memory, depressive, anxiety and schizoaffective symptoms, as well as pain. The development of these conditions often occurs on the backdrop of pre-existing physical illnesses which give rise to increased activation of the immune system, such as cancer, obesity, infection and autoimmune disorders. Similarly, psychological states can alter regulation of the immune system. This has been most extensively studied in the context of stress and immune function. Understanding the underlying mechanisms that lead to the onset of inflammation-induced neuropathology and stress-induced immune suppression will contribute to the development of novel and effective treatment strategies for both the disease and its neurological side effects. In this research topic we explored the relationship between the immune system and the brain throughout life. We include both original research and review papers from animal, clinical and molecular perspectives.
