Download or read book Neuroimmunology Research Focus written by Paulo V. Broglio and published by Nova Publishers. This book was released on 2007 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neuroimmunology is a rapidly-growing branch of biomedical science that studies of all aspects of the interactions between the immune system and nervous system. It deals with, among other things, the physiological functioning of the neuroimmune system in states of both health and disease; malfunctions of the neuroimmune system in disorders (autoimmune diseases, hypersensitivities, immune deficiency), the physical, chemical and physiological characteristics of the components of the neuroimmune system in vitro, in situ, and in vivo. Despite the brain's status as an immune privileged site, an extensive bi-directional communication takes place between the nervous and the immune system in both health and disease. Immune cells and neuroimmune molecules such as cytokines, chemokines, and growth factors modulate brain function through multiple signalling pathways throughout the lifespan. Immunological, physiological and psychological stressors engage cytokines and other immune molecules as mediators of interactions with neuroendocrine, neuropeptide, and neurotransmitter systems. For example, brain cytokine levels increase following stress exposure, while treatments designed to alleviate stress reverse this effect. This book presents leading research in the field.
Download or read book Neuroimmunity written by Michal Schwartz and published by Yale University Press. This book was released on 2015-01-01 with total page 316 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pathbreaking research offers new hope for treating brain diseases and injuries and for maintaining brain health even into old age In the past, the brain was considered an autonomous organ, self-contained and completely separate from the body's immune system. But over the past twenty years, neuroimmunologist Michal Schwartz, together with her research team, not only has overturned this misconception but has brought to light revolutionary new understandings of brain health and repair. In this book Schwartz describes her research journey, her experiments, and the triumphs and setbacks that led to the discovery of connections between immune system and brain. Michal Schwartz, with Anat London, also explains the significance of the findings for future treatments of brain disorders and injuries, spinal cord injuries, glaucoma, depression, and other conditions such as brain aging and Alzheimer's and Parkinson's diseases. Scientists, physicians, medical students, and all readers with an interest in brain function and its relationship to the immune system in health and disease will find this book a valuable resource. With general readers in mind, the authors provide a useful primer to explain scientific terms and concepts discussed in the book.
Download or read book The Neuroimmunological Basis of Behavior and Mental Disorders written by Allan Siegel and published by Springer Science & Business Media. This book was released on 2008-11-09 with total page 437 pages. Available in PDF, EPUB and Kindle. Book excerpt: For many years, the immune and central nervous systems were thought to function independently with little or no interaction between the two. This view has und- gone dramatic changes over the past three decades. Indeed, we now know that there exists various feedback loops between the brain and immune systems that impact signi cantly upon different behavioral processes, including normal behavior and mental disorders. Pioneering efforts in generating this change were initiated by a number of early investigators. Included were those whose efforts were directed at establishing neuroimmune connections as well as others whose research focused upon the relationship between immunity, cytokines, and behavior. This book brings together outstanding scientists and clinicians who have made major contributions to the rapidly developing eld investigating the relationship between immunity and behavior. The book is divided into three parts. The rst part describes pathways by which the brain and immune systems communicate and int- act with each other. In the chapter “Cytokines and the Blood–Brain Barrier” p- vides insight into interactions between the blood–brain barrier and cytokines. Such interactions underlie basic communication between the immune system and brain that are present in normal as well as in disease conditions. In the chapter “Neu- chemical and Endocrine Responses to Immune Activation: The Role of Cytokines,” the neurochemical and endocrine consequences of immune challenge and cytokine administration on central neurotransmitter activity are discussed.
Download or read book Neuroimmunology written by Amanda L. Piquet and published by Springer Nature. This book was released on 2021-03-08 with total page 536 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a clinical focus on neuroinflammatory diseases as well as a review in pathophysiology and treatment approaches. Organized into six parts, the book begins with a basic review of the immune system and concepts for learning and treating neuroimmune conditions. The next four sections cover specific subfields of neuroimmunology and autoimmune neurology - the clinical and diagnostic features of multiple sclerosis, other autoimmune conditions of the central nervous system, autoimmune conditions of the peripheral nervous system, and systemic autoimmune conditions that affect the nervous system. To conclude, Section six discusses various clinical approaches to specific presentations in neuroimmunology, including pediatric demyelinating diseases. These sections provide practical clinical information to improve the reader’s knowledge in this complex field. The chapters are written by world renown authors with extensive knowledge to help provide up to date information. The full scope of autoimmune neurology is discussed, which is a unique feature of this book. Neuroimmunology serves as a resource for those in training including residents and fellows to provide clear clinical reasoning and background in a rapidly advancing field.
Download or read book Neuro Immuno Gastroenterology written by Cris S. Constantinescu and published by Springer. This book was released on 2016-05-24 with total page 345 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book addresses important issues regarding the interaction between the nervous system, the immune system, and the digestive system. Gut flora has a profound influence on the shaping of the immune response, not only in the gastrointestinal system but also in the nervous system. Fascinatingly, manipulation of intestinal immune responses can be used to modulate neurological disease. Conversely, the nervous system and the psyche have significant effects on the functioning of the gut and liver. After introductory chapters on the neurology, the immunology and microbiology of the gut, the effects of the gut immune system and gut flora and its manipulation on neurological disease are discussed, followed by molecular mimicry and immune tolerance in neuroimmune diseases. Additionally, several chapters deal with gastrointestinal manifestations of neurological diseases. Neuro-Immuno-Gastroenterology is aimed at neurologists, gastroenterologists, and immunologists.
Download or read book Translational Methods for Multiple Sclerosis Research written by Sergiu Groppa and published by Humana. This book was released on 2021-08-03 with total page 335 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume explores the recent advances in the study of translational paths in central inflammation and focuses on ongoing pathophysiological processes and the transition between inflammatory stages and progressive states with neurodegeneration. Chapters cover topics such as pathophysiological hallmarks of neuroinflammation from tissue damage to reorganization; connecting studies of mouse models; and investigations of humans with multiple sclerosis. In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory. Cutting-edge and practical, Translational Methods for Multiple Sclerosis Research is a valuable resource for researchers who want to learn more about this chronic ad progressive disease, and pave the way for new advancements.
Download or read book Mayo Clinic Cases in Neuroimmunology written by Andrew McKeon and published by Oxford University Press. This book was released on 2022-01-18 with total page 329 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mayo Clinic Cases in Neuroimmunology delivers a case-based walk-through of demyelinating, autoimmune, and other inflammatory neurologic disorders and their mimics. The authors present cases from their own extensive experience with common and rare neuroimmunologic disorders. The format of this case-based book was developed to stimulate consideration of the differential diagnosis as the reader reviews the history and examination narratives of each of the 83 cases. Videos of autoimmune movement disorders supplement the clinical descriptions, where pertinent. In addition, test results from radiology, electrophysiology, and laboratory studies are presented, and treatment and outcome data are also included. Clinical pearls and radiologic clues to assist informed diagnostic decision-making are emphasized. Each case is followed by discussion, including therapeutic guidance and key take-home points. More than 150 multiple-choice questions with answers are also given to test readers' comprehension and retention. This new addition to the Mayo Clinic Scientific Press series is a comprehensive volume on neuroimmunology that will stimulate and inform those aiming for clinical mastery.
Download or read book Autoimmune Neurology written by and published by Elsevier. This book was released on 2016-03-11 with total page 569 pages. Available in PDF, EPUB and Kindle. Book excerpt: Autoimmune Neurology presents the latest information on autoimmune neurologic disease, the immune response to the body where organs run wild, causing the immune system to attack itself. Autoimmunity is a main element in numerous nervous system diseases and can target any structure within the central or peripheral nervous system. Over the past 20 years, significant advances in our understanding of the pathophysiology of autoimmune disorders, including the use of biomarkers has led to new diagnosis and treatment options. Neurologic conditions associated with autoimmune reactions include dementia, neuromuscular disease, epilepsy, sleep disorders, diabetes, and other common neurologic disorders and disease. This current tutorial-reference will be a must-have title for clinical neurologists, research neurologists, neuroscientists, and any medical professional working with autoimmune disease and disorders. - Includes comprehensive coverage of autoimmune neurology - Details the latest techniques for the study, diagnosis, and treatment of diseases and disorders, including dementia, neuromuscular disease, epilepsy, and sleep disorders - Presents a focused reference for clinical practitioners and the clinical neurology and neurology research communities
Download or read book Recent Advances in Psychiatry from Psycho Neuro Immunology Research Autoimmunencephalitis Autoimmune Encephalopathy Mild Encephalitis written by Karl Bechter and published by Frontiers Media SA. This book was released on 2019-08-12 with total page 189 pages. Available in PDF, EPUB and Kindle. Book excerpt: Growing evidence derived from cerebrospinal fluid (CSF), neuropathological, imaging, genetic, and epidemiological studies link neuroinflammation and immune dysregulation to a subset of individuals with a variety of severe mental disorders (SMDs), including affective and non-affective psychotic disorders. Further, the recent discoveries of neuronal surface antibodies (NSAs) in autoimmune encephalitis (AE) presenting with diverse neuropsychiatric disorders such as psychosis and cognitive decline, among many others, provides further support to the notion that CNS autoimmunity and neuroinflammation can contribute to the neurobiology of psychiatric disturbances. Further, these immune mechanisms may contribute to a subset of patients currently diagnosed as having treatment-resistant SMDs such as schizophrenia and major depressive disorder. Additionally, mounting data indicate that various infections can serve as an immunological trigger of aberrant immune responses, presumably by causing release of excess neural antigen, thereby giving rise to NSAs or aberrant immune cellular responses to give rise to primary or secondary psychiatric disorders such as schizophrenia and those associated with AE, respectively. Collectively, these findings support the “mild encephalitis” hypothesis of SMD. The significant overlap among AE-associated psychosis, systemic autoimmune disorder-associated psychosis, and psychotic disorders associated with pathological processes involving inflammation and immune dysregulation has also prompted some authors to adopt the term “autoimmune psychosis” (AP). This term reflects that this psychosis subtype is mechanistically linked to complex neuroimmune and inflammatory signalling abnormalities that can be responsive to early immunomodulatory treatment. It also suggests that a subset of AP might represent an incomplete or “forme fruste” subtype of AE presenting with dominant or pure psychiatric symptoms mimicking primary psychiatric illnesses. Because data indicate that delayed diagnosis and treatment may lead to permanent sequelae, early recognition of AP utilizing neurodiagnostic workup (e.g., CSF analysis, neuroimaging, and EEG) and its early treatment with appropriate immunotherapy are paramount to a meaningful recovery. This eBook will provide an overview of the current knowledge and research areas from epidemiology, risk factors and diagnosis to the management of these conditions, in this rapidly emerging field, helping to bridge the gaps in knowledge that currently exist in the disciplines of Psychiatry, Neurology, and Neuroimmunology.
Download or read book Immunology of the Nervous System written by Robert W. Keane and published by Oxford University Press, USA. This book was released on 1997 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This graduate reference provides a comprehensive survey of neuroimmunology, covering the normal interactions between the nervous and immune systems as well as disease states that alter these processes.
Download or read book Neuroimmunology written by Bibiana Bielekova and published by . This book was released on 2019 with total page 329 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neuroimmunology, the latest volume in the Contemporary Neurology Series, provides a practical, clinical, and scientific background on a diverse group of neurological disorders in this rapidly expanding field. The clinical chapters cover epidemiology, pathology, pathogenesis, and pathophysiology of the different diseases along with clinical presentation, diagnostic testing, differential diagnosis, and treatment. All are presented in an accessible, practical format, making this volume a valuable resource for physicians and other healthcare providers that will care for persons with neuroimmunologic diseases.
Download or read book Neurorheumatology written by Tracey A. Cho and published by Springer. This book was released on 2019-06-29 with total page 287 pages. Available in PDF, EPUB and Kindle. Book excerpt: This detailed, practical textbook focuses on immune mediated disorders of the nervous system with particular focus on systemic autoimmune disorders. Divided into three sections, the first discusses the neuroanatomical and pathophysiologic basis of immune mediated disorders of the nervous system. Following this are 25 chapters devoted to individual clinical conditions. To conclude, the final section explains what is known about the mechanisms of immunomodulatory treatments and practical points about monitoring patients on these treatments. Neurorheumatology: A Comprehensive Guide to Immune Mediated Disorders of the Nervous System bridges the gaps among different branches of medicine and is an indispensable resource for rheumatologists and neurologists looking to develop a firm understanding of these dynamic disorders
Download or read book Positive Neuroscience written by Joshua D. Greene and published by Oxford University Press. This book was released on 2016-05-10 with total page 257 pages. Available in PDF, EPUB and Kindle. Book excerpt: How do we thrive in our behaviors and experiences? Positive neuroscience research illuminates the brain mechanisms that enable human flourishing. Supported by the John Templeton Foundation's Positive Neuroscience Project, which Martin E. P. Seligman established in 2008, Positive Neuroscience provides an intersection between neuroscience and positive psychology. In this edited volume, leading researchers describe the neuroscience of social bonding, altruism, and the capacities for resilience and creativity. Part I (Social Bonds) describes the mechanisms that enable humans to connect with one another. Part II (Altruism) focuses on the neural mechanisms underlying the human ability and willingness to confer costly benefits on others. Part III (Resilience and Creativity) examines the mechanisms by which human brains overcome adversity, create, and discover. Specific topics include: a newly discovered nerve type that appears to be specialized for emotional communication; the effects of parenting on the male brain; how human altruism differs from that of other primates; the neural features of extraordinary altruists who have donated kidneys to strangers; and distinctive patterns of brain wiring that endow some people with exceptional musical abilities. Accessible to a broad academic audience, from advanced undergraduates to senior scholars, these subjects have generated a fascinating and highly convergent set of ideas and results, shaping our understanding of human nature.
Download or read book Clinical Neuroimmunology written by Jack P. Antel and published by . This book was released on 2005 with total page 467 pages. Available in PDF, EPUB and Kindle. Book excerpt: Clinical Neurimmunology is the major reference text in the field, providing broad and comprehensive coverage of the interaction between the nervous and immune systems in both normal and diseased states. Understanding this interaction is fundamental to developing therapeutic approaches to disease and injury of the nervous system that are currently only marginally amenable to therapy. Neuroimmunology is a well-recognised and growing specialty world wide, both at the basic science and clinical level. It is a fast moving field and this is the most up to date text available. Chapters are dedicated to the role of the immune system in disorders affecting both the central and peripheral nervous systems, including important neurodegenerative diseases (such as multiple sclerosis and HIV-related neural degeneration) which cause life-long disability. Extensive coverage is given to a whole array of immune-directed therapies. The book has a strong international team of well respected, high profile editors and authors. The first edition published to extensive and positive reviews and has established itself as the principal reference source in the field. This second edition summarizes recent advances in clinical neuroimmunology in a comprehensive and unbiased way.
Download or read book Neuroimmunology written by Bibiana Bielekova MD and published by Oxford University Press. This book was released on 2019-06-21 with total page 329 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neuroimmunology, the latest volume in the Contemporary Neurology Series, provides a practical, clinical, and scientific background on a diverse group of neurological disorders in this rapidly expanding field. The book includes chapters on multiple sclerosis and related disorders in adults and children, neuromyelitis optica spectrum disorder, Guillain-Barre Syndrome, chronic inflammatory demyelinating polyradiculoneuropathy and variants, immune-mediated disorders of the neuromuscular junction, inflammatory myopathies, paraneoplastic disorders and autoimmune encephalitities, and neurologic manifestations of systemic immune-mediated diseases. Unique to the work, the authors have included an introductory chapter on the basics of immunology and another on mechanisms of action of therapies used in neuroimmunologic disorders. The clinical chapters cover epidemiology, pathology, pathogenesis, and pathophysiology of the different diseases along with clinical presentation, diagnostic testing, differential diagnosis, and treatment. All are presented in an accessible, practical format, making this volume a valuable resource for physicians and other healthcare providers that will care for persons with neuroimmunologic diseases.
Download or read book Handbook of Innovations in Central Nervous System Regenerative Medicine written by António Salgado and published by Elsevier. This book was released on 2020-06-10 with total page 712 pages. Available in PDF, EPUB and Kindle. Book excerpt: Handbook of Innovations in CNS Regenerative Medicine provides a comprehensive overview of the CNS regenerative medicine field. The book describes the basic biology and anatomy of the CNS and how injury and disease affect its balance and the limitations of the present therapies used in the clinics. It also introduces recent trends in different fields of CNS regenerative medicine, including cell transplantation, bio and neuro-engineering, molecular/pharmacotherapy therapies and enabling technologies. Finally, the book presents successful cases of translation of basic research to first-in-human trials and the steps needed to follow this path. Areas such as cell transplantation approaches, bio and neuro-engineering, molecular/pharmacotherapy therapies and enabling technologies are key in regenerative medicine are covered in the book, along with regulatory and ethical issues. - Describes the basic biology and anatomy of the CNS and how injury and disease affect its balance - Discusses the limitations of present therapies used in the clinics - Introduces the recent trends in different fields of CNS regenerative medicine, including cell transplantation, bio and neuro-engineering, molecular/pharmacotherapy therapies, and enabling technologies - Presents successful cases of translation of basic research to first-in-human trials, along with the steps needed to follow this path
Download or read book Brain Banking written by and published by Elsevier. This book was released on 2018-02-27 with total page 448 pages. Available in PDF, EPUB and Kindle. Book excerpt: Brain Banking, Volume 150, serves as the only book on the market offering comprehensive coverage of the functional realities of brain banking. It focuses on brain donor recruitment strategies, brain bank networks, ethical issues, brain dissection/tissue processing/tissue dissemination, neuropathological diagnosis, brain donor data, and techniques in brain tissue analysis. In accordance with massive initiatives, such as BRAIN and the EU Human Brain Project, abnormalities and potential therapeutic targets of neurological and psychiatric disorders need to be validated in human brain tissue, thus requiring substantial numbers of well characterized human brains of high tissue quality with neurological and psychiatric diseases. - Offers comprehensive coverage of the functional realities of brain banking, with a focus on brain donor recruitment strategies, brain bank networks, ethical issues, and more - Serves as a valuable resource for staff in existing brain banks by highlighting best practices - Enhances the sharing of expertise between existing banks and highlights a range of techniques applicable to banked tissue for neuroscience researchers - Authored by leaders from brain banks around the globe – the broadest, most expert coverage available
