Download or read book Application of Systematic Review Methods in an Overall Strategy for Evaluating Low Dose Toxicity from Endocrine Active Chemicals written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2017-08-14 with total page 423 pages. Available in PDF, EPUB and Kindle. Book excerpt: To safeguard public health, the US Environmental Protection Agency (EPA) must keep abreast of new scientific information and emerging technologies so that it can apply them to regulatory decision-making. For decades the agency has dealt with questions about what animal-testing data to use to make predictions about human health hazards, how to perform dose-response extrapolations, how to identify and protect susceptible subpopulations, and how to address uncertainties. As alternatives to traditional toxicity testing have emerged, the agency has been faced with additional questions about how to incorporate data from such tests into its chemical assessments and whether such tests can replace some traditional testing methods. Endocrine active chemicals (EACs) have raised concerns that traditional toxicity-testing protocols might be inadequate to identify all potential hazards to human health because they have the ability to modulate normal hormone function, and small alterations in hormone concentrations, particularly during sensitive life stages, can have lasting and significant effects. To address concerns about potential human health effects from EACs at low doses, this report develops a strategy to evaluate the evidence for such low-dose effects.

Download or read book Human Exposure to Polybrominated Diphenyl Ethers PBDES in the Indoor Environment written by Deborah Jean Watkins and published by . This book was released on 2011 with total page 298 pages. Available in PDF, EPUB and Kindle. Book excerpt: Abstract: Polybrominated diphenyl ethers (PBDEs) are a class of brominated flame retardants that have been widely added to consumer products such as polyurethane foam furniture and electronics. Exposure to PBDEs has been associated with adverse effects on neurodevelopment and the endocrine system. House dust and diet are thought to be main sources of PBDE exposure, but the process by which these compounds are released from products and subsequently enter people is somewhat unclear. In addition, PBDE exposure in offices and vehicles has not been well characterized. The objectives of this work were to examine pathways of PBDE exposure in multiple indoor microenvironments among a population of 31 office workers. Associations between concurrent measures of PBDEs in office dust, air, and surface wipes, home dust, vehicle dust, handwipes, and serum were examined. Dietary exposure to PBDEs was also explored using a food frequency questionnaire. In Chapter 2 we report positive correlations between PBDEs in office air, dust, and surface wipes. Associations between the three samples types were influenced by the volatility of individual congeners, as well as characteristics of the surrounding environment. PentaBDEs in handwipes were equally correlated with office air, dust, and surface wipes, suggesting that the office microenvironment is a significant source of PentaBDE exposure among office workers. In Chapter 3 we explore relationships between PBDEs in office dust, handwipes, and serum. We found that handwipes collected in the office microenvironment were correlated with both office dust and serum, providing a link between the office microenvironment and body burden. This suggests that handwipes may provide a measure of personal exposure to PBDEs in the surrounding environment, and exposure likely occurs via hands, either through incidental ingestion or dermal absorption. In Chapter 4 we examine the relative contributions of diet and dust from the home, office, and car microenvironments to PentaBDE body burden. We found that the main living area and bedroom microenvironments of the home were the most predictive of PentaBDE concentrations in serum. Although previous studies found associations between meat and dairy intake and PentaBDE body burden, diet did not predict PentaBDEs in serum in this study population.

Download or read book Polybrominated Diphenyl Ethers Disturb Neural Development in Mice and Men written by Sebastian Timm Schreiber and published by . This book was released on 2010 with total page 205 pages. Available in PDF, EPUB and Kindle. Book excerpt: Polybrominated diphenyl ethers (PBDEs) are persistent and bioaccumulative flame retardants that are of concern as they are ubiquitous and potentially toxic; and they have been found at rapidly rising levels in humans during the past few decades. The greatest concern of PBDEs for potential adverse health effects relates to their developmental neurotoxicity (DNT). Various PBDE congeners caused behavioral alterations like hyperactivity and disrupted performance in learning and memory tests in perinatally exposed mice and rats. To facilitate hazard assessment for humans, the impact of PBDEs on human and murine neurodevelopment in vitro and the mechanisms underlying these changes were investigated.

Download or read book Exposure of Humans to Polybrominated Diphenyl Ethers PBDEs Via Residential Indoor Environment in the U S written by Hua He and published by . This book was released on 2012 with total page 74 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Everyday Environmental Toxins written by Areej Hassan and published by CRC Press. This book was released on 2015-03-16 with total page 347 pages. Available in PDF, EPUB and Kindle. Book excerpt: This title includes a number of Open Access chapters.This collection of timely chapters presents a nuanced study of environmental toxins and the risks they pose to children's development. The book details the impact of a number of commonplace environmental toxins, focusing on everyday exposure to tobacco smoke, lead, pesticides, and flame retardant

Download or read book Child specific Exposure Factors Handbook written by and published by . This book was released on 2002 with total page 452 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Nondetects and Data Analysis written by Dennis R. Helsel and published by Wiley-Interscience. This book was released on 2005 with total page 276 pages. Available in PDF, EPUB and Kindle. Book excerpt: STATISTICS IN PRACTICE Statistical methods for interpreting and analyzing censored environmental data Nondetects And Data Analysis: Statistics for Censored Environmental Data provides solutions for environmental scientists and professionals who need to interpret and analyze data that fall below the laboratory detection limit. Adapting survival analysis methods that have been successfully used in medical and industrial research, the author demonstrates, for the first time, their practical applications for studies of trace chemicals in air, water, soils, and biota. Readers quickly become proficient in these methods through the use of real-world examples that are solved using MINITAB® Release 14, a popular statistical software package, as well as other commonly used software packages. Everything needed to master these innovative statistical methods is provided, including: Accompanying Web site featuring answers to book exercises and datasets, as well as MINITAB® macros to perform methods, which are not available in the commercial version Methods for data with multiple detection limits Solutions for research studies in which all data are below detection limits Techniques for constructing confidence, prediction, and tolerance intervals for data with nond-tects Methods for data with multiple detection limits Chapters are organized by objective, such as computing intervals, comparing groups, and correlations, which enables readers to more easily apply the text to their particular research and goals. Extensive references to the literature for more in-depth research are provided; however, the text itself avoids complex math and calculus making it accessible to anyone in the environmental sciences. Environmental scientists and professionals will find the hands-on guidance and practical examples invaluable.

Download or read book The Oxford Handbook of Externalizing Spectrum Disorders written by Theodore P. Beauchaine and published by Oxford University Press. This book was released on 2015-10-01 with total page 545 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent developments in the conceptualization of externalizing spectrum disorders, including attention-deficit/hyperactivity disorder, conduct disorder, antisocial personality disorder, and substance use disorders, suggest common genetic and neural substrates. Despite this, neither shared vulnerabilities nor their implications for developmental models of externalizing conduct are captured by prevailing nosologic and diagnostic systems, such as the DSM-5. The Oxford Handbook of Externalizing Spectrum Disorders is the first book of its kind to capture the developmental psychopathology of externalizing spectrum disorders by examining causal factors across levels of analysis and developmental epochs, while departing from the categorical perspective. World renowned experts on externalizing psychopathology demonstrate how shared genetic and neural vulnerabilities predispose to trait impulsivity, a highly heritable personality construct that is often shaped by adverse environments into increasingly intractable forms of externalizing conduct across development. Consistent with contemporary models of almost all forms of psychopathology, the Handbook emphasizes the importance of neurobiological vulnerability and environmental risk interactions in the expression of externalizing behavior across the lifespan. The volume concludes with an integrative, ontogenic process model of externalizing psychopathology in which diverse equifinal and multifinal pathways to disorder are specified.

Download or read book Environmental Epigenetics written by L. Joseph Su and published by Springer. This book was released on 2015-05-18 with total page 327 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book examines the toxicological and health implications of environmental epigenetics and provides knowledge through an interdisciplinary approach. Included in this volume are chapters outlining various environmental risk factors such as phthalates and dietary components, life states such as pregnancy and ageing, hormonal and metabolic considerations and specific disease risks such as cancer cardiovascular diseases and other non-communicable diseases. Environmental Epigenetics imparts integrative knowledge of the science of epigenetics and the issues raised in environmental epidemiology. This book is intended to serve both as a reference compendium on environmental epigenetics for scientists in academia, industry and laboratories and as a textbook for graduate level environmental health courses. Environmental Epigenetics imparts integrative knowledge of the science of epigenetics and the issues raised in environmental epidemiology. This book is intended to serve both as a reference compendium on environmental epigenetics for scientists in academia, industry and laboratories and as a textbook for graduate level environmental health courses.

Download or read book Neonatal Developmental Neurotoxicity of Brominated Flame Retardants the Polybrominated Diphenyl Ethers PBDEs written by Henrik Viberg and published by . This book was released on 2004 with total page 62 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Health Impacts of Developmental Exposure to Environmental Chemicals written by Reiko Kishi and published by Springer Nature. This book was released on 2019-12-13 with total page 554 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides concise and cutting-edge studies on threats resulting from exposure to environmental chemicals that can affect human health and development, with a particular emphasis on the DOHaD concept. The book is divided into five main parts, the first of which includes an introduction to the impacts of developmental exposure to environmental chemicals and historical perspectives, while the second focuses on how environmental chemicals can affect human organs, including neurodevelopment, immune functions, etc. In turn, the third part addresses the characteristics of specific chemicals and their effects on human health and development, while the fourth part provides a basis for future studies by highlighting the latest innovations in toxicology, remaining challenges, and promising strategies in children’s environmental health research, as well as ideas on how to bridge the gap between research evidence and practical policymaking. The fifth and last part outlines further research directions and related policymaking aspects. Health Impacts of Developmental Exposure to Environmental Chemicals will appeal to young and veteran researchers, students, and physicians (especially gynecologists and pediatricians) who are seeking comprehensive information on how children’s health can be affected by harmful chemicals and other environmental toxicants.

Download or read book Handbook of Psychoeducational Assessment written by and published by Elsevier. This book was released on 2001-04-17 with total page 541 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Handbook of Psychoeducational Assessment is a practical guide for educational and psychological professionals using norm-referenced tests in the ability, achievement, and behavioral assessment of children. Written by key individuals involved in the construction and evolution of the most widely used tests, this book provides critical information on the nature and scope of commonly used tests, their reliability and validity, administration, scoring and interpretation, and on how the tests may differ and complement each other in their utility with specific populations. Part 1 of the Handbook of Psychoeducational Assessment focuses on ability assessment and the use of full battery intelligence tests as well as brief scales and short forms. Part 2 discusses achievement and the expanded role of psychologists in consultation with educators. Part 3 covers behavior assessment with special attention given to discussion of which tests are most suitable for assessing specific behavioral problems such as ADHD, anxiety, and depression. The final section recognizes the importance of context and person sensitive assessment practices, discussing cross-cultural assessment, neuropsychological assessment, and the usefulness of dynamic assessment for program planning and intervention delivery. Key Features: - Covers the most commonly used and newest assessment instruments - Describes the nature, scope, reliability, and validity of each test - Discusses the administration, scoring, and interpretation of tests - Provides empirical findings on patterns of performance with tested populations - Includes case studies to highlight the utility of specific tests for specific populations - Illustrates new developments in instrumentation and unique features - Covers the most commonly used and newest assessment instruments - Describes the nature, scope, reliability, and validity of each test - Discusses the administration, scoring, and interpretation of tests - Provides empirical findings on patterns of performance with tested populations - Includes case studies to highlight the utility of specific tests for specific populations - Illustrates new developments in instrumentation and unique features

Download or read book Toxicological Risks of Selected Flame Retardant Chemicals written by National Research Council and published by National Academies Press. This book was released on 2000-07-06 with total page 534 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ignition of upholstered furniture by small open flames from matches, cigarette lighters, and candles is one of the leading causes of residential-fire deaths in the United States. These fires accounted for about 16% of civilian fire deaths in 1996. On average, each year since 1990, about 90 deaths (primarily of children), 440 injuries, and property losses amounting to 50 million dollars have resulted from fires caused by the ignition of upholstered furniture by small open flames. Certain commercial seating products (such as aircraft and bus seats) are subject to flammability standards and sometimes incorporate FR-treated upholstery cover materials, but there is no federal-government requirement for residential upholstered furniture, and it is generally not treated with FR chemicals. It is estimated that less than 0.2% of all U.S. residential upholstery fabric is treated with flame-retardant (FR) chemicals. The Consumer Product Safety Act of 1972 created the U.S. Consumer Product Safety Commission (CPSC) as an independent federal regulatory agency whose mission is to protect the public from unreasonable risks of injury and death associated with consumer products. CPSC also administers the Flammable Fabrics Act, under which it regulates flammability hazards and the Federal Hazardous Substances Act (FHSA), which regulates hazardous substances including chemicals. In 1993, the National Association of State Fire Marshals petitioned CPSC to issue a performance-based flammability standard for upholstered furniture to reduce the risk of residential fires. The Commission granted that portion of the petition relating to small open flame ignition risks. In response to concerns regarding the safety of FR chemicals, Congress, in the fiscal year 1999 appropriations report for CPSC, requested that the National Research Council conduct an independent study of the health risks to consumers posed by exposure to FR chemicals that are likely to be used in residential upholstered furniture to meet a CPSC standard. The National Research Council assigned the project to the Committee on Toxicology (COT) of the Commission on Life Sciences' Board on Environmental Studies and Toxicology. COT convened the Subcommittee on Flame-Retardant Chemicals, which prepared this report. Subcommittee members were chosen for their recognized expertise in toxicology, pharmacology, epidemiology, chemistry, exposure assessment, risk assessment, and biostatistics. Toxicological Risks of Selected Flame-Retardant Chemicals is organized into 18 chapters and two appendices. Chapter 2 describes the risk assessment process used by the subcommittee in determining the risk associated with potential exposure to the various FR chemicals. Chapter 3 describes the method the subcommittee used to measure and estimate the intensity, frequency, extent, and duration of human exposure to FR chemicals. Chapters 4-19 provide the subcommittee's review and assessment of health risks posed by exposure to each of the 16 FR chemicals. Data gaps and research needs are provided at the end of these chapters.

Download or read book America s Children and the Environment written by U.s. Environmental Protection Agency and published by Createspace Independent Publishing Platform. This book was released on 2017-05-31 with total page 502 pages. Available in PDF, EPUB and Kindle. Book excerpt: "America's Children and the Environment (ACE)" is EPA's report presenting data on children's environmental health. ACE brings together information from a variety of sources to provide national indicators in the following areas: Environments and Contaminants, Biomonitoring, and Health. Environments and Contaminants indicators describe conditions in the environment, such as levels of air pollution. Biomonitoring indicators include contaminants measured in the bodies of children and women of child-bearing age, such as children's blood lead levels. Health indicators report the rates at which selected health outcomes occur among U.S. children, such as the annual percentage of children who currently have asthma. Accompanying each indicator is text discussing the relevance of the issue to children's environmental health and describing the data used in preparing the indicator. Wherever possible, the indicators are based on data sources that are updated in a consistent manner, so that indicator values may be compared over time.

Download or read book Human Biomonitoring for Environmental Chemicals written by National Research Council and published by National Academies Press. This book was released on 2006-11-30 with total page 317 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biomonitoring—a method for measuring amounts of toxic chemicals in human tissues—is a valuable tool for studying potentially harmful environmental chemicals. Biomonitoring data have been used to confirm exposures to chemicals and validate public health policies. For example, population biomonitoring data showing high blood lead concentrations resulted in the U.S. Environmental Protection Agency's (EPA's) regulatory reduction of lead in gasoline; biomonitoring data confirmed a resultant drop in blood lead concentrations. Despite recent advances, the science needed to understand the implications of the biomonitoring data for human health is still in its nascent stages. Use of the data also raises communication and ethical challenges. In response to a congressional request, EPA asked the National Research Council to address those challenges in an independent study. Human Biomonitoring for Environmental Chemicals provides a framework for improving the use of biomonitoring data including developing and using biomarkers (measures of exposure), research to improve the interpretation of data, ways to communicate findings to the public, and a review of ethical issues.

Download or read book Emerging Pollutants written by Francisco G. Calvo-Flores and published by John Wiley & Sons. This book was released on 2018-02-20 with total page 528 pages. Available in PDF, EPUB and Kindle. Book excerpt: An excellent, concise, and interdisciplinary overview of different classes of emerging pollutants arising, for example, from pharmaceuticals, pesticides, personal care products, and industrial chemicals and their impact on water, soil, and air. Following an introduction to chemical pollutants, with special attention focused on organic compounds and their properties, the book goes on to describe major emerging pollutants grouped according to their applications in different sectors of industrial or economic activity. For each type of compound, the chemical structure, main properties, and source are presented, along with their fate in the environment as pollutants, the latest analytical methods for detection, possible health or ecology consequences, as well as current regulatory laws. New developments, such as nanotechnology as a pollution source, are also included. The book closes with a chapter devoted to conclusions and future perspectives.

Download or read book Microplastics in Water and Wastewater written by Hrissi K. Karapanagioti and published by IWA Publishing. This book was released on 2019-09-15 with total page 237 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers the topic of microplastics in water and wastewater. The chapters start with introductory issues related to the growing interest in the scientific community on microplastics and the human water cycle and point out where the microplastics could interact with water. The subsequent chapters examine evidence of the microplastic presence in freshwater, such as in both rivers and lakes, in freshwater biota, and hazardous chemicals associated with microplastics in such systems. Another set of chapters discuss the presence of microplastics in wastewater: their sources; their transfer through a wastewater treatment plant; the concentration of microplastics in effluents throughout the world; the plastic biomedia used in wastewater treatment plants and the effect on the surrounding environment of effluent wastewater pipes. These chapters also discuss the sampling methods, the sample treatment and analysis techniques used so far for microplastics in wastewater. Additionally, the presence of microplastics in sewage sludge and in soils irrigated with wastewater or fertilized with sludge are discussed. The possible impact of plastics and their additives on plants, microalgae, and humans are reviewed and presented in a critical way. Finally, a chapter summarizes all the relevant regulations and initiatives that point to the necessity of a global directive for the protection of the environment from plastic and microplastic pollution. The topic of microplastics in freshwater systems and in wastewater has scarcely been studied and requires more attention. Microplastics in Water and Wastewater aims to bring these initial findings to the attention of a broader audience and especially to operators and managers of freshwater and wastewater systems. It will also be helpful to people already aware of the marine debris problem to understand the sources of microplastics in the oceans, from freshwater systems and wastewater treatment plants.