Download or read book Neural Grafting in the Mammalian CNS written by Anders Björklund and published by Elsevier Publishing Company. This book was released on 1985 with total page 746 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Transplantation Into the Mammalian CNS written by Don M. Gash and published by Elsevier. This book was released on 1988 with total page 697 pages. Available in PDF, EPUB and Kindle. Book excerpt: Transplantation into the Mammalian CNS presents a comprehensive critical overview of recent advances of basic and clinical research in neural transplantation. Special emphasis is devoted to the emerging studies on the use of clinical grafts for the treatment of parkinsonism, the extension of this technology to additional models of neurological deficits, the immunobiology of neural implants, the exploration of trophic factors, and other new directions in the field of transplantation. Due to the extensive list of contents, only content headings are given. Full details can be obtained from the Publisher upon request.
Download or read book Neural Transplants written by John R. Sladek and published by . This book was released on 2014-01-15 with total page 488 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Neural Transplants written by John R. Sladek and published by Springer. This book was released on 2012-04-06 with total page 454 pages. Available in PDF, EPUB and Kindle. Book excerpt: The story of mammalian neural transplantation really begins eighty-one years ago. In Chicago in December of 1903, a 34-year-old physician, Elizabeth Hopkins Dunn, working as a research assistant in neurology, initiated a series of experiments to examine the ability of neonatal rat cerebral tissue to survive transplantation into the brain of matched littermates. Out of 46 attempts, four clearly successful grafts were identified. The publication of Dunn's results in 1917, the first credible report to demonstrate the feasibility of mammalian CNS transplants, generated little interest. In fact, the next significant experiment in this field did not appear until 1930. The field continued to grow slowly and quietly as investigators gradually realized the value of neural trans plantation to study problems of development and plasticity in the mammalian nervous system. With the discovery in 1979 that grafted neurons were capable of appropriate and functional interactions with the host brain, interest in neural transplantation esca lated sharply. The extraordinary opportunities created by using functional neural trans plants in investigating basic issues in neurobiology, as well as the clinical implications, excited both scientists and the public. The popularity of neural transplantation has been growing rapidly in the past five years and shows no signs of abating. The present volume was designed to meet two needs created by the rapid growth of this subdiscipline of neurobiology. The first was to provide a thorough review of the experimental foundations of neural transplantation.
Download or read book Neural Grafting written by United States. Congress. Office of Technology Assessment and published by . This book was released on 1990 with total page 206 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Grafting in the Mammalian Central Nervous System written by Lars Olson and published by . This book was released on 1988 with total page 73 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Axonal Regeneration in the Mammalian Central Nervous System written by Dorothy E. Oorschot and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 196 pages. Available in PDF, EPUB and Kindle. Book excerpt: This state-of-the-art review links the experimental data into a cohesive and critical account of CNS regeneration. Research findings are discussed in terms of their relevance to one (or more) of thirteen hypotheses concerned with regeneration in the mammalian CNS. Research findings reviewed include: regeneration in developing mammals and in submammalian vertebrates, the use of transplants and/or pharmacological treatments, in vitro studies on neurotrophic and neurite promoting factors and their potential relevance to CNS regeneration in vivo, and in vitro studies on the types of glial cells that may be responsible for enhancing or suppressing axonal re-growth.
Download or read book Neural Transplantation CNS Neuronal Injury and Regeneration written by Joe Marwah and published by CRC Press. This book was released on 1994-02-23 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt: This unique reference presents studies from leading laboratories that are studying the effects of CNS transplants on neuronal plasticity and recovery of function after CNS injury. Topics covered include tropic influences, reinnervation patterns, and prevention of cell death that range from pre-clinical models of Parkinson's disease in primates to studies of restoration of circadian rhythms in rats. Techniques of neurotransplantation are presented, including current limitations and future projections of advancement.
Download or read book Functional Neural Transplantation written by Stephen B. Dunnett and published by Lippincott Williams & Wilkins. This book was released on 1994 with total page 616 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Expression and Distribution of Neural Cell Adhesion and Extracellular Matrix Molecules After Injury To and Peripheral Nerve Grafting Into the Adult Mammalian CNS written by and published by . This book was released on 1996 with total page 516 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Adult Mammalian Central Nervous System Regeneration written by Bo Peng Lear and published by . This book was released on 2023 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: When the mammalian central nervous system (CNS), the brain and spinal cord, is damaged or degenerates, there is limited to no regeneration, leading to permanent and debilitating functional impairments resulting in high rates of mortality. Neural repair is so difficult because of both the inhibitory environment and the lack of intrinsic potential to regenerate which is further exacerbated with aging. Even with decades of scientific studies, our understanding of how to make the CNS regenerate is still unknown. Scientists have been testing different methods to increase neural repair, either exogenous or endogenous. Exogenous repair, such as transplanting induced pluripotent stem cell (iPSC)-derived or fetal tissue-derived neural progenitors into the brain or spinal cord, can be used to replace injured neurons. Separately, endogenous regeneration, such as replenishing neurons in cases of traumatic or neurodegenerative neurological diseases from stem cells in neurogenic niches lining the ventricles and the hippocampus, can be harnessed to replace from within. Additionally, when there is damage to the neuron's projections, as in the case of spinal cord injury, the neuron could be endogenously enhanced to regenerate its axon to regain function. However, many of these potential regenerative options are still clinically unproven to be effective as therapy for neural repair. To address these knowledge gaps, my thesis investigates two different avenues of enhancing mammalian CNS regeneration. In the first two chapters of my thesis, I explore the molecular drivers that result in limited human spinal cord regeneration post injury. Decades of rodent research still have not yielded a feasible therapeutic target for CNS axon regeneration. Here, I present a novel mechanism of a nucleosome remodeler protein being an important human-specific, age-related driver of endogenous axon regeneration. In the latter two chapters using mouse models, I explore molecular methods to enhance hippocampal neuronal regeneration using the brain's endogenous neural stem cell (NSC) supply. Despite having been 7 decades since the discovery of the existence of adult mammalian NSCs, we still no do not have a clinical treatment to replace neurons in the adult brain from endogenous NSCs. Here, I present a novel mechanism of using post-transcriptional regulation to encourage neurogenesis using adult mouse in vitro and in vivo model systems. Together these data provide two different perspectives on the molecular targets of neural repair, with the goals of enhancing endogenous mammalian CNS regeneration.
Download or read book Transplantation in the Mammalian CNS written by and published by . This book was released on 1984 with total page 52 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Transplantation into the Mammalian CNS written by and published by Elsevier. This book was released on 1988-12-01 with total page 697 pages. Available in PDF, EPUB and Kindle. Book excerpt: Transplantation into the Mammalian CNS
Download or read book Neural Tissue Transplantation Research written by R.B. Wallace and published by Springer. This book was released on 2011-11-01 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: During the last decade research on neural transplantation in mammals has grown extensively, and has attracted the attention of many young inquisitive scientists. This growth, as the critics point out, has been somewhat random, and has resulted neither in the formulation of basic concepts nor in any other significant achievement. For instance, they question-how is it possible to jump into functional research with clinical bearing when the basic morphological work has not yet been conducted? The criticism, objectively speaking, is valid and is supported by the fact that every investigator who has stepped into this unex plored field of neurosciences has formulated questions in his own way, has followed his own "model" oftransplantation, and has arrived at his own unique conclusions. The potential danger, as the critics emphasize, in this type of approach lies in that instead of evolving into a scientifically solid and valuable field of research, it may end in a confusing and conflicting mass of questionable claims and subjective opinions. The present situation, very likely, is a reflection of unrestrained enthusiasm and imaginativeness of the investigators, and the demands of the times for the so-called "newsworthy" and "breakthrough" publications. Despite these limitations, two important facts have been estab lished in this field. First, as far as transplantation of neural tissues per se is concerned, what was considered impossible by some critics about 10-12 years ago has been shown to be possible.
Download or read book Neural Grafting written by United States. Congress. Office of Technology Assessment and published by . This book was released on 1990 with total page 208 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Genetic Manipulation of the Nervous System written by and published by Elsevier. This book was released on 1995-11-24 with total page 297 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neuroscience Perspectives provides multidisciplinary reviews of topics in one of the most diverse and rapidly advancing fields in the life sciences. Whether you are a new recruit to neuroscience, or an established expert, look to this series for 'one-stop' sources of the historical, physiological, pharmacological, biochemical, molecular biological and therapeutic aspects of chosen research areas. The recent development of Gene Therapy procedures which allow specific genes to be delivered to human patients who lack functional copies of them is of major therapeutic importance. In addition such gene delivery methods can be used in other organisms to define the function of particular genes. These studies are of particular interest in the nervous system where there are many incurable diseases like Alzheimer's and Parkinson's diseases which may benefit from therapies of this kind. Unfortunately gene delivery methods for use in the nervous system have lagged behind those in other systems due to the fact that the methods developed in other systems are often not applicable to cells like neurons which do not divide. This book discusses a wide range of methods which have now been developed to overcome these problems and allow safe and efficient delivery of particular genes to the brain. Methods discussed include virological methods, physical methods (such as liposomes) and the transplantation of genetically modified cells. In a single volume therefore this book provides a complete view of these methods and indicates how they can be applied to the development of therapies for treating previously incurable neurological disorders.
Download or read book Neural grafting repairing the brain and spinal cord written by and published by DIANE Publishing. This book was released on with total page 193 pages. Available in PDF, EPUB and Kindle. Book excerpt:
