Download or read book Neoplasms Principles of Development and Diversity written by Jules J. Berman and published by Jones & Bartlett Learning. This book was released on 2009 with total page 454 pages. Available in PDF, EPUB and Kindle. Book excerpt: This unique text is devoted to the full range of neoplastic properties exhibited by the comprehensive collection of human neoplasms. Like no other book of it's kind, it approaches cancer biology by surveying the diversity of neoplasms and by building a classification of neoplasms based on an understanding of the cellular options for tumor development. By grouping neoplasms into a comprehensive classification, we can develop class-specific methods to prevent, detect, and treat cancers. The book is divided into three broad units: speciation, classification and eradication. In the process of developing a classification for neoplasms, dozens of the fundamental questions in neoplastic development are asked and answered. Neoplasms provides readers with a fascinating and enjoyable way to learn the otherwise arcane and dense subject of human tumor diversity.

Download or read book Precision Medicine and the Reinvention of Human Disease written by Jules J. Berman and published by Academic Press. This book was released on 2018-01-15 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: Despite what you may have read in the popular press and in social media, Precision Medicine is not devoted to finding unique treatments for individuals, based on analyzing their DNA. To the contrary, the goal of Precision Medicine is to find general treatments that are highly effective for large numbers of individuals who fall into precisely diagnosed groups. We now know that every disease develops over time, through a sequence of defined biological steps, and that these steps may differ among individuals, based on genetic and environmental conditions. We are currently developing rational therapies and preventive measures, based on our precise understanding of the steps leading to the clinical expression of diseases. Precision Medicine and the Reinvention of Human Disease explains the scientific breakthroughs that have changed the way that we understand diseases, and reveals how medical scientists are using this new knowledge to launch a medical revolution. - Clarifies the foundational concepts of Precision Medicine, distinguishing this field from its predecessors such as genomics, pharmacogenetics, and personalized medicine - Gathers the chief conceptual advances in the fields of genetics, pathology, and bioinformatics, and synthesizes a coherent narrative for the field of Precision Medicine - Delivers its message in plain language, and in a relaxed, conversational writing style, making it easy to understand the complex subject matter - Guides the reader through a coherent and logical narrative, gradually providing expertise and skills along the way - Covers the importance of data sharing in Precision Medicine, and the many data-related challenges that confront this fragile new field

Download or read book Principles and Practice of Big Data written by Jules J. Berman and published by Academic Press. This book was released on 2018-07-23 with total page 482 pages. Available in PDF, EPUB and Kindle. Book excerpt: Principles and Practice of Big Data: Preparing, Sharing, and Analyzing Complex Information, Second Edition updates and expands on the first edition, bringing a set of techniques and algorithms that are tailored to Big Data projects. The book stresses the point that most data analyses conducted on large, complex data sets can be achieved without the use of specialized suites of software (e.g., Hadoop), and without expensive hardware (e.g., supercomputers). The core of every algorithm described in the book can be implemented in a few lines of code using just about any popular programming language (Python snippets are provided). Through the use of new multiple examples, this edition demonstrates that if we understand our data, and if we know how to ask the right questions, we can learn a great deal from large and complex data collections. The book will assist students and professionals from all scientific backgrounds who are interested in stepping outside the traditional boundaries of their chosen academic disciplines. - Presents new methodologies that are widely applicable to just about any project involving large and complex datasets - Offers readers informative new case studies across a range scientific and engineering disciplines - Provides insights into semantics, identification, de-identification, vulnerabilities and regulatory/legal issues - Utilizes a combination of pseudocode and very short snippets of Python code to show readers how they may develop their own projects without downloading or learning new software

Download or read book Evolution s Clinical Guidebook written by Jules J. Berman and published by Academic Press. This book was released on 2019-04-25 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt: Evolution's Clinical Guidebook: Translating Ancient Genes into Precision Medicine demonstrates, through well-documented examples, how an understanding of the phylogenetic ancestry of humans allows us to make sense out of the flood of genetic data streaming from modern laboratories and how it can lead us to new ways to prevent, diagnose and treat diseases. Topics cover evolution and human genome, meiosis and other recombinants events, embryology, speciation, phylogeny, rare and common diseases, and the evolution of aging. This book is a valuable source for bioinformaticians and those in the biomedical field who need knowledge, down to gene level, to fully comprehend currently available data. - Offers an innovative approach, focusing on how disease-associated pathways evolved - Explains how the fields of phylogeny and embryology have become closely tied to the fields of genetics and bioinformatics - Demonstrates how students and biomedical professionals can apply the knowledge obtained in this book to the theory and practice of precision medicine

Download or read book Methods in Medical Informatics written by Jules J. Berman and published by CRC Press. This book was released on 2010-09-22 with total page 402 pages. Available in PDF, EPUB and Kindle. Book excerpt: Too often, healthcare workers are led to believe that medical informatics is a complex field that can only be mastered by teams of professional programmers. This is simply not the case. With just a few dozen simple algorithms, easily implemented with open source programming languages, you can fully utilize the medical information contained in clini

Download or read book Rare Diseases and Orphan Drugs written by Jules J. Berman and published by Academic Press. This book was released on 2014-05-26 with total page 407 pages. Available in PDF, EPUB and Kindle. Book excerpt: Rare Diseases and Orphan Drugs shows that much of what we now know about common diseases has been achieved by studying rare diseases. It proposes that future advances in the prevention, diagnosis, and treatment of common diseases will come as a consequence of our accelerating progress in the field of rare diseases. Understanding the complex steps in the development of common diseases, such as cancer, cardiovascular disease, and metabolic diseases, has proven a difficult problem. Rare diseases, however, are often caused by aberrations of a single gene. In rare diseases, we may study how specific genetic defects can trigger a series of events that lead to the expression of a particular disease. Often, the disease process manifested in a certain rare disease is strikingly similar to the disease process observed in a common disease. This work ties the lessons learned about rare diseases to our understanding of common ones. Chapters covering the number of common diseases are minimized, while rare diseases are introduced as single diseases or as members of diseases classes. After reading this book, readers will appreciate how further research into the rare diseases may lead to new methods for preventing, diagnosing, and treating all diseases, rare or common. - Makes rare diseases relevant to clinicians and researchers by tying lessons learned about the rare diseases to our understanding of the common diseases - Stresses basic pathologic mechanisms that account for human disease (e.g., disorders of cell development, replication, maintenance, function and structure), that can be understood without prior training in pathology - Discusses advanced concepts in molecular biology and genetics in a simple, functional context appropriate for medical trainees and new researchers - Offers insights into how further research into rare diseases may lead to new methods for preventing, diagnosing, and treating all diseases

Download or read book Precancer The Beginning and the End of Cancer written by Jules J. Berman and published by Jones & Bartlett Learning. This book was released on 2009-08-11 with total page 201 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nearly every type of cancer passes through a precancer phase, during which it cannot metastasize or invade other tissues. While medicine is not always successful in treating or curing advanced stages of cancers, recent advances in our understanding of carcinogenesis have helped us to develop strategies to prevent, diagnose, and treat many cancers at the precancer stage. Research in this field is escalating rapidly as the evidence increasingly shows that the number of annual cancer deaths could be drastically reduced through the effective treatment and cure of precancer lesions. This book begins by explaining why it has been so difficult to cure cancers, followed by a review of precancer biology, with descriptions of the most common precancer lesions. The final chapters provide practical socio-political and medical goals for precancer treatment, including discussions of the economics and politics of treating precancers.

Download or read book Classification Made Relevant written by Jules J. Berman and published by Academic Press. This book was released on 2022-01-25 with total page 446 pages. Available in PDF, EPUB and Kindle. Book excerpt: Classification Made Relevant: How Scientists Build and Use Classifications and Ontologies explains how classifications and ontologies are designed and used to analyze scientific information. The book presents the fundamentals of classification, leading up to a description of how computer scientists use object-oriented programming languages to model classifications and ontologies. Numerous examples are chosen from the Classification of Life, the Periodic Table of the Elements, and the symmetry relationships contained within the Classification Theorem of Finite Simple Groups. When these three classifications are tied together, they provide a relational hierarchy connecting all of the natural sciences. The book's chapters introduce and describe general concepts that can be understood by any intelligent reader. With each new concept, they follow practical examples selected from various scientific disciplines. In these cases, technical points and specialized vocabulary are linked to glossary items where the item is clarified and expanded. - Explains the theory and practice of classification, emphasizing the importance of classifications and ontologies to the modern fields of mathematics, physics, chemistry, biology and medicine - Includes numerous real-world examples that demonstrate how bad construction technique can destroy the value of classifications and ontologies - Explains how we define and understand the relationships among the classes within a classification and how the properties of a class are inherited by its subclasses - Describes ontologies and how they differ from classifications and explains conditions under which ontologies are useful

Download or read book Data Simplification written by Jules J. Berman and published by Morgan Kaufmann. This book was released on 2016-03-10 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: Data Simplification: Taming Information With Open Source Tools addresses the simple fact that modern data is too big and complex to analyze in its native form. Data simplification is the process whereby large and complex data is rendered usable. Complex data must be simplified before it can be analyzed, but the process of data simplification is anything but simple, requiring a specialized set of skills and tools. This book provides data scientists from every scientific discipline with the methods and tools to simplify their data for immediate analysis or long-term storage in a form that can be readily repurposed or integrated with other data. Drawing upon years of practical experience, and using numerous examples and use cases, Jules Berman discusses the principles, methods, and tools that must be studied and mastered to achieve data simplification, open source tools, free utilities and snippets of code that can be reused and repurposed to simplify data, natural language processing and machine translation as a tool to simplify data, and data summarization and visualization and the role they play in making data useful for the end user. - Discusses data simplification principles, methods, and tools that must be studied and mastered - Provides open source tools, free utilities, and snippets of code that can be reused and repurposed to simplify data - Explains how to best utilize indexes to search, retrieve, and analyze textual data - Shows the data scientist how to apply ontologies, classifications, classes, properties, and instances to data using tried and true methods

Download or read book Logic and Critical Thinking in the Biomedical Sciences written by Jules J. Berman and published by Academic Press. This book was released on 2020-07-03 with total page 308 pages. Available in PDF, EPUB and Kindle. Book excerpt: Science is not a collection of facts. Science is the process by which we draw inferences from facts. Volume I of Logic and Critical Thinking in the Biomedical Sciences invites readers to linger over a collection of common observations to see what inferences can be drawn, when one applies a bit of deductive logic. If we just think about what we observe, it is often possible to discover profound biomedical insights.Volumes 1 and 2 of Logic and Critical Thinking in the Biomedical Sciences are written for biomedical scientists and college-level students engaged in any of the life sciences, including bioinformatics and related data sciences. - Provides a strong introduction to deductive methods that can be directly applied to the biomedical sciences - Using hundreds of examples, shows how creative scientists draw important inferences from observations that are often ignored by their peers - Discusses complex biological and medical concepts in a relaxed manner, intended to focus the reader's attention on the deductive process, without dwelling excessively on details

Download or read book Repurposing Legacy Data written by Jules J. Berman and published by Elsevier. This book was released on 2015-03-13 with total page 169 pages. Available in PDF, EPUB and Kindle. Book excerpt: Repurposing Legacy Data: Innovative Case Studies takes a look at how data scientists have re-purposed legacy data, whether their own, or legacy data that has been donated to the public domain. Most of the data stored worldwide is legacy data—data created some time in the past, for a particular purpose, and left in obsolete formats. As with keepsakes in an attic, we retain this information thinking it may have value in the future, though we have no current use for it. The case studies in this book, from such diverse fields as cosmology, quantum physics, high-energy physics, microbiology, psychiatry, medicine, and hospital administration, all serve to demonstrate how innovative people draw value from legacy data. By following the case examples, readers will learn how legacy data is restored, merged, and analyzed for purposes that were never imagined by the original data creators. - Discusses how combining existing data with other data sets of the same kind can produce an aggregate data set that serves to answer questions that could not be answered with any of the original data - Presents a method for re-analyzing original data sets using alternate or improved methods that can provide outcomes more precise and reliable than those produced in the original analysis - Explains how to integrate heterogeneous data sets for the purpose of answering questions or developing concepts that span several different scientific fields

Download or read book Cancer Targeted Drug Delivery written by You Han Bae and published by Springer Science & Business Media. This book was released on 2013-08-31 with total page 717 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book was conceived from a simple question as to why cancer is so difficult to treat. Ultimately we want to find ways to cure cancers, but that may be an elusive dream at least with the technologies we have now and expect to have in the near future. This leads the question of whether it is possible to improve current cancer treatment methods, especially from the perspective of enhancing targeted drug delivery to tumors. This volume is designed to provide information related to the difficulties in treating cancers through targeted drug delivery, our current understanding of cancer biology, and potential technologies that might be used to achieve enhanced drug delivery to tumors. An ideal drug delivery system for treating cancers would maximize the therapeutic efficacy with minimal side effects in clinical applications. The seemingly improved anticancer efficacy of the current nanoparticle-based formulations needs to be viewed from the context of very poor success rates for translation to human applications. The results of in vitro cell culture models and small animal in vivo experiments have not been extrapolated to clinical applications. Finding the reasons for the lack of successful translation is required if we are to discover approaches to substantially extend the survival time of cancer patients, and hopefully identify cures. Cancer Targeted Drug Delivery: Elusive Dream describes some answers of achieving the so far elusive dream of treating cancers like other chronic diseases with therapies that focus using improved drug delivery systems designed to better align with the unique biological and physiological properties of cancer.

Download or read book Essentials of Surgery written by Lazar J. Greenfield and published by Lippincott Williams & Wilkins. This book was released on 1997 with total page 874 pages. Available in PDF, EPUB and Kindle. Book excerpt: This condensed version of the classic textbook, Surgery: Scientific Principles and Practice, Second Edition, provides students and surgeons with an easily accessible compendium of essential information. It is the ideal guide for students in six-to-eight-week surgical rotations and an excellent resource for surgical residents and surgeons needing a concise and portable reference. The first part of the book, Scientific Principles, presents clinically relevant scientific information, and includes chapters on cytokines, human gene therapy, and the immunobiology of organ transplants. The second part, Surgical Practice, consists of 20 sections devoted to specific organ systems, plus a section on pediatric surgery. Each section provides the information the surgeon needs on anatomy and physiology and describes surgical procedures for specific diseases.

Download or read book Cancer Principles Practice of Oncology written by Vincent T. DeVita Jr. and published by Lippincott Williams & Wilkins. This book was released on 2015-04-15 with total page 976 pages. Available in PDF, EPUB and Kindle. Book excerpt: Understand and apply the scientific advances that are revolutionizing cancer research and practice with Cancer: Principles and Practice of Oncology: Primer of the Molecular Biology of Cancer. Derived from DeVita, Hellman, and Rosenberg’s Cancer: Principles and Practice of Oncology – widely hailed as the definitive clinical reference in oncology – the second editon of this popular Primer focuses on the molecular biology information that is of critical importance to research scientists and clinical oncologists alike. Get up-to-date, dependable coverage of every important frontier in aspect of the molecular biology of cancer with contributions from a noteworthy roster of leading scientists and clinicians, featuring an updated version of the classic “Hallmarks of Cancer” by Hanahan and Weinberg See how molecular biology advances are impacting clinical practice with separate chapters on each of the 19 most common cancer types. Navigate the challenges and ethical dilemmas of cancer genetics with a thorough section chapters on genetic counseling and genetic testing.

Download or read book DeVita Hellman and Rosenberg s Cancer Principles Practice of Oncology written by Vincent T. DeVita Jr. and published by Lippincott Williams & Wilkins. This book was released on 2015-01-07 with total page 6697 pages. Available in PDF, EPUB and Kindle. Book excerpt: DeVita, Hellman, and Rosenberg's Cancer: Principles & Practice of Oncology, 10th edition has garnered universal acclaim as the world’s definitive, standard-setting oncology reference. More than 400 respected luminaries explore today’s most effective strategies for managing every type of cancer by stage of presentation - discussing the role of all appropriate therapeutic modalities as well as combined-modality treatments. This multidisciplinary approach will help your cancer team collaboratively face the toughest clinical challenges and provide the best possible care for every cancer patient. Access the complete contents online or on your mobile device, with quarterly updates reflecting late-breaking developments in cancer care, free for the first year on LWW Health Library. Take full advantage of the latest advances with brand-new chapters on Hallmarks of Cancer, Molecular Methods in Cancer, Oncogenic Viruses, Cancer Screening, and new sections on Genetic testing and counseling for cancer, plus comprehensive updates throughout – including coverage of the newest biologic therapies. Make optimal, well-coordinated use of all appropriate therapies with balanced, multidisciplinary advice from a surgeon, a medical oncologist, and a radiation oncologist in each major treatment chapter. Review the latest molecular biology knowledge for each type of cancer and its implications for improved management. Make the best decisions on cancer screening and prevention, palliative care, supportive oncology, and quality-of-life issues

Download or read book Essential Genetics written by Daniel Hartl and published by Jones & Bartlett Learning. This book was released on 2011 with total page 600 pages. Available in PDF, EPUB and Kindle. Book excerpt: Updated to reflect the latest discoveries in the field, the Fifth Edition of Hartl's classic text provides an accessible, student-friendly introduction to contemporary genetics. Designed for the shorter, less comprehensive introductory course, Essential Genetics: A Genomic Perspective, Fifth Edition includes carefully chosen topics that provide a solid foundation to the basic understanding of gene mutation, expression, and regulation. New and updated sections on genetic analysis, molecular genetics, probability in genetics, and pathogenicity islands ensure that students are kept up-to-date on current key topics. The text also provides students with a sense of the social and historical context in which genetics has developed. The updated companion web site provides numerous study tools, such as animated flashcards, crosswords, practice quizzes and more! New and expanded end-of-chapter material allows for a mastery of key genetics concepts and is ideal for homework assignments and in-class discussion.

Download or read book Principles of Cancer Biotherapy written by Robert K. Oldham and published by Springer Science & Business Media. This book was released on 2009-08-29 with total page 743 pages. Available in PDF, EPUB and Kindle. Book excerpt: At the time of the first edition of Principles of Cancer Biotherapy in 1987, this book represented the first comprehensive textbook on biological therapy. In 1991, when the second edition was published, there was still some doubt on the part of many oncologists and cancer researchers as to the therapeutic value of these new approaches. By 2003 and the fourth edition, it was generally agreed that biopharmaceuticals were producing major opportunities for new cancer therapies. Cancer biotherapy has now truly matured into the fourth modality of cancer treatment. This fifth revised edition describes the tremendous progress that has been made in recent years using biologicals in cancer treatment. This book summarizes an evolving science and a rapidly changing medical practice in biotherapy. In this new millennium, it is now possible to envision a much more diversified system of cancer research and treatment that will afford greater opportunities for a patient’s personalized cancer treatment. This was first envisioned in the 1987 initial edition of this textbook and is now a “new” and popular approach to cancer treatment. Some forms of cancer biotherapy use the strategy of tumor stabilization and control through continued biological therapy, akin to the use of insulin in the treatment of diabetes. This textbook illustrates new methods of thinking and new strategies for control of cancer. It is always difficult to move from past dogma to future opportunity, but this fifth edition of Principles of Cancer Biotherapy illustrates why it is so important to the patients for researchers and clinicians to explore and quickly apply these new opportunities in cancer biotherapy.