Download or read book Negotiating Pharmaceutical Uncertainty written by Eirik Saethre and published by . This book was released on 2017 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: How a clinical trial can impact lives far beyond those of the participants
Download or read book Negotiating Pharmaceutical Uncertainty written by Eirik Saethre and published by Vanderbilt University Press. This book was released on 2017-04-25 with total page 257 pages. Available in PDF, EPUB and Kindle. Book excerpt: Telling the story of a clinical trial testing an innovative gel designed to prevent women from contracting HIV, Negotiating Pharmaceutical Uncertainty provides new insight into the complex and contradictory relationship between medical researchers and their subjects. Although clinical trials attempt to control and monitor participants' bodies, Saethre and Stadler argue that the inherent uncertainty of medical testing can create unanticipated opportunities for women to exercise control over their health, sexuality, and social relationships. Combining a critical analysis of the social production of biomedical knowledge and technologies with a detailed ethnography of the lives of female South African trial participants, this book brings to light issues of economic exclusion, racial disparity, and spiritual insecurity in Johannesburg's townships. Built on a series of tales ranging from strategy sessions at the National Institutes of Health to witchcraft accusations against the trial, Negotiating Pharmaceutical Uncertainty illuminates the everyday social lives of clinical trials. As embedded anthropologists, Saethre and Stadler provide a unique and nuanced perspective of the reality of a clinical trial that is often hidden from view.
Download or read book Negotiating Pharmaceutical Uncertainty written by Eirik Saethre and published by Vanderbilt University Press. This book was released on 2017-04-25 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt: Telling the story of a clinical trial testing an innovative gel designed to prevent women from contracting HIV, Negotiating Pharmaceutical Uncertainty provides new insight into the complex and contradictory relationship between medical researchers and their subjects. Although clinical trials attempt to control and monitor participants' bodies, Saethre and Stadler argue that the inherent uncertainty of medical testing can create unanticipated opportunities for women to exercise control over their health, sexuality, and social relationships. Combining a critical analysis of the social production of biomedical knowledge and technologies with a detailed ethnography of the lives of female South African trial participants, this book brings to light issues of economic exclusion, racial disparity, and spiritual insecurity in Johannesburg's townships. Built on a series of tales ranging from strategy sessions at the National Institutes of Health to witchcraft accusations against the trial, Negotiating Pharmaceutical Uncertainty illuminates the everyday social lives of clinical trials. As embedded anthropologists, Saethre and Stadler provide a unique and nuanced perspective of the reality of a clinical trial that is often hidden from view.
Download or read book Bodies in Flux written by Christa Teston and published by University of Chicago Press. This book was released on 2017-05-05 with total page 254 pages. Available in PDF, EPUB and Kindle. Book excerpt: Medical professionals, scientists, and patients have long grappled with the dubious nature of medical certainty regarding diagnosis, treatment, and prognosis of disease states. Modern Western medicine strives for certainty by monitoring symptoms, modeling risk, and controlling knowledge. In the 1990s, evidence-based medicine became coin of the realm for managing uncertainty. This turn toward evidence-based medicine has proved highly contentious, however. Considerable scholarship has emerged exploring the complex nature of evidence-based medical decision making. Many scholars have sought to account for affect, logic, intuition, persuasion, and experiential knowledge in medicine. But what of the pre-deliberative practices that render the grounds upon which decisions are made? What of the agentic capacity of evidence itself? Inspired by these questions, in Bodies in Flux: Scientific Methods for Negotiating Uncertainty, technical communication scholar Christa Teston explores the discursive and material methods by which medical evidence is designed and the pre-deliberative, rhetorical design work that affords grounds upon which uncertainty is identified and managed when medical decisions are made. She explores specific sites (pathology laboratories and FDA drug hearings) and methodological practices (statistical analysis and genetic sequencing) of medical decision making to reveal the real-time assemblages of people, bodies, practices, and objects that create evidences that are later used to make decisions about treatment. In doing so she reveals the complexity of this work and demonstrates ways in which medical evidence is not definitively objective. Rather than viewing construction of certainty as an exclusively human enterprise, she demonstrates how humans and nonhuman agents co-construct certainty in real-world medical settings where life-and-death decisions must be made.
Download or read book Mapping Uncertainty in Medicne written by Avril Danczak and published by Royal College of General Practitioners. This book was released on 2016-02-28 with total page 342 pages. Available in PDF, EPUB and Kindle. Book excerpt: Uncertainty is the norm in medical practice, yet often gives rise to distress in clinicians, who fear they will make shameful or guilt inducing errors. This book offers a succinct method to clinicians for classifying uncertainty and finding the right skills to manage different types of uncertainty successfully. Every clinician experiences moments when 'they don't know what to do'. Modern medicine is increasingly complex and training has also become more complicated. The days of 'see one, do one, teach one' are over. Yet, both younger clinicians and senior practitioners describe uncertainty as one of the most challenging and stressful aspects of clinical work. If uncertainty is uncomfortable or threatening to individual practitioners, it also provides complex educational challenges. How can we learn to cope with uncertainty effectively ourselves? How can we teach others to understand and manage uncertainty? In this ground breaking book, the authors propose ways to cut through uncertainty, which is explored as an inevitable (and even desirable) component of clinical practice. A Map of Uncertainty in Medicine (MUM) is used to classify uncertainty and to define the skills that will help find a way though practical difficulties. It is always good to have your MUM with you in a tricky situation!
Download or read book Making Medicines Affordable written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2018-03-01 with total page 235 pages. Available in PDF, EPUB and Kindle. Book excerpt: Thanks to remarkable advances in modern health care attributable to science, engineering, and medicine, it is now possible to cure or manage illnesses that were long deemed untreatable. At the same time, however, the United States is facing the vexing challenge of a seemingly uncontrolled rise in the cost of health care. Total medical expenditures are rapidly approaching 20 percent of the gross domestic product and are crowding out other priorities of national importance. The use of increasingly expensive prescription drugs is a significant part of this problem, making the cost of biopharmaceuticals a serious national concern with broad political implications. Especially with the highly visible and very large price increases for prescription drugs that have occurred in recent years, finding a way to make prescription medicinesâ€"and health care at largeâ€"more affordable for everyone has become a socioeconomic imperative. Affordability is a complex function of factors, including not just the prices of the drugs themselves, but also the details of an individual's insurance coverage and the number of medical conditions that an individual or family confronts. Therefore, any solution to the affordability issue will require considering all of these factors together. The current high and increasing costs of prescription drugsâ€"coupled with the broader trends in overall health care costsâ€"is unsustainable to society as a whole. Making Medicines Affordable examines patient access to affordable and effective therapies, with emphasis on drug pricing, inflation in the cost of drugs, and insurance design. This report explores structural and policy factors influencing drug pricing, drug access programs, the emerging role of comparative effectiveness assessments in payment policies, changing finances of medical practice with regard to drug costs and reimbursement, and measures to prevent drug shortages and foster continued innovation in drug development. It makes recommendations for policy actions that could address drug price trends, improve patient access to affordable and effective treatments, and encourage innovations that address significant needs in health care.
Download or read book The Role of NIH in Drug Development Innovation and Its Impact on Patient Access written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2020-01-27 with total page 103 pages. Available in PDF, EPUB and Kindle. Book excerpt: To explore the role of the National Institutes of Health (NIH) in innovative drug development and its impact on patient access, the Board on Health Care Services and the Board on Health Sciences Policy of the National Academies jointly hosted a public workshop on July 24â€"25, 2019, in Washington, DC. Workshop speakers and participants discussed the ways in which federal investments in biomedical research are translated into innovative therapies and considered approaches to ensure that the public has affordable access to the resulting new drugs. This publication summarizes the presentations and discussions from the workshop.
Download or read book Unequal Treatment written by Institute of Medicine and published by National Academies Press. This book was released on 2009-02-06 with total page 781 pages. Available in PDF, EPUB and Kindle. Book excerpt: Racial and ethnic disparities in health care are known to reflect access to care and other issues that arise from differing socioeconomic conditions. There is, however, increasing evidence that even after such differences are accounted for, race and ethnicity remain significant predictors of the quality of health care received. In Unequal Treatment, a panel of experts documents this evidence and explores how persons of color experience the health care environment. The book examines how disparities in treatment may arise in health care systems and looks at aspects of the clinical encounter that may contribute to such disparities. Patients' and providers' attitudes, expectations, and behavior are analyzed. How to intervene? Unequal Treatment offers recommendations for improvements in medical care financing, allocation of care, availability of language translation, community-based care, and other arenas. The committee highlights the potential of cross-cultural education to improve provider-patient communication and offers a detailed look at how to integrate cross-cultural learning within the health professions. The book concludes with recommendations for data collection and research initiatives. Unequal Treatment will be vitally important to health care policymakers, administrators, providers, educators, and students as well as advocates for people of color.
Download or read book How Doctors Think written by Kathryn Montgomery and published by Oxford University Press. This book was released on 2006 with total page 258 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Although physicians make use of science, this book argues that medicine is not itself a science, but rather an interpretive practice that relies heavily on clinical reasoning." "In How Doctors Think, Kathryn Montgomery contends that assuming medicine is strictly a science can have adverse effects. She suggests these can be significantly reduced by recognizing the vital role of clinical judgment."--BOOK JACKET.
Download or read book Technoscience in Progress Managing the Uncertainty of Nanotechnology written by S. Arnaldi and published by IOS Press. This book was released on 2009-07-29 with total page 160 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nanotechnology seems to escape boundaries and definitions. The “Rush to Nanoscale” spreads throughout different sites and arenas, involving a multiplicity of actors, meanings, and spaces in which they emerge. The ‘uncertainty of nanotechnology’ appears to be both a condition and a consequence of this situation. This volume adds to the collective effort of charting the multiple and heterogeneous dimensions that characterise nanotechnology, by analysing the numerous modalities through which different stakeholders and actors provide definitions, attribute meaning and sense to nano-enabled innovations. The chapters of the book attempt to highlight how nanotechnologies, their discourse, and their actual and potential implications cannot be isolated in laboratories, factories, markets, and separate discussion arenas. Also, the volume examines how it is apparently not possible to bind and/or confine the definition of nanotechnology by referring exclusively to present-day research and applications, as well as to geographical, cultural, and even disciplinary boundaries. Considered together, this collection of essays suggests that the ‘societal experiment’ of nanotechnology has to be explored with a vocabulary that is not just scientific and technical, in order to cross the frontiers between multiple domains, actors, identities, translations, and negotiation processes that occur in the nanotechnology field.
Download or read book WHO guideline on country pharmaceutical pricing policies written by and published by World Health Organization. This book was released on 2020-09-29 with total page 70 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years, high prices of pharmaceutical products have posed challenges in high- and low-income countries alike. In many instances, high prices of pharmaceutical products have led to significant financial hardship for individuals and negatively impacted on healthcare systems' ability to provide population-wide access to essential medicines. Pharmaceutical pricing policies need to be carefully planned, carried out, and regularly checked and revised according to changing conditions. Strong, well-thought-out policies can guide well-informed and balanced decisions to achieve affordable access to essential health products. This guideline replaces the 2015 WHO guideline on country pharmaceutical pricing policies, revised to reflect the growing body of literature since the last evidence review in 2010. This update also recognizes country experiences in managing the prices of pharmaceutical products.
Download or read book Research and Development in the Pharmaceutical Industry A CBO Study written by Congressional Budget Office and published by Lulu.com. This book was released on 2013-06-09 with total page 65 pages. Available in PDF, EPUB and Kindle. Book excerpt: Perceptions that the pace of new-drug development has slowed and that the pharmaceutical industry is highly profitable have sparked concerns that significant problems loom for future drug development. This Congressional Budget Office (CBO) study-prepared at the request of the Senate Majority Leader-reviews basic facts about the drug industry's recent spending on research and development (R&D) and its output of new drugs. The study also examines issues relating to the costs of R&D, the federal government's role in pharmaceutical research, the performance of the pharmaceutical industry in developing innovative drugs, and the role of expected profits in private firms' decisions about investing in drug R&D. In keeping with CBO's mandate to provide objective, impartial analysis, the study makes no recommendations. David H. Austin prepared this report under the supervision of Joseph Kile and David Moore. Colin Baker provided valuable consultation...
Download or read book Compliance written by Will Rollason and published by Berghahn Books. This book was released on 2023-12-08 with total page 232 pages. Available in PDF, EPUB and Kindle. Book excerpt: Exploring compliance from an anthropological perspective, this book offers a varied and international selection of chapters covering taxation, corporate governance, medicine, development, carbon offsetting, irregular migration and the building trade. Compliance emerges as more than the opposite of resistance: instead, it appears as a valuable heuristic approach for understanding collective life, as a means by which actors strive to accommodate themselves to others. This perspective transcends conventional distinctions between power and resistance, and offers to open up new avenues of anthropological enquiry.
Download or read book Drug Prices written by United States. General Accounting Office and published by . This book was released on 1997 with total page 32 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Synthesizing Hope written by Anne Pollock and published by University of Chicago Press. This book was released on 2019-05-08 with total page 198 pages. Available in PDF, EPUB and Kindle. Book excerpt: Synthesizing Hope opens up the material and social world of pharmaceuticals by focusing on an unexpected place: iThemba Pharmaceuticals. Founded in 2009 with a name taken from the Zulu word for hope, the small South African startup with an elite international scientific board was tasked with drug discovery for tuberculosis, HIV, and malaria. Anne Pollock uses this company as an entry point for exploring how the location of scientific knowledge production matters, not only for the raw materials, manufacture, licensing, and distribution of pharmaceuticals but also for the making of basic scientific knowledge. Consideration of this case exposes the limitations of global health frameworks that implicitly posit rich countries as the only sites of knowledge production. Analysis of iThemba identifies the problems inherent in global north/south divides at the same time as it highlights what is at stake in who makes knowledge and where. It also provides a concrete example for consideration of the contexts and practices of postcolonial science, its constraints, and its promise. Synthesizing Hope explores the many legacies that create conditions of possibility for South African drug discovery, especially the specific form of settler colonialism characterized by apartheid and resource extraction. Paying attention to the infrastructures and laboratory processes of drug discovery underscores the materiality of pharmaceuticals from the perspective of their makers, and tracing the intellectual and material infrastructures of South African drug discovery contributes new insights about larger social, political, and economic orders.
Download or read book Willful Ignorance written by Herbert I. Weisberg and published by John Wiley & Sons. This book was released on 2014-08-04 with total page 469 pages. Available in PDF, EPUB and Kindle. Book excerpt: An original account of willful ignorance and how this principle relates to modern probability and statistical methods Through a series of colorful stories about great thinkers and the problems they chose to solve, the author traces the historical evolution of probability and explains how statistical methods have helped to propel scientific research. However, the past success of statistics has depended on vast, deliberate simplifications amounting to willful ignorance, and this very success now threatens future advances in medicine, the social sciences, and other fields. Limitations of existing methods result in frequent reversals of scientific findings and recommendations, to the consternation of both scientists and the lay public. Willful Ignorance: The Mismeasure of Uncertainty exposes the fallacy of regarding probability as the full measure of our uncertainty. The book explains how statistical methodology, though enormously productive and influential over the past century, is approaching a crisis. The deep and troubling divide between qualitative and quantitative modes of research, and between research and practice, are reflections of this underlying problem. The author outlines a path toward the re-engineering of data analysis to help close these gaps and accelerate scientific discovery. Willful Ignorance: The Mismeasure of Uncertainty presents essential information and novel ideas that should be of interest to anyone concerned about the future of scientific research. The book is especially pertinent for professionals in statistics and related fields, including practicing and research clinicians, biomedical and social science researchers, business leaders, and policy-makers.
Download or read book Communicating Certainty and Uncertainty in Medical Supportive and Scientific Contexts written by Andrzej Zuczkowski and published by John Benjamins Publishing Company. This book was released on 2014-11-15 with total page 423 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume is a collection of 18 papers on the communication of certainty and uncertainty. The first part introduces recent theoretical developments and general models on the topic and its relations with modality, subjectivity, inter-subjectivity, epistemicity, evidentiality, hedging, mitigation and speech acts. In the second part, results from empirical studies in medical and supportive contexts are presented, all of which are based on a conversational analysis approach. These papers report on professional dialogues including advice giving in gynecological consultations, breaking diagnostic bad news to patients, emergency calls, addiction therapeutic community meetings and bureaucratic-institutional interactions. The final part concerns the qualitative and quantitative analysis of corpora, addressing scientific writing (both research and popular articles) and academic communication in English, German, Spanish and Romanian. The collection is addressed to scholars concerned with the topical issues from a theoretical and analytical perspective and to health professionals interested in the practical implications of communicating certainty or uncertainty.
