Download or read book Natural Products As Antiviral Agents written by Chung Chu and published by . This book was released on 2014-01-15 with total page 292 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Natural Products as Antiviral Agents written by C.K. Chu and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 279 pages. Available in PDF, EPUB and Kindle. Book excerpt: During the past fifty years, thousands of natural products have been isolated from plants, fungi, and bacteria. Apart from intense searches by pharmaceutical companies for medicinals and the concentrated effort mounted by the National Cancer Institute, many of these have not been tested in biological systems. The major reasons for this appear to be, at least, twofold. First, individual researchers looking for biologically active natural products will often isolate only small amounts of material sufficient to determine a structure and calculate the specific activity for their particular bioassay systems: insufficient funds preclude re-isolating the compound unless industrial potential is foreseen. Second, the difficulty with which original structures were proved prior to 1972. This required the isolation of relatively large quantities of a natural product and there followed extensive degradation, elemental analyses of the parent and its fragments, then synthesis, piece by piece, of the molecule. All this took time and energy. No wonder that when the structure was proved the chemist was enervated. And coupled to this was the fact that many chemists were not trained to test their materials in biological systems. In contrast, today a natural product can be isolated, its mass and molecular formula determined and, if there is some serendipity, crystals may be obtained for single crystal x-ray analysis. If conditions are near perfect, it is possible to isolate and identify a novel compound in a month.
Download or read book Antiviral Drug Discovery and Development written by Xinyong Liu and published by Springer Nature. This book was released on 2021-07-13 with total page 357 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book summarizes state-of-the-art antiviral drug design and discovery approaches starting from natural products to de novo design, and provides a timely update on recently approved antiviral drugs and compounds in advanced clinical development. Special attention is paid to viral infections with a high impact on the world population or highly relevant from the public health perspective (HIV, hepatitis C, influenza virus, etc.). In these chapters, limitations associated with adverse effects and emergence of drug resistance are discussed in detail. In addition to classical antiviral strategies, chapters will be dedicated to discuss the non-classical drug development strategies to block viral infection, for instance, allosteric inhibitors, covalent antiviral agents, or antiviral compounds targeting protein–protein interactions. Finally, current prospects for producing broad-spectrum antiviral inhibitors will be also addressed. The book is distinctive in providing the most recent update in the rapidly evolving field of antiviral therapeutics. Authoritative reviews are written by international scientists well known for their contributions in their topics of research, which makes this book suitable for researchers not only within the antiviral research community but also attractive to a broad audience in the drug discovery field. This book covers molecular structures and biochemical mechanisms mediating the antiviral effects, while discussing various ligand design strategies, which include traditional medicinal chemistry, computational chemistry, and chemical biology approaches. The book provides a comprehensive review of antiviral drug discovery and development approaches, particularly focusing on current innovations and future trends.
Download or read book Laurie Pippen s All Natural Antiviral Agents written by Laurie Pippen and published by Eiram Publishing. This book was released on 2015-05-23 with total page 192 pages. Available in PDF, EPUB and Kindle. Book excerpt: The classification antiviral includes anything that destroys viruses or inhibits their ability to grow and reproduce. Herbals approach viral infection from two directions. They stimulate the immune system to produce more immune cells aiding your body’s ability to fight the infection and they act in direct opposition to viruses by inhibiting their ability to grow and reproduce so they cannot survive. The first line of defense against viral infection is prevention . Disinfecting surfaces with known antiviral cleaners, maintaining good health through diet, rest, and exercise and minimizing exposure to infectious agents is far more effective than any treatment plan in the continued battle against viruses. Regardless of the preventative care you take, there are always times where treating an infection will be necessary. Traditionally, viral infection is fought by blending herbals that support the body’s own natural defenses with those that act to kill the virus. Using a combination that blends both actions helps to minimize the duration and severity of any infection. Many herbs and oils act as natural immunostimulant and antiviral agents. Some of these natural products work as well as or even better than the products sold in your local pharmacy. Some of the items in your local pharmacy are even created based on the chemical constituents of plants you might have growing in your own yard. This guide contains antiviral agents that act as both disinfectants for infected air and surfaces and disease fighting agents for the body. Both categories eliminate harmful viruses. It is important that you read the traditional uses and side effects of each plant and discuss any alternative treatment with a qualified herbalist or physician prior to choosing a natural product.
Download or read book Antiviral Compounds From Plants written by James B. Hudson and published by CRC Press. This book was released on 2018-01-10 with total page 377 pages. Available in PDF, EPUB and Kindle. Book excerpt: This timely publication describes the botanical sources and chemical features of antiviral compounds. It covers their mechanisms of action and evaluates their therapeutic potential. Included is a discussion of synthetic analogues where appropriate. The book states that antiviral compounds in so-called medicinal plants may constitute some of their "active ingredients." It explains that many are photosensitizers, their antiviral activity dependent upon or augmented by light of specific wavelengths. This book is of value to microbiologists, phytochemists, virologists, natural-product chemists, ethnobotanists, pharmacologists, medical and veterinary researchers, and others interested in the application of plant compounds to therapy of infectious diseases.
Download or read book Coronavirus Drug Discovery written by Chukwuebuka Egbuna and published by Elsevier. This book was released on 2022-07-07 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt: Coronavirus Drug Discovery, Volume Two: Antiviral Agents from Natural Products and Nanotechnological Applications presents detailed information on drug discovery against COVID-19. Sections in this volume present chapters that focus on the various antiviral agents from natural products that have the propensity to be used as chemical scaffolds for the development of drugs against COVID-19. Also captured are the dietary sources of antioxidant bioactives that may help boost the immune system for the management of COVID-19. Other chapters describe the application of nanotechnology for efficient and effective delivery of drugs against COVID-19. Written by global team of experts, this book is an excellent resource for drug developers, medicinal chemists, pharmaceutical companies in R&D and research institutes in both academia and industry. Presents the various antiviral bioactive compounds from natural products Discusses the roles of antioxidant in the prevention and management of COVID-19 Details the application of nanotechnology for efficient and effective drug delivery
Download or read book Plant Products for Antiviral Therapeutics written by Banasri Hazra and published by Frontiers Media SA. This book was released on 2022-11-18 with total page 249 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Alternative Medicine Interventions for COVID 19 written by and published by . This book was released on 2021 with total page 291 pages. Available in PDF, EPUB and Kindle. Book excerpt: This research volume examines the available alternative, complementary, pharmaceutical and vaccine methods for treating, mitigating, or preventing COVID-19. Coverage includes traditional Chinese medicine, herbal remedies, nutraceutical/dietary options, and drug/vaccine therapies. All the methods discussed will be critically examined to provide readers with a full, unbiased overview that includes pros/cons of each method. While the nature of COVID-19 is still being studied, and new research and theories are being published daily, this book endeavors to provide readers with a comprehensive summary of current research on alternative and mainstream treatment and prevention methods.
Download or read book Discovery and Development of Antidiabetic Agents from Natural Products written by Goutam Brahmachari and published by Elsevier. This book was released on 2016-10-11 with total page 332 pages. Available in PDF, EPUB and Kindle. Book excerpt: Discovery and Development of Antidiabetic Agents from Natural Products brings together global research on the medicinal chemistry of active agents from natural sources for the prevention and treatment of diabetes and associated disorders. From the identification of promising leads, to the extraction and synthesis of bioactive molecules, this book explores a range of important topics to support chemists in the discovery and development of safer, more economical therapeutics that are desperately needed in response to this emerging global epidemic. Beginning with an overview of bioactive chemical compounds from plants with anti-diabetic properties, the book goes on to outline the identification and extraction of anti-diabetic agents and antioxidants from natural sources. It then explores anti-diabetic plants from specific regions before looking more closely at the background, isolation, and synthesis of key therapeutic compounds and their derivatives, including Mangiferin, Resveratrol, natural saponins, and alpha-glucosidase enzyme inhibitors. The book concludes with a consideration of current and potential future applications. Combining the expertise of specialists from around the world, this volume aims to support and encourage medicinal chemists investigating natural sources as starting points for the development of standardized, safe, and effective antidiabetic therapeutics. Contains chapters written by active researchers and leading global experts who are deeply engaged in the research field of natural product chemistry for drug discovery Provides comprehensive coverage of cutting-edge research advances in the design of medicinal natural products with potential as preventives and therapeutics for diabetes and related metabolic issues Presents a practical review of the identification, isolation, and extraction techniques that help support medicinal chemists in the lab
Download or read book Laurie Pippen s All Natural Antiviral Agents written by Laurie Pippen and published by . This book was released on 2015-05-24 with total page 194 pages. Available in PDF, EPUB and Kindle. Book excerpt: The classification antiviral includes anything that destroys viruses or inhibits their ability to grow and reproduce. Herbals approach viral infection from two directions. They stimulate the immune system to produce more immune cells aiding your body's ability to fight the infection and they act in direct opposition to viruses by inhibiting their ability to grow and reproduce so they cannot survive. The first line of defense against viral infection is prevention . Disinfecting surfaces with known antiviral cleaners, maintaining good health through diet, rest, and exercise and minimizing exposure to infectious agents is far more effective than any treatment plan in the continued battle against viruses. Regardless of the preventative care you take, there are always times where treating an infection will be necessary. Traditionally, viral infection is fought by blending herbals that support the body's own natural defenses with those that act to kill the virus. Using a combination that blends both actions helps to minimize the duration and severity of any infection. Many herbs and oils act as natural immunostimulant and antiviral agents. Some of these natural products work as well as or even better than the products sold in your local pharmacy. Some of the items in your local pharmacy are even created based on the chemical constituents of plants you might have growing in your own yard. This guide contains antiviral agents that act as both disinfectants for infected air and surfaces and disease fighting agents for the body. Both categories eliminate harmful viruses. It is important that you read the traditional uses and side effects of each plant and discuss any alternative treatment with a qualified herbalist or physician prior to choosing a natural product.
Download or read book Natural Antimicrobial Agents written by Jean-Michel Mérillon and published by Springer. This book was released on 2018-02-08 with total page 337 pages. Available in PDF, EPUB and Kindle. Book excerpt: Documenting the latest research in the field of different pathogenic organisms, this book presents the current scenario about promising antimicrobials in the following areas: Part I. Plants as source of antibacterials, Part II. Naturally occurring antifungal natural products, Part III. Antiparasitic natural products, Part IV. Antiviral natural products. Renowned scientists from the globe have been selected as authors to contribute chapters. Use of plants for various ailments is as old as human civilization and continuous efforts are being made to improve medicinal plants or to product their bioactive secondary metabolites in high amounts through various technologies. About 200,000 natural products of plant origin are known and many more are being identified from higher plants and micro-organisms. Some plants based drugs are used since centuries and there is no alternative medicine for many such drugs as cardiac glycosides. Drug discovery from medicinal plants or marine micro-organisms continues to provide an important source of new drug leads. Research on new antibacterials represents a real and timely challenge of this century, particularly for the treatment of infections caused by clinical isolates that show multidrug resistance. The main microorganisms involved in the resistance process have been identified and given the acronym ESKAPE for Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumanii, Pseudomonas aeruginosa and Enterobacteriaceae. Multidrug resistant Mycobacterium tuberculosis including highly drug-resistant strains (XDR-TB) has also emerged as one of the most important clinical challenges of this century. Plants of diverse taxa and marine micro-organisms are rich source of these antimicrobials. An attempt has been made to compile the recent information about natural sources of antibacterials and their sustainable utilization. Increased panic of these pathogens warrants a growing demand for research to undertake the threat of multidrug resistance. The search for new antifungal, antiparasitic and antiviral natural products is far from devoid of interest. According to the WHO report in 2013, malaria still represents some 207 million cases worldwide and more than 3 billion of people are still exposed to this risk. Similarly, about 350 million people are considered at risk of contracting leishmaniasis. The fight against some viruses also requires that the research on natural products continue. For example, even if an antiretroviral with direct action was recently approved in Europe in 2013, its high cost does not allow to offer it to an exposed population in countries where the cost of drugs remains a problem for a large part of the population. These books are useful to researchers and students in microbiology, biotechnology, pharmacology, chemistry and biology as well as medical professionals.
Download or read book Chemistry of Biologically Potent Natural Products and Synthetic Compounds written by Shahid Ul-Islam and published by John Wiley & Sons. This book was released on 2021-06-29 with total page 434 pages. Available in PDF, EPUB and Kindle. Book excerpt: In view of their promising biological and pharmaceutical activities, natural product inspired and heterocyclic compounds have recently gained a reputation in the field of medicinal chemistry. Over the past decades, intensive research efforts have been ongoing to understand the synthesis, biochemistry and engineering involved in their preparation and action mechanisms. Several novel natural product derivatives, heterocyclic and other synthetic compounds, have been reported to have shown interesting biological activities including anticancer, antimicrobial, anti-inflammatory, anti-glycemic, anti-allergy and antiviral etc. Chemistry of Biologically Potent Natural Products and Synthetic Compounds provides up-to-date information on new developments and most recent medicinal applications of the natural products and derivatives, as well as the chemistry and synthesis of heterocyclic and other related compounds.
Download or read book Human Herpesvirus Infection written by Ronaldo Luis Thomasini and published by BoD – Books on Demand. This book was released on 2020-04-01 with total page 130 pages. Available in PDF, EPUB and Kindle. Book excerpt: The relationship between herpesviruses and humans probably dates from thousands of years ago. In the last few decades, many aspects of herpesvirus infections have been understood, such as infections with a range of manifestations (severe, mild, or subclinical). Herpesvirus can remain latent during a lifetime and sometimes their reactivation can cause different clinical features in the patient. Several conditions have been related to herpesvirus reactivation such as complications in transplant organ recipients and immune regulatory modification in the elderly. Aspects of human herpesvirus simples, varicella-zoster virus, and cytomegalovirus are presented and discussed in this book.
Download or read book Antiviral Methods and Protocols written by Derek Kinchington and published by Springer Science & Business Media. This book was released on 2008-02-01 with total page 398 pages. Available in PDF, EPUB and Kindle. Book excerpt: This latest addition to the Methods in Molecular Medicine series, Anti- ral Methods and Protocols, is opportune because there is an increasing int- est in discovering compounds that are effective against both chronic and acute viral infections. A number of the methods described in the volume are unp- lished and their inclusion indicates the speed at which this field is moving. This volume is not a review but each chapter contains methods validated by the experts who have spent time in developing the protocols. The hallmark of this series is the comprehensive way in which the me- ods are described, which includes a list of all the reagents needed for each protocol. Of importance is the section on tips and pitfalls that the authors have discovered while developing their protocols. The manual itself is designed to be used by researchers in universities and industry who are familiar with a range of biological techniques but who want to set up quickly a novel assay system. We encourage a dialog between readers and authors, which may also result in useful collaborations.
Download or read book Application of Natural Products in SARS CoV 2 written by Kamal Niaz and published by Elsevier. This book was released on 2022-10-20 with total page 548 pages. Available in PDF, EPUB and Kindle. Book excerpt: Application of Natural Products in SARS-CoV-2 examines the potential for natural products to treat COVID-19, bringing together the most recent research. SARS-CoV-2 is a novel disease H54 that is still being researched despite being globally prevalent. There are still few proven treatments, so repurposing existing drugs and treatments is essential. While there have been many articles published on the subject, this book is the first to bring together data and research on the topic. It includes information about molecular mechanism, dosage and safety profiles, and an essential resource for all scientists and researchers working to combat SARS-CoV-2. Collates known data and research on COVID-19 and natural products in a single and easy to find place Includes information about molecular mechanism, dosage and safety profiles Provides information from a diverse group of academics and industrial scientists
Download or read book Plant derived Natural Products written by Anne E. Osbourn and published by Springer Science & Business Media. This book was released on 2009-07-07 with total page 588 pages. Available in PDF, EPUB and Kindle. Book excerpt: Plants produce a huge array of natural products (secondary metabolites). These compounds have important ecological functions, providing protection against attack by herbivores and microbes and serving as attractants for pollinators and seed-dispersing agents. They may also contribute to competition and invasiveness by suppressing the growth of neighboring plant species (a phenomenon known as allelopathy). Humans exploit natural products as sources of drugs, flavoring agents, fragrances and for a wide range of other applications. Rapid progress has been made in recent years in understanding natural product synthesis, regulation and function and the evolution of metabolic diversity. It is timely to bring this information together with contemporary advances in chemistry, plant biology, ecology, agronomy and human health to provide a comprehensive guide to plant-derived natural products. Plant-derived natural products: synthesis, function and application provides an informative and accessible overview of the different facets of the field, ranging from an introduction to the different classes of natural products through developments in natural product chemistry and biology to ecological interactions and the significance of plant-derived natural products for humans. In the final section of the book a series of chapters on new trends covers metabolic engineering, genome-wide approaches, the metabolic consequences of genetic modification, developments in traditional medicines and nutraceuticals, natural products as leads for drug discovery and novel non-food crops.
Download or read book Antiviral Drug Strategies written by Erik De Clercq and published by John Wiley & Sons. This book was released on 2011-04-08 with total page 632 pages. Available in PDF, EPUB and Kindle. Book excerpt: By focusing on general molecular mechanisms of antiviral drugs rather than therapies for individual viruses, this ready reference provides the critical knowledge needed to develop entirely novel therapeutics and to target new viruses. It begins with a general discussion of antiviral strategies, followed by a broad survey of known viral targets, such as reverse transcriptases, proteases, neuraminidases, RNA polymerases, helicases and primases, as well as their known inhibitors. The final section contains several cases studies of recent successful antiviral drug development. Edited by Erik de Clercq, the world authority on small molecule antiviral drugs, who has developed more new antivirals than anyone else.
