Download or read book Nasal Toxicity And Dosimetry Of Inhaled Xenobiotics written by Fred J. Miller and published by CRC Press. This book was released on 1995-02-14 with total page 469 pages. Available in PDF, EPUB and Kindle. Book excerpt: The location and severity of toxic responses in the noses of laboratory animals following inhalation of various compounds is attracting a growing number of researchers. This interest has arisen not only due to types of responses observed, but also because of the increased use of animal toxicological data for assessing human health risks from exposure to these compounds. This work addresses nasal dosimetry and toxicity of Inhaled Xenobiotics.; Originally Published As A Special Issue Of The journal "Inhalation Toxicology", the contributions are derived from a Chemical Industry Institute of Toxicology CIIT symposium held in September 1993 in Durham, North Carolina. The overview articles, covering topics like end points and responses of concern in humans, enable the reader to integrate information contained in later articles which treat the overview subjects in greater depth.; Next, mathematical and physical models that can be used to study the deposition of inhaled compounds in the upper respiratory tracts of humans and animals are considered. Approaches for experimental dosimetry studies and a number of dosimetry case studies are presented. The third series of articles examine chemically induced nasal responses in animals and humans. Integrating all the previous information, the final section discusses the use of nasal dosimetry and toxicity data for assessing human health implications and establishing appropriate exposure limits.
Download or read book Nasal Toxicity and Dosimetry of Inhaled Xenibiotics written by and published by . This book was released on 1995 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Environmental Health Perspectives written by and published by . This book was released on 1995 with total page 474 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Concepts In Inhalation Toxicology written by Roger O. McClellan and published by CRC Press. This book was released on 1995-09-25 with total page 678 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent developments have provided new data on the subject of inhalation toxicology, requiring an update of the previous edition of this popular text. Like the first, this second edition explains the basic concepts and quantitative approaches in inhalation toxicology, and it gives a comprehensive treatment of evaluations of respiratory responses to inhaled particles and gases. The author here explores new understanding of the role of cytokines in pulmonary inflammation and risk assessment. Immunologists, oncologists, respiratory specialists and students in those fields will find Concepts In Inhalation Toxicology to be essential to their practice.
Download or read book Inhalation Toxicology written by Harry Salem and published by CRC Press. This book was released on 2005-12-22 with total page 1055 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by internationally recognized scientists from academic, industrial, and governmental sectors, Inhalation Toxicology, Second Edition details the methods and materials used in the theoretical and applied aspects of inhalation toxicology. The editors emphasize the relationship between the respiratory system and toxicology of inhaled substances
Download or read book Review of the Environmental Protection Agency s Draft IRIS Assessment of Formaldehyde written by National Research Council and published by National Academies Press. This book was released on 2011-05-31 with total page 204 pages. Available in PDF, EPUB and Kindle. Book excerpt: Formaldehyde is ubiquitous in indoor and outdoor air, and everyone is exposed to formaldehyde at some concentration daily. Formaldehyde is used to produce a wide array of products, particularly building materials; it is emitted from many sources, including power plants, cars, gas and wood stoves, and cigarettes; it is a natural product in come foods; and it is naturally present in the human body as a metabolic intermediate. Much research has been conducted on the health effects of exposure to formaldehyde, including effects on the upper airway, where formaldehyde is deposited when inhaled, and effects on tissues distant from the site of initial contact. The U.S. Environmental Protection Agency (EPA) released noncancer and cancer assessments of formaldehyde for its Intergated Risk Information System (IRIS) in 1990 and 1991, respectively. The agency began reassessing formaldehyde in 1998 and released a draft IRIS assessment in June 2010. Given the complexity of the issues and the knowledge that the assessment will be used as the basis of regulatory decisions, EPA asked the National Research Council (NRC) to conduct an independent scientific review of the draft IRIS assessment. In this report, the Committee to Review EPA's Draft IRIS Assessment of Formaldehyde first addresses some general issues associated with the draft IRIS assessment. The committee next focuses on questions concerning specific aspects of the draft assessment, including derivation of the reference concentrations and the cancer unit risk estimates for formaldehyde. The committee closes with recommendations for improving the IRIS assessment of formaldehyde and provides some general comments on the IRIS development process.
Download or read book Toxicologic Pathology written by Pritam S. Sahota and published by CRC Press. This book was released on 2013-04-09 with total page 1019 pages. Available in PDF, EPUB and Kindle. Book excerpt: As drug development shifts over time to address unmet medical needs and more targeted therapies are developed, previously unseen pharmacological or off-target effects may occur in treatment. Designed to provide practical information for the bench toxicologic pathologist working in pharmaceutical drug research, Toxicologic Pathology: Nonclinical Safety Assessment presents a histopathologic description of lesions observed during drug development and discusses their implication in the drug development process. Divided into two sections, the book systematically assists pathologists in making a determination as to the origin and potential importance of a lesion and its relevance for assessing human risk. The first section includes eight "concept" chapters to orient pathologists in areas that are important for effective interaction with other pathologists as well as the many non-pathologists involved in drug development. The second section is made up of organ-based chapters, each including light microscopic and electron microscopic descriptions of pathological lesions, differential diagnoses, biological consequences, pathogenesis, mechanism of lesion formation, and the expected clinical pathology correlates. This volume presents critical information—both published and unpublished and gained through personal experience—to improve the quality of drug safety evaluation and to expedite and improve the efficiency of the process. This book is crafted to assist students, residents, and toxicologic pathologists in their early career phase by serving as a resource that can effectively be used as a ready reference next to the microscope. In addition, more experienced pathologists will find this volume to be invaluable during their assessments. The book is also a valuable reference for toxicologists to assist in understanding compound-related pathological findings and to provide background for working on a range of toxicological problems.
Download or read book Comprehensive Toxicology written by and published by Elsevier. This book was released on 2010-06-01 with total page 6448 pages. Available in PDF, EPUB and Kindle. Book excerpt: An explosive increase in the knowledge of the effects of chemical and physical agents on biological systems has led to an increased understanding of normal cellular functions and the consequences of their perturbations. The 14-volume Second Edition of Comprehensive Toxicology has been revised and updated to reflect new advances in toxicology research, including content by some of the leading researchers in the field. It remains the premier resource for toxicologists in academia, medicine, and corporations. Comprehensive Toxicology Second Edition provides a unique organ-systems structure that allows the user to explore the toxic effects of various substances on each human system, aiding in providing diagnoses and proving essential in situations where the toxic substance is unknown but its effects on a system are obvious. Comprehensive Toxicology Second Edition is the most complete and valuable toxicology work available to researchers today. Contents updated and revised to reflect developments in toxicology research Organized with a unique organ-system approach Features full color throughout Available electronically on sciencedirect.com, as well as in a limited-edition print version
Download or read book Toxicology of the Lung written by Donald E. Gardner and published by CRC Press. This book was released on 2000-01-20 with total page 684 pages. Available in PDF, EPUB and Kindle. Book excerpt: Thoroughly revised and updated, the third edition of Toxicology of the Lung brings together the latest accomplishments and advancements in concepts, approaches, and procedures now used to evaluate the risks associated with airborne contaminants. With chapters from leading authorities, including nine new chapters and a number of new topic areas, this edition describes how and why the lung and respiratory system respond as they do to toxicants and provides a clear understanding of human health risks associated with chemical exposure. This one-of-a-kind reference on inhalation toxicology will be invaluable to all professionals in academia, industry, clinics, research laboratories, and government agencies.
Download or read book The Urban Atmosphere and Its Effects written by Peter Brimblecombe and published by World Scientific. This book was released on 2001 with total page 394 pages. Available in PDF, EPUB and Kindle. Book excerpt: Air Pollution Reviews will provide state-of-the-art reviews of key problems in air pollution science. Leading research workers and key figures from the regulatory and industrial communities will contribute detailed and yet accessible accounts of areas in which they have recognised expertise. The series will run to five volumes, the first being more general than the succeeding volumes. In Volume 1, current perceptions of the effects of air pollutants on health will be reviewed. Recent epidemiological data on the links between particles and effects on health and the methods used to investigate these associations will be critically assessed. For students reading environmental science and those beginning research on air pollution and its effects, regulatory toxicologists and physicians with an interest in environmental medicine, this series will be a central source of up-to-date, critically reviewed information.
Download or read book Animal Welfare Information Center Newsletter written by and published by . This book was released on 1990 with total page 420 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Haschek and Rousseaux s Handbook of Toxicologic Pathology written by Wanda M. Haschek and published by Elsevier. This book was released on 2001-10-16 with total page 2160 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive understanding of toxicologic pathology is essential for those in industry, academia, and government who make decisions concerning the safety and efficacy of drugs and chemicals. Toxicologic pathology relies heavily on the fields of both toxicology and pathology, which are well covered individually in various texts and references; however, there are few texts that address the field of toxicologic pathology. The Handbook of Toxicologic Pathology fills this void and is thus essential for all health professionals within or interacting with the field of toxicologic pathology. This two-volume set provides the reader with a single reference for toxicologic pathology. In volume I, the book covers toxicologic pathology in its basic aspects, including its definition, the basic biochemical and morphologic mechanisms underlying the discipline, the basic practice of toxicologic pathology (including special techniques) and issues essential to the understanding of toxicologic pathology such as risk assessment, experimental design, and statistical analysis. Next, the book moves to specific issues affecting the "practice" toxicologic pathology, including issues such as knowledge management, regulatory affairs and writing pathology reports. Finally, Volume I closes with several chapters that deal with specific classes of environmental toxicants such as endocrine disruptors and heavy metals. Volume II addresses the toxicologic pathology in a thoroughly standardized systems manner, addressing the basic structure and function of a particular organ system, its response to toxic injury, mechanisms of injury and methods of evaluation of such injury. Key Features * Easy to find, up-to-date reference information * Graphic and photographic plates * Current hot topics and anticipated changes in toxicologic pathology * Standardized chapter format * Topics that are addressed in both a broad and deep manner, resulting in a stand alone text * Added coverage of important environmental toxicants * Chapters authored by internationally recognized experts and peer-reviewed
Download or read book Environmental Medicine written by Jon Ayres and published by CRC Press. This book was released on 2010-07-30 with total page 715 pages. Available in PDF, EPUB and Kindle. Book excerpt: Environmental Medicine is an indispensable aid to the investigation, diagnosis and treatment of a wide variety of environmentally-acquired disorders. It brings into sharp focus the increasing importance of the practice of environmental medicine, drawing together the many different strands that make up this modern discipline, and putting topical and
Download or read book Comprehensive Toxicology written by Charlene A. McQueen and published by Pergamon. This book was released on 1997-07-01 with total page 688 pages. Available in PDF, EPUB and Kindle. Book excerpt: Comprehensive Toxicology - the first comprehensive reference work in toxicology, is an in-depth, state-of-the-art review of toxicology of unrivalled quality. It is designed to encompass investigation from a molecular level to the intact organism. Presented in a 13-volume printed form.
Download or read book Biological Concepts and Techniques in Toxicology written by Jim E. Riviere and published by CRC Press. This book was released on 2006-03-06 with total page 412 pages. Available in PDF, EPUB and Kindle. Book excerpt: Highlighting the latest advances in molecular biology, mathematical modeling, quantitative risk assessment, and biopharmaceutical development, this reference presents how current scientific applications and methods impact and revolutionize mainstream toxicological research. Presenting findings from disciplines that will impact the future of toxicol
Download or read book Air Pollution and Health written by Robert L. Maynard and published by Elsevier. This book was released on 1999-04-21 with total page 1083 pages. Available in PDF, EPUB and Kindle. Book excerpt: Concern about the impact of air pollution has led governments and local authorities across the world to regulate, among other things, the burning of fossil fuels, industrial effluence, cigarette smoke, and aerosols. This legislation has often followed dramatic findings about the impact of pollution on human health. At the same time there have been significant developments in our ability to detect and quantify pollutants and a proliferation of urban and rural air pollution networks to monitor levels of atmospheric contamination. Air Pollution and Health is the first fully comprehensive and current account of air pollution science and it impact on human health. It ranges in scope from meteorology, atmospheric chemistry, and particle physics to the causes and scope of allergic reactions and respiratory, cardiovascular, and related disorders. The book has substantial international coverage and includes sections on cost implications, risk assessment, regulation, standards, and information networks. The multidisciplinary approach and the wide range of issues covered makes this an essential book for all concerned with monitoring and regulating air pollution as well as those concerned with its impact on human health. Only comprehensive text covering all the important air pollutants and relating these to human health and regulatory bodies Brings together a wide range of issues concerning air pollution in an easily accessible format Contributions from government agencies in the US and UK provide information on public policy and resource networks in the areas of health promotion and environmental protection
Download or read book IPCS Mode of Action Framework written by International Program on Chemical Safety and published by World Health Organization. This book was released on 2007 with total page 129 pages. Available in PDF, EPUB and Kindle. Book excerpt: The use of structured frameworks in chemical risk assessment promotes transparent, harmonized approaches. This publication presents two IPCS frameworks originally published in Critical reviews in toxicology. The frameworks provide a means of ensuring a transparent evaluation of the data, identification of key data gaps and of information that would be of value in the further risk assessment of the chemical in question.--Publisher's description.
