Download or read book Nanomaterials for Liquid Chromatography and Laser Desorption Ionization Mass Spectrometry written by Tian Lu and published by Springer. This book was released on 2015-05-07 with total page 118 pages. Available in PDF, EPUB and Kindle. Book excerpt: Tian Lu's dissertation describes major advances in ultrathin-layer chromatography (UTLC), liquid chromatography and surface-assisted laser desorption ionization (SALDI), and matrix-enhanced SALDI (ME-SALDI) mass spectrometry. Lu describes the fabrication of electrospun polyvinyl alcohol (PVA) UTLC plates using an in-situ crosslinking electrospinning technique. The author improved the efficiency of PVA plates greatly compared to the efficiency of silica HPTLC plates. Also highlighted in this thesis is an edge-plane based ordered-carbon surface that provides unique selectivity in liquid chromatography. Further developments include polar analytes, such as amino acids, nucleotides and nucleosides which can be well-retained and separated in the edge-plane ordered-carbon stationary phase. Also, the author studied and detected mass spectra of organic polymers as high as 900,000 Da, the highest molecular weight that has been studied by SALDI to date using the carbon nanofibrous substrate. This thesis has led to a number of publications in high-impact journals.
Download or read book Bioanalysis of Surface assisted Laser Desorption Ionization Mass Spectrometry Using Nanomaterials written by 陳玟岑 and published by . This book was released on 2013 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Small Molecule Matrix free Laser Desorption ionization Mass Spectrometry written by and published by . This book was released on 2006 with total page 186 pages. Available in PDF, EPUB and Kindle. Book excerpt: Modified Si wafers and nanoparticles (5-50 nm) have been developed and explored to assist laser desorption ionization mass spectrometry (LDI-MS) for small molecule analysis. DIOS (desorption/ionization on silicon) plates were prepared according to published protocols. DIOS was tested and compared with the optimized silicon nanoparticles derivatized by penterfluorophenylchlorosilane (PFP). SPALDI (Si nanoparticle assisted LDI) requires less laser flux than common MALDI and DIOS thus provides significant less background and higher ionization efficiency. It has higher surface homogeneity, relative salt tolerance and high selectivity which may origin from analyte dependent pre-charging. Surface characterization has been investigated. And different analytes including drugs, peptides, pesticides and acids in both biological and environmental samples have been applied by positive or negative ionization mode. Detection limits, down to the low femtomole per microliter levels have been achieved for propafenone and verapamil. SPALDI is an easily applicable practical tool at a potential low cost.
Download or read book Development of Matrix assisted Laser Desorption ionization and Liquid Chromatography Electrospray Ionization Based Mass Spectrometric Techniques for Characterizing and Quantifying Endogenous and Therapeutic Biomolecules written by Bingming Chen and published by . This book was released on 2017 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Endogenous biomolecules, such as neuropeptide, protein and carbohydrates, play important roles in biological and physiological processes. Over the last two decades, therapeutic biomolecules, including therapeutic peptides, proteins and monoclonal antibodies, have become large and fast-growing segments of the pharmaceutical industry. However, analyzing biomolecules is challenging due to their large size, complex structure and various modifications. In situ analysis of biomolecules is even more challenging due to the large dynamic range and complex microenvironments on tissue surface. In this dissertation, matrix-assisted laser desorption/ionization (MALDI) and liquid chromatography (LC) -- electrospray ionization (ESI) based mass spectrometric techniques were developed to characterize and quantify endogenous and therapeutic biomolecules. Specifically, this work developed novel ionization techniques and mass spectrometry imaging workflows to study the sequence and in situ distribution of biomolecules on high resolution accurate mass instrument platforms. Moreover, absolute or relative quantifications of biomolecules, such as therapeutic peptide or N-glycans, were measured by cutting-edge quantification workflows. In summary, this work not only improves current analytical methodology for characterizing biomolecules, but also demonstrates its potential applications in pharmaceutical industry and clinical settings.
Download or read book Mass Spectrometry in Food and Environmental Chemistry written by Yolanda Picó and published by Springer Nature. This book was released on 2022-12-16 with total page 383 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book reviews the latest advances in mass spectrometry (MS) techniques applied to food safety and environment quality, and it discusses the recent improvements in sample preparation and MS platforms for screening of emerging contaminants. Expert contributors discuss the current applications from omics to the screening of emerging contaminants and nanomaterials in food and environmental matrices, and particular attention is given to the opportunities that MS offers for guarantying food security and promoting the sustainable use of ecosystems. Divided into 13 chapters, the book covers topics such as the handling and preparation of food and environmental samples for MS, foodomics, environmental omics, ambient ionization techniques in food and environmental chemistry, and chip-based separation devices coupled to MS. Readers will also find a comprehensive overview of several MS techniques applied to food and environmental chemistry, including elemental, isotopic, chiral, ion mobility, chromatographic and imaging MS. This book will appeal not only to students and researchers, but also to professionals working with MS platforms in food safety and environmental quality. The different advances and promising applications described in this work will be of paramount importance for ensuring food safety and environment health for current and future generations.
Download or read book Carbon Nanomaterials Sourcebook written by Klaus D. Sattler and published by CRC Press. This book was released on 2016-04-06 with total page 608 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Carbon Nanomaterials Sourcebook contains extensive, interdisciplinary coverage of carbon nanomaterials, encompassing the full scope of the field-from physics, chemistry, and materials science to molecular biology, engineering, and medicine-in two comprehensive volumes.Written in a tutorial style, this first volume of the sourcebook:Focuses on g
Download or read book Liquid Chromatography written by Salvatore Fanali and published by Elsevier. This book was released on 2017-06-23 with total page 840 pages. Available in PDF, EPUB and Kindle. Book excerpt: Liquid Chromatography: Applications, Second Edition,is a single source of authoritative information on all aspects of the practice of modern liquid chromatography. It gives those working in both academia and industry the opportunity to learn, refresh, and deepen their knowledge of the wide variety of applications in the field. In the years since the first edition was published, thousands of papers have been released on new achievements in liquid chromatography, including the development of new stationary phases, improvement of instrumentation, development of theory, and new applications in biomedicine, metabolomics, proteomics, foodomics, pharmaceuticals, and more. This second edition addresses these new developments with updated chapters from the most expert researchers in the field. Emphasizes the integration of chromatographic methods and sample preparation Explains how liquid chromatography is used in different industrial sectors Covers the most interesting and valuable applications in different fields, e.g., proteomic, metabolomics, foodomics, pollutants and contaminants, and drug analysis (forensic, toxicological, pharmaceutical, biomedical) Includes references and tables with commonly used data to facilitate research, practical work, comparison of results, and decision-making
Download or read book Toxicology of Nanomaterials written by Yuliang Zhao and published by John Wiley & Sons. This book was released on 2016-12-12 with total page 434 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides the reader with a comprehensive view of analytical methods for nanotoxicology studies. After an introduction to nanomaterials and toxicological studies, the book discusses various characterization methods of nanomaterials and continues with the detection of nanoparticles in vivo as well as in vitro. A variety of techniques in molecular toxicology of nanomaterials is presented, followed by a detailed explanation of interaction between nanoparticles and biomacromolecules, including the structure-toxicity relationships of nanomaterials. Finally, the book concludes with the advantages and challenges of the analytical methods for nanotoxicology.
Download or read book Green Chemical Analysis and Sample Preparations written by Mahmoud H. El-Maghrabey and published by Springer Nature. This book was released on 2022-06-20 with total page 553 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume focuses on the most recent trends for greening analytical activities beginning with an introduction to green analytical chemistry followed by a discussion of green analytical chemistry metrics and life-cycle assessment approach to analytical method development. The chapters discuss two main topics; first is the most recent techniques for greening sample pretreatment steps, and second is modern trends for tailoring analytical techniques and instrumentation to implement the green analytical chemistry concept. The role of different kinds of green solvents, such as ionic liquids, supercritical fluids, deep eutectic solvents, bio-based solvents, and surfactants, as well as nanomaterials and green sorption materials in greening sample extraction steps is also a focus of this book. Furthermore, different approaches for greening chromatography as a key analytical technique are discussed. The applications of nanomaterials in analytical procedures are deeply reviewed, and miniaturization of spectrometers is also discussed as a recently evolved approach for efficient green on-site analysis. This book will appeal to a wide readership of academic and industrial researchers in different fields. It can be used in the classroom for undergraduate and postgraduate students focusing on the development of new analytical procedures for organic and inorganic compounds determination in different kinds of samples characterized by complex matrices composition. The book will also be useful for researchers that are interested in both chemical analysis and environment protection.
Download or read book Laser Desorption Ionization Mass Spectrometry Based on Nanophotonic Structure From Material Design to Mechanistic Understanding written by Moon-Ju Kim and published by Springer Nature. This book was released on 2023-11-11 with total page 107 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents innovative laser desorption ionization (LDI)-active nanophotonic structures for addressing the challenges that matrix-assisted laser desorption ionization mass spectrometry (MALDI-MS) is currently facing and for enhancing LDI efficiency. It presents a variety of cutting-edge nanophotonic structures to satisfy the mass-analytical needs of sensitivity, reproducibility, and quantification. As opposed to the commercialized, conventional organic matrix used in MALDI-MS, these nanostructures are validated to be highly effective in detecting small metabolites and drugs, highlighting their considerable potential in the mass spectrometry field. It also systematically elucidates fundamental LDI processes in terms of the photo-thermal, electronic, and structural characteristics of nanophotonic structures, offering mechanistic knowledge of LDI-MS. Even though LDI-MS performance is heavily influenced by a number of nanostructure parameters, relatively little is known about the LDI processes associated with those characteristics. An in-depth understanding of nanostructure characteristics and LDI mechanisms thus paves the way for more effective, rational design and development of nanostructures with improved LDI capabilities. Further, with a focus on multiple cascades in nanostructure functions in response to laser pulse stimuli, this book provides detailed, step-by-step procedures to design and construct a nanophotonic, LDI-active platform, which may serve as a roadmap for graduate students in the field of mass spectrometry. Readers, including graduate students, researchers, and experts working in the related areas of mass spectrometry, nanophotonics, and material science and material engineering, will find a wealth of useful information in this book.
Download or read book Advanced Mass Spectrometry for Food Safety and Quality written by and published by Elsevier. This book was released on 2015-05-08 with total page 733 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advanced Mass Spectrometry for Food Safety and Quality provides information on recent advancements made in mass spectrometry-based techniques and their applications in food safety and quality, also covering the major challenges associated with implementing these technologies for more effective identification of unknown compounds, food profiling, or candidate biomarker discovery. Recent advances in mass spectrometry technologies have uncovered tremendous opportunities for a range of food-related applications. However, the distinctive characteristics of food, such as the wide range of the different components and their extreme complexity present enormous challenges. This text brings together the most recent data on the topic, providing an important resource towards greater food safety and quality. Presents critical applications for a sustainable, affordable and safe food supply Covers emerging problems in food safety and quality with many specific examples. Encompasses the characteristics, advantages, and limitations of mass spectrometry, and the current strategies in method development and validation Provides the most recent data on the important topic of food safety and quality
Download or read book Applications of Nanomaterials in Proteomics written by Nianrong Sun and published by Springer Nature. This book was released on 2021-09-28 with total page 431 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive and systematic overview of the latest advances in nanomaterials for proteomics, both theoretical and practical. Consisting of seven chapters, it first covers the synthesis methods, characterization, principles, and performance of functional nanomaterials in various branches of proteomics in detail. This is followed by the applications of nanomaterials for the separation and analysis of various proteins and peptides. Given its scope, the book appeals to a broad readership, including those active in proteomics and materials science; it can also serve as a reference book for students majoring in proteomics analysis.
Download or read book Novel Nanomaterials for Biomedical Environmental and Energy Applications written by Xiaoru Wang and published by Elsevier. This book was released on 2018-11-16 with total page 496 pages. Available in PDF, EPUB and Kindle. Book excerpt: Novel Nanomaterials for Biomedical, Environmental, and Energy Applications is a comprehensive study on the cutting-edge progress in the synthesis and characterization of novel nanomaterials and their subsequent advances and uses in biomedical, environmental and energy applications. Covering novel concepts and key points of interest, this book explores the frontier applications of nanomaterials. Chapters discuss the overall progress of novel nanomaterial applications in the biomedical, environmental and energy fields, introduce the synthesis, characterization, properties and applications of novel nanomaterials, discuss biomedical applications, and cover the electrocatalytical and photothermal effects of novel nanomaterials for efficient energy applications. The book will be invaluable to academic researchers and biomedical clinicians working with nanomaterials. Offers comprehensive details on novel and emerging nanomaterials Presents a comprehensive view of new and emerging tactics for the synthesis of efficient nanomaterials Describes and monitors the functions of applications of new and emerging nanomaterials in the biomedical, environmental and energy fields
Download or read book Comprehensive Foodomics written by and published by Elsevier. This book was released on 2020-11-12 with total page 2444 pages. Available in PDF, EPUB and Kindle. Book excerpt: Comprehensive Foodomics, Three Volume Set offers a definitive collection of over 150 articles that provide researchers with innovative answers to crucial questions relating to food quality, safety and its vital and complex links to our health. Topics covered include transcriptomics, proteomics, metabolomics, genomics, green foodomics, epigenetics and noncoding RNA, food safety, food bioactivity and health, food quality and traceability, data treatment and systems biology. Logically structured into 10 focused sections, each article is authored by world leading scientists who cover the whole breadth of Omics and related technologies, including the latest advances and applications. By bringing all this information together in an easily navigable reference, food scientists and nutritionists in both academia and industry will find it the perfect, modern day compendium for frequent reference. List of sections and Section Editors: Genomics - Olivia McAuliffe, Dept of Food Biosciences, Moorepark, Fermoy, Co. Cork, Ireland Epigenetics & Noncoding RNA - Juan Cui, Department of Computer Science & Engineering, University of Nebraska-Lincoln, Lincoln, NE Transcriptomics - Robert Henry, Queensland Alliance for Agriculture and Food Innovation, The University of Queensland, St Lucia, Australia Proteomics - Jens Brockmeyer, Institute of Biochemistry and Technical Biochemistry, University Stuttgart, Germany Metabolomics - Philippe Schmitt-Kopplin, Research Unit Analytical BioGeoChemistry, Neuherberg, Germany Omics data treatment, System Biology and Foodomics - Carlos Leon Canseco, Visiting Professor, Biomedical Engineering, Universidad Carlos III de Madrid Green Foodomics - Elena Ibanez, Foodomics Lab, CIAL, CSIC, Madrid, Spain Food safety and Foodomics - Djuro Josic, Professor Medicine (Research) Warren Alpert Medical School, Brown University, Providence, RI, USA & Sandra Kraljevic Pavelic, University of Rijeka, Department of Biotechnology, Rijeka, Croatia Food Quality, Traceability and Foodomics - Daniel Cozzolino, Centre for Nutrition and Food Sciences, The University of Queensland, Queensland, Australia Food Bioactivity, Health and Foodomics - Miguel Herrero, Department of Bioactivity and Food Analysis, Foodomics Lab, CIAL, CSIC, Madrid, Spain Brings all relevant foodomics information together in one place, offering readers a ‘one-stop,’ comprehensive resource for access to a wealth of information Includes articles written by academics and practitioners from various fields and regions Provides an ideal resource for students, researchers and professionals who need to find relevant information quickly and easily Includes content from high quality authors from across the globe
Download or read book Laser Desorption Ionisation of Forensically Significant Samples An Investigation Into Low Mass Analysis written by Rachel West and published by . This book was released on 2021 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Forensically significant samples, such as drugs and propellants can be analysed using a range of standard techniques like Hight Performance Liquid Chromatography (HPLC) and Gas Chromatography Mass Spectrometry (GCMS). These methods can often be time-consuming, require complex sample preparation or extraction, with multiple steps and additional components. The drug samples investigated are those that have been inlaid in fibres, in this form to either mimic oral fluid based roadside drug tests or drug laden clothing and other fabrics used in smuggling cases. The analysis of these samples is important and can be complicated by the need for extraction of the analytes from the fibres and the possible destruction of evidence required to perform said analysis. -- Laser Desorption Ionization (LDI) techniques are an intriguing alternative to these standard techniques as they can perform high throughput analysis with little sample preparation and often generate simple spectra. LDI is highly sensitive and specific and is compatible with less stable sample-types. -- The initial issue for LDI analysis of drug samples was associated with low mass interference experienced when such low mass analytes encounter similar mass matrices. Several alternatives to traditional matrices were explored, and it was successfully overcome for on-plate and fibre-based analyses using a layer of gold nanomaterials which provided increased laser absorption without the low mass interference. -- LDI was also explored as a method of analysing complex propellant samples. Propellants contain several different species, which vary among manufacturers and as samples age. They often require multiple techniques for their analysis with different sample preparation techniques. LDI was compared to standard techniques as well as some more interesting alternatives, to successfully differentiate several diverse propellant samples.
Download or read book Bioactivity of Engineered Nanoparticles written by Bing Yan and published by Springer. This book was released on 2017-08-17 with total page 383 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book brings together reviews from international experts who are exploring the biological activities of nanomaterials for medical applications or to better understand nanotoxicity. Topics include but are not limited to the following: 1) mechanistic understanding of nanostructure-bioactivity relationships; 2) the regulation of nanoparticles’ bioactivity by means of chemical modification; 3) the new methodologies and standard methods used to assess nanoparticles’ bioactivity; 4) the mechanisms involved in nanoparticle-biomolecule interactions and nanoparticle-cell interactions; and 5) biomedical applications of nanotechnology. The book will be a valuable resource for a broad readership in various subfields of chemical science, engineering, biology, environment, and medicine.
Download or read book Biointeractions of Nanomaterials written by Vijaykumar B. Sutariya and published by CRC Press. This book was released on 2014-07-29 with total page 484 pages. Available in PDF, EPUB and Kindle. Book excerpt: An examination of the widespread application of nano materials in biology, medicine, and pharmaceuticals and the accompanying safety concerns, Bio-interactions of Nano Materials addresses the issues related to toxicity and safety of nano materials and nano systems. It covers the interactions in biological systems and presents various tools and methods used to evaluate the nano toxicity and nano safety issues. Written by leading scientists, the book focuses on the bio-interaction of nano materials, covering various techniques and tests which have been developed to evaluate the toxicity of materials at the nano level. The book highlights the challenges of bio-interactions of nano materials and possible solutions to those challenges. It addresses the assessment and characterization of nano systems in bio-environments, toxicity and bio-sensing devices for toxicity assessment, carbon nano tubes and pulmonary toxicity, and nano toxicity of solid lipid nanoparticles. It also discusses nano safety concerns and solutions, including the effects of nano particles on different organs and regulatory implications of nano materials. These particles may be used to encapsulate drugs, recognize biological markers, or visualize body tissues among many other possibilities, all enabling their widespread application in biology, medicine, and pharmaceutics. Indeed, these nano materials may have beneficial effects that have not even been imagined. This book gives you an understanding of the safety issues, how to assess for them, and how to mitigate them to move forward in research and development of new applications for nano materials.
